In Western society competing in physically demanding sport is not considered the domain of older people. For the majority of the twentieth century older people were stereotyped as frail, socially withdrawn and dependent on health and social welfare systems. Competitive athletes on the other hand are commonly viewed as being young, strong, aggressive, physically competent and independent. Although today’s older generation are encouraged to be physically active, society does not recognise serious competition or physically intense sports as age-appropriate activities for them. If older people choose to participate in sport they are expected to be doing it to have fun, make friends and keep fit. The growing leisure phenomenon of older athletes who compete to win, achieve a personal best, break world records or push their bodies to the limit presents a challenge to these orthodoxies. The purpose of this thesis is to explain why competing in physically demanding sport is significant to some older people given the accepted view that it is not their domain. In particular, the thesis explores the multiple ways in which a group of older people negotiate conflicting discourses of both sport and ageing, as well as the contradiction between their identity as an athlete and their ageing bodies, as they talk about and experience competing in physically strenuous individual and team sports. The key themes through which this negotiation process is played out relate to friendship and fun, competition, youthfulness, and the ageing body. It is revealed that the process of competing in sport can be simultaneously empowering and problematic at both the individual and social levels. The thesis draws on insights from post-structural theories of resistance and empowerment, traditional and postmodern understandings of identity management in later life, and life-stage theories to interpret the phenomenon of older people competing in physically demanding sport. To achieve the above aims, a qualitative study exploring the experiences of a group of Masters athletes aged over 55 years who regularly compete in physically strenuous individual or team sports was undertaken. It was found that despite age-appropriate norms, competition is significant to many of the participants. Study participants embrace the ideologies and practices of competitive sport and use them to define ageing in terms of youthfulness, physical ability and personal empowerment. Simultaneously however, a denial of, or desperate resistance to, the physical ageing process accompanies this feeling of empowerment. The participants in this study were not only competing in sport, but also ‘competing for life����. It is argued that a multi-faceted and conflicting interplay of resistance and conformity, empowerment and denial, identity and the ageing body is embedded in the phenomenon of older people competing in physically demanding sport. These contradictory findings expose alternative ways of understanding sport, competition, ageing and older people in the West and raise many questions requiring further investigation. The study also points to potential applications of these findings to policy-making and provision of leisure services for older people. / PhD Doctorate

This hermeneutical study interprets and describes the phenomena of ageing and living with disability. The lived experiences of 14 older men and the horizon of this researcher developed an understanding of what it is like for men to grow old and, for some, to live with the effects of a major disability. The study is grounded in the philosophical hermeneutics of Gadamer and framed in the context of embodiment, masculinity, and narrative. I conducted multiple in-depth interviews with older men aged from 67 to 83 years of age. Seven of the participants had experienced a stroke and I was able to explore the phenomenon of disability with them. Through thematic and narrative analyses of the textual data interpretations were developed that identified common meanings and understandings of the phenomena of ageing and disability. These themes and narratives reveal that the men�s understandings are at odds with conventional negative views of ageing and disability. These older men are �alive and kicking�, they voice counternarratives to the dominant construction of ageing as decline and weakness, and have succeeded in remaking the lifeworld after stroke. Overall I have come to understand an overarching meaning of older men �working it out� as illustrative of a strong face of ageing and disability. Older men seek out opportunities to participate actively in community life and, despite the challenges of ageing and disability, lead significant and meaningful lives. These findings challenge and extend our limited understandings of men�s experiences of ageing and living with disability. This interpretation offers gendered directions for policy development, clinical practice, and future research.

