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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

A scheme of qualitative analysis involving the use of organic reagents

Brennan, William Johnson 05 1900 (has links)
No description available.
2

An investigation of the possibility of separating group III qualitative analysis into two subdivisions

Pitts, Frank Patrick January 1927 (has links)
The important facts developed by the investigation are: Group III can be subdivided into two divisions without much injury to the delicacy of the individual tests. [See document for Scheme of Analysis For Group III] [See document for Diagramatic Scheme of Group III] The successful division of this group has eliminated the possibility of certain metals oxidizing during their initial precipitation and washing.* That the present of chromium precipitates an additional eleven per cent of zinc, but does not appreciably effect manganese. That different concentrations of ammonium hydroxide and ammonium chloride will precipitate varying amounts of zinc and manganese. The writer feels quite sure that his method requires less time and is less expensive than other methods.* / M.S.
3

Triterpenoid constituents of psidium guaijava

許慧嫻, Hui, Wai-haan. January 1954 (has links)
published_or_final_version / Chemistry / Master / Master of Science
4

The preparation of videotapes for the chemistry laboratory and their effects on student performance

Weishaar, Ronald Eugene, 1951- January 1975 (has links)
No description available.
5

Study of algorithms for analysis of xrf spectra to automate inspection of carpets

Mahuteau, Laurent 25 August 2008 (has links)
The objective of this thesis is to categorize carpet types according to their XRF spectra and verify if further classification of carpets is possible for use of an XRF analysis system in the carpet manufacturing line. This thesis consists of (1) implementing and studying effective algorithms for automated analysis of X-ray spectra, (2) comparing known algorithms for X-ray spectra analysis, and (3) implementing our own algorithm for classification of carpets spectra obtained for further fluorine online analysis of XRF inspected carpets. This research is intended for quick and accurate automated analysis of raw XRF spectra and matching analysis results to a database of XRF spectra of raw carpets. The research uses spectrum signal processing and spectrum analysis regarding efficacy of combined methods for XRF inspected carpets. X-Ray Fluorescence is a key technology for detection of chemical elements. Fluorine is a key element for carpet's quality. XRF has been chosen to be a potential candidate to measure fluorine since it is a versatile tool for low concentration element detection. Due to specific XRF background spectrum for each different carpet type, carpet samples may need specific calibrations for further computation of carpet fluorine concentration. Automating the detection of the carpet type is intended to help in automating the XRF calibration.
6

Avaliação da degradação biótica do poli(ácido lático), do polipropileno e suas misturas pela ação de fungos basidiomicetos

