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Illicit drug abuse and addiction is a major problem in New Zealand and worldwide with approximately 12% of illicit drug users classified as having drug dependence or drug-use disorders. The chronically relapsing nature of drug addiction is a prominent feature of this disorder and a significant barrier to treating addiction. Amphetamine-type drugs, more than any other class of drugs, have seen an increase in global usage since the early 1990's. The lack of approved medications for the treatment of stimulant addiction together with an increasing treatment demand drives the need for pharmaceutical intervention. Substitute treatment approaches primarily focus on the dopamine (DA) system. However, several lines of research implicate a dual role for serotonin (5-HT). Using a benztropine (BZT) analogue, JHW 007 (JHW), and an atypical antidepressant, trazodone (TRAZ), we sought to test whether the combined modulation of DA and 5-HT during a period of extinction produced greater attenuation to drug-induced reinstatement compared to either DA or 5-HT alone. One hundred and two (102) male Long Evans rats were tested using an extinction-reinstatement model of methamphetamine (MA) addiction in conditioned place preference (CPP) (n=72) and self-administration (n=30) experimental designs. We hypothesised that a combined DA/5-HT treatment would further attenuate MA-induced reinstatement. Findings showed that JHW significantly attenuated MA-induced reinstatement in our self-administration model but not CPP, while TRAZ failed to significantly attenuate reinstatement in both experiments. The combination treatment group showed a mild attenuation to drug seeking with CPP, but this finding was not significant. Due to time restrictions, we did not test the combination group using a self-administration procedure. Unfortunately we were unable to fully address our initially proposed hypothesis, but our results with JHW add further support to this BZT analogue as a promising stimulant abuse medication.

This thesis is an exploration into the design of configurable analog block (CAB) for field programmable analog arrays (FPAAs) designed in modern complementary metal-oxide-semiconductor (CMOS) technologies. Specifically, this thesis develops a single configurable analog block (CAB) using an operational transconductance amplifier (OTA). A fully differential OTA is selected for its flexibility and the reliability of differential signals with respect to noise when compared to single-ended signals. The OTA is combined with a set of switches, controlled by a serial shift register, to allow for reconfiguration of the internal wiring, and two capacitor arrays used to fine-tune the frequency response of the circuit. Simulation results are provided for an OTA, the OTA operating in situ, and a band-pass filter, thus demonstrating the use of the CAB. A single CAB is constructed on a 0.13 µm CMOS chip. / Integrated Circuits and Systems

Thesis (Ph. D.)--Ohio University, August, 1990. / Title from PDF t.p.

Thesis (M.S.)--Worcester Polytechnic Institute. / Keywords: error correction, calibration, successive approximation. Includes bibliographical references (leaves 89-91).

Thesis (M.E. 1975) from the Department of Electrical Engineering, University of Adelaide.

Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (p. 90-97) Also available in print.

Thesis (M.S.)--University of Wisconsin--Madison, 1965. / eContent provider-neutral record in process. Description based on print version record. Bibliography: l. 43-44.