The challenges of the Great Recession of 2008 have impacted the field of education to the point that many intern programs have ceased to exist. Alternative (or Intern) teacher preparation programs have also become an increasingly popular topic, especially since the term "highly qualified teachers" will soon be up for re-assessment. Concerns over the quality of teacher preparation programs have yet to yield conclusive results and seems to be an unending debate. This study has provided a glimpse into two intern programs and the process by which these programs have evolved. There were 6 major themes that emerged out of this study: Communication & Collaboration, Support, Financial Influences, Individual Dynamics, Beyond Curriculum and How Programs have Evolved to Remain Current. This study described participant perspectives that relate only not how these two intern programs survived during the challenging economic crisis, but how they have managed to thrive. Efforts were made by each program to utilize low intern enrollment to their benefit by providing added supports and individualized programming to better meet the needs of interns/teachers in training. Three intern participants, two Intern program directors and four intern program instructors have provided their perceptions on their programs to illustrate a clearer picture of how their respective intern programs have evolved to remain current in this challenging economically turbulent time.

A dengue é doença causada pelo vírus dengue (DENV), que acomete cerca de 390 milhões de pessoas no mundo, representando uma ameaça à saúde pública mundial. Até o momento não se dispõe de tratamento específico ou de vacinas para a maioria da população. Um dos maiores obstáculos para o desenvolvimento de vacinas ou para a compreensão da biologia do vírus é a falta de modelos animais que mimetizem a doença vista em humanos. Neste trabalho, o principal objetivo foi a busca de modelos alternativos de infecção com um isolado clínico (JHA1) de DENV sorotipo 2 (DENV2) capaz de infectar camundongos imonocompetentes após administração pela via intracraniana. Foram testadas duas vias alternativas de inoculação viral (intraperitoneal e intravenosa) em camundongos adultos imunocompetentes, além da via intracraniana em camundongos C57BL/6. Por fim, tentativas de mapeamento de mutações relacionadas à neurovirulência do JHA1 em camundongos imunocompetentes. Os resultados obtidos contribuem para a caracterização do JHA1 e para a busca de modelos experimentais alternativos de DENV. / Dengue fever is a disease caused by the dengue virus (DENV), which affects around 390 million people worldwide, posing a threat to global public health. To date, there is no specific treatment or vaccination for the majority of the population. One of the major obstacles to vaccine development or understanding the biology of the virus is the lack of animal models that mimic the disease seen in humans. In this work, the main objective was to search for alternative models of infection with a clinical isolate (JHA1) of DENV serotype 2 (DENV2) capable of infecting immunocompetent mice after administration by the intracranial route. Two alternative routes of viral inoculation (intraperitoneal and intravenous) were tested in immunocompetent adult mice, in addition to the intracranial route in C57BL/6 mice. Finally, attempts to map mutations related to JHA1 neurovirulence in immunocompetent mice. The results obtained contribute to the characterization of JHA1 and to the search for alternative experimental models of DENV.