Abstract Image The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The new compounds are potent DNA alkylators and have antitumor activity independent of the O6-methylguanine-DNA methyltransferase and DNA mismatch repair constraints that limit the use of Temozolomide.

There has been no real attempt to explore the contribution and effectiveness of inspection as a catalyst for change and improving service provision. In England the Government is currently reviewing the way that one regulatory body, the Commission for Social Care Inspection (CSCI), operates and carries out its inspection functions in relation to care homes for older people. This article reports on a study carried out in 2004 that asked managers of care homes for older people about their views and experiences of inspection and ways to improve the process. The findings endorse inspection as a necessary intervention. Managers identified that the main purposes of inspection were: to ensure the well-being of residents; to achieve or comply with standards; to check that the home was running properly and to act as a double check against the homes own audits. The two most useful aspects of inspection were as a means of providing feedback and as support and guidance to managers. The expertise of the inspector needs to be better deployed to drive up standards of care and maximise their influence to promote an improvement in services and innovation in practice.

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The book provides critical perspectives that reach beyond the technical approaches of international financial institutions and proponents of the liberal peace formula. It investigates political economies characterized by the legacies of disruption to production and exchange, by population displacement, poverty, and by 'criminality'.

The Bode-Fano integral can be used as an objective tool for assessing the bandwidth of antennas, and especially schemes for bandwidth improvement. Results for U-slot and E-slot dual resonant patch antennas suggest that the Fano integral is invariantly related to the overall volume. The Bode-Fano and Youla theories of broadband matching have been applied to the narrowband and wideband lumped equivalent circuit of microstrip antennas to calculate the maximum achievable return loss-bandwidth product of linearly polarized microstrip antennas. Curves are presented showing the relation between the antenna bandwidth, maximum achievable return loss, and parameters of the equivalent circuit. It has been shown that creating parallel slots on the patch despite all potential advantages, may reduce the potential bandwidth of patch antennas.

No / Perceived time is inherently malleable. For example, adaptation to relatively long or short sensory events leads to a repulsive aftereffect such that subsequent events appear to be contracted or expanded (duration adaptation). Perceived visual duration can also be distorted via concurrent presentation of discrepant auditory durations (multisensory integration). The neural loci of both distortions remain unknown. In the current study we use a psychophysical approach to establish their relative positioning within the sensory processing hierarchy. We show that audiovisual integration induces marked distortions of perceived visual duration. We proceed to use these distorted durations as visual adapting stimuli yet find subsequent visual duration aftereffects to be consistent with physical rather than perceived visual duration. Conversely, the concurrent presentation of adapted auditory durations with nonadapted visual durations results in multisensory integration patterns consistent with perceived, rather than physical, auditory duration. These results demonstrate that recent sensory history modifies human duration perception prior to the combination of temporal information across sensory modalities and provides support for adaptation mechanisms mediated by duration selective neurons situated in early areas of the visual and auditory nervous system (Aubie, Sayegh, & Faure, 2012; Duysens, Schaafsma, & Orban, 1996; Leary, Edwards, & Rose, 2008). / Wellcome Trust (WT85315 & WT097387), and The Federation of Ophthalmic and Dispensing Opticians

Magíster en Ciencias, Mención Geofísica / El terremoto de Iquique ocurrió el 1 de Abril de 2014 en la zona norte de Chile, donde no se ha producido un evento de magnitud mayor a 8.5 desde el megaterremoto de 1877. El terremoto Mw 8.1 de Iquique 2014 fue precedido por una fuerte actividad precursora, la cual mostró su máximo de actividad el 16 de Marzo con un sismo superficial de magnitud Mw 6.7. Posteriormente, entre los meses de Abril y Julio de 2014, se observaron más de 3000 réplicas con diversas profundidades y mecanismos focales, que ocurrieron tanto en el contacto sismogénico como en la placa Sudamericana, indicando la complejidad de la secuencia sísmica. El norte de Chile presenta una buena cobertura con estaciones sismológicas instaladas por el Centro Sismológico Nacional (CSN) y la red de colaboración internacional IPOC. Con los datos registrados producto de los sismos de Iquique es posible estudiar la distribución espacial de la sismicidad registrada, así como analizar y comprender la relación entre el proceso de ruptura de un gran terremoto y la sismotectónica de la zona. Para cumplir con este objetivo se localizaron 210 eventos del catálogo del CSN, con magnitud local mayor o igual a 4.5, observados entre los meses de Marzo y Julio de 2014, y luego a través de la inversión del tensor de momento sísmico se obtuvo la solución de mecanismo focal para un subconjunto de 150 sismos. A partir del catálogo de mecanismos focales obtenidos se clasificó la sismicidad observada, identificando eventos de tipo inverso, normales y algunos con mecanismos focales atípicos para la zona de estudio. Estos se clasifican, además, en sismos de contacto interplaca e intraplaca superficiales. Luego, se discutió la naturaleza de la sismicidad de contacto de tipo inversa registrada en las cercanías de la fosa, identificando eventos de alto dip, los que se podrían asociar a la subducción de altos batimétricos de la placa de Nazca. Por otra parte, la generación eventos de tipo normal, se puede asociar al outer rise previo a la subducción de la placa de Nazca, mientras que los sismos atípicos y superficiales son generados, probablemente, por la transferencia de esfuerzos del proceso de subducción hacia la placa Sudamericana. Por último, se analizó la distribución en torno al acoplamiento intersísmico y al deslizamiento cosísmico generado por el terremoto de Iquique de 2014. Se observó como los eventos, posteriores al terremoto de Iquique, rodearon una zona de bajo acoplamiento que podría estar deslizando asísmicamente, y además se concentraron en el límite Oeste del área con mayor deslizamiento cosísmico, mostrando un comportamiento similar a lo observado en otros terremotos de subducción.

