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Process Safety Management (PSM) is concerned with the safe handling of products, safe production of products and the safe operation of the process as confirmed by Thrower (2013). The Occupational Safety and Health Administration (OSHA) (2012) promulgated the PSM standard in 1992, which incorporated fourteen elements, to decrease the occurrence of process safety incidents. Walt and Frank (2007) described the cracks in the implementation of PSM programs, emanating from major process safety incidents and compliance audits. This was confirmed by the decaying process safety performance observed in recent years. It was thus proposed that an analysis into the diverse process safety incident causes and its comparison against the implemented OSHA PSM program, would suggest its associated shortcomings. The aim of the study was to determine the most effective approach to implement and sustain PSM in an organisation to prevent and manage the occurrence of major industrial catastrophes. A semi-qualitative study was conducted through the employment of a survey questionnaire and published incident investigation reports. A total of fifty random process safety incidents were interpreted from published and accredited secondary literature. Most of the secondary literature was obtained from the Health and Safety Executive (HSE) and Centre for Chemical Process Safety (CCPS) databases. From the study findings, Mechanical Integrity (MI) failures were found to significantly and consistently contribute to process safety incidents. Further analysis specifically concluded that equipment or control failure was the significant cause. Employee Participation (EP) was found to statistically correlate with the other elements. The researcher found that literature agreed with the aforementioned findings and this study verified that the EP element was instrumental in the implementation of the other elements. The researcher used literature to confirm that safety culture and leadership commitment was crucial to effective and sustainable PSM programs. The case study analysis validated this observation. Therefore the most effective approach to implement and sustain PSM was to adopt the DuPont, Centre for Chemical Process Safety (CCPS), Risk Based PSM framework or Energy Institute (EI) models. To conclude, this study was effective as all the objectives and the aim was achieved. / MIng (Development and Management Engineering), North-West University, Potchefstroom Campus, 2014

Doctor of Philosophy / Department of Counseling and Educational Psychology / Doris J. Carroll / This study investigated the differences in own behavior and perception of peer behavior among undergraduates among gender, age, race/ethnicity and major. The participants were part of a census of undergraduate students at a Midwestern land grant university. There were 2,759 useable responses to a survey using McCabe’s Academic Integrity Scale. The findings found significant differences between age and gender comparisons. Younger women reported the most behavior in academic dishonesty, and older women reported the lowest behavior in academic dishonesty. The race/ethnicity and major comparisons yielded no differences. Finally, the findings suggest the need for further systematic research on academic dishonesty.

Process Safety Management (PSM) is concerned with the safe handling of products, safe production of products and the safe operation of the process as confirmed by Thrower (2013). The Occupational Safety and Health Administration (OSHA) (2012) promulgated the PSM standard in 1992, which incorporated fourteen elements, to decrease the occurrence of process safety incidents. Walt and Frank (2007) described the cracks in the implementation of PSM programs, emanating from major process safety incidents and compliance audits. This was confirmed by the decaying process safety performance observed in recent years. It was thus proposed that an analysis into the diverse process safety incident causes and its comparison against the implemented OSHA PSM program, would suggest its associated shortcomings. The aim of the study was to determine the most effective approach to implement and sustain PSM in an organisation to prevent and manage the occurrence of major industrial catastrophes. A semi-qualitative study was conducted through the employment of a survey questionnaire and published incident investigation reports. A total of fifty random process safety incidents were interpreted from published and accredited secondary literature. Most of the secondary literature was obtained from the Health and Safety Executive (HSE) and Centre for Chemical Process Safety (CCPS) databases. From the study findings, Mechanical Integrity (MI) failures were found to significantly and consistently contribute to process safety incidents. Further analysis specifically concluded that equipment or control failure was the significant cause. Employee Participation (EP) was found to statistically correlate with the other elements. The researcher found that literature agreed with the aforementioned findings and this study verified that the EP element was instrumental in the implementation of the other elements. The researcher used literature to confirm that safety culture and leadership commitment was crucial to effective and sustainable PSM programs. The case study analysis validated this observation. Therefore the most effective approach to implement and sustain PSM was to adopt the DuPont, Centre for Chemical Process Safety (CCPS), Risk Based PSM framework or Energy Institute (EI) models. To conclude, this study was effective as all the objectives and the aim was achieved. / MIng (Development and Management Engineering), North-West University, Potchefstroom Campus, 2014

