The objective of this project was to develop a physically realistic method for predicting the flowrates in short tubes. A physically realistic model, though based on tests with one refrigerant, could be extrapolated to other refrigerants and to other refrigeration systems. Most of the existing methods of predicting flowrates are achieved by doing a lot of experimental work and developing empirical or semi-empirical relations; because of the high degree of empiricism they are only valid for the refrigerant used in the experiment. Eliminating material constraints and high degrees of empiricism from the prediction model was considered as a matter of utmost importance. A critical flow model was developed based on a vapor generation model. The model is built on the observation that choked short tube flow consist of a liquid core and a vapor annulus. Only three empirical factors were used, two to account for the assumptions made in the model development and the other to account for the area reduction due to vena contracta. The critical flow model predicted CFC and HCFC flow data with a maximum error of 13%. It failed in predicting flow data on water. / Master of Science

Master of Science

Pressurized metered-dose inhalers (pMDIs) are the most widely-prescribed inhaler devices for therapeutic aerosol delivery in the treatment of lung diseases. In spite of its undoubted therapeutic and commercial success, the propellant flow mechanics and aerosol formation by the pMDIs is poorly understood. The process involves a complex transient cavitating turbulent fluid that flashes into rapidly evaporating droplets, but details remain elusive, partly due to the difficulty of performing experiments at the small length scales and short time scales. The objective of the current work is the development of a numerical model to predict the internal flow conditions (pressure, temperature, velocity, void fraction, quality, etc.) and provide deeper insight into the atomization process and fluid mechanics involved in the twin-orifice of pMDIs. The main focus is propellant metastability, which has been identified by several past authors as a key element that is missing in accounts of pMDI performance. First the flashing propellant flow through single orifice systems (both long and short capillary tubes) was investigated using three different models : homogeneous equilibrium model (HEM), delayed equilibrium model (DEM) and improved delayed equilibrium model (IDEM). Both, the pure propellants and the propellant mixtures were used as working fluid. The numerical results were compared with the experimental data. For long capillary tubes the three models gave reasonable predictions, but the present results showed that DEM predicts the mass flow rate well for pure propellants and IDEM predicts the mass flow rate well for propellant mixtures. For short capillary tubes, the present results showed that DEM predicts the mass flow rate and pressure distribution along the short tube better compared to HEM and IDEM. The geometry of the twin-orifice system of a pMDI is complex and involves several singularities (sudden enlargements and sudden contractions). Various assumptions were made to evaluate their effect on the vaporisation process and to evaluate the flow variables after the shock at the exit of the spray orifice when the flow is choked. Also, three different propellant flow regimes were explored at the inlet of the valve orifice. A specific combination of assumptions, which offers good agreement with the experimental data was selected for further computations. Numerical investigations were carried out using delayed equilibrium model (DEM) with these new assumptions to validate the two-phase metastable flow through twin-orifice systems with continuous flows of various propellants studied previously by Fletcher (1975) and Clark (1991). A new correlation was developed for the coefficient in the relaxation equation. Along with this correlation a constant coefficient was used in the relaxation equation to model the metastability. Both the coefficients showed good agreement against the Fletcher's experimental data. The comparison with the Clark s experimental data showed that the new correlation coefficient predicted the mass flow rate well in compare to that of the constant coefficient, but over predicted the expansion chamber pressure. The DEM with both the coefficients for continuous discharge flows were applied to investigate the quasi-steady flashing flow inside the metered discharge flows at various time instants. The DEM results were compared with the Clark s metered discharge experimental data and the well established homogeneous equilibrium model (HEM). The comparison between the HEM and DEM with Clark s (1991) experimental data showed that the DEM predicted the mass flow well in compare to that of HEM. Moreover, both the models underpredicted the expansion chamber pressure and temperature. The findings of the present thesis have given a better understanding of the role played by the propellant metastability inside the twin-orifice system of pMDIs. Also, these have provided detailed knowledge of thermodynamic state, void fraction and critical velocity of the propellant at the spray orifice exit, which are essential step towards the development of improved atomisation models. Improved understanding of the fluid mechanics of pMDIs will contribute to the development of next-generation pMDI devices with higher treatment efficacy, capable of delivering a wider range of therapeutic agents including novel therapies based around.

