Made available in DSpace on 2014-06-11T19:22:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-07-29Bitstream added on 2014-06-13T20:29:15Z : No. of bitstreams: 1 santiago_prp_me_rcla.pdf: 3425550 bytes, checksum: a0a50357f1a0683f95e5172e6c8be332 (MD5) / Universidade Estadual Paulista (UNESP) / O objetivo desta pesquisa foi comparar os padrões cinemáticos dos membros inferiores, durante chutes com a parte medial do pé, realizados por 14 praticantes jogadores, de futebol sendo 7 de nacionalidade brasileira e 7 de japonesa. Cada participante realizou 15 chutes a gol, simulando uma cobrança de falta com barreira. Esses chutes foram filmados por 4 câmeras digitais, focalizando o membro de chute e de apoio dos participantes, nos quais foram colocados 5 marcadores passivos, nos pontos anatômicos de interesse, definindo, assim, os segmentos coxa, perna e pé. Os dados tridimensionais foram obtidos através de procedimentos de cinemetria. Em seguida, estes foram suavizados e realizou-se a projeção estereográfica dos vetores normalizados, obtendo-se, assim, curvas no plano que descrevem a movimentação dos segmentos, durante a execução do chute ao longo do tempo. Realizou-se o cálculo de uma curva média para as 15 curvas da projeção estereográfica de cada segmento (coxa, perna e pé) do membro de chute e apoio para cada um dos 14 participantes. Através das curvas médias de cada um, aplicou-se a análise por cluster, para cada segmento isoladamente, entre todas as curvas médias projetadas, a cada instante de tempo. Neste caso, foram definidos dois grupos e identificados em quais partes do ciclo do movimento houve uma separação em função do país do qual o participante era oriundo. Através dos resultados obtidos concluiu-se que o comportamento dos segmentos inferiores entre os grupos estudados (brasileiros e japoneses) apresentaram padrões cinemáticos semelhantes. Com relação ao acerto dos chutes, verificou-se que os comportamentos dos segmentos inferiores entre os chutes acertaram e os imprecisos apresentaram padrões cinemáticos semelhantes. Deste modo, não foram encontradas relações entre os chutes que acertaram o alvo e os chutes que não acertaram o alvo. / The purpose of this research has been to compare the kinematics patterns of the lower limbs during kicks with the medial part of the foot (pass kicks), performed by soccer practitioners of both Brazilian and Japanese nationalities. Each one performed 15 goal kicks, simulating a foul kick with a barrier. These kicks were registered in films, by 4 digital cameras, focusing the kick and the participantsþ support limbs, in which 5 passive markers were placed in the anatomical spots of interest, thus identifying the thigh, leg and foot segments. The 3D data were obtained through the kinemetry processes. Then, data were smoothed, and finally, a stereographic projection of normalized vectors was accomplished, producing curves in a plan, which described the placement frame by body segments during the kick. The average curve among each participant þs 15 curves was estimated. Through the average curves, a cluster analysis for each segment among all the projected average curves was applied separately, at every moment. In this case, two groups were defined and identified in order to be studied, and parts of the movement cycle in which there had been a separation were considered, due to the participant þs nationality. Through the results it was concluded that the behavior of the lower limbs between the groups -Brazilian X Japanese- presented a similar kinematic pattern. In relation to precision, two situations were presented. The first one, in which the kicks were precise, and the second one, in which they weren't. It was observed that the limb behavior in these two situations also presented similar kinematic patterns. Therefore, no relationship could be found between those kicks which hit the target, and the ones which didn't.

