D.Cur. / The nurses who work in the hospitals are constantly in interaction with the patients. As the HIV infection has now reached the AIDS phase, most people who were infected five to ten years back are now sick due to HIV/AIDS compromised conditions. The statistics inform us that mostly young people are dying. This has reversed nature, in that elders are now burying the youth. The HIV/AIDS infected people who are ill are admitted to general hospitals for health care. At present the patients are cared for in the general wards with other patients who may not be HIV/AIDS infected. In the hospitals they are cared for by the health team, of which the nurses are with these patients for 24 hours a day. This study focused on the interaction between nurses and admitted patients who are HIV/AIDS positive. The patients may have been admitted due to opportunistic diseases or any other illnesses. Most patients with HIV/AIDS suffer from opportunistic diseases, pain and stress. Nurses become aware of the patient’s HIV/AIDS status for health care reasons. Nurses are in most institutions the first contact in health care. Therefore the nurses are engaged in established relationships with patient, families, friends and the community for the purpose of the provision of health care services. These relationships entail interaction. The interaction between the nurse and the patients plays a major role in the care of the patient. This interaction between the nurses and patients entails a number of aspects, such as communication, be it verbal or non-verbal. The latter includes behavioural and affective aspects, such as attitudes, the way care is provided and how the parties feel about the interaction. Nursing is a human interaction. In this interaction the nurse and the patient build a therapeutic relationship, resulting in assistance to facilitate the wellbeing of the patient and rapid recovery. The HIV /Aids infection affects the patient as a whole because of the stigma attached to the disease, therefore the affected patients need to be assisted in order to cope with the illness and its consequences. Therefore the purpose of the study was to: • To explore and describe the nurses’ and patients’ (who are HIV AIDS infected) experience of their interaction. • To develop and describe a model that would assist the nurses to facilitate the promotion of mental health in patients who are HIV/AIDS infected. A theory generation research which is qualitative, descriptive and explorative and contextual in nature was conducted with permission from the Department of Health authorities, hospital authorities, admitted patients with HIV/AIDS, the NGO that looks after the patients in the community after discharge, the nurses who work in the general wards and the University of Johannesburg Ethical and Research committee. Pilot interviews were conducted with one nurse-participant and patientparticipant that met the selection criteria.

Magister Artium - MA / Refugees are not a new phenomenon and their plight has been felt the world over. Africa continues to see large numbers of people displaced through armed conflict, producing more refugees on the worlds’ most poverty stricken continent than any other. The implications of these displacements of people dislocated from their places of habitual residence create much concern, particularly in the wake of the HIV/AIDS pandemic. Such dislocations and displacements imply separation from family and communities, including socio-economic benefits that accrue to them. There is an apparent problem of accessing health services, educational services, sources of livelihood and protection from sexual and emotional abuse. Refugee children and women are said to be the most vulnerable, although until recently adolescents in armed conflict were not considered as a special group of children requiring special attention. The main objective of this research was to investigate levels of risk for HIV among refugee adolescents in Zambia and to determine how location relates to risk. Of particular interest was the difference in risk experienced in rural and urban areas. The researcher’s hypothesis was that refugee adolescents in rural camps of Zambia are at greater risk because they lack adequate sources of income, health, and education in comparison to urban areas. The research was located within two theoretical underpinnings namely the social cognitive theory and the AIDS Risk Reduction Model (ARRM). The theory posits that a reciprocal relationship exists between environmental contexts, personal factors and behavior. The model explains how people change behavior that reduces risk for HIV by changing perceptions on sexual activity and when they enact the knowledge obtained from HIV preventive programmes. The methodology was located within both the qualitative and quantitative research approaches. Qualitative because firstly, the research is a comparative case study and secondly, it is the first time such a study is being conducted. The researcher also made use of the quantitative through the survey and secondary HIV/AIDS statistical data. / South Africa

Master of Public Health - MPH / The way gender relations influence access to care and treatment particularly access to antiretroviral medicines is a challenge to HIV/AIDS programmes and to the individuals and families with HIV. Gender norms that push women and men to adhere to dominant ideals of femininity and masculinity may restrict women's access to economic resources, health care and fuel the spread of HIV. The aim of this study was to determine the role of gender relations in influencing decision-making for access to antiretroviral medicines between partners and in the family. / South Africa

