• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 341
  • 101
  • 32
  • 32
  • 14
  • 8
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • Tagged with
  • 645
  • 123
  • 85
  • 66
  • 65
  • 63
  • 55
  • 54
  • 45
  • 45
  • 45
  • 43
  • 40
  • 38
  • 36
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

The mechanism of carcinogenesis by urethane

Kitson, Sean Leslie January 1993 (has links)
No description available.
22

The intracellular targeting and regulation of PDE4 cyclic AMP-specific phosphodiesterase enzymes

Peden, Alexander Howard January 2000 (has links)
No description available.
23

An investigation of paired pulse interactions between evoked field potentials in normal and bicuculline-superfused rat hippocampal slices

Higgins, Michael Joseph January 1996 (has links)
No description available.
24

ATP dependent calcium signalling in guinea pig vas deferens

Burns, L. E. A. January 2003 (has links)
No description available.
25

Studies on adenosine and insulin sensitivity in skeletal muscle

Zhao, J. January 1987 (has links)
No description available.
26

Determining the subcellular localization of adenosine kinase and SAH hydrolase and their roles in adenosine metabolism

Schoor, Sarah 06 November 2014 (has links)
Housekeeping enzymes are vital to the metabolism of all plant cells. Two such enzymes adenosine kinase (ADK) and S-adenosylhomocysteine (SAH) hydrolase share a similar function: both sustain S-adenosylmethionine-dependent methylation reactions by removing inhibitory by-products. SAH hydrolase breaks down SAH which is a competitive inhibitor of all methyltransferase activities. ADK phosphorylates the Ado produced by SAH hydrolase and in doing so drives this reversible reaction in the hydrolysis direction. By catalyzing the phosphorylation of Ado into adenosine monophosphate, ADK not only prevents SAH from re-forming but also initiates the recycling of Ado into adenylate nucleotides and cofactors. This thesis documents two distinct research topics related to methyl recycling in plants. The first goal was to identify ADK-deficient mutants to establish the contribution of this enzyme activity to adenosine salvage. The second goal was to determine the subcellular localization of ADK and SAH hydrolase in Arabidopsis thaliana (Columbia). T-DNA insertion lines for highly similar ADK isoforms (ADK1 and ADK2) and silencing lines of overall ADK activity (sADK) were compared to WT Arabidopsis to identify phenotypic abnormalities associated with ADK deficiency. In addition to following their growth, microscopic analysis was performed on the sADK lines. While removal of either ADK1 or ADK2 had no phenotypic effect, lowering ADK levels to 6-20% that of WT lead to several changes including small, wavy rosette leaves, delayed leaf senescence, decreased internode length, reduced branching, clustered inflorescences and lack of petal abscission and silique dehiscence. Further analysis linked the abnormal phenotype to increased levels of hypomethylation throughout the plant (K Engel unpublished data), as was expected; however higher levels of active cytokinin were also observed. Thus ADK appears to be integral in regulating cytokinin levels as well as recycling methylation intermediates. To investigate the relationship between the subcellular localization of SAH production and its metabolism, immunogold labelling was performed on leaf and meristematic tissues of Arabidopsis using antibodies specific for either ADK or SAH hydrolase. As well, ???-glucuronidase and green fluorescent protein translational fusions of each enzyme were examined (S. Lee unpublished data). Results of both the immunogold labelling and fusion lines revealed that all ADK and SAH hydrolase isoforms localize to the cytosol, chloroplast and nucleus. Further analysis of purified chloroplasts has given varying results regarding the targeting of these enzymes to the organelle, and further research will be required before ADK and SAH hydrolase can be conclusively localized to the chloroplast.
27

The effects of adenosine on cyclic amp-mediated processes in mammalian fat cells

Reid, David Mark January 1991 (has links)
No description available.
28

Effect of opiates on the transport of neurotransmitters in rat brain synaptosomes.

January 1983 (has links)
by Chung-wing Chau. / Bibliography: leaves 170-183 / Thesis (M.Phil.) -- Chinese University of Hong Kong, 1983
29

The chemistry of an active adenosine A1 receptor ligand and its related analogs.

