Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1992. / Vita. Abstract. Includes bibliographical references (leaves 62-63). Also available via the Internet.

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The principle of operation of a novel rotating disk ultrasonic intensity meter is studied. Its characteristics are explained by a competition between acoustic radiation pressure and viscous drag on the disk. Acoustic streaming does not play a significant role in the operation of this meter as it is now configured. Experiments are described which were done to find the optimum dimensions and position for a nylon disk. In this optimum configuration, the rotation rate of the disk is related to the ultrasonic intensity by a power law. This relationship is theoretically predicted and found to hold as the ultrasonic intensity varies by a factor of at least ten. / Science, Faculty of / Physics and Astronomy, Department of / Graduate

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The relationship between distinctive characteristic fluid-flow regimes and the sound radiation generated by them has been investigated, over a range of Reynolds numbers, for various single plates and two-plate arrays in nominally two-dimensional flows. In preliminary experiments, the characteristics of flow over single plates with rectangular cross-section and faired leading edges and over tandem arrays of an upstream plate with rectangular cross-section and faired leading edges and a downstream plate of rectangular cross-section were investigated, together with the sound radiation produced. However, the main investigation has been concentrated on single plates of rectangular cross-section with various chord-to-thickness ratios C and on arrays of two plates of rectangular cross-section in tandem having various chord-to-thickness ratios C₁ and C₂ and a range of gaps (with gap-to-thickness ratios G) between them. The range of Reynolds number based on plate thickness t and free-stream velocity U, Re[subscript]t = Ut/ν (where ν is the kinematic viscosity of fluid) covered in the measurements is 3.2 x 10[superscript]3 ≤ Re[subscript]t 53 x 10[superscript]3. Spectra of velocity fluctuations in the flow and radiated sound have been measured and their characteristic frequencies related. An attempt has been made to measure force fluctuations on surfaces of the plates in order to relate them to flow characteristics and radiated sound power. Mean and fluctuating pressures associated with the force fluctuations on the plates have also been obtained. The lengths of separation bubbles on long rectangular plates have also been determined. In most cases, the measurements have been complemented by flow-visualisation in a water tunnel to provide additional detailed insight into the flow patterns. Three flow regimes have been identified for single plates of rectangular cross-section. In the first regime (1 ≤ C ≤ 3.13), shear layers separated from the leading edges form a vortex street downstream of the plate without reattachment to it. Associated force fluctuations on the plate are the main source of acoustic radiation. In the second regime (3.05 ≤ C ≤ 9.65), the separated shear layers reattach intermittently to the streamwise plate surfaces. Vortex formation in the shear layer is the dominant cause of sound radiation but the effect becomes weaker as C increases. In the third regime (6.52 ≤ C ≤ 68), the separated shear layers form closed leading-edge separation bubbles. Weak vortex shedding, with only a small contribution to the sound radiation, occurs only at the trailing edges of the plate. Bistable behaviour of the flow over a plate, with random switching between the regimes, occurs for C ≈ 3 and 6.52 ≤ C ≤ 9.65. A proposed classification of possible flow regimes for the flow around two plates of rectangular cross-section in tandem has been confirmed experimentally. For small G, the flow in the gap between the plates is isolated from the external flow. When the gap G between the plates is increased to or beyond a critical value (between 2 and 3.5), the shear layers separated from the upstream plate form a von Karman vortex street in the gap before interacting with the downstream plate. Flow and acoustic measurements indicate that this transition is associated with dramatic changes in the flow character. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1320474 / Thesis (Ph.D.) -- University of Adelaide, School of Mechanical Engineering, 2008

