京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第19921号 / 理博第4221号 / 新制||理||1606(附属図書館) / 33007 / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 友永 雅己, 准教授 後藤 幸織, 教授 平井 啓久 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

With use of deuterium-labeled isotopes of RRR-and all-rac-α-tocopheryl acetate, the transport of vitamin E in pregnancy was evaluated to determine whether the placenta discriminates between these compounds. Fifteen pregnant subjects were recruited 5 d before delivery to receive 15, 30, 75, 150, or 300 mg vitamin E/d in capsules containing d3-RRR-α-tocopheryl acetate and d6-all-rac-α-tocopheryl acetate (1:1, by wt). Maternal blood was obtained before dosing, at hospital admission, and at parturition. Cord blood samples were obtained at parturition. Deuterium-labeled and unlabeled tocopherol contents were determined by gas chromatography-mass spectrometry in plasma and lipoproteins (chylomicrons, VLDL, LDL, and HDL). Maternal plasma and lipoproteins obtained at delivery had higher concentrations of d3-RRR-α- tocopherol than d6-all-rac-α-tocopherol regardless of the vitamin E dose administered (P < 0.05). Cord plasma at delivery also had higher concentrations of d3-RRR-α-tocopherol than d6-all-rac-α-tocopherol in plasma irrespective of the dose administered (P < 0.05). In lipoproteins isolated from cord blood, tocopherol concentrations were greatest in the HDL fraction (P < 0.05), whereas in maternal blood they were greatest in the LDL fraction (P < 0.05). We conclude that the placental-fetal unit, the fetal liver, or both further discriminate between RRR- and all-rac-α-tocopherol.

Participants demonstrate the Stroop effect when, in naming the color in which a word appears, reaction times are longer when the color and word are incongruent (e.g., "yellow" printed in blue) compared to when they are congruent (e.g., "yellow" printed in yellow). The literature commonly refers to the difference in reaction times as a measure of the interference of word stimuli upon color stimuli, and is taken as support for the theory of automaticity. This study asks whether the Stroop effect can be analyzed as interactions within and across stimulus classes. Adult participants learned three 3-member classes (color, word, and pattern) in a serialized order of training. In the testing phase, participants were presented with compound stimuli formed from combinations of members within and across classes (e.g., word and color), and reaction times were recorded in similar fashion to the Stroop task. Results show that averaged participants' reaction times are faster to compound stimuli comprised of members within the same class, compared to compound stimuli formed with members from different classes. These group-level data are consistent with the Stroop literature in that congruent compounds produce faster reaction times relative to incongruent compounds. However, individual participant data do not consistently reflect the Stroop effect. Further considerations for future research in this area are discussed.

Successful architecture is an engagement of space that fosters learning and growth. It is the space in which we are drawn away from the distractions around us, allowing us to focus on the present. It offers the opportunity to not only learn and grow relationships, but also to rehabilitate broken and fractured ones. Through this learning and growth, we become better understanding and loving toward each other. Thus, architecture stands as a true mediator of the relationships that exist around the world. Architecture is not exclusive toward human to human engagement. Architecture can extend beyond the understanding of human and engage many species such as canines. This thesis proposes to investigate a cross-species architecture serving to rehabilitate broken and fractured interspecies relationships. Focusing on one of the strongest human-interspecies relationships to exist, this thesis will conduct research-based design on the human and dog relationship. Although the human and dog relationship are one of the stronger cross-species relationships, there remains complex and fractured components. For example, in many aspects across homeless and stray dogs, the human and dog relationship has vii become one that is extremely broken and fractured. This thesis proposes to take an in depth look at the historical context and the present human-canine relationship and understanding how architecture can be used to grow the relationship. In allowing cross-species architecture to act the mediator in rehabilitating the fractured components of the human and dog relationship, the level of learning and growth within the human and dog relationship can reach new heights.

BACKGROUND: A social media campaign for mothers aimed at reducing indoor tanning (IT) by adolescent daughters reduced mothers' permissiveness toward IT in an immediate posttest. Whether the effects persisted at 6 months after the campaign remains to be determined. METHODS: Mothers (N = 869) of daughters ages 14-17 in 34 states without bans on IT by minors were enrolled in a randomized trial. All mothers received an adolescent health campaign over 12 months with posts on preventing IT (intervention) or prescription drug misuse (control). Mothers completed a follow-up at 18 months post-randomization measuring IT permissiveness, attitudes, intentions, communication, and behavior, and support for state bans. Daughters (n = 469; 54.0%) just completed baseline and follow-up surveys. RESULTS: Structural equation modeling showed that intervention-group mothers were less permissive of IT by daughters [unstandardized coefficient, -0.17; 95% confidence interval (CI), -0.31 to -0.03], had greater self-efficacy to refuse daughter's IT requests (0.17; 95% CI, 0.06-0.29) and lower IT intentions themselves (-0.18; 95% CI, -0.35 to -0.01), and were more supportive of bans on IT by minors (0.23; 95% CI, 0.02-0.43) than control-group mothers. Intervention-group daughters expressed less positive IT attitudes than controls (-0.16; 95% CI, 0.31 to -0.01). CONCLUSIONS: The social media campaign may have had a persisting effect of convincing mothers to withhold permission for daughters to indoor tan for 6 months after its conclusion. Reduced IT intentions and increased support for bans on IT by minors also persisted among mothers. IMPACT: Social media may increase support among mothers to place more restrictions on IT by minors.

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In 2013, a bunch of us ran around collecting paper surveys off chairs after a plenary address at the Collaborative Family Healthcare Association's (CFHA) annual conference. From 150 responses, we found that less than a quarter would take the time to attend a workshop about research and evaluation. Fast forward 5 years: The organization showed robust attendance at research and evaluation training sessions, and interest in a preconference had risen to 77%. What prompted this shift? In response to survey findings, the Research and Evaluation Committee (REC), supported by the CFHA, engaged a data-informed and stakeholder-responsive approach to cultivating empiricism within the CFHA. The activities led by the REC demonstrate the need for creativity and leadership in this area and the CFHA's strong. organizational values around such efforts. As past and present leaders in the CFHA's REC initiatives, we write this editorial to make explicit the value of research to the organization and the value of the organization to the evidence base. In addition, we document some key institutional history in this area and, with input from the CFHA's current chief executive officer, Neftali Serrano, and REC chair, Will Lusenhop, forecast a vision for the future. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

What is the Primary Care Behavioral Health (PCBH) model of service delivery? Clinician innovators, administrators, and researchers have continued to refine the answer to this question. In the same way a recipe for mac n cheese provides the resources needed (i.e., ingredients), processes to make the dish, and expected outcomes (e.g., number of servings), a comprehensive operational definition for PCBH is needed to help improve the rigor of research being conducted. This recipe can also help clinicians/administrators identify a basic recipe for PCBH that standardizes the necessary components and amounts to achieve the expected outcomes. In this editorial, we provide a comprehensive operational recipe for PCBH based on current research. We are calling people to assist us by (a) utilizing the recipe to help improve the reporting and rigor of PCBH research and (b) applying the proposed operational definitions and targets within the recipe to help us refine and validate them. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Esophageal and biliary stents are indwelling devices used in the treatment of selected gastrointestinal and biliary disorders. Stenting is accepted as a standard procedure for palliation of malignant obstruction of the esophagus and biliary system. Review of the early and late complications associated with these devices is made with emphasis on the clinical and radiographic features. A suggested approach to diagnosis and treatment recommendations are made for each complication that the emergency department physician may encounter.

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