The prevalence of chronic pain is known to increase with advancing age, with over 50% of community dwelling older adults (aged 65 years and over) and up to 80% of those residing in nursing homes estimated to be suffering some form of persistent or recurring pain complaint. In addition to a greater likelihood of pain, advancing age is associated with increased reports of pain interference. It is possible to ascribe age-related changes in pain report and impact to increased disease prevalence and severity in older people. However, there is also evidence that ageing has effects on pain perception, central pain processing, and plasticity of pain responses that are not explained by co-morbid disease. / The increased prevalence of chronic pain in older adults represents a major public health concern. As a result of increased life expectancy and the post-World War II baby boom, there will be a dramatic change in the demographic structure of our population over the coming decades, with older adults representing the fastest-growing segment of our communities. The proportion of the total population over the age of 65 in Australia has risen from 9% in 1976, to 12% in 2001, and is predicted to reach 16% by the year 2016. Pain that is undetected or under-treated can adversely affect quality of life for older adults, leading to diminished mood, impaired cognition, behavioural problems, as well as increased functional dependence. This in turn contributes to greater demands for daily personal care and a resultant increase in health-care costs. / Pain management is a particularly salient issue in the case of older adults with dementia, who are at increased risk of undetected pain on account of impaired cognition and communication skills. Indeed, clinical reports show that patients with Alzheimer’s disease (AD) are routinely administered fewer pain-relief medications compared with their cognitively-intact peers. Understandably, reports of reduced analgesia in AD have sparked considerable research interest, and over recent years there has been a marked increase in the number of studies aimed at better characterising the experience of pain in patients with AD. However, despite these efforts, the effects of neurodegeneration on pain processing, and the specific ways in which the disease process impacts on brain responses to noxious stimulation and the ensuing experience of pain have not been previously determined. / Improved management of pain is fundamental to the clinical care of older adults, particularly those with dementia. However, the potential to adequately counteract pro-nociceptive processes and facilitate endogenous inhibitory mechanisms in the treatment of ongoing pain in older adults will only become possible once the effects of ageing and age-related neurodegeneration on central pain processing are identified and described. The overarching goal of this thesis was therefore to improve current understanding of the ways in which normal ageing and Alzheimer’s disease impact on the perception and central nervous system processing of pain. The findings of this thesis provide valuable new insights into the impact of ageing and AD on the central mechanisms contributing to pain perception, and may therefore contribute toward better management and treatment of pain in this vulnerable and rapidly growing sector of our community. / Thesis outline: Chapter 2 provides a review of the background literature and rationale for the thesis. The chapter begins with a discussion of current understanding of pain as a multidimensional phenomenon shaped by sensory, emotional and cognitive components, and leads into a description of neural mechanisms of nociception, as well as the supraspinal processes involved in the elaboration of nociceptive signals into these aspects of pain. The impact of ageing on the structure and function of central nervous system regions underlying these processes are discussed, along with the findings from previous clinical and empirical data which suggest age-related changes in pain perception. Current understanding of the neuropathological and clinical aspects of AD is reviewed, with particular emphasis on potential ways in which the disease may impact on central nociceptive processing and the behavioural response to pain. This is followed by a review of the previous clinical and empirical literature examining pain perception in AD. Finally, the aims of the current thesis are outlined. / Chapter 3 describes the general methods which were employed in the subsequent empirical chapters in order to address the aims of the thesis. The equipment and psychophysical procedures used to assess pain perception in healthy young and older adults and patients with AD are described. The basic principals of magnetic resonance imaging (MRI) are then outlined, and the utility of structural and functional MRI for assessing age-related and disease-related changes to brain regions involved in pain perception and processing are discussed. The empirical studies which were undertaken to identify the impact of ageing and AD on central pain processing are presented in the next three chapters. / Chapter 4 begins with psychophysical studies comparing sensory and emotional responses to pain in healthy young and older adults, and follows with MRI investigations of age-related differences in brain volumetry and pain-related brain activity. Studies of pain sensitivity and pain-evoked brain activity in patients with AD compared with age-matched controls are presented in Chapter 5. Following on from these findings of AD-related differences in pain-evoked brain activation, the study described in Chapter 6 used functional connectivity analysis in order to assess the impact of AD on the functional integration of brain regions underlying the sensory, emotional, and cognitive aspects of pain. / The key findings presented in the preceding three chapters are summarized in a general discussion in Chapter 7. The implications of the findings, in terms of the clinical management of pain in older adults with and without Alzheimer’s disease are discussed. The opportunity is also taken to discuss some of the limitations of the present research, and finally, recommendations are made for future research directions.

