Political communication scholars aim to understand the effect of messages on political attitudes and behavior. Past scholarship has identified three sources of influence in forming attitudes and behavior: affective, cognitive, and personality factors. While much attention has been paid to the impact of each single factor, little research has attempted to integrate them. Using the Affective Intelligence model as a theoretical point of departure (Marcus, & MacKuen, 1993; Marcus et al., 2000), this dissertation explored the simultaneous--and, in some cases, interactive relationships--between these attitudinal and behavioral influences. An experiment was conducted to answer three questions: first, do the causal claims made by Marcus and colleagues regarding the impact of emotion on political attitudes and behavior hold-up outside the realm of survey research? Second, what role does cognitive appraisals of messages play in the political persuasion process? Finally, does political efficacy moderate the relationships between induced emotional response, cognitive appraisals of messages, and political attitudes and behavior? Alternatively stated, does political efficacy link these factors together?The results of this study should be carefully interpreted as the causal instrument underlying manipulated attitudes was not transparent. The desired experimental manipulation--induced anxiety--was not unidimensional. While inductions did induce negative affect, they simultaneously induced positive affect. Within the confines of this document, this result is discussed at length and numerous possible explanations are offered.Structural equation modeling indicated that affect had a small impact on political attitudes and behavior. Likewise, the impact of cognitive appraisals of messages on attitudes and behavior was small. Alternatively, internal efficacy had a substantial main effect--not an interactive effect--on political attitudes and behavior.In summary, the results demonstrated the power of personality in predicting political attitudes and behavior. By trait, some individuals are more politically efficacious than others. Those with higher levels of internal efficacy tended to identify experimental messages as relevant to the attitudes they held, indicating that confidence in one's ability to comprehend politics and understand political happenings leads to identifying message content as applicable or appropriate. Additionally, these same individuals were likely to seek out more information about politics.

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As much as 10% of the US population will experience at least one bout of depression within their lifetime. It has been reported that an increased time spent with major depressive disorder (MDD) results in a decreased volume in the hippocampus. This decreased volume is the result of apoptosis, or programmed cell death. In recent years it has become known that new neurons (neurogenesis) are continuously born in the hippocampus of humans. In fact, it now appears that antidepressant drug efficacy may be dependent on adult neurogenesis in the hippocampus. At least six epidemiological studies have shown an inverse correlation between seafood intake and prevalence of mood disorders (p [less than]0.05 or better). There is mounting evidence that this result is due to fish oils containing the long-chain, poly-unsaturated, omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Although extensive study has been undertaken using both of these omega-3s together, very little has been done to determine which fatty acid has the greater effect. Although previously thought to be readily interconvertible, there is mounting evidence that these two lipids are not treated equally in the body. EPA has produced greater cell proliferation over DHA in the B-lymphocyte cells, and DHA has even been known to cause a decrease at higher concentrations. Differences have also been reported in both molecular and behavioral outcomes. This research tested the hypothesis that EPA facilitates proliferation and survival of neuronal precursor cells to a greater extent than does DHA. Human neuronal precursor cells were grown in the presence of EPA, DHA, and varying ratios of EPA and DHA to determine their dose-response relationships. While there were no large effects on proliferation or differentiation, EPA, but not DHA, protected cells from iron-induced oxidative stress. This protection appears to be, at least in part, the result of altered p53 translocation in EPA-treated cells. Future work will be needed to determine the role of this molecular protection in the antidepressant activity of EPA. / A Dissertation submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements for the degree of Master of Science. / July 16, 2009. / Includes bibliographical references. / Cathy Levenson, Professor Directing Theis; Jodee Dorsey, Committee Member; Michael Meredith, Committee Member.