<p>This dissertation investigates the use of intraprocedure acoustic radiation force impulse (ARFI) imaging for visualization of radiofrequency ablation (RFA) lesions during cardiac transcatheter ablation (TCA) procedures. Tens of thousands of TCA procedures are performed annually to treat atrial fibrillation (AF) and other cardiac arrhythmias. Despite the use of sophisticated electroanatomical mapping (EAM) techniques to validate the modification of the electrical substrate, post-procedure arrhythmia recurrence is common due to incomplete lesion delivery and electrical conduction through lesion line discontinuities. The clinical demand for an imaging modality that can visually confirm the presence and completeness of RFA lesion lines motivated this research.</p><p>ARFI imaging is an ultrasound-based technique that transmits radiation force impulses to locally displace tissue and uses the tissue deformation response to generate images of relative tissue stiffness. RF-induced heating causes irreversible tissue necrosis and contractile protein denaturation that increases the stiffness of the ablated region. Preliminary in vitro and in vivo feasibility studies determined RF ablated myocardium appears stiffer in ARFI images.</p><p>This thesis describes results for ARFI imaging of RFA lesions for three research milestones: 1) an in vivo experimental verification model, 2) a clinically translative animal study, and 3) a preliminary clinical feasibility trial in human patients. In all studies, 2-D ARFI images were acquired in normal sinus rhythm and during diastole to maximize the stiffness contrast between the ablated and unablated myocardium and to minimize the bulk cardiac motion during the acquisition time.</p><p>The first in vivo experiment confirmed there was a significant decrease in the measured ARFI-induced displacement at ablation sites during and after focal RFA; the displacements in the lesion border zone and the detected lesion area stabilized over the first several minutes post-ablation. The implications of these results for ARFI imaging methods and the clinical relevance of the findings are discussed.</p><p>The second and third research chapters of this thesis describe the system integration and implementation of a multi-modality intracardiac ARFI imaging-EAM system for intraprocedure lesion evaluation. EAM was used to guide the 2-D ARFI imaging plane to targeted ablation sites in the canine right atrium (RA); the presence of EAM lesions markers and conduction disturbances in the local activation time (LAT) maps were used to find the sensitivity and specificity of predicting the presence of RFA lesion with ARFI imaging. The contrast and contrast-to-noise ratio between RFA lesion and unablated myocardium were calculated for ARFI and conventional ICE images. The opportunities and potential developments for clinical translation are discussed. </p><p>The last research chapter in this thesis describes a feasibility study of intracardiac ARFI imaging of RFA lesions in clinical patients. ARFI images of clinically relevant ablation sites were acquired, and this pilot study determined ARFI-induced displacements in human myocardium decreased at targeted ablation sites after RF-delivery. The challenges and successes of this pilot study are discussed.</p><p>This work provides evidence that intraprocedure ARFI imaging is a promising technology for the visualization of RFA lesions during cardiac TCA procedures. The clinical significance of this research is discussed, as well as challenges and considerations for future iterations of this technology aiming for clinical translation.</p> / Dissertation

The relationship between distinctive characteristic fluid-flow regimes and the sound radiation generated by them has been investigated, over a range of Reynolds numbers, for various single plates and two-plate arrays in nominally two-dimensional flows. In preliminary experiments, the characteristics of flow over single plates with rectangular cross-section and faired leading edges and over tandem arrays of an upstream plate with rectangular cross-section and faired leading edges and a downstream plate of rectangular cross-section were investigated, together with the sound radiation produced. However, the main investigation has been concentrated on single plates of rectangular cross-section with various chord-to-thickness ratios C and on arrays of two plates of rectangular cross-section in tandem having various chord-to-thickness ratios C₁ and C₂ and a range of gaps (with gap-to-thickness ratios G) between them. The range of Reynolds number based on plate thickness t and free-stream velocity U, Re[subscript]t = Ut/ν (where ν is the kinematic viscosity of fluid) covered in the measurements is 3.2 x 10[superscript]3 ≤ Re[subscript]t 53 x 10[superscript]3. Spectra of velocity fluctuations in the flow and radiated sound have been measured and their characteristic frequencies related. An attempt has been made to measure force fluctuations on surfaces of the plates in order to relate them to flow characteristics and radiated sound power. Mean and fluctuating pressures associated with the force fluctuations on the plates have also been obtained. The lengths of separation bubbles on long rectangular plates have also been determined. In most cases, the measurements have been complemented by flow-visualisation in a water tunnel to provide additional detailed insight into the flow patterns. Three flow regimes have been identified for single plates of rectangular cross-section. In the first regime (1 ≤ C ≤ 3.13), shear layers separated from the leading edges form a vortex street downstream of the plate without reattachment to it. Associated force fluctuations on the plate are the main source of acoustic radiation. In the second regime (3.05 ≤ C ≤ 9.65), the separated shear layers reattach intermittently to the streamwise plate surfaces. Vortex formation in the shear layer is the dominant cause of sound radiation but the effect becomes weaker as C increases. In the third regime (6.52 ≤ C ≤ 68), the separated shear layers form closed leading-edge separation bubbles. Weak vortex shedding, with only a small contribution to the sound radiation, occurs only at the trailing edges of the plate. Bistable behaviour of the flow over a plate, with random switching between the regimes, occurs for C ≈ 3 and 6.52 ≤ C ≤ 9.65. A proposed classification of possible flow regimes for the flow around two plates of rectangular cross-section in tandem has been confirmed experimentally. For small G, the flow in the gap between the plates is isolated from the external flow. When the gap G between the plates is increased to or beyond a critical value (between 2 and 3.5), the shear layers separated from the upstream plate form a von Karman vortex street in the gap before interacting with the downstream plate. Flow and acoustic measurements indicate that this transition is associated with dramatic changes in the flow character. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1320474 / Thesis (Ph.D.) -- University of Adelaide, School of Mechanical Engineering, 2008

Thesis (Ph.D.) -- University of Adelaide, Department of Mechanical Engineering, 1978.