Due to the duration of human ageing, researchers must rely on models such as animals and cells. Replicative senescence and stress-induced premature senescence (SIPS) are two cellular models sharing many features. Although telomeres play a major role in replicative senescence, their involvement in SIPS is unclear. In this work, we first wanted to investigate how accurate models of ageing are. We published a new model of the evolution of human ageing, which offers a refined view of the evolution of ageing in humans and suggests that human models should be favoured. Though studying other mammals, reptiles, and birds may also be useful, we conclude that lower life forms such as yeast and invertebrates are not representative of the human ageing process. Secondly, we wanted to elucidate the importance of telomeres in SIPS and study gene expression and regulatory networks. Using a telomerase-immortalized cell line, we found no evidence that damage specific to the telomeres is at the origin of SIPS. In our published model, neither the TGF-â1 pathway nor telomeres appear to play a crucial role in SIPS. We suggest that widespread damage to the DNA causes SIPS and propose a rearrangement of gene expression networks as a result of stress. Moreover, we advise caution in using telomerase in anti-ageing therapies since telomerase expression may alter the normal cellular functions and promote tumorogenesis. Lastly, we published strategies to integrate the modern computational approaches to research ageing. Although we find it unlikely that a full understanding of ageing may be achieved within a near future, we argue that understanding the structure and finding key regulatory genes of the human ageing process is possible.

Background: This thesis explores the retirement behaviour of older people approaching retirement decisions. The research questions in focus deal with the attitudes toward work, the retirement preferences and the subjective well-being of the "youngest old", i.e. people aged 55–64. The included studies analyse the social determinants of these subjective evaluations and how they predict the timing of retirement and post-retirement well-being. Methods: In the included studies, methods are used that allow us to follow developments over time. Repeated cross-sectional analyses are employed to examine general developments pertaining to the older work force. These include OLS and logistic regression analysis. Longitudinal analyses are used to follow individual developments over time. These include Structural equation modelling and Cox regression analysis. Results: The results indicate that subjective evaluations such as attitudes to work and retirement preferences, as well as subjective well-being, are closely related to the structural conditions to which individuals are exposed, i.e. class position and work environment. The results also indicate that subjective evaluations such as preferred exit age and subjective well-being reported while in the work force are determinants of both the timing of retirement (in the case of preferred exit age and pre-retirement subjective well-being) and post-retirement subjective well-being (in the case of pre-retirement subjective well-being). Also, results indicate that recent policy changes in the Swedish pension systems are reflected in the retirement preferences of the older work force. A comparison of two time-points representing the incentive structure of the old and the new pension systems indicates that preferences were delayed with pension reform. Conclusion: The thesis contributes a temporal perspective to a research field that is dominated by research studying retirement behaviour at a single point of in time. The included studies underline the value of understanding retirement behaviour as a process rather than an isolated event. The way people evaluate their work, their well-being and their retirement prospects is intimately intertwined with their earlier experience. These subjective evaluations affect future retirement outcomes. Life course approaches offer illuminating tools for examining and explaining the significance of the biographies behind retirement behaviour. / Panel Survey of ageing and the elderly