Ce travail de thèse porte sur l'élaboration de tubes souples pour cosmétiques, à partir de matériaux issus des agro-ressources. Les tubes commerciaux, actuellement en PE, possèdent des propriétés mécaniques adéquates et une perméabilité à la vapeur d'eau faible. Cette dernière étant plus importante pour les polymères issus des agro-ressources, elle en limite le développement. Cependant, l'ajout d'argile nanométrique est une solution de choix pour réduire la perméabilité d'une matrice polymère.Des nanocomposites PLA/PBS/argile et PHA/PBS/argile ont ainsi été étudiés. Deux argiles, la Dellite® 67G (D67G) et la Cloisite® 30B (Cl30B), qui différent de part leur modifiant organique, ont été utilisées. Les nanocomposites ont été élaborés par mélange à l'état fondu dans une extrudeuse bivis de laboratoire. Les analyses en DRX couplées à la rhéologie ont montré une structure partiellement intercalée/exfoliée pour tous les nanocomposites. Le niveau d'exfoliation augmente avec le taux de Cl30B mais présente un optimum avec la D67G. Le module d'Young augmente avec le taux d'argile et la présence de gros agrégats résiduels d'argile est à l'origine d'un comportement cassant pour des hauts taux de charges. Même si l'ajout de Cl30B a diminué significativement les perméabilités des différents mélanges (jusqu'à 50 %), leur perméabilité à la vapeur d'eau est toujours supérieure à celle du PE. Un test de vieillissement accéléré (spécifique aux tubes en PE) réalisé sur des tubes remplis de crème a montré une perte de masse du contenu des tubes agro-ressourcés (au minimum 16 %) largement supérieure à celles des tubes en PE (< 1 %). / This PhD thesis deals with the elaboration of flexible tubes for cosmetics, made from agro-resources. Nowadays, flexible tubes for cosmetic applications are made with PE for its good mechanical properties and its very low water vapor permeability. What can limit the development of polyesters made from agro-resources in the packaging area is precisely their bad water vapor barrier properties. Now incorporating nanoclays in a polymer matrix is one of the most promising techniques to decrease the permeability of the matrix.Then PLA/PBS/clay and PHA/PBS/clay were studied. Two organoclays, with two different organic modifiers, were used: the Dellite® 67G (D67G) and the Cloisite® 30B (Cl30B). The nanocomposites were prepared by melt mixing in a laboratory scale twin screw extruder. XRD and rheological measurements indicated a mixed partial intercalated and exfoliated structure. The exfoliation level was shown to increase with Cl30B content but had an optimum using D67G. The Young's modulus increased when increasing clay content and the presence of residual large clay aggregates leads to brittle blends for the high clay content. Even if the incorporation of Cl30B enhances significantly the water vapor barrier properties of PLA/PBS and PHA/PLA blends (up to 50%), it could not yet concurrence PE. An accelerated ageing test (specific for PE tubes) on our tubes filled with cream showed very important weight loss (16%) compared to the PE tubes (<1%).

