Background: Heart failure and diabetes are common coexisting diseases. Elevated levels of glucose in the blood caused by insulin resistance can damage blood vessels and nerves, and eventually lead to heart disease. A poor diet and obesity can also contribute to the progression of diabetes and heart disease. Objective: The purpose of this study was to determine if diet and lifestyle factors between adult heart failure patients with and without diabetes who are participating in the EducatioN, and Supportive Partners Improving Self-CaRE (ENSPIRE) study are associated with comorbidities such as diabetes, and if so then how current dietary recommendations in this population should be modified based on diabetes status. Methods: Using data collected from the EducatioN and Supportive Partners Improving Self-CaRE (ENSPIRE) study from 2006 to 2009 which was a prospective, randomized, controlled clinical trial, a secondary data analysis was conducted. Daily dietary intake of calories, sodium, carbohydrate, fat, sugar, and fiber was assessed via a 3-day food record. Differences in anthropometric measures, smoking history, education level and health literacy score between the two groups were also assessed. 117 heart failure patients were included in the analysis. Of these, 39% had diabetes. Statistical analysis: Statistical analyses included the t-test, Chi-square analysis, and Mann Whitney U test used to compare anthropometric data, lifestyle factors, and disease states. Results: Weight was higher in heart failure patients with vs. without diabetes (104.9 vs. 92.6 kg, respectively; P Conclusion: Weight was significantly higher in heart failure patients with diabetes and they consumed fewer carbohydrates than their non-diabetic counterparts. We recommend encouraging these individuals to closely monitor their macronutrient intake, specifically limiting fat in the diet. Meeting with a dietitian to ensure adequate nutrient intake is strongly recommended.

There has been a lack of information and research as to the reasons students did not graduate from high school with a diploma, or GED certificate, or certificate of completion, even though they were given the opportunity to attend an alternative drop-out or credit recovery program. This study identified the reasons why some students failed to complete an alternative education program in a K-12 school district in Texas. Of the 29 former PACE students failing to graduate with either a diploma or GED certificate that participated in this research, a little less than half either quit the program or were administratively dropped because they felt that earning money from their job was more important than graduating from high school. Each of the others had this excuse as well as many other excuses for not graduating. Three inter-locking conclusions were reached by the researcher after interviewing 29 of the students that did not complete the PACE program. The first conclusion was that students did not understand the value of a high school diploma at the time they were attending PACE. The second was that money, even in the form of a minimum wage job, was more important than an education. The final conclusion was that each student did not have a plan for their life beyond the coming evening or weekend. All students that failed to graduate or earn a GED had at least one of these misconceptions, while most had two, and a few had all three.

According to the American Heart Association, there are currently 5 million Americans diagnosed with congestive heart failure and that number is steadily increasing (AHA, 2003). The alarming problem of congestive heart failure and other related medical complications has created a need for devices that not only assist the heart but also help the heart to grow and remodel back to its normal configuration. Currently, there are several direct cardiac compression devices (DCCDs) that do assist the heart, however, they do not help the heart to grow and remodel correctly. Dr. John C. Criscione of Texas A&M University has proposed a novel DCCD, in which the compression of the device reinforces the natural curvature of the heart, helping it to grow and remodel correctly. It is hypothesized that with the support of the device, the cells of the heart will be stimulated to grow and remodel back to their normal size and return to their proper function. Two key components necessary to the novel DCCD were designed and constructed for this study. The first component was an adjustable outer shell which enabled the device to become smaller as the failing heart returned to normal size. The second component was an inflatable inner membrane that applies direct pressure to the outer wall of the heart in a way that promotes physiological stress and strain patterns.

Thesis (Ph. D.)--Florida State University, 2003. / Advisor: Daniel R. Boroto, Florida State University, College of Arts and Sciences, Department of Psychology. Title and description from dissertation home page (viewed Apr. 8, 2004). Includes bibliographical references.

