Wilfrid Sellars has made familiar a distinction between manifest and scientific images of man-in-the-world. The manifest image is 'a sophistication and refinement of the image in terms of which man first came to be aware of himself as man-in-the-world' ([2], p.18)/ and in its methodology 'limits itself to what correlational techniques can tell us about perceptible and introspectible events' (p.19). The scientific image, on the other hand, 'postulates imperceptible objects and events for the purpose of explaining correlations among perceptibles.' (ib.) This thesis is centred on a consideration of two difficulties facing anyone who takes the manifest image seriously as an autonomous image of man. In chapter 1 I consider the connection between perception and its objects, and argue that there is a disharmony between the manifest and scientific accounts of this connection. But I also suggest that the manifest image, which incorporates a certain Cartesianism or internalism, cannot lightly be dispensed with in our understanding of the nature of experience. Chapter 2 is a companion piece to chapter 1: in it I argue that the manifest view of experience accords a certain metaphysical priority to secondary over primary qualities in the constitution of any world capable of being experienced; I also suggest that the scientific image is dependent on the manifest image/ and so cannot subvert it. In chapter 3 I turn to the other main area of difficulty: freedom. I argue that free will as the incompatibilist contrues it is constitutive of the time-order; but that it carries with it implicit internal contradictions. The conflict here lies within the manifest image; the scientific image discerns no such freedom/ and so incurs no such problems. But if I am right that freedom constitutes time/ it will not be an option for us to disembarrass ourselves of the contradictions. I also argue that there is a relation of mutual dependence between freedom/ incompatibilistically construed/ and internalism. The manifest image as a whole - deeply problematic as it is - is therefore grounded in and entailed by something quite ineluctable/ namely the reality of the time-series. This is the principal conclusion of the thesis. If I succeed here/ I provide support for the claim that our difficulties with the manifest image cannot be solved by abandoning it: the manifest image/ problems and all/ must just be lived with. The remainder of the thesis explores topics related to this main thrust. Chapter 4 is really an appendix to chapter 3; it shows how no parallel difficulties attend the constitution of experiential space/ because space is (unlike time) not transcendental. In chapter 5 I examine the commitments of the notion of the transcendental self/ whose existence was deduced in chapter 3 as a condition of freedom. In particular, I aim to show how that self inherits some of the difficulties of its parent concept of freedom; but also how a distinction between transcendental and empirical components in the self can help us with the problem of privacy.

可信度是網路服務首要解決的問題，我們從數位憑證，認證、授權、委任授權等安全層面去研究代理者可信度，並提出一套完整可信度規則分類機制當作信任度判斷的依據。在此篇論文中，我們論證如何將規則概念應用在代理者的溝通協定、服務流程控制上。我們並同時整合語意網規則和本體論的技術，以達到可信的網路服務環境。 / Trust is one of the most important issues for Web Services. We studied the agent trust problem based on security technologies, such as digital certificates, authentication, authorization, and delegation, etc. Furthermore, we propose a complete trust rule taxonomy mechanism to assistant us on the evaluation of agent trustworthiness. In this thesis, we justify the feasibility of using rule concepts on the agent communication protocol and service process control. We also demonstrated how to integrate the semantic web rules and ontologies to have a trusted web services environment.

<p>The company Kiviks Musteri AB produces a pear base wine that forms stable foam, which is problematic from a production perspective. The aim of this thesis was to investigate the factors underlying foam stability in the pear base wine and to find means for its reduction. This was done by foam testing wines and varying several variables, such as the fining agents normally used in the wine production (bentonite, gelatin, siliceous earth and activated carbon), enzyme treatment, and by changing the fermenting yeast species.</p><p>Results: The wine started to form stable foam during fermentation, and foam stability could be reduced by using more bentonite and carbon during the fining process. The other fining agents appeared to have only limited impact on foaming characteristics. No pectin was present according to the pectin test, but protein bands were evident from SDS PAGE analysis, though absent in samples treated with increased doses of bentonite.</p><p>In conclusion, pectin is not a major foaming agent in the wine, the yeast is most likely the producer of the foaming agents, carbon and bentonite have a reducing effect on foam stability, bentonite also reduces protein content. Proteins are likely to be involved in the foam stabilization but are not the sole contributors to stable foam.</p>

No description available.