Both VEGF and its receptor proteins were localized by immunostaining technique in the luminal epithelium, smooth muscle cells and blood vessels within the oviduct. Moreover, by means of semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) techniques, it has been demonstrated that mRNA of VEGF and its receptors in both healthy and diseased oviduct is expressed preferentially at the time and place where the amount of oviduct fluid is prominent. This supports the notion that VEGF may be a regulator of oviductal secretion. This thesis has consistently demonstrated a modulation pattern of flt-1 expression that is similar to its ligand VEGF in both physiological and pathological conditions. This suggests that flt-1 may be the main receptor responsible for the action of VEGF in the oviduct. As illustrated in both the in-vivo and in-vitro models, the expression of VEGF and flt-1 in the human oviduct is stimulated directly by gonadotropins without the influence of ovarian sex hormones. / Increased knowledge on the regulatory mechanisms of oviductal fluid formation, the first environment that human embryos are exposed to, will be valuable from the clinical management point of view. / Oviductal fluid is a complex mixture of plasma-derived constituents and proteins synthesized by the oviduct epithelium. It has been postulated that vascular endothelial growth factor (VEGF), a known permeability promoter, may be an important regulator of oviductal fluid secretion by stimulating vascular permeability and so serum transudation. However, little is known about the expression of VEGF in the human oviduct. This thesis investigated the modulation of VEGF and its receptors (flt-1 and KDR) in the healthy oviducts, from fertile women undergoing tubal sterilization for unwanted fertility or hysterectomy for benign gynecological conditions, as well as in the hydrosalpinges from sterile women undergoing salpingectomy before the treatment of in-vitro fertilization and embryo transfer. / Lam Po Mui. / Adviser: Christopher J. Haines. / Source: Dissertation Abstracts International, Volume: 73-01, Section: B, page: . / Thesis (M.D.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (leaves 147-179). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [201-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.

An introduction to the fundamental concepts of X-ray physics and X-ray tube design is given. This discussion also includes a brief description of various X-ray tube types available commercially for a number of different industrial applications. The design of a high-energy MgO cold cathode X-ray tube, which is to be used in an X-ray fluorescence (XRF) spectrometer, is described in detail with emphasis placed on the electron beam focusing mechanism and the theory of operation as well as the construction of the X-ray tube MgO cold cathode, which functioned as the electron emitter of the device. A detailed account is also given of the output characteristics of the X-ray tube power supply, which has a direct effect on the design requirements and consequently the performance of the X-ray tube. An investigation into the manufacture of the vacuum envelope with particular attention focused on the production of reliable metal-to-ceramic seals was performed. A number of tests were conducted especially with regard to the maximum temperature that such seals may withstand without becoming permanently damaged. These tests were essential, since high temperature gradients tend to develop in an X-ray tube during operation, which the metal-to-cerarnic seals of the tube must be capable of withstanding if damage to the device is to be avoided. The set-up of the XRF spectrometer in which the completed X-ray tube was tested is discussed, in which the X-ray current and voltage measuring techniques are described. Furthermore a detailed account of the operation of the X-ray detector system and the multichannel analyser is given, which was used to detect and record spectra of the sample elements excited by the primary radiation of the X-ray tube. Finally the measured X-ray tube performance characteristics are discussed and compared to the predicted results. / Thesis (M.Sc.Eng.)-University of Natal, Durban, 2000.

<p>The lightweight and good strength of oriented thermoplastic tubes, produced through the ram extrusion process, renders this class of material advantageous from an automotive structural part forming perspective. An analytical model, capable of predicting the forming limits for these materials at elevated temperatures, would avoid the need for difficult and time-consuming tube forming experiments.</p> <p> The uniaxial tensile stress-strain properties of the oriented polypropylene (OPP) tubes along the axial and hoop direction wene determined while methods were developed for obtaining the uniaxial compressive properties of the tube. The uniaxial and biaxial testing of the OPP tubes enabled representation of the experimental plastic work contours for the material at a range of temperatures. The use of the pressure-modified Hill criterion, the concept of plastic work contours in stress space, and the stress strain data from uniaxial testing of the tube allowed accurate prediction of the plastic work contours for the OPP tubes as a function of temperature. The analytical prediction was able to capture the anisotropy, pressure dependency and anisotropic hardening exhibited by the material at elevated temperatures. In addition, the use of a localized necking criterion, which involved the point at which the maximum force along the hoop direction of the tube was reached, allowed the temperature dependent forming limits for the material to be predicted. The forming limits increased with temperature for all of the strain paths considered. In addition, at a given temperature, the forming limits decreased with increasing strain ratio. The limiting strains achieved with axial end feeding were markedly higher than those in which no axial end feeding was used. </p> <p> Good agreement was observed between the predicted forming limits and the results from tube forming tests of the material, along a range of strain paths and at various temperatures.</p> / Thesis / Doctor of Philosophy (PhD)

