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Se realizó un estudio retrospectivo de casos y controles para evaluar los factores predictivos de eficacia del tratamiento combinado con interferón pegilado alfa (Peg IFN) y ribavirina (RBV) contra la hepatitis C crónica en un hospital de Lima Perú, años 2006-2011. Se incluyó 34 casos consecutivos de sujetos con Respuesta Virológica Sostenida (RVS) y 36 controles temporales sin RVS, entre quienes se determinó 16 variables epidemiológicas, clínicas y de tratamiento. Se utilizó el análisis univariado de regresión logística a través del programa estadístico Epi Info. Los hallazgos fueron: ninguno de los factores epidemiológicos, como edad, género, procedencia e ingesta alcohólica se relacionó con la RVS; de los factores clínicos evaluados, como: IMC, score Child-Pugh, índice MELD, transaminasemia y grado de fibrosis, solo el estadío Child A (OR=9,45; p<0,05) se relacionó con RVS; y de los factores de tratamiento, la carga viral ≤ 600 mil UI/mL (OR=2,68; p<0,05), la Respuesta Virológica Rápida (RVR; OR=58,4; p<0,01), y la Respuesta Virológica Precoz (RVP; OR=14,5; p<0,05) se asociaron con la RVS. En conclusión, los factores predictores de la RVS en los pacientes con terapia para VHC fueron: la enfermedad hepática compensada (Child-Pugh A), la RVP, y sobretodo, la RVR. Palabras Claves: Hepatitis C crónica (HCC), Virus de hepatitis C (VHC), Respuesta Virológica Sostenida (RVS). / --- We performed a retrospective study of cases and controls to assess predictors of efficacy of combination therapy with pegylated interferon alpha (Peg IFN-) and ribavirin (RBV) for hepatitis C infection in a hospital in Lima Peru, years 2006 2011. It included 34 consecutive cases of patients with Sustained Virological Response (SVR) and 36 controls without SVR, among whom was determined 16 variables epidemiological, clinical and treatment. We used univariate logistic regression analysis through statistical program Epi Info. The findings were: none of the epidemiological factors such as age, gender, origin and alcohol intake, were associated with SVR; clinical factors evaluated, as: BMI, Child-Pugh score, MELD index, transaminasemia and degree of fibrosis; only stage Child A (OR = 9,45; p <0.05) was associated with SVR, and treatment factors, the load viral ≤ 600 000 IU/mL (OR = 2,68; p <0.05), Rapid Virological Response (RVR; OR = 58.4; p <0.01), and Early Virological Response (EVR; OR = 14,5 ; p <0.05) were associated with SVR. In conclusion, predictors of SVR in patients with HCV therapy were: the compensated liver disease (Child-Pugh A), the RVP, and above all, the RVR. Keywords: Hepatitis C Chronic (HCC), Hepatitis C Virus (HCV), Sustained Virological Response (SVR).