Orientador: Sergio Augusto Cunha / Banca: Ana Maria Pellegrini / Banca: Luciano Allegretti Mercadante / Resumo: O objetivo desta pesquisa foi comparar os padrões cinemáticos dos membros inferiores, durante chutes com a parte medial do pé, realizados por 14 praticantes jogadores, de futebol sendo 7 de nacionalidade brasileira e 7 de japonesa. Cada participante realizou 15 chutes a gol, simulando uma cobrança de falta com barreira. Esses chutes foram filmados por 4 câmeras digitais, focalizando o membro de chute e de apoio dos participantes, nos quais foram colocados 5 marcadores passivos, nos pontos anatômicos de interesse, definindo, assim, os segmentos coxa, perna e pé. Os dados tridimensionais foram obtidos através de procedimentos de cinemetria. Em seguida, estes foram suavizados e realizou-se a projeção estereográfica dos vetores normalizados, obtendo-se, assim, curvas no plano que descrevem a movimentação dos segmentos, durante a execução do chute ao longo do tempo. Realizou-se o cálculo de uma curva média para as 15 curvas da projeção estereográfica de cada segmento (coxa, perna e pé) do membro de chute e apoio para cada um dos 14 participantes. Através das curvas médias de cada um, aplicou-se a análise por cluster, para cada segmento isoladamente, entre todas as curvas médias projetadas, a cada instante de tempo. Neste caso, foram definidos dois grupos e identificados em quais partes do ciclo do movimento houve uma separação em função do país do qual o participante era oriundo. Através dos resultados obtidos concluiu-se que o comportamento dos segmentos inferiores entre os grupos estudados (brasileiros e japoneses) apresentaram padrões cinemáticos semelhantes. Com relação ao acerto dos chutes, verificou-se que os comportamentos dos segmentos inferiores entre os chutes acertaram e os imprecisos apresentaram padrões cinemáticos semelhantes. Deste modo, não foram encontradas relações entre os chutes que acertaram o alvo e os chutes que não acertaram o alvo. / Abstract: The purpose of this research has been to compare the kinematics patterns of the lower limbs during kicks with the medial part of the foot (pass kicks), performed by soccer practitioners of both Brazilian and Japanese nationalities. Each one performed 15 goal kicks, simulating a foul kick with a barrier. These kicks were registered in films, by 4 digital cameras, focusing the kick and the participantsþ support limbs, in which 5 passive markers were placed in the anatomical spots of interest, thus identifying the thigh, leg and foot segments. The 3D data were obtained through the kinemetry processes. Then, data were smoothed, and finally, a stereographic projection of normalized vectors was accomplished, producing curves in a plan, which described the placement frame by body segments during the kick. The average curve among each participant þs 15 curves was estimated. Through the average curves, a cluster analysis for each segment among all the projected average curves was applied separately, at every moment. In this case, two groups were defined and identified in order to be studied, and parts of the movement cycle in which there had been a separation were considered, due to the participant þs nationality. Through the results it was concluded that the behavior of the lower limbs between the groups -Brazilian X Japanese- presented a similar kinematic pattern. In relation to precision, two situations were presented. The first one, in which the kicks were precise, and the second one, in which they weren't. It was observed that the limb behavior in these two situations also presented similar kinematic patterns. Therefore, no relationship could be found between those kicks which hit the target, and the ones which didn't. / Mestre

Le Lebanese Atomic Energy Commission (LAEC) poursuit un programme de développement des techniques analytiques pour compléter l’analyse par faisceau d’ions (IBA). Il a décidé de s’équiper d’un spectromètre de masse couplée à l’imagerie 2D puis récemment 3D avec l’acquisition d’un spectromètre de masse IONTOF V™ équipé de deux colonnes ioniques délivrant des faisceaux d’agrégats de bismuth et d’argon. Dans ce cadre, mon sujet de thèse a porté sur l'optimisation de l’instrument nouvellement acquis pour l’analyse d’échantillons contenant des composés organiques. Les premiers sujets de recherche sont la mise au point du protocole d’analyse quantitative de médicaments en utilisant la technique « cluster-SIMS-imaging » et l’analyse de la météorite Paris pour localiser la matière organique et déterminer sa composition. Dans les deux cas une approche multi-technique a été utilisée : IBA au LAEC, µ-Raman et µ-IR autour des équipements de Soleil et µPIXE réalisée auprès de l’accélérateur AGLAE (Centre de recherche et de restauration des musées de France, C2RMF).L’analyse de médicaments a été initiée au Liban en collaboration avec un fabricant local de produits pharmaceutiques (Mediphar Laboratories) dans le but d’établir de nouveaux procédés de contrôle qualité de produits finis. Mon étude a montré la complexité du dosage de médicament due à la présence de plusieurs molécules actives (Principe Actif, PA) et de substances organiques et minérales inactives (excipients) mélangées dans des conditions secrètes. Les effets de matrice sont dominants et modifient l’émission ionique conduisant à des erreurs systématiques importantes. Cette complexité a été analysée avec l’étude du Fludinium™ possédant deux PAs. Les résultats de cette étude ont permis d’obtenir la première courbe d’étalonnage du rapport des deux PAs et de quantifier ceux-ci dans les conditions du médicament commercial. Le protocole pour effectuer cette courbe