Vortex Tube (VT) is a simple device having no moving mechanical parts, in which compressed gas at high pressure is injected through one or more tangential nozzles into a vortex chamber resulting in the separation of the inlet flow into two low pressure streams. One of the streams is the peripheral flow that is warmer than the inlet stream while the other is the central (core) flow that is colder than the inlet stream. This separation of the inlet flow into high and low temperature streams is known as temperature or energy separation. It is suggested by many investigators that compressed air of few atmospheres pressure and at room temperature can produce temperatures as high as +200ºC at the hot end (peripheral flow exit) and as low as -50ºC at the cold end (core flow exit) of the VT. Though VTs have large potential for simple heating and cooling applications, the mechanism of energy separation is not clear so far. Based on their studies, many investigators have suggested various theories, different from each other, but having specific lacunas and is an unresolved issue. Also, till date, experimental and industrial designs of the VTs are based purely on empirical correlations. Apart from heating and cooling applications, VTs can also be used for separation of binary gas mixtures and separation of oxygen from two-phase precooled air stream. The conceptual futuristic cryogenic launch vehicle designs are being attempted with in-flight liquid oxygen (LOX) collection system that significantly improves the pay load fraction. Vortex tube technology is one of the few promising technologies for futuristic in-flight LOX separation based launch vehicles. This technology has significant advantages over its counterparts as it is a simple, compact and light weight, and most importantly have no moving parts and unaffected by gravity and orientation. In order that VTs become an acceptable technology for in-flight LOX separation system, it is necessary to achieve minimum oxygen purity of 90% with more than 60% yield (separation efficiency) for the oxygen enriched stream in the VT. A survey of the available open literature has shown very little reported details, in particular, on achieving the required specifications for in-flight LOX separation systems. Till date, the highest LOX purity of 60% with 40% separation efficiency has been reported with VT technology. In view of the above mentioned facts, the work carried out has been focused on to: • Optimize the critical parameters of the VT to achieve maximum energy separation by CFD and experimental studies. • Understand the flow behaviour in the VT by estimating the velocity, temperature and pressure profiles at various locations in the VT and validation of secondary circulation flow and its effect on the performance of energy separation in VT. • Estimation of the energy transfer between the core and the peripheral layers of fluid flow in VT by analytical and CFD methods to propose the most appropriate mechanism of energy separation in VT. • Design and development of a dedicated experimental setup for both energy separation and LOX separation studies in VTs. • Design and fabrication of straight and conical VTs and experimental programme on energy separation and LOX separation. • Development of the VT air separation technology to achieve the required specifications of in-flight LOX separation system for futuristic launch vehicles. With these specific objectives and motivations, the total work was carried out with the following planned and sequential steps: • The first step was the CFD modeling of the VT with the available CFD software (Star-CD) and obtain the energy separation phenomena for a 12mm diameter VT. After gaining sufficient confidence level, optimization of the critical parameters like the air injection nozzle profile, number of nozzles, cold end orifice diameter dc, length to diameter (L/D) ratio, hot gas fraction etc of the VT was carried out through CFD and experimental studies. • The studies show that 6 convergent nozzles perform better in comparison to other configurations like circular helical, rectangular helical, 2 convergent and 6 straight nozzles. The studies also show that cold end orifice diameter (dc) plays an important role on energy separation and bring out the existence of secondary circulation flow with improper design of cold end orifice diameter. Through our studies, the effect of cold end diameter on the secondary circulation flow has been evaluated for the first time. Also, the mechanism of energy transfer in VT based on heat pump mechanism enabled by secondary circulation flow as suggested by some investigators has been evaluated in our studies. The studies