Thesis (Ph. D.)--University of Wisconsin--Madison, 1970. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Bibliography: leaves 595-616.

Thesis (Ph. D.)--University of Chicago, 1943. / Bibliography: leaves 162-167.

Thesis (M.A.)--University of Alabama at Birmingham, 2010. / Title from PDF t.p. (viewed June 30, 2010). Additional advisors: Daniel Anderson, Michele Forman, Daniel Siegel. Short stories. Includes bibliographical references (p. vi).

No description available.

Dissertation (Ph.D.)--Auburn University, 2006. / Abstract. Includes bibliographic references.

Cette thèse visait à évaluer l’effet d’une alimentation pourvue en graines de lin riches en acide a-linolénique (ALA) et en microalgues riches en acide docosahexaenoïque (DHA) sur le métabolisme des lipides et la qualité de la viande de porc. Les régimes n’ont pas eu d’effet sur les performances de croissance et les critères de qualité de la carcasse mesurés en abattoir. La digestibilité des acides gras polyinsaturés (AGPI) n-3, leurs quantités dans les régimes et les traitements technologiques subis par la graine de lin ont impacté le dépôt d’ALA et de DHA dans les lipides totaux et les fractions neutres et polaires des tissus. La quantité de malonaldéhyde, représentatif de la peroxydation des acides gras, du muscle longissimus dorsi et du tissu adipeux sous cutané dorsal (TAD) a été augmentée avec un apport de microalgues.Une odeur plus prononcée des rôtis issus du régime microalgues a été identifiée par un jury entrainé. Enfin, les activités et l’expression des gènes de la lipogenèse et de la synthèse des AGPI n-3 ont été diminuées au niveau hépatique avec l’apport de microalgues. Un second objectif visait à recenser les facteurs de variation du dépôt des AGPI n-3 dans les tissus porcins pour les intégrer dans un modèle prédictif de ce dépôt. En raison d’une grande variabilité entre individus, seuls des modèles linéaires ont pu être établis en considérant les quantités digestibles d’ALA et de DHA ingérées, le sexe des animaux et l’effet du lot. Enfin, la thèse a permis de proposer des équations de calibration de spectrométrie en proche infra-rouge (SPIR) afin de déterm / Pigs used in this thesis were fed linseed rich in a-linolenic acid (ALA) and microalgae rich in docosahexaenoic acid (DHA) to evaluate the effect of diet on lipid metabolism and pork quality. Fatty acid (FA) composition of the diets did not have any effect on pig performances and carcass parameters measured at slaughter. The digestive utilization, the quantity of n-3 polyunsaturated FA (PUFA) in the diet and the technological treatment applied to linseed were identified as modifiers of the deposition of ALA and DHA in total, neutral and polar lipids. They also had an impact on the activity of lipogenesis enzymes and on the gene expression involved in n-3 PUFA synthesis in the liver. The malonaldehyde content, representative of the FA lipoperoxydation, measured in longissimus dorsi muscle and subcutaneous adipose tissue of the back (SCB),significantly increased with the supply of microalgae and with linseed to a lesser extent. Finally, the odor of the meat from pigs fed microalgae was more pronounced than meat from pigs fed linseed or a mix 75%/25% of linseed and microalgae. From results obtained in animal experiments, linear models were built to predict n-3 PUFA deposition in pig tissues from quantities of digestible ALA and DHA ingested by animals. Finally, a last part of the thesis allowed characterizing the FA composition of the SCB by near infrared spectroscopy (NIRS) in order to quickly identify the meat enriched with n-3 PUFA.

Neste trabalho foi investigada a ação fotodinâmica dos pró-fármacos 5-ALA e 8-ALA incorporados em nanopartículas de quitosana, através da incidência de luz em células de melanoma, utilizando sinergicamente a Eletroquimioterapia e a Terapia Fotodinâmica. O ácido 5-aminolevulínico (5-ALA) e seus ésteres derivados são precursores metabólicos da protoporfirina IX (PpIX) e apresentam uma penetração limitada no estrato córneo. Portanto, o objetivo desse trabalho foi desenvolver, caracterizar e avaliar o efeito fotodinâmico das nanopartículas de quitosana contendo os pró-fármacos 5-ALA e seu éster derivado 8-ALA e investigar a produção efetiva de PpIX. Concomitantemente, o efeito sinérgico da Eletroquimioterapia (ECT) com a TFD também foi estudado com a finalidade de aumentar a permeação dos fármacos fotossensibilizantes através da pele, aumentando a eficiência da TFD no tratamento de neoplasias cutâneas. As nanopartículas de quitosana foram obtidas pelo método de gelificação ionotrópica, produzindo nanopartículas em tamanho nanométrico (636,0 nm ± 6,5), com uma distribuição de tamanho homogênea (0,37), além de apresentar um potencial zeta significantemente positivo + 35,3 mV (± 2,21). Seu perfil de liberação e capacidade de incorporação de 80% dos pró-fármacos também foi determinado. Os estudos de citotoxicidade na ausência de luz demonstraram o caráter biocompatível das nanopartículas de quitosana desenvolvidas, assim como a produção significativa de PpIX e foi possível comprovar o excelente efeito fototóxico da formulação desenvolvida. Os estudos de sinergismo da ECT com a TFD comprovaram que a combinação das nanopartículas de quitosana contendo os pró-fármacos, com aplicação de microcorrentes de 400 ?A e dose de luz de 3 J/cm2, nestas condições apresentou uma morte celular significativa. / This study investigated the photodynamic action of the prodrug 5-ALA and 8-ALA into chitosan nanoparticles, through the light incidence in melanoma cells, using synergistically the Electrochemotherapy and Photodynamic Therapy. The 5- aminolevulinic acid (5-ALA) and its ester derivatives are metabolic precursors of protoporphyrin IX (PpIX) and have a limited penetration in the stratum corneum. Therefore, the objective of this study was to develop, characterize and evaluate the photodynamic effect of chitosan nanoparticles containing the prodrug 5-ALA and its ester derivative 8-ALA. Besides, was investigated the effective production of PpIX. Concomitantly, the synergistic effect of Electrochemotherapy (ECT) with PDT was also studied for the purpose of increasing the permeation of drugs through the skin, enhancing the efficiency of the PDT in the treatment of skin cancers. Chitosan nanoparticles were obtained by the ionotropic gelation producing nanoparticles in nanosize (636.0 ± 6.5 nm), with a homogenous size distribution (0.37), and present a significantly positive zeta potential + 35.3 mV (± 2.21). Release profile and ability to incorporate 80% of the prodrug was also determined. The cytotoxicity studies demonstrated in the absence of light the biocompatible nature of chitosan nanoparticles developed, as well as the significant production of PpIX and it was possible to demonstrate the excellent effect of phototoxic formulation developed. The synergism studies of ECT with PDT have shown that the combination of chitosan nanoparticles containing prodrugs, applying microcurrents 400 ?A and light dose of 3 J/cm2 under these conditions showed a significant cell death.

Thesis(M.S.)--Auburn University, 2005. / Abstract. Includes bibliographic references.

Dissertation (Ph.D.)--Auburn University, 2006. / Abstract. Vita. Includes bibliographic references.

Thesis (Ph. D.)--New York University, 1926. / On cover: 1874-1896. Includes bibliographical references (p. [183]-196).