Entity linking (EL) is the task to disambiguate entity names from text by linking them to a specific entity in a knowledge base (KB). While more and more features are exploited to help the task, document context, as the most important hint, is currently handled using traditional Bag-of-Words methods. These traditional methods have limitations in handling ambiguity and logical relationship of vocabulary terms. / We propose a new context model for EL that makes use of ontology structure to handle ambiguity and logical relationship of document context. We also decompose the semantic meaning of entities and use a different ontology for each semantic dimension. This model benefits from: 1) sensitivity to ambiguous terms; 2) sub-concept relationship captured by the ontology structure and; 3) precise representation of semantic information by the multiple dimension design. The new model yields significantly better performance over existing methods from the experiments. / 實體鏈接是為文本中的本體名稱鏈接一個在知識庫內的實體，以消除歧義。雖然有越來越多的特徵項被提出及採用，當中最重要的上下文資訊卻一直透過經典的詞語包方法來運用。這頖經典方法在處理歧義和詞彙的邏輯關係方面存在一定限制。 / 為此我們提出一個新的用於實體鏈接的上下文模型。它運用本體結構來處理上下文中的歧義和邏輯關係，更把實體的語意分拆，並使用不同的本體來分別處理不同語意方向。此模型的優勢來自以下幾點︰一、對帶歧義詞項的感受性；二、通過本體結構妥善利用子概念關係；三、被分拆在不同語意方向讓語意可得到更精確的處理。實驗證實，使用此模型取代現有方法能顯著地提升實體鏈接表現。 / Chung, On Yip. / Thesis M.Phil. Chinese University of Hong Kong 2014. / Includes bibliographical references (leaves 77-79). / Abstracts also in Chinese. / Title from PDF title page (viewed on 18, October, 2016). / Detailed summary in vernacular field only. / Detailed summary in vernacular field only.

Ce projet de recherche de type exploratoire étudie le rôle du réseau social dans la trajectoire thérapeutique des adolescents aux prises avec des difficultés liées à leur consommation d’alcool ou de drogues. Il s’intéresse à l’influence du réseau social sur la demande d’aide et sur la persévérance en traitement. Ce rôle est exploré par 1) l’analyse secondaire de données collectées au sein du projet intitulé Évaluation des mécanismes d’accès jeunesse en toxicomanie (Tremblay et al., 2014) et 2) l’analyse de données recueillies spécifiquement pour cette étude. Au total neuf adolescents ayant fait une demande d’aide auprès d’un Centre de réadaptation en dépendance participant au projet ont été rencontrés en entrevues semi-structurées. Les analyses qualitatives du matériel collecté suggèrent que les membres significatifs du réseau social ont un rôle sur la trajectoire thérapeutique des adolescents au sein des services spécialisés en dépendance. Leurs impacts peuvent être positifs ou négatifs.

Le présent mémoire s’intéresse à l’intégration sociale et économique des femmes immigrantes en région éloignée et examine plus précisément le cas de Rouyn-Noranda. Ses objectifs sont de 1) mieux comprendre le processus d’intégration sociale et économique des femmes immigrantes à Rouyn-Noranda et 2) analyser les facteurs qui favorisent, et ceux qui nuisent, à l’intégration sociale et économique de ces femmes. Pour ce faire, des entrevues semi-structurées ont été réalisées auprès de treize femmes immigrantes venues d'Amérique latine, d'ailleurs en Amérique du Nord, d'Afrique et d’Europe. Cette étude qualitative, de nature exploratoire, repose sur le modèle interculturel systémique. Le discours des femmes interviewées montre, que les principaux obstacles liés à l’intégration sociale et économique en région éloignée passent par des barrières linguistiques, la non-reconnaissance des diplômes ou des acquis, le manque de formations universitaires adaptées aux femmes et l’impact des conditions hivernales de la région sur la santé psychologique des femmes. / The present study examines the social and economic integration of immigrant women inRouyn-Noranda, a remote city in the province of Quebec, Canada. Two specific objectives were pursued:1) to understand the social and economic integration process of immigrant women living in Rouyn-Noranda, and 2) to analyze the positive and negative factors that influence their integration. In order to achieve these objectives, semi-structured interviews were conducted with thirteen female participants who had immigrated from Latin America, North America, Africa, and Europe. This exploratory, qualitative study draws on the intercultural model. The findings show that participants mentioned linguistic barriers, non-recognition of education and experience gained abroad, lack of higher training adapted to women’s realities, and psychological health impact (frustration, depression and stress) of local winter conditions as the main obstacles to their social and economic integration.