show that cold end orifice diameter dc = 7mm is optimum for 12mm diameter VT, which matches fairly with the correlations given by other investigators. The studies confirms that CFD modeling carried out in this work is capable of selecting the correct dc value for a VT, without resorting to the empirical correlations as a design guide or a laborious experimental programme. • Through the CFD and experimental studies on different length to diameter (L/D) ratios and hot gas fractions, maximum hot gas temperature of 391K was obtained for L/D = 30 with hot gas fraction of 12-15 % and minimum cold gas temperature of 267K for L/D = 35 was obtained for cold gas fraction ≈ 60% (lowest cold gas fraction possible with the present experimental system). • CFD analysis has been carried out to investigate the variation of static and total temperatures, static and total pressures as well as the velocity components of the particles as it progresses in the flow field, starting from the entry through the nozzles to the exit of the VT by tracking the particles to understand the flow phenomenon and energy transfer mechanism inside the VT. The studies indicate that the mechanism of energy transfer from the core flow to the peripheral flow in VT is predominantly occurs by the tangential shear work. Thus the investigations reported in the thesis have given a clear understanding of the contributing mechanism for energy separation in VT, which has been an unresolved issue for long time. The net energy transfer between the core and the peripheral fluid has been calculated analytically and compared with the values obtained by CFD model for VTs of L/D ratios equal to 10 and 30. The net energy transfer by analytical and CFD model for VT with L/D = 10 is 159.87W and 154.2W respectively whereas the net energy transfer by analytical and CFD model for VT with L/D = 30 is 199.87W and 192.3W respectively. The results show that CFD results are in very good agreement with the analytical results and CFD can be used as a tool for optimization of the critical parameters and to analyze the flow parameters and heat transfer analysis for VTs. Also, the net energy transfer between the core and peripheral fluids calculated analytically matches very well with that of the net energy transfer by CFD analysis, without considering the effect of acoustic streaming. Thus acoustic streaming may not be the mechanism of energy separation in VT as suggested by some investigators. • By optimizing the critical parameters of the 12mm diameter straight VT through CFD and experimental studies, LOX separation studies have been carried out using both straight and conical VTs of dc = 7mm and of different L/D ratios for high LOX purity and separation efficiency. It is observed that conical (3º divergence) VTs perform better as compared to straight VTs for LOX separation whereas straight VTs perform better for energy separation. The better performance of conical VT as compared to straight VTs can be attributed to its increased surface area for condensation-evaporation phenomenon of oxygen and nitrogen molecules. Experimental studies have been conducted to evaluate the influence of the inlet pressure and the inlet temperature (liquid fraction) on LOX purity. Studies indicate that for achieving high LOX purity for the studied experimental system, the inlet pressure is to be in the range of 6-6.5bar and there exists a very narrow band of inlet temperature zone in which high LOX purity can be achieved. Experimental studies on VTs show that VT can be optimized suitably either for high LOX purity with low separation efficiency or low LOX purity with high separation efficiency by adjusting the hot end mass fraction accordingly. It is also observed that it is not possible to obtain both high purity and high separation efficiency simultaneously with the single VT. Staging approach has to be adapted to achieve higher LOX purity with higher separation efficiency. By staging the VTs, the enriched air stream (hot end outlet flow) from the first stage of VTs is introduced to the inlet of the second stage of VTs. Experimental studies have been conducted to evaluate the design parameters on staging of VTs. LOX purity of 48% with 89% separation efficiency has been achieved for conical first stage VT of L/D = 25. LOX purity of about 94% with separation efficiency of 84% has been achieved for 50% oxygen content at the inlet of the second stage VT. Similarly, LOX purity of 96% with separation efficiency of 73.5% has been achieved for 60% oxygen content at the inlet of the VT. This is the highest LOX purity and separation efficiency reported so far indicating that, conical VT of optimized diameter, L/D ratio and orifice diameter can yield the hot end flow very close to the target value of futuristic in-flight LOX separation based launch vehicles. The present investigation has focused the optimization of the critical parameters of VTs through CFD and experimental studies. It has also given an insight to the mechanism of energy transfer between the core and peripheral flow in VT by evaluating two of the existing theories on mechanism of energy transfer in VT. The studies also highlighted the fact that custom designed and precision fabricated VTs can be very useful for obtaining maximum / minimum temperatures of fluid flow as well as LOX separation with high purity and high separation efficiency needed for futuristic in-flight LOX separation based space launch vehicles.