Linear genomes end in characteristic structures consisting of repetitive DNA and proteins: the telomeres. These play two critical roles: on one hand they avoid the of loss of genetic information due to the incomplete replication of the chromosome ends and on the other, they provide capping structures for chromosome termini, differentiating them from double strand breaks. Telomeres contain specialized proteins (the shelterin complex), as well as proteins present elsewhere on the chromosomes (chromatin remodelling, DNA damage repair and response factors). Interestingly, several DNA damage factors are required for proper telomere maintenance, drawing a thin line between telomere protection and their recognition as broken DNA ends. Loss of telomere integrity has severe consequences for the cell, namely it can induce replicative senescence and cellular aging, or it can contribute to tumorigenesis. How telomeres are capped and how they are perceived by the cell when they become dysfunctional is essential for our understanding of the contribution of loss of telomere integrity to aging and disease. In order to unravel new factors involved in telomere maintenance, siRNA screens were performed. The optimization process has confirmed both telomeric foci and telomere dysfunction-induced foci (TIFs) as suitable readouts and the screens performed generated a list of potential candidate genes involved in telomere biology. Although some of the candidate genes tested in this work failed the validation process, other genes deserve further analysis. In addition this work also studied the role of several DNA damage factors at uncapped telomeres. Furthermore, BRCA1, CtIP and EXO1 were found to be critical for the formation of end-to-end fusions generated after TRF2 inactivation. The requirement of this proteins in this process, suggests that not only that not only the classical non-homologous end joining (C-NHEJ) pathway is active at TRF2-depelted telomeres, but emphasises the multiplicity of mechanisms that act to repair dysfunctional telomeres.

Environmental restoration is emerging as a major driver in the repair and reversal of some of the world’s most severely degraded landscape systems, with growing interest in the status and composition of restoration efforts. Although much has already been written about the theory and practice of environmental restoration, both positive and negative, hitherto the literature has tended to overlook the complexity bound up in defining restoration discourses, and perhaps more importantly, the physical, material consequences instilled through such human choice. The mutability of discourses of environmental restoration means that it can be moulded and (re-)shaped by different actors and contexts, with different values and meanings attached to ‘nature’. There exist multiple and contested natures of environmental restoration - nature(s) both in the sense o f the properties of restoration, and also that which is restored to a site. In this doctoral thesis, I demonstrate how discourses of environmental restoration are defined and interpreted, which discourses (if any) appear to dominate, and how these are mobilised to produce ‘restored nature’. Attention is also awarded to the environmental implications incurred when such discourses are played out on the ground. The research is grounded empirically through reference to the case studies o f the Eden Project (Cornwall, UK), the National Forest Company (Derbyshire, UK), and the Walden Woods Project (Lincoln, MA) and their adoption of restoration practices. Analysing the processes and practices of environmental restoration within a framework of social nature and cultural landscapes serves to destabilise the dualism distancing nature from society - a preserve of environmental ethics and philosophy - for such synergy not only highlights how ideas of (restored) nature are socially constructed, but also addresses the material production of nature, reinforcing the interactions between natural and societal actors.

Information security is a complex issue, which is very critical for success of modern businesses. It can be implemented with the help of well-tested global standards and best practices. However, it has been studied that the human aspects of information security compliance pose significant challenge to its practitioners. There has been significant interest in the recent past on how human compliance to information security policy can be achieved in an organization. Various models have been proposed by these researchers. However, there are very few models that have tried to link human commitment attributes with information security governance of an organization. The research problem of this study was to identify the security controls and mechanisms to govern information security effectively. The proposed model was based on agency theory and comprises a relationship between human commitment variables (ethics, integrity and trust) with security governance variables (structural, relational and process) referred as systemic variables in the research. The resulting correlation is further related with governance objectives (goal congruence and reducing information asymmetry) to hypothesize an effective information security in an organization. The research model proposed was tested employing confirmatory factor analysis (CFA) and structural equation modeling (SEM). There were four models tested in this research. The first model (initial measurement model) comprised human variables linked with relational and the systemic variables linked with goal congruence and information asymmetry. This model could not get through the CFA tests. A modified model comprising human and systemic attributes related with goal congruence and information asymmetry, separately, was taken forward to SEM. This model returned low model fitment scores and hence two alternate models were tested. In the first alternative, the human attributes were related with goal congruence and systemic attributes were linked with information asymmetry. In the second alternative, the relationships of the first alternatives were retained and two alternate relationships were introduced - integrity was linked with information asymmetry and structural was linked with goal congruence. Both models are very close to good model fitment scores. However, the second alternative returned better results and hence, was chosen as the final outcome of the research. The model reflects that human attributes and systemic attributes are fairly independent in an effective information security framework, and drive goal congruence and information asymmetry, respectively. However, integrity is an important human commitment for ensuring information asymmetry and the right organizational structure and roles are important for ensuring goal congruence.