Master of Public Health - MPH / Each year approximately 600 000 infants, most of them in Sub-Saharan Africa are born with HIV infection as a result of mother to child transmission of HIV. Whereas significant progress has been made in reduction of mother to child transmission of HIV in developed countries, the situation remains desperate in developing countries. Progress has been hampered by shortage of staff, facilities, limited access to voluntary counselling and testing and lack of support for women by their partners and communities. The challenge is to increase voluntary counselling and testing uptake during antenatal care. Onandjokwe district in Northern Namibia is currently introducing the Prevention of Mother to Child Transmission Program (PMTCT). It has been found the previous PMTCT programs have failed because they adopted a top down approach where there was no community consultation. This study was conducted to explore the community perceptions, knowledge and attitudes regarding mother to child transmission of HIV through focus group discussions and in-depth interviews of key community members. / South Africa

Magister Artium - MA / This study focuses on the impact of HIV/AIDS on women in Namibia. Namibia, with a population of only 1.7 million people, is ranked as the seventh highest country in the world in terms of HIV/AIDS infections. The percentage of women living with HIV/AIDS in Namibia accounts for 54% of the total of 68 196 people in the country living with the virus. Women are also diagnosed with the disease at a younger age (30) in comparison to their male counterparts (35 years). Desoite their needs, women living with HIV/AIDS bear a triple burden of caring for those living with HIV/AIDS, caring for themselves and coping with the responses to their infection. There are few focused intervention strategies to support and care for women living with HIV/AIDS in Namibia. / South Africa

This project has focused on exploring the application of Baylis-Hillman (BH) {a.k.a. Morita-Baylis-Hillman (MBH)} scaffolds in the construction of various compounds with medicinal potential. A series of 2-nitrobenzaldehydes has been treated under BH conditions, with two different activated alkenes, viz., (MVK) and methyl acrylate, using (DABCO) or (3-HQ) as catalyst. While most of the BH reactions were carried out at room temperature, some reactions were conducted using microwave irradiation. The resulting BH adducts have been subjected to dehydration, conjugate addition and allylic substitution to obtain appropriate intermediates, which have been used in turn, to synthesize possible lead compounds, viz., cinnamate esters as HIV-1 integrase inhibitors, 3-(aminomethyl)quinolines and quinolones as anti-malarials and cinnamate ester-AZT conjugates as dual-action HIV-1 integrase-reverse transcriptase (IN-RT) inhibitors. Conjugate addition reactions of methyl acrylate-derived BH β-hydroxy esters with the amines, piperidine, propargylamine and 2-amino-5-(diethylamino)pentane, has afforded a range of products as diastereomeric mixtures in moderate to excellent yields. Catalytic hydrogenation of the aminomethy β-hydroxy esters derivatives, using a palladium-oncarbon (Pd-C) catalyst, has afforded the corresponding, novel 3-aminomethyl-2- quinolone derivatives in moderate yields. Effective allylic substitution reactions of the MVK-derived BH β-hydroxy ketones (via a conjugate addition-elimination pathway) using in situ-generated HCl has afforded the corresponding α-chloromethyl derivatives, which have been reacted with various amines, including piperidine, piperazine, propargylamine and 2-amino-5-(diethylamino)pentane, to yield α-aminomethyl derivatives. Catalytic hydrogenation of selected α-aminomethyl derivatives, using a Pd-C catalyst, has afforded the corresponding, novel 3- (aminomethyl)-2-methylquinoline derivatives in low to moderate yields. A bioassay, conducted on a 6-hydroxy-2-methyl-3-[(piperidin-1-yl)methyl]quinoline isolated early in the study indicated anti-malarial activity and prompted further efforts in the synthesis of analogous compounds. Reaction of the methyl acrylate-derived BH adducts with POCl3 has provided access to α-(chloromethyl)cinnamate ester derivatives, which have been aminated to afford α- (aminomethyl)cinnamate ester derivatives as potential HIV-1 integrase inhibitors. The α- (propargylaminomethyl)cinnamates were used, in turn, as substrates for the “click chemistry” reaction with 3'-azido-3'-deoxythymidine (AZT– an azide and an established reverse transcriptase HIV-1 inhibitor) to afford cinnamate ester-AZT conjugates as potential dual-action HIV-1 integrase-reverse transcriptase (IN-RT) inhibitors. Computer modelling and docking studies of a cinnamate ester-AZT conjugate into the HIV-1 integrase and reverse transcriptase active-sites revealed potential hydrogen-bonding interactions with amino acid residues within the receptor cavities. The isolated products have been appropriately characterized using IR, 1- and 2-D NMR and HRMS techniques, while elucidation of the stereochemistry of the double bond in the BH-derived halomethyl derivatives has been assigned on the basis of NOE, computer modelling and X-ray crystallographic data.