The research literature proposes that the concept of identity may be central to understanding responses to having severe and enduring mental health problems. Theorists hypothesise a relationship between identity and the individual's acceptance of having mental health problems mediated by societal pressures. Given the inconclusive findings from research carried out a decade ago, this study has attempted to explore whether the participants' identification as a community member or patient affected, or was affected by, their belief that they have mental health problems, need medication, need to see healthcare professionals and their awareness of disabilities. A quantitative methodology was employed to examine the main variables. Forty five individuals living in the community with a diagnosis of schizophrenia, bipolar affective disorder or schizoaffective disorder were interviewed. Both within-group and between-group analyses were employed. The relationship between the independent variables and their relationships with sociodemographic and diagnostic factors, self-esteem and health and social functioning were explored. Measures that had been either standardised or used in previous related research were employed. The three central measures were taken from previous research studies in this area. Socio-demographic information was obtained from clinical files. Neither beliefs about mental health problems nor awareness of disabilities were found to be associated with identity, as measured in this study. Health and social functioning and work-related variables appeared to contribute to an identification as a community member. It is suggested that defensive responses to disabilities existed to protect the individual's sense of self-worth. Furthermore, socially valued experiences prior to illness and level of ability may have contributed to the participants' identification as a community member. The clinical implications are discussed.

Objective: Pregnancy requires thorough monitoring and management because not only is it a time where normal physiological and psychological changes put a mother under stress and strain, but maternal sensitivity begins to develop, and the developing foetus needs a well regulated intrauterine environment. Such important processes can be compromised by abnormal or inconsistent physiological and emotional regulation. The study aimed to explore pregnant women’s regulation capacity at rest and their physiological reactivity, and return to physiological baseline, in response to infant related stimuli. Methods: Extended analyses of previously acquired psycho-physiological data at baseline, and pre- and post-presentation of relevant audio-visual stimuli. Results: Baseline physiological activity was significantly different between pregnant participants and controls. There were, however, no other differences in reactivity. Conclusion: Findings were inconsistent with previous research which indicates infant stimuli to become increasingly salient throughout pregnancy.