Sammanfattning Bakgrund: I Halmstad har områdeschefer en mellanposition i den kommunala distributionen av hemtjänst. Studien undersöker hur dessa mellanchefer uppfattar krav eller önskemål från politikerna och från brukarna. Studiens fokusering är brukarnas efterfrågan och de politiska målen för den kommunala hemtjänsten. Syfte: Syftet med studien är att undersöka hur distributionen av den kommunala hemtjänstens insatser kan förstås utifrån områdeschefers perspektiv. Metod: Den metod vi har valt för att kunna få en förståelse för områdeschefernas uppfattningar har en kvalitativ ansats och utgörs av intervjuer med totalt 6 intervjupersoner. Resultat: Områdescheferna uppfattar att det finns en efterfrågan av de återkommande insatser som redan ges men att det dessutom finns en efterfrågan från brukarna på andra insatser som beror på t.ex. tillfälliga händelser eller önskemål. Det finns dessutom en efterfrågan på en större flexibilitet i insatserna och en högre personkontinuitet från brukarna. Områdescheferna uppfattar de politiska målen för den kommunala hemtjänsten som övergripande mål och flera områdeschefer anser att dessa mål behöver brytas ner till delmål för att kunna implementeras och användas i den praktiska verksamheten.

<p>Sammanfattning</p><p>Bakgrund: I Halmstad har områdeschefer en mellanposition i den kommunala distributionen av hemtjänst. Studien undersöker hur dessa mellanchefer uppfattar krav eller önskemål från politikerna och från brukarna. Studiens fokusering är brukarnas efterfrågan och de politiska målen för den kommunala hemtjänsten.</p><p>Syfte: Syftet med studien är att undersöka hur distributionen av den kommunala hemtjänstens insatser kan förstås utifrån områdeschefers perspektiv.</p><p>Metod: Den metod vi har valt för att kunna få en förståelse för områdeschefernas uppfattningar har en kvalitativ ansats och utgörs av intervjuer med totalt 6 intervjupersoner.</p><p>Resultat: Områdescheferna uppfattar att det finns en efterfrågan av de återkommande insatser som redan ges men att det dessutom finns en efterfrågan från brukarna på andra insatser som beror på t.ex. tillfälliga händelser eller önskemål. Det finns dessutom en efterfrågan på en större flexibilitet i insatserna och en högre personkontinuitet från brukarna. Områdescheferna uppfattar de politiska målen för den kommunala hemtjänsten som övergripande mål och flera områdeschefer anser att dessa mål behöver brytas ner till delmål för att kunna implementeras och användas i den praktiska verksamheten.</p>

For the fishing village of Sambro, Nova Scotia, Canada, this project proposes affordable elderly housing, interactive and mixed use spaces where a self-supporting ethos is cultivated among independent and service living accommodations. It reveals the connectors within the project itself and the community at large that will build a healthy, healing, adaptable environment that will not only benefit its residents by actuating the paradigm of ageing as lifestyle, but will also contribute to the unification and physical manifestation of the community.

Six different lots of soya beans (Glycine max (L.) Merr.) were examined. Seed hydroperoxide levels were highly correlated with viability, but not with moisture contents. It was proposed that moisture contents may exert a similar antioxidant effect at intermediate levels as has been observed in dry foods. Seeds treated with ferrous sulphate were significantly (S% level) invigorated. Furthermore, this treatment was observed to give rise to a reduction in the peroxide value of soya bean axes over the first hour of imbibition, an increase in 2,3,S-triphenyl-tetrazolium chloride reduction and protein synthesis, and a decline in electrolyte leakage. It was proposed that this was due to the antioxidant activity of the ferrous iron, leading to an attenuation of free-radical induced autoxidation. Ferrous sulphate treated seeds produced more aldehydes than untreated seeds. This result suggested that aldehydes may not be responsible for declining seed vigour. Hexanal, pentanal and butanal production from heated dry seeds was significantly correlated with seed germination, CVG and hydroperoxide levels. The thermal breakdown of the hydroperoxides was postulated to be the source of these compounds. A GC technique was developed using model systems of oxidized methyl oleate, linoleate, linolenate and soya bean bulk oil. The analysis of seed lipid oxidation products revealed marked differences in the proportions of the products compared to bulk and monolayer oxidation. The selective production of the 13-hydroperoxide implicated enzymatic or metalloprotein involvement. The implications of the results of this study with regard to the present theories of seed ageing were discussed. / Thesis (Ph.D.)-University of Natal, Durban, 1990.