Al 7050-T7451 alloy with good combinations of strength, stress corrosion cracking resistance and toughness, is used broadly in the aerospace/aviation industry for fatigue-critical airframe structural components. However, it is also considered as a highly anisotropic alloy as the crack growth behavior along the short transverse direction is very different from the one in the long transverse direction, due to the inhomogeneous microstructure with the elongated grains distributed in the work material used in the sheet/plate applications. Further processes on these materials are needed to improve its mechanical and material properties and broaden its applications. The material with ultra-fine or nano grains exhibits improved wear and corrosion resistance, higher hardness and better fatigue life, compared to the one with coarse grains. In recent times, the development of novel processing technologies has gained great attention in the research community to enhance the properties of the materials employed in the aerospace, biomedical, precision instrument, automotive, nuclear/power industries. These novel processing technologies modify the microstructure of this alloy and improve the properties. The aim of this dissertation is to investigate the effects of cryogenic processes, including friction stir processing (FSP), machining and burnishing, on Al 7050-T7451 alloy to solve the inhomogeneity issue and improve its surface integrity. FSP is applied to modify the microstructure of Al 7050-T7451 alloy for achieving more homogeneous structure with near ultra-fine grains (UFG) which were less than 2 µm, particularly in cryogenic FSP with liquid nitrogen as the coolant. Approximately 10% increase could be observed from the hardness measurement from the samples processed by cryogenic FSP, in contrast to dry FSP. Also, the texture change from Al (200) to Al (111) could be achieved in all the samples processed by dry and cryogenic FSP. Cryogenic machining and burnishing processes were also applied to enhance the surface integrity of the manufactured components with near-UFG structure. The highest cutting temperature was reduced by up to 44.7% due to the rapid cooling effect of liquid nitrogen in cryogenic machining, compared with dry machining. Nano grains were produced in the refined layers induced by cryogenic burnishing. And, up to 35.4% hardness increase was obtained within the layer depth of 200 µm in the cryogenically-burnished surface. A numerical finite element method (FEM) model was developed for predicting the process performance in burnishing. Less than 10% difference between the experimental and predicted burnishing forces was achieved in the simulation of cryogenic burnishing, and reasonable predictions were also achieved for temperatures, severe plastic deformation (SPD) layers.

Effective power delivery in Double-sided 3-D glass interposer packages was proposed, investigated, and demonstrated towards achieving high logic-to-memory bandwidth. Such 3-D interposers enable a simpler alternative to direct 3-D stacking by providing low-loss, wide-I/O channels between the logic device on one side of the ultra-thin glass interposer and memory stack on the other side, eliminating the need for complex TSVs in the logic die. A simplified PDN design approach with power-ground planes was proposed to overcome resonance challenges from (a) added parasitic inductance in the lateral power delivery path from the printed wiring board (PWB), due to die placement on the bottom side of the interposer, and (b) the low-loss property of the glass substrate. Based on this approach, this dissertation developed three important suppression solutions using, (a) the 3-D interposer package configuration, (b) the selection of embedded and SMT-based decoupling capacitors, and (c) coaxial power-ground planes with TPVs. The self-impedance of the 3-D glass interposer PDN was simulated using electromagnetic solvers, including printed-wiring-board (PWB) and chip-level models. Two-metal and four-metal layer test vehicles were fabricated on 30-μm and 100-μm thick glass substrates using a panel-based double-side fabrication process, for potential lower cost and improved electrical performance. The PDN test structures were characterized upto 20 GHz, to demonstrate the measured verification of (a) 3-D glass interposer power delivery network and (b) resonance suppression. The data and analysis presented in this dissertation prove that the objectives of this research were met successfully, leading to the first demonstration of effective PDN design in ultra-thin (30-100μm), and 3-D double-sided glass BGA packages, by suppressing the PDN noise from mode resonances.