This research reports on narratives of people whose lives had been infected and affected by the devastating disease - HIV/AIDS. The core information, on which this study is based, comes from experiences of those infected and/or affected by HIV/AIDS as well as from caregivers. It sweeps away statistics and places those seeking to offer help in the midst of those seeking to be helped. This mutual subject-to-subject relationship becomes the stage on which research/therapy, interviews and conversations are conducted. This study therefore opts for an approach that is informed by the experiences of those infected and/or affected and that addresses the realities of their lives. Care and/or lack of care is identified as a phenomenon, which is a direct reflection on how therapy (research) is done by those providing the care and perceived by those receiving the care. In the light of the experiences (stories) shared by the companions, it became evident that there is an existing need for alternative therapeutic ways, which seeks to embrace a therapeutic approach, which will minimize the external authority, or power of the therapist and at the same time maximizes the authority of those seeking therapy. The Narrative approach is explored as a possible therapeutic approach that could be used to empower those infected and/or affected pastorally in a less¬knowledgeable fashion that is not-controlling, not-manipulative, not¬-authoritative and not-knowing - as "guiding" metaphor which will permit the infected and/or affected to use their own thinking, understanding, emotions, creativity and own resources in a way that best fits them in bringing meaning to their own lives. The entire study seeks to emphasise the importance of a therapeutic approach, which seeks to symbolically embrace the "clouded" story of the infected and affected in a story of God's hope. In this approach the therapist simply becomes aware of the presence of a person(s) for whom the devastating reality of HIV/AIDS is an every day reality. This research does not claim to have the solutions or quick fix miracle answer to the complex HIV/AIDS phenomenon, and it neither claims to have the power to bring any neat conclusion to the HIV/AIDS story, but rather have the potential to stimulate a new story of hope and purpose in the lives of the infected and affected. This research emphasises a position where the infected and affected can inhabit and lay claim to the many possibilities of their own lives that lie beyond the knowledge, assumptions, expectations, goals and understandings of the therapist. A position in which the therapist simply becomes available to talk, listen and support. A position that will empower those infected and affected to tell: • the story of need as broadly as possible, • the story of the past, • the future story in the story of the past, • the reinterpreted story of the past, • the imagined story of the future. (Muller 1999:84) / Thesis (PhD (Practical Theology))--University of Pretoria, 2006. / Practical Theology / unrestricted

Worldwide millions of children are victims of neglect and physical and mental harm, including sexual abuse and exploitation. South Africa, however, is widely believed to have not only one of the highest incidences of rape in the world, but also one of the highest levels of Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) transmission. With research findings showing that HIV and other Sexually Transmitted Infections (STIs) are rapidly increasing globally, young people are, and continue to be, at the forefront of the AIDS pandemic. Therefore, it is suggested that prevention programmes should be aimed particularly at the young. Schools have specifically been recognized as the setting for preventative Life Skills Programmes, having the potential to reach billions of children worldwide. The aim of this study is to explore and describe the perceptions of grade eight and nine learners with regard to the Life Skills Programme that focuses on HIV/AIDS and STI's, rape and child abuse education in the Port Elizabeth region. In order to fulfil the above aim, a qualitative study was undertaken within an exploratory descriptive approach. A non-probability sample of four schools was selected. Focus groups, utilising an unstructured interview, were used to gather qualitative data on the learners' perceptions of the Life Skills Programme. The focus groups consisted of 10 - 12 grade eight and nine learners who were selected using simple random sampling. The data was thematically analysed using Tesch's approach. The major findings of the present study, based on the six general themes, include the following: 1. Most of the learners perceived the educators, as well as the teaching methods utilised by the educators, positively. 2. Although the learners perceived the presenters of the Life Skills Programme positively, it was suggested that teachers, health care professionals, family members and peers should be involved in presenting the Life Skills Programme. 3. Learners reported various levels of comfort discussing different topics presented in the Life Skills Programme. 4. Learners of all the schools perceived the Life Skills Programme to be very relevant. 5. Learners recommended that more children, especially children from deprived communities, should be included in the programme. In addition, learners felt that counselling services should be available in conjunction with the Life Skills Programme. 6. Differences were noted in completing the first and the second questionnaire. Learners reported that they felt more comfortable completing the second questionnaire. They perceived the interviewing process positively.