Angiogenesis is a fundamental driver of tumor biology and many other important aspect of human health. Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) has been shown to be a valuable biomarker for the indirect assessment of angiogenesis. However, DCE-MRI is very specialized technique that has limitations. In this dissertation new models and contrast agents to address some of these limitations are presented. Chapter 1 presents an introduction to DCE-MRI, the rationale to asses tumor biology with this technique, the MRI pulses sequences and the standard pharmacokinetic modeling used for the analysis of DCE- MRI data. Chapter 2 describes the application of DCE-MRI to asses the response to the hypoxia-activated drug TH-302. It is shown that DCE-MRI can detect a response after only 24 hours of initiating therapy. In Chapter 3, a new model for the analysis of DCE-MRI is presented, the so-called Linear Reference Region Model (LRRM). This new model improves upon existing models and it was demonstrated that it is ~620 faster than current algorithms and 5 times less sensitive to noise, and more importantly less sensitive to temporal resolution which enables the analysis of DCE-MRI data obtained in the clinical setting, which opens a new area of study in clinical MRI. Chapter 4 describes the extension of the LRRM to estimate the absolute permeability of two fluorinated contrast agents; we call this approach the Reference Agent Model (RAM). In order to make this new model an experimental reality, a novel pulse sequence and contrast agents (CA) for ¹⁹F MRI were developed. Two contributions to the field of DCE-MRI are presented in this chapter, the first simultaneous ¹⁹F-DCE-MRI detection of two fluorinated CA in a mouse model of breast cancer, and the estimation of their relative permeability. RAM eliminates some of the physiological variables that affect DCE-MRI, which may improve its sensitivity and specificity. Finally, new potential applications of LRRM and RAM are discussed in Chapter 5.

No description available.

No description available.

In the recent years, the concept of “port community” has been adopted by the maritime transport industry in order to achieve a higher degree of coordination and cooperation amongst organizations involved in the transfer of goods through the port area. The business processes of the port community supply chain form a complicated process which involves several process steps, multiple actors, and numerous information exchanges. One of the widely used applications of ICT in ports is the Port Community System (PCS) which is implemented in ports in order to reduce paperwork and to facilitate the information flow related to port operations and cargo clearance. However, existing PCSs are limited in functionalities that facilitate the management and coordination of material, financial, and information flows within the port community supply chain. This research programme addresses the use of agent technology to introduce business process management functionalities, which are vital for port communities, aiming to the enhancement of the performance of the port community supply chain. The investigation begins with an examination of the current state in view of the business perspective and the technical perspective. The business perspective focuses on understanding the nature of the port community, its main characteristics, and its problems. Accordingly, a number of requirements are identified as essential amendments to information systems in seaports. On the other hand, the technical perspective focuses on technologies that are convenient for solving problems in business process management within port communities. The research focuses on three technologies; the workflow technology, agent technology, and service orientation. An analysis of information systems across port communities enables an examination of the current PCSs with regard to their coordination and workflow management capabilities. The most important finding of this analysis is that the performance of the business processes, and in particular the performance of the port community supply chain, is not in the scope of the examined PCSs. Accordingly, the Agent-Based Middleware for Port Community Management (ABMPCM) is proposed as an approach for providing essential functionalities that would facilitate collaborative planning and business process management. As a core component of the ABMPCM, the Collaborative Planning Facility (CPF) is described in further details. A CPF prototype has been developed as an agent-based system for the domain of inland transport of containers to demonstrate its practical effectiveness. To evaluate the practical application of the CPF, a simulation environment is introduced in order to facilitate the evaluation process. The research started with the definition of a multi-agent simulation framework for port community supply chain. Then, a prototype has been implemented and employed for the evaluation of the CPF. The results of the simulation experiments demonstrate that our agent-based approach effectively enhances the performance of business process in the port community.