Senescence was examined in the economic weed Bidens pilosa, with the objectives to a) determine the effects of deflowering and defruiting on growth, chlorophyll content, photosynthesis and transpiration; b) to identify the stage of development of the head at which the flowers, seeds/fruit produce senescence signals; and c) to test for senescence activity in plant extracts made from the receptacles and leaves of Bidens pilosa. Total chlorophyll content in the controls, in association with the development of fruit, was lower in the final harvests when compared with earlier harvests in both pot and field-grown plant experiments. Deflowered Bidens pilosa plants had a higher chlorophyll concentration than both defruited and control plants in both pot and field-grown plants. Stem death of the control plants was higher than that of deflowered plants in both field and pot experiments. The present results suggest that deflowering is essential if the leaves are to be harvested commercially because it retards senescence and maintains growth. Fruit and flower heads were responsible for the reduction in leaf and stem growth after flowering in Bidens pilosa. Removing these organs slowed plant decline, suggesting that the flower head and especially the fruit are responsible for senescence. In contrast, the fruit were the main organs responsible for the decline in leaf chlorophyll concentration. In pot-grown plants in full sunlight, photosynthesis and transpiration were low in deflowered plants compared with the control and defruited plants 45 days after treatment, and it coincided with a low stomatal conductance. These results suggest that stomatal conductance played a role in lowering photosynthesis in deflowered plants. In contrast, the control plants had a higher stomatal conductance than deflowered plants 75 days after treatment, yet photosynthesis and transpiration rates were the same in both treatments. Thus stomatal conductance alone does not successfully explain differences in photosynthesis in these treatments. The dry weight of head with mature dry fruit was higher in plants grown at high light intensities than at medium or low light intensities. It coincided with a greater decline in chlorophyll concentration in the leaf nearest to the head and fruit. In contrast, photosynthesis was the same at all light intensities in the leaf nearest to the head and fruit. This suggests that high light accelerated the process of fruit maturation of the fruit which then influenced senescence in the leaf nearest to the flower head. Ethanolic and water extracts of senescent receptacles purified using paper chromatography, induced senescence of leaves in light but not in the dark. In ethanolic extracts, activity was detected in R[f]s 0.1, 0.2 and 0.3. In water extracts, activity was detected in R[f] 0.1. Senescent leaf extracts purified using column chromatography also induced senescence in light under greenhouse conditions. At high concentrations, activity was detected in fraction 10 eluted with ethyl acetate: methanol (55:45); fraction 11 eluted with ethyl acetate: methanol (50:50); fraction 12 eluted with methanol (100%) and in fraction 13 eluted with ethylacetate : isopropanol: water: acetic acid (52:28:28:4). Under growth room conditions, activity was detected in fractions 12, eluted with methanol (100%) and 13, eluted with ethyl acetate: isopropanol: water: acetic acid (52:28:28:4) in the presence of light. Fraction 1 (R[f] 0.00-0.10) from senescent receptacles, non-senescent and senescent leaves, obtained following thin layer chromatography of ethanolic extracts induced senescence under light. Fraction 1 was eluted with methanol. This fraction lacked activity when eluted with ethyl acetate. Fraction 4 (R[f] 0.25 - 0.35) from non-senescent leaf extracts, which co-chromatographed with 4-chloroindole acetic acid, gave activity in bean cuttings kept under continuous low light. Senescent leaf extracts showed no activity. Fraction 7 (R[f] 0.9 - 1.0) from non-senescent leaf extracts, also induced senescence in bean cuttings under light. The same Fraction from senescent leaf extracts lacked activity. / Thesis (Ph.D.)-University of Natal, Pietermaritzburg, 2000.