Made available in DSpace on 2014-06-11T19:31:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-11Bitstream added on 2014-06-13T20:41:03Z : No. of bitstreams: 1 khalil_oak_dr_araiq_parcial.pdf: 122903 bytes, checksum: 87266cce24ee42f91603bd596a620467 (MD5) Bitstreams deleted on 2015-07-02T12:36:14Z: khalil_oak_dr_araiq_parcial.pdf,. Added 1 bitstream(s) on 2015-07-02T12:37:34Z : No. of bitstreams: 1 000690213_20400528.pdf: 122681 bytes, checksum: c32b117b1b8d8496aaf7f3e5de89fbf4 (MD5) / Universidade Estadual Paulista (UNESP) / O excesso na geração de espécies reativas como os radicais livres pode resultar num desequilíbrio que, embora benéfico em casos específicos como no combate a microrganismos patógenos, está implicado na etiologia de diversas patologias crônicas e com o envelhecimento precoce. Muitos pesquisadores indicam o uso de antioxidantes como potenciais para a prevenção destas patologias e inclusive, algumas pesquisas com antioxidantes como a curcumina estão em etapas finais do desenvolvimento de novos medicamentos. Embora atividades biológicas como a antimicrobiana e antioxidante sejam bastante exploradas para várias substâncias, há um grande potencial para a investigação em relação às atividades de duas ou mais substâncias associadas. O ácido ascórbico, por exemplo, possui algumas atividades biológicas semelhantes às da curcumina, entretanto seu uso e custo são mais acessíveis. Deste modo, há perspectivas para investigações sobre os efeitos resultantes da associação entre a curcumina e o ácido ascórbico em relação a algumas atividades biológicas, com destaque para a curcumina. Assim, este trabalho objetivou determinar os efeitos resultantes desta associação em relação ao perfil de atividades antimicrobiana, antioxidante, hemolítica e na estabilidade da curcumina. Foram utilizadas metodologias de análise de atividade antioxidante como os ensaios de ação scavenger do DPPH·, ABTS·+, O2 ·-, HOCl e também por análise do sistema oxidativo catalisado por peroxidase. Em relação às análises celulares e antimicrobianas, foi determinada a toxicidade sobre eritrócitos e a atividade em relação à Sthaphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans e Candida krusei. A estabilidade da curcumina foi determinada por espectrofotometria... / The excessive generation of reactive species such as free radicals can result in an imbalance which is implicated in the etiology of various chronic diseases and premature aging, although it is beneficial in specific cases, such as in against microbial pathogens. Many researchers suggest the antioxidants usage to prevent these diseases. Some researches about curcumin and others antioxidants are even in final stages of developing new medicines. Although some biological activities are fully explored for various substances, there is great potential of research about the activities of two or more associated substances. Ascorbic acid, for example, has some biological activities similar to those of curcumin, but its use and cost are more accessible. Thus, there are prospects for research on the effects of the association between these molecules, especially curcumin, in relation to some biological activities. This study aimed to determine the effects of this association on antioxidant, antimicrobial and hemolytic activities of curcumin. Since this association can prevent the oxidative degradation of curcumin, it was also aimed to analyze the effects of ascorbic acid on the curcumin stability. Antioxidant activities were evaluated through DPPH , ABTS +, O2 - and HOCl scavenging assays and guaiacol oxidation catalyzed by peroxidase. Regarding the cellular and microbial analysis, the toxicity was determined on erythrocytes and the antimicrobial activity was studied to Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Candida krusei. The stability of curcumin was determined spectrophotometrically. The combination resulted in a increase in antioxidant activity of curcumin against DPPH , ABTS + and HOCl. We were unable to determine the effect of the association against... (Complete abstract click electronic access below)

Diss. (sammanfattning) Örebro : Örebro universitet, 2009. / Härtill 4 uppsatser.

Thesis (M.A.)--Trinity International University, 2001. / Abstract. Includes bibliographical references (leaves 116-125).

Thesis (M.A.)--Briercrest Biblical Seminary, 2002. / Abstract. Includes bibliographical references (leaves 123-132).