Research report: Faculty of Health Sciences / ABSTRACT Labour induction in an underresourced environment poses a tremendous challenge. While labour induction is a common obstetric procedure, it poses potential hazards for mother and fetus. This is largely dependent on method and agent used and can be expensive on limited resources because of high purchase prices, refrigerated storage, monitoring equipment and manpower. Misoprostol is a unique anti-ulcer agent that has good properties as an induction agent, but as yet not fully evaluated. It is relatively cheap, easily available, simple to store and has a long shelf life, and would amount to considerable cost saving in an underresourced setting if it were proven to be effective and safe for induction of labour. A simple reliable method of administration and appropriate dosage regimen of misoprostol for the purposes of induction of labour is needed. This study was undertaken in two phases; Part A. The clinical trial where an oral misoprostol suspension was given in a stepwise manner for the induction of labour alone or in combination with an inexpensive mechanical method (Foley catheter bulb) is compared with the “standard” method of induction i.e. dinoprostone 2 mg gel in a randomized controlled trial. Altogether 750 patients (250 in each arm) were recruited. Part B. (a) In vitro study to verify if misoprostol has a direct stimulatory effect on gut smooth muscle similar to sihlambezo.1 There is an increase in the incidence of meconium stained liquor in women who have taken sihlambezo or castor oil and misoprostol.2 It is postulated that misoprostol crosses the placenta and stimulates foetal bowel activity directly rather than as a result of asphyxia caused by excessive uterine contractions due to misoprostol. Strips of rat uterine and intestinal smooth muscle were mounted on a strain gauge with a chart recorder in a physiological bath as was done in the Pharmacology department for the original sihlambezo studies. The model was perfused with doubling concentrations of each test substance, and the concentration noted at which the first uterine muscle and the first bowel muscle activity was detected. The test substances were: #1; prostaglandin E2 (Dinoprostone) #1; oxytocin (Syntocinon) #1; misoprostol freshly dissolved in water #1; misoprostol freshly dissolved in a weak hydrochloric acid solution to approximate stomach content pH #1; misoprostol dissolved in water and stored for 2 hours, 6 hours, 24 hours and 1 year. For each substance, the ratio between the minimum stimulatory concentration for uterine to bowel smooth muscle was calculated, and these ratios compared between substances. The absolute minimum stimulatory concentrations were compared between the different misoprostol preparations to determine the effects of storage and acidification. (b) In vitro study to find out if misoprostol dissolved in water is stable and over what duration of time. This has practical importance, because if it is unstable, it may imply that a fresh sample has to be prepared each time the induction agent is given, and this may be several times per patient per induction. This would escalate the cost of the drug, especially in an underresourced setting such as ours, and would mean more manpower i.e. nursing staff, would be required for each case of induction. We also wanted to establish if acidification of the preparation would affect misoprostol stability as was implied to happen when misoprostol is given vaginally3. References 1 Mitri F, Hofmeyr GJ, van Gelderen CJ. Meconium during labor, self medication and other associations. S Afr Med J 1987: 71: 431-433. 2 Hofmeyr GJ, Gulmezoglu AM. Vaginal misoprostol for cervical ripening and labor induction in late pregnancy (Cochrane Review). In: The Cochrane Library, Issue 3, 1999. Oxford: Update Software. 3 Gunalp S, Bildirici I. The effect of vaginal pH on the efficacy of vaginal misoprostol for induction of labour. Acta Obstet Gynaecol Scand 2000; 79(4): 283-5.

Mobile agents require an appropriate platform that can facilitate their migration and execution. In particular, the design and implementation of such a system must balance several factors that will ensure that its constituent agents are executed without problems. Besides the basic requirements of migration and execution, an agent system must also provide mechanisms to ensure the security and survivability of an agent when it migrates between hosts. In addition, the system should be simple enough to facilitate its widespread use across large scale networks (i.e Internet). To address these issues, this thesis discusses the design and implementation of the Distributed Agent Delivery System (DADS). The DADS provides a de-coupled design that separates agent acceptance from agent execution. Using functional modules, the DADS provides services ranging from language execution and security to fault-tolerance and compression. Modules allow the administrator(s) of hosts to declare, at run-time, the services that they want to provide. Since each administrative domain is different, the DADS provides a platform that can be adapted to exchange heterogeneous blends of agents across large scale networks.