d’étalonnage et les contrôles « qualité » ont été déterminés. Ceux-ci incorporeront une analyse en profil pour contrôler l’homogénéité des échantillons et l’obtention d’étalons produits par le fabricant en suivant ses processus de fabrication. En effet, les expériences ont montré que la réalisation du médicament en laboratoire à partir de ses éléments (PAs et excipients) ne donnait pas la même réponse ionique que le médicament commercial. L’analyse de la météorite Paris a été initiée par une collaboration avec une équipe de l’Institut d’Astrophysique Spatial d’Orsay impliquée dans l’exobiologie et la recherche des premières molécules pré-biotiques dans des échantillons extraterrestres. Le but des recherches est de caractériser la matière organique représentant quelques pourcents en poids dans une matrice minérale complexe, sans utiliser des méthodes chimiques pouvant induire une modification de ces molécules. Cette étude a démontré l’intérêt de l’approche multi-technique centrée autour de la spectrométrie de masse couplée à l’imagerie ionique pour déterminer les éléments principaux de la matrice minérale et organique. L’analyse par µPIXE avec une cartographie micrométrique a permis d’attribuer les distributions d’ions moléculaires et agrégats des spectres de masse aux différents composés minéraux. Ces attributions se poursuivent avec la constitution d’une base de données de spectres de référence. La composante organique a été extraite et les premières hypothèses de composition ont été envisagées autour des HAPs (Hydrocarbure Aromatique Polycyclique), MOI (Matière Organique Insoluble) et analogues de carbone amorphe produits par irradiation UV de glaces dont les compositions en gaz représentent différentes hypothèses pour les nuages interstellaires. Les protocoles d’analyses multi-techniques établis (incorporant un suivi de l’échantillon par spectrométrie de masse et imagerie ionique) permettent le démarrage d’analyse d’autres échantillons extra-terrestres collectés sur terre ou dans l’espace. / The Lebanese Atomic Energy Commission (LAEC) is incorporated in a development program of the analytical techniques in order to complete the Ion Beam Analysis (IBA). It was decided to get a mass spectrometer coupled to 2D and recently to 3D imaging, by acquiring an ION TOFVTM system equipped with two ionic columns delivering bismuth and argon cluster beams.In this context, my thesis is focused on the optimization of the instrument, recently purchased, for the analysis of samples containing organic compounds. The first subjects of research are the development of a protocol for quantitative analysis of drugs using the « cluster-SIMS-imaging » technique and the Paris meteorite analysis to determine its composition and to localize the organic matter. In the last case a multi-techniques approach was used : IBA in LAEC, µ-Raman et µ-IR around the Soleil synchrotron equipments and µPIXE carried with the AGLAE accelerator (Centre de recherche et de restauration des musées de France, C2RMF).The drug analysis was initiated in Lebanon in collaboration with a local pharmaceutical manufacturer (Mediphar Laboratories) in order to establish new processes for quality control of the final products. My study showed the complexity of the drug quantification which is due to the presence of several active ingredients (AI) and inactive organic and minerals components (excipients) mixed in secret conditions. Matrix effects are dominant and modify the ionic emission leading to significant systematic errors. This complexity has been analyzed with the study of FludiniumTM with two active ingredients. The results of this study allowed to obtain the first calibration curves of the ratio between the two AIs and to quantify them in the commercial drug. The protocol to perform the calibration curve and the « quality» controls were determined. These incorporate a profile analysis to control the homogeneity of the samples and the obtaining standards produced by the pharmaceutical manufacturer following the same process used for the commercial drug. Indeed, the experiments have shown that the preparation of the drug in the laboratory from its elements (AIs and excipients) doesn’t give the same ionic emission as for the commercial drug.The Paris meteorite analysis was initiated by a collaboration with the Institut d’Astrophysique Spatiale d’Orsay team involved in the exobiology and the research of the first prebiotic molecules in the extraterrestrial samples. The work objective is to characterize the organic matter representing few percents in mass in a complex mineral matrix, without any chemical extraction that can induce a modification of these molecules. This study has demonstrated the interest of the multi-techniques approach centered on the mass spectrometry coupled to the ionic imaging for the determination of the main mineral and organic elements of the matrix. µPIXE analysis coupled to the micrometric mapping permits to attribute the distribution of molecular ions and clusters of the mass spectra with different mineral compounds. These attributions continue with the creation of the data base of standard spectra. The organic component was determined and the first hypotheses were considered concerning PAHs (Polycyclic Aromatic Hydrocarbon), IOM (Insoluble Organic Matter) and analogues of amorphous carbon produced par UV irradiation of ices with a gas composition representing different hypotheses for the interstellar clouds. The establish protocols for multi-techniques (incorporating a follow of the sample by mass spectrometry and ion imaging) permits to start the analysis of other extra terrestrial samples collected on earth or in space.