The cost effectiveness of using novel HCV treatment option, telaprevir and boceprevir, should depend on patients’ respond to conventional PEG-INFα and ribavirin therapy. The study of pharmacogenomics, interleukin-28B (IL-28B) polymorphisms, accompanied with the information of HCV genotypes are suggested to have the strongest predictive value of treatment outcomes and prognosis of disease in individuals infected with HCV who are undergoing conventional PEG-INFα and ribavirin therapy. It is extremely valuable in HCV/HIV co-infected patients as these groups of patients require a complex treatment regimen and demonstrate poor sustained viral response (SVR) rate. The development of a fast and promising IL-28B genotyping assay is urgently needed. A total of 47 blood samples randomly selected from HCV and HIV co-infected patients were used in this investigation. The aims of this study are to evaluate and compare the performance of newly developed IL-28B HybProbe real-time PCR assay using LightCycler® system against Sanger Sequencing method in determining IL-28B polymorphisms on rs12979860 and rs8099917 and to estimate the prevalence of IL-28B polymorphisms among HCV/HIV co-infected patients in Hong Kong. In addition, the genotypic distribution of HCV among the same patient group is identified by using in-house Sanger Sequencing method. It was found that the newly developed IL-28B real-time HybProbe assay resulted in 100% concordance with the traditionally used Sanger Sequencing method. The allele frequencies of C and T were 96% and 4% in rs12979860 and T and G were 97% and 3% in rs8099917 respectively. The CC and TT wild type are predominating in rs12979860 and rs8099917 with frequencies of 93.62% and 95.74% respectively. The most favorable compound genotype CC/TT with both homozygous wild types on both SNPs was the most predominant type with a high prevalence of 93.61%. Among all the samples, 50% samples were found to be HCV genotype 1, 41.18% were genotype 6 and 8.82% were genotype 3. A simple and efficient IL-28B real-time HybProbe assay was developed in this study and proved to show excellent performance on IL-28B genotyping although further optimization is suggested before it can be applied in the clinical setting. The favourable wild type genotypes of rs12979860 and rs8099917 accounted for the most predominant genotypes which is similar to other findings obtained from an Asian population. A comparatively high prevalence of HCV genotype 6 was found in the HCV/HIV co-infected group. Future study with the information of treatment outcomes (HCV viral load) can further evaluate the predictive value of IL-28B polymorphisms on SVR in different HCV genotypes. / published_or_final_version / Medical Sciences / Master / Master of Medical Sciences

One of the more formidable challenges in the synthesis of complex organic molecules remains the efficient formation of carbon-carbon bonds. The development of a broad class of reactions to achieve this goal involves the addition of carbon based nucleophiles to carbonyl and imine compounds. Until recently, classical approaches to carbon-carbon bond formation generally required the use of stoichiometric pre-formed organometallic reagents to serve as nucleophiles, which translate into stoichiometric organometallic byproducts. In an effort to minimize nucleophile pre-activation and byproduct formation, our lab has developed efficient methods for carbonyl and imine additions via in situ formation of alkyl metal nucleophiles from π-unsaturates. The research reported herein describes our advances in an assortment of transition metal-catalyzed carbon-carbon bond forming reactions mediated by transfer hydrogenation, including regioselective hydrohydroxymethylation, hydrohydroxyfluoroalkylation, and hydroaminomethylation. Additionally, the investigation of regioselective carbonyl vinylation is reported. / text

Šiame darbe yra apžvelgta programavimo kalbų istorija ir jų raida, pradedant nuo pačios pirmosios programos ir pirmosios programuotojos ir baigiant šiuolaikinėmis programavimo kalbomis. Taip pat apžvelgiama programavimo kalbų filosofija ir jų populiarumas šiuo metu, analizuojamos programų populiarumo pasikeitimo tendencijos. Taip pat yra atlikti anketiniai ir eksperimentiniai tyrimai, parodantys programavimo kalbų populiarumą mokyklose, pateikti mokinių gebėjimų įvertinimai mokinantis skirtingas programavimo kalbas. Mokyklinio kurso lygmenyje išanalizuotos informacinių technologijų valstybiniame brandos egzamine naudojamos programavimo kalbos, jų struktūra, sintaksė ir galimybės. / This paper is an overview of the history of programming languages ​​and their evolution, starting from the first program and the first programmer and ending with modern programming languages. It also provides an overview of the programming language and the philosophy of their popularity this time, the popularity of the programs analyzed the change in trend. There are also carried out the survey and experimental studies demonstrating the popularity of programming languages ​​in schools, give students skills assessments in teaching different programming languages. School-level course analysis of information technology in the public examination of maturity used programming languages, their structure, syntax and options.

Thesis (M.S.)--Indiana University, 2005. / Includes bibliographical references. Also available online (PDF file) by a subscription to the set or by purchasing the individual file.