Schools play a major role in shaping the attitudes, opinions and behaviour of young people and so are ideal environments for teaching the social, as well as biological aspects of HIV and AIDS. However, literature indicates that learners are displaying “AIDS fatigue” and may be resistant to teaching around HIV and AIDS. In order to enhance learner engagement and learning, there is therefore a need for teachers to employ interactive teaching and learning strategies that are interactive, inexpensive and fun. This dissertation outlines the research design of an investigation into how such strategies can be used in HIV and AIDS prevention education. An action research design was made use of in this study and the manner in which several teachers presented HIV and AIDS education to his/her learners was initially observed. In addition, qualitative interviews were used to determine the teachers‟ need for development in this regard. Based on the findings of the problem identification step, teachers were introduced to active teaching and learning strategies and supported to implement them. Evaluation and refinement of the strategies, developmental workshops and training followed, which in turn lead to recommendations and the formulation of guidelines to influence teacher education with regard to HIV and AIDS prevention education.

Human Immune Deficiency Virus (HIV), which results in Acquired Immune Deficiency Syndrome (AIDS), has many manifestations. Literature reveals that some of these manifestations may compromise the infected individual’s sense of well-being and negatively impact on health related quality of life. As the number of people living with HIV/AIDS disease grows, so does the need for their care. In the early days of the AIDS epidemic, care was primarily handled by special agencies, hospitals and clinics. These agencies have been inundated with the demands of people living with HIV/AIDS, while their resources are shrinking. As it stands now, the total assistance given to people living with HIV/AIDS is provided by relatives and this responsibility of caregiving will more increasingly rest with families. This situation is particularly salient for the rural community in South Africa, which has been disproportionately affected by the AIDS epidemic. AIDS has a tremendous impact on the entire family system, particularly on the individual who has primary responsibility for caregiving. The caregiver must cope with many circumstances that are frustrating and often beyond their control. Caring for a Person Living with HIV/AIDS (PLWHA) appears to be a major stressor in the lives of caregivers, and can be very demanding, impacting on carers financially, physically, emotionally and socially. Given the lack of research on HIV/AIDS family caregiving from a salutogenic approach, this study aimed to explore and describe the sense of coherence and coping of family caregivers of HIV/AIDS patients in the Kwazakhele area in Port Elizabeth. The sample consisted of 50 participants aged between 21 and 65 years, recruited via the Kwazakhele Masizakhe Project. An exploratory-descriptive design was employed. Data was obtained by a biographical questionnaire, the Coping Resources Inventory (CRI) and the Sense of Coherence (SOC-29) Questionnaire. A non-probability convenience sample of adult male and female family caregivers were sampled. Descriptive statistics and correlation coefficients were utilized to describe and explore the coping and sense of coherence of the family caregivers and the correlation between these constructs, respectively. The data obtained from the biographical questionnaire was analysed by using descriptive statistics and frequency counts. Key findings include the following: Results from the coping resources measure indicated that this sample perceived themselves as having an average level of coping resources. The sample tended to rely more readily on spiritual resources and less on cognitive resources. Results from the SOC-29 revealed fairly high mean scores. There is no positive relationship between the SOC-29 and the CRI for the current sample. No significant relationship existed between the SOC and the subscales of the CRI. Suggestions are made for future research, the limitations and value of research were outlined.