January 1992 (has links)
by Zhen Yang. / On t.p. "1" is subscript following A in the title. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1992. / Includes bibliographical references (leaves 138-139). / Acknowledgements --- p.i / List of Nomenclature --- p.ii-ix / "Abstracts (for Chapter 2,Chapter 3,and Chapter 4)" --- p.x / Chapter Chapter 1. --- General Introduction --- p.1-8 / Chapter Chapter 2. --- Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'- hydroxyphenyl)-benzo[b]furan-3-carbaldehyde (XH14) (18) / Chapter 2.1. --- Introduction --- p.9-12 / Chapter 2.2. --- Isolation and Structure Elucidation of XH14 (18) / Chapter 2.2.1. --- Material and method --- p.13-17 / Chapter 2.2.2. --- Structure elucidation --- p.18-23 / Chapter 2.3. --- Results and Discussion / Chapter 2.3.1. --- Total synthesis of XH14 (18) --- p.24-52 / Chapter 2.3.2. --- Chemical modification of XH14 (18) / Chapter (a) --- Synthesis of 3-hydroxymethyl-5-(3-hydroxypropyl)- 7-methoxy-2-(3'-methoxy-4'-hydroxy phenyl)-benzo[b] furan(49) and 3-hydroxymethyl-5-(2-methoxycarbonyl ethyl)-7-methoxy-2-(3'-methoxy-4'-hydroxy phenyl)- benzo[b]furan (66) --- p.53-54 / Chapter (b) --- Synthesis of 5-(2-carboxyethyl)-7-methoxy-2-(3'- methoxy-4'-hydroxyphenyl)-benzo[b]furan-3- carbaldehyde (67) --- p.54 / Chapter (c) --- Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-3- methyl-2-(3'-methoxy-4'-hydroxyphenyl)- benzo[b]furan (68) and 5-(2-methoxycarbonylethyl)-7- methoxy-3-methyl-2-(3'-methoxy-4'-hydroxyphenyl)- benzo[b]furan (69) --- p.54-55 / Chapter (d) --- Synthesis of 5-(2-carboxy-trans-ethenyl)-7- methoxy-2-(3'-methoxy-4'- hydroxy phenyl) benzo[b]furan-3-carbaldehyde (70) --- p.55-56 / Chapter (e) --- Synthesis of 4-bromo-5-(3-hydroxypropyI)-7- methoxy-2-(3'-methoxy-4'- hydroxy phenyl)- benzo[b]furan-3-carbaldehyde (72) --- p.56-57 / Chapter (f) --- Synthesis of 4-acetyl-5-(3-hydroxypropyl)-7- methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-benzo [b]furan (73) and 3-acetyI-5-(3-hydroxypropyl)-7- methoxy-2-(3'-methoxy-4'-hydroxy phenyl)- benzo[b]furan (75) --- p.57-61 / Chapter (g) --- Synthesis of 3-nitro-5-(3-hydroxypropyl)-7- methoxy -2-(3'-methoxy-4'-hydroxyphenyl)- benzo[b]furan (77) and 4-nitro-5-(3-hydroxyphenyl)-7- methoxy-2-(3'-methoxy-4'-hydroxyphenyl)- benzo[b]furan (78) --- p.61-64 / Chapter (h) --- Synthesis of 3-(α-hydroxyethyl)-5-(3-hydroxy propyl) -7-methoxy-2- (3'-methoxy-4' -hydroxyphenyl) - benzo[b]furan (81) --- p.64 / Chapter (i) --- Synthesis of 5-(3-hydroxypropyl)-7-methoxy-2-(3'- methoxy-4'-benzyloxyphenyl )-benzo[b]furan-4- carbaldehyde (82) --- p.64 / Chapter 2.4. --- Structure-activity Relationship of A1 Antagonists --- p.65-71 / Chapter 2.5. --- Conclusion --- p.72 / Chapter 2.6. --- Experimental Section --- p.73-97 / Chapter 2.7. --- References --- p.98-103 / Chapter Chapter 3. --- "Synthesis of 9,10-Dihydro-10,10-dimethoxyanthracen-9-one" / Chapter 3.1. --- Introduction --- p.104 / Chapter 3.2 --- Results and Discussion --- p.105-118 / Chapter 3.3. --- Experimental Section --- p.119-124 / Chapter 3.4. --- References --- p.125-128 / Chapter Chapter 4. --- "Synthesis of 10,11-Dimethoxydibenz[b,f]oxep in" / Chapter 3.1. --- Introduction --- p.129 / Chapter 3.2. --- Results and Discussion --- p.130-133 / Chapter 3.3. --- Experimental Section --- p.134-137 / Chapter 3.4. --- References --- p.138-139 / Appendix / Spectra --- p.140-145
30

Characterization of the vacuolar H r-AtPase of higher plants

Manolson, Morris F. January 1988 (has links)
No description available.

Page generated in 0.0982 seconds