Das serotonerge System bildet schon seit Jahrzehnten einen Schwerpunkt in der psychiatrischen Grundlagenforschung. Seinen weit verzweigten Leitungsbahnen wird eine global-modulatorische Eigenschaft für die Aufrechterhaltung des Gleichgewichts zwischen unterschiedlichen Hirnregionen und unterschiedlichen Neurotransmitter-systemen zugeschrieben (Hüther und Rüther, 2000). Darüber hinaus ist die serotonerge Neurotransmission ein Hauptmodulator emotionalen Verhaltens, das Angst und Ängstlichkeit ebenso umfasst wie Aggression und Impulsivität (Lesch et al., 2003). In der vorliegenden Arbeit wurden im Sinne eines Kandidatengenansatzes zwei Assoziationsstudien durchgeführt. Im ersten Teil wurde versucht, eine mögliche Assoziation zwischen der Erkrankung an affektiven Störungen und drei vorbeschriebenen SNPs des FEV-Gens aufzudecken. FEV ist das humane Homolog des in mehreren Tierversuchen untersuchten Pet-1-Gens, dem vor allem eine zentrale Bedeutung in der embryonalen Entwicklung des serotonergen Systems zugeschrieben wird. Zusätzlich wurde ein 286 bp langer Abschnitt des Exon 3 sequenziert, um die Häufigkeit der sieben in diesem Abschnitt beschriebenen SNPs bei unipolar depressiven Patienten abzuschätzen und ggf. neue Varianten zu detektieren. Der zweite Teil untersuchte das Auftreten zweier bereits von anderen Autoren beschriebener SNPs des TPH2-Gen bei an der adulten Form des ADHS leidenden Patienten im Vergleich zu einer Kontrollgruppe. Die im zentralen serotonergen System dominierende Tryptophanhydroxylase 2 (TPH2) ist das erste, geschwindigkeitsbegrenzende Enzym der Serotonin-Biosynthese. Die Genotypisierung der einzelnen SNPs erfolgte mit unterschiedlichen Methoden. So kam sowohl die PCR, der Restriktionsenzymverdau, die Minisequenzierung (SNaPshot®) als auch die MALDI-ToF Massenspektrometrie und die Sequenzierung zum Einsatz, die Auftrennung einzelner Schnittprodukte erfolgte durch die Gelelektrophorese. Die erste Stichprobe umfasste 270 Patienten (davon 179 weiblich) mittleren Alters mit einer Diagnose aus dem affektiven Formenkreis (180 mit bipolar-affektiver Störung gemäß den DSM-IV Kriterien, weitere 90 Patienten mit einer rezidivierenden unipolaren depressiven Störung) sowie 362 (davon 174 weibliche) Kontrollpersonen. Die Stichproben der zweiten Studie umfassten 284 am adulten ADHS (Diagnose nach DSM IV) leidende Patienten (140 davon weiblich) und 120 Kontrollpersonen (61 davon weiblich). Statistisch wurden die Daten sowohl auf Einzelmarker- als auch auf Haplotypniveau ausgewertet. In beiden Studien konnte keine Assoziation der untersuchten Polymorphismen des FEV- bzw. TPH2-Gens mit der jeweiligen Erkrankung (affektive Störung / adultes ADHS), weder auf Einzelmarker- noch auf Haplotypniveau, nachgewiesen werden. Die Sequenzierung des 286 bp langen Abschnitts von Exon 3 des FEV-Gens zeigt eine ausgeprägte Konservierung der Sequenz dieses Gens, wie sie auch von anderen Autoren beschrieben wurde. Die hier untersuchten Kandidatengene FEV und TPH2 sind auch weiterhin interessante Ansatzpunkte für die psychiatrische Grundlagenforschung. Die Aufklärung der genauen Wirkungsweise von FEV und seine Rolle in der Entwicklung des menschlichen serotonergen Systems erscheint jedoch vordergründig, um zunächst Funktion, Interaktionen und mögliche pathogenetische Mechanismen aufzudecken und dann gezielter die Einflüsse bestimmter Polymorphismen zu untersuchen. / Since decades, the serotonergic system is one major focus of basic research in psychiatry. The widely branched serotonergic network is thought to have global-modulatory impact on diverse brain regions and transmitter systems (Hüther & Rüther, 2000). Moreover, serotonergic neurotransmission plays a key modulatory role in emotional behavior, including for example fear, anxiety, aggression and impulsivity (Lesch et al., 2003). Within the present manuscript, two association studies focussing on two candidate genes of the serotonergic system are presented. The first study aimed at investigating the association between affective disorders and three previously described SNPs of the FEV gene. FEV is considered the human homolog of the murine Pet-1-gene and has been suggested to be of key importance for the embryonic development of the serotonergic system. In addition, the study aimed at detecting new variants, and therefore assessed the frequency of seven new SNPs located on a 286 bp long part of the Exon 3, and tested for their association with unipolar depressive disorder. The second study aimed to compare the frequency of two previously described SNPs of the TPH2- gene between a sample of adult ADHD patients and a sample of healthy controls. TPH2 is thought to be the dominating speed reducing enzyme to central serotonergic biosynthesis. While genotyping of the respective SNPs was done using different methods, i.e. PCR, restriction enzyme digest, SNaPshot®, MALDI-ToF mass spectrometry as well as sequencing, all cleavage products were separated using gel-electrophoresis. The first studies‘ sample consisted of N=270 middle-aged patients (179 female) diagnosed for affective disorders according to DSM-IV criteria (i.e. n=180 bipolar disorder, n=90 unipolar depression), and N=362 (174 female) healthy controls. Within the second study, N=284 patients suffering from adult ADHD (140 female) and 120 healthy controls (61 female) were investigated. Data within both studies have been analyzed for single-marker as well as for haplotype associations. In both studies, no associations between the polymorphisms under investigation and the respective disorders were found (neither on the single-marker nor on the haplotype level). In accordance with previous reports, a marked conservation of a section of the Exon 3 sequence (286 bp) of the FEV gene was found. Although both candidate genes (FEV, TPH2) are of further interest for basic research into Psychiatry, unraveling the role of FEV in the development of the human serotonergic system seems to be of primary importance. Once the functional associations, interactions and pathogenic mechanisms have been discovered, future research might be able to more specifically target the role of single polymorphisms within the serotonergic network.