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Cardiovascular disease (CVD) is the leading cause of death in the United States. Oxidative stress plays an important role in the pathogenesis of CVD. Heart failure is the end point of many forms of CVD. The purpose of this study is to identify novel cardiac specific indicators of oxidative injury useful for early and convenient diagnosis of heart failure.To determine the most suitable method for identification of non-invasive oxidative injury indicators in general, human diploid fibroblasts (HDFs) were treated with H2O2 for collection of mRNA, cell lysates and conditioned media to perform cDNA microarray and LC-MS/MS based Multidimensional Protein Identification Technology (MudPIT) analyses. Electron Spray Ionization (ESI)-LC-MS/MS analysis of the conditioned media led to the finding of IGFBP-6 as a non-invasive biomarker of cell oxidative injuy in vitro and in vivo. The data obtained from this study indicate that proteomic analysis of conditioned media is useful to identify non-invasive biomarkers valuable for diagnosis or management of diseases.Cardiomyocyts (CMCs) and Cardiac fibroblasts (CFs) in culture were used to identify cardiac specific indicators of oxidative stress. Increased level of Cystatin C was detected in the conditioned medium of CMCs due to H2O2 treatment. In vivo models of oxidative stress were used to validate the increase of Cystatin C. Cystatin C levels increased in the plasma of mice with doxorubicin induced cardiomyopathy and coronary artery occlusion induced myocardial infarction (MI). These data indicate that Cystatin C can be a potential indicator of CMC oxidative injury in vitro and in vivo.Cystatin C is a cysteine protease inhibitor. The finding that oxidative stress induces Cystatin C led us to investigate a novel pathway regulating cardiac extracellular matrix (ECM) with CFs in culture, increased levels of ECM protein and decreased levels of Cathepsin B (CTB) protein and activity were detected upon Cystatin C treatment. With coronary artery occlusion induced MI mouse model, increased levels of Cystatin C and ECM protein and decreased levels of CTB protein and activity were detected in the infarcted area of the myocardium. These data indicate that Cystatin C serves as a potential fibrotic factor during myocardial remodeling.

Two studies tested a theory of how trait self-esteem moderates behavioral and cognitive persistence in the face of failure. Three primary hypotheses were examined. First, that high self-esteem (HSE) individuals persist more than low self-esteem (LSE) individuals when their initial attempts to reach a goal fail, but subsequent or repeated failures lead HSE individuals to reduce behavioral persistence and pursue goal alternatives more quickly than LSE individuals. Second, that when no goal alternatives are available, HSE individuals behaviorally persist more than LSE individuals. Third, despite reductions in behavioral persistence, LSE individuals do not "give up" on the failed goal but continue to persist cognitively, in the form of aversive ruminations about the failed goal. In a factorial experiment, persistence was examined as a function of self-esteem, degree of failure, and the availability of goal alternatives. As hypothesized, HSE participants behaviorally persisted more than LSE participants after a single failure, but less after repeated failure. However, selfesteem differences in behavioral persistence did not emerge when goal alternatives were unavailable. Partial support was received for the hypothesis that LSE individuals engage in more ruminative persistence than HSE individuals-LSE participants showed higher levels of ruminative persistence on one of two measures of ruminative persistence. The findings regarding behavioral persistence were conceptually replicated, and the hypothesis regarding ruminative persistence received stronger support, in a longitudinal field study in which HSE and LSE participants initially listed their goals and reported on their behavioral and ruminative persistence regarding these goals 5 months later. HSE participants exhibited better calibration between perceptions of goal failure and behavioral pursuit than LSE participants, indicating that increasing perceptions of goal failure were associated with reductions in behavioral pursuit more for HSE than LSE participants. Although they reduced behavioral pursuit relative to HSE participants, LSE participants continued to persist cognitively, by ruminating about their goals more than HSE participants. Discussion focuses on the need to revise traditional views of HSE individuals that emphasize their tenacious persistence and views of LSE individuals that emphasize their tendency to give up in the face of failure.

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