Corrosion of steel reinforcement causes continual degradation to the worldwide infrastructures and it has prompted the need for challenges to those involved with reinforced concrete structures. Recently, the use of fibre-reinforced polymers (FRP) tubes as structurally integrated stay-in-place forms for concrete members, such as beams, columns, bridge piers, piles and fender piles has emerged as an innovative solution to the corrosion problem. In such integrated systems, the FRP tubes may act as a permanent form, often as a protective jacket for concrete, and especially as external reinforcement in the primary and secondary directions such as for confinement. Furthermore, the use of concrete-filled FRP tubes (CFFT) technique is predicated on performance attributes linked to their high strength-to-weight ratios, expand the service life of structures, enhance corrosion resistance, and potentially high durability. This dissertation evaluates the axial and flexural performances of reinforced CFFT through experimental and analytical investigations. The details description and the findings of the investigations are presented through seven articles. To fulfill the objectives of this research, an experimental program has been designed including pure compression tests (33 specimens), axial-eccentric load tests (4 specimens) and pure flexure tests (10 specimens). Experimental investigations of the behaviour of CFFT have generally been carried out without using internal longitudinal reinforcement. The CFFT system of this study consists basically of filament-wound glass FRP tubes filled with concrete and reinforced internally with steel or FRP bars. Five types of new FRP tubes have been used with different thicknesses and two different diameters, 152 and 213 mm. Pure compression tests have been conducted on 40 specimens with a total height ranging from 305 mm to 1520 mm. One of the main objectives of testing these specimens is to evaluate the design equations of the North American codes and design guidelines to predict the ultimate load capacities of reinforced and unreinforced short CFFT columns. In addition, the effect of three parameters and their interactions on the buckling behaviour were investigated for these specimens; namely, the FRP tube thickness, concrete compressive strength, and slenderness ratio. The effect of eccentric load on the behaviour of four CFFT specimens of diameters 152mm and long 912mm, has been evaluated using four different eccentricity values (15, 30, 45 and 60 mm). Based on the finding of experimental and theoretical investigation for the CFFT columns, a new confinement model is proposed for the confined concrete compressive strength of the CFFT cylinders. Also, the design equations are modified to accurately predict the ultimate and yield loads capacities of internally reinforced and unreinforced short CFFT columns. In addition, the theoretical analysis was utilized to correlate the slenderness ratio of the CFFT columns to various material characteristics and geometric properties of the FRP tubes and concrete. It was found that a slenderness ratio of 12 gave a safe value for the design purposes. However a more precise formula for the slenderness ratio was proposed to control the buckling mode of failure. Pure flexural tests have been conducted on 10 RCFFT and RC beams of a total length 2000 mm with constant diameter 213 mm. The test variables were the type of internal reinforcements (steel or GFRP bars), the FRP tube thickness, concrete compressive strength and the type of transverse reinforcements (spiral steel or FRP tubes). The influence of the considered variables on the flexural behaviour of the tested RCFFT beams is presented. A simplified analytical method is developed to predict the yield and resisting moments corresponding to the failure modes of the tested RCFFT beams. The analysis was conducted according to the equations derived from linear elastic analysis. This analysis was found to be acceptable for predicting the ultimate and yield moments capacities of the FRP or steel-RCFFT beams. In addition, an analytical investigation to examine the validity of the available design provisions for predicting the load-deflection response of CFFT is conducted. The effective moments of inertia of the tested beams are analyzed using the different available code, manuals and design guidelines equations. The results of the analysis are compared with the experimental values. It has been found that the predicted tension stiffening for steel or FRP-RCFFT beams using the conventional equations (steel or FRP-RC member) is underestimated and hence the predicted deflections are overestimated. Based on the experimental data obtained in this study, new proposed equations and a modified expression for the effective moment of inertia of a simply supported CFFT beams reinforced with steel or GFRP bars are introduced.

The folding station is one step of the packing process taking place in the metal tube filling machines. The purpose of this project is to develop and design a folding station for metal tubes. With this aim, a product design process has been created and as a result of the application of a deductive method, ten concepts have been discovered and the most suitable one has been developed later on.