Syftet med föreliggande studie var att försöka reda i litteraturen kring två välkända begrepp inom Affective Forecasting nämligen Impact Bias, som innebär att människor har en tendens att överskatta i vilken utsträckning de kommer att uppleva en viss känsla i en framtida situation än vad som senare visar sig vara fallet, och Empathy Gaps, som innebär att människor har en tendens att underskatta i vilken grad känslotillstånd kommer att påverka deras preferenser i en framtida situation samt pröva dessa begrepp i en och samma enkätundersökning. Etthundra sextiotvå studenter, slumpvist uppdelade i två grupper, Känslogrupp och Preferensgrupp, deltog frivilligt i undersökningen. Enkätundersökningen var en mixad design med grupp (känsla kontra preferens) som mellangruppsfaktor och förtest kontra eftertest som inomgruppsfaktor. I studien visade samtliga gruppers resultat i linje med Impact Bias teorin, dvs. att deltagarna i både Känslogrupp och Preferensgrupp skattade lägre i eftertest (actual) än pretest (forecasting). Resultatet diskuteras bla. utifrån Construal Level Theory, CLT. Förslag på vidare forskning ges.

User interface design is becoming more reliant on user emotional states to improve usability, adapt to the users state, and allow greater expressiveness. Historically, usability has relied on performance metrics for evaluation, but user experience, with an emphasis on aesthetics and emotions, has become recognized as important for improving user interfaces. Research is ongoing into systems that automatically adapt to users states such as expertise or physical impairments and emotions are the next frontier for adaptive user interfaces. Improving the emotional expressiveness of computers adds a missing element that exists in human face-to-face interactions. The first step of incorporating users emotions into usability evaluation, adaptive interfaces, and expressive interfaces is to sense and gather the users emotional responses. Affective computing research has used predictive modeling to determine user emotional states, but studies are usually performed in controlled laboratory settings and lack realism. Field studies can be conducted to improve realism, but there are a number of logistical challenges with field studies: user activity data is difficult to gather, emotional state ground truth is difficult to collect, and relating the two is difficult. In this thesis, we describe a software solution that addresses the logistical issues of conducting affective computing field studies and we also describe an evaluation of the software using a field study. Based on the results of our study, we found that a software solution can reduce the logistical issues of conducting an affective computing field study and we provide some suggestions for future affective computing field studies.

User interface design is becoming more reliant on user emotional states to improve usability, adapt to the users state, and allow greater expressiveness. Historically, usability has relied on performance metrics for evaluation, but user experience, with an emphasis on aesthetics and emotions, has become recognized as important for improving user interfaces. Research is ongoing into systems that automatically adapt to users states such as expertise or physical impairments and emotions are the next frontier for adaptive user interfaces. Improving the emotional expressiveness of computers adds a missing element that exists in human face-to-face interactions. The first step of incorporating users emotions into usability evaluation, adaptive interfaces, and expressive interfaces is to sense and gather the users emotional responses. Affective computing research has used predictive modeling to determine user emotional states, but studies are usually performed in controlled laboratory settings and lack realism. Field studies can be conducted to improve realism, but there are a number of logistical challenges with field studies: user activity data is difficult to gather, emotional state ground truth is difficult to collect, and relating the two is difficult. In this thesis, we describe a software solution that addresses the logistical issues of conducting affective computing field studies and we also describe an evaluation of the software using a field study. Based on the results of our study, we found that a software solution can reduce the logistical issues of conducting an affective computing field study and we provide some suggestions for future affective computing field studies.

Thesis (Ed. D.)--West Virginia University, 2001. / Title from document title page. Document formatted into pages; contains viii, 90 p. Vita. Includes abstract. Includes bibliographical references (p. 61-66).