Menegotto, Morgana 31 October 2014 (has links)
Resíduos poliméricos, quando destinados em ambientes inadequados, associados a sua resistência à degradação, podem promover poluição ambiental. Desta forma, estudos que possibilitam favorecer a degradação de alguns polímeros vêm crescendo e são considerados como alternativa para os atuais problemas de poluição ambiental. Outra alternativa que possibilita alterar características de interesse dos polímeros é por meio do desenvolvimento de misturas poliméricas, sendo que suas propriedades físicas e químicas podem ser alteradas para uma vasta gama de aplicações, proporcionando desempenho desejável ao produto final. Neste trabalho foi desenvolvida misturas poliméricas entre o polipropileno (PP), polímero sintético, e o poli(ácido lático) (PLA), polímero biodegradável com e sem a presença de agente compatibilizante (AC) a base de PP modificado com anidrido maleico. O objetivo do trabalho foi avaliar as propriedades da mistura de PLA e PP sem e com a presença de agente compatibilizante, bem como a ação de 10 fungos asidiomicetos isolados dos biomas mata atlântica e pampa na degradação individualmente dos polímeros e da mistura de PLA/PP. As misturas poliméricas foram produzidas por processo de extrusão e injeção e verificadas as propriedades morfológicas, térmicas, químicas e mecânicas. Para o processo de degradação biológica em cultivo sólido in vitro foram produzidos filmes de PP, PLA e suas misturas, por moldagem por compressão. Os polímeros puros foram submetidos à exposição aos 10 fungos por períodos de 14, 28 e 75 dias a 28°C sendo os fungos Trametes villosa (Sw.) Kreisel 82I.6, Schizophyllum cf. commune (Fr.) 85E.16 e Auricularia bull Ex. Juss. 551.9B os que proporcionaram indícios de degradação nos filmes de PLA e o fungo T. villosa (Sw.) Kreisel 82I.6 nos filmes de PP. A mistura de PLA/AC/PP (75/3/25) selecionada por apresentar maior caráter hidrofílico, foi submetida à exposição ao fungo T. villosa (Sw.) Kreisel 82I.6 por 14, 28 e 60 dias a 28°C. Após o período avaliado, foram verificadas as propriedades físicas (perda de massa), morfológicas (microscopia ótica e microscopia eletrônica de varredura) e características químicas (espectroscopia no infravermelho com transformada de Fourier). Como resultados das propriedades das misturas, estas mostraram-se imiscíveis e as propriedades mecânicas foram inferiores as do PLA, sem alteração da estabilidade térmica e mudança da hidrofilia com o aumento de PP. O PLA diminuiu sua cristalinidade após o processamento e o PP aumentou. Foram produzidos extratos em cultivo líquido do PLA com os fungos T. villosa (Sw.) Kreisel 82I.6, S. cf. commune (Fr.) 85E.16 e A. bull Ex. Juss. 551.9B e do PP com o fungo T. villosa (Sw.) Kreisel 82I.6, contudo as enzimas não foram eficientes quanto a degradação biológica nos caldos. Os fungos que apresentaram maior potencial de degradação em cultivo sólido do PLA foram o T. villosa (Sw.) Kreisel 82I.6, S. cf. commune (Fr.) 85E.16 e A. bull Ex. Juss 551.9B e para o PP foi o fungo T. villosa (Sw.) Kreisel 82I.6; evidenciado na colonização da superfície com remoção de material após 28 e 75 dias de incubação. O fungo T. villosa (Sw.) Kreisel 82I.6 utilizado no processo de degradação em cultivo sólido da mistura PLA/AC/PP (75/3/25) propiciou que fosse identificado indícios de degradação nos períodos estudados. / Submitted by Ana Guimarães Pereira (agpereir@ucs.br) on 2015-02-20T16:07:37Z No. of bitstreams: 1 Dissertacao Morgana Menegotto.pdf: 4833989 bytes, checksum: 9e911dfa8cf78af6b06ea5d15a320088 (MD5) / Made available in DSpace on 2015-02-20T16:07:37Z (GMT). No. of bitstreams: 1 Dissertacao Morgana Menegotto.pdf: 4833989 bytes, checksum: 9e911dfa8cf78af6b06ea5d15a320088 (MD5) / Bolsa de Desenvolvimento Tecnológico e Inovação / Polymeric wastes when intended improperly, associated with its resistance to degradation may promote environmental pollution. Therefore, studies involving the degradation of some polymers are considered as an alternative to current environmental pollution problems. Another alternative that allows changing the characteristics of interest of the polymers is through the development of polyblends, and their physical and chemical properties can be changed to a wide range of applications, providing desirable performance to the final product. In this work were used polypropylene (PP), synthetic polymer, and polylactic acid (PLA), biodegradable polymer with and without the presence of compatibilizer (AC) based maleic anhydride modified PP. The objective of this study was to evaluate the properties of the blend of PLA and PP with and without the presence of compatibilizer as well the action of 10 basidiomycete fungi isolated from biomes, rainforest and pampa in as individually degradation polymers and the blends of PLA/PP. Polyblends of PP and PLA with and without the presence of a compatibilizer were produced by extrusion and injection process and morphological analysis, thermal, chemical and mechanical properties. For the process of biological degradation in solid culture in vitro were produced films of PP, PLA and their blend by compression molding. The pure polymers were subjected to exposure to the ten basidiomycete fungi for a period of 14, 28 and 75 days at 28°C, being the fungi Trametes villosa (Sw.) Kreisel 82I.6, Schizophyllum cf. commune (Fr.) 85E.16 and Auricularia bull Ex. Juss. 551.9B those who have provided evidence of degradation in the films of PLA and the fungus T. villosa (Sw.) Kreisel 82I.6 in the films of PP. A blend of PLA/AC/PP 75/3/25 selected due to its higher hydrophilic character, was subjected to exposure to the fungus T. villosa (Sw.) Kreisel 82I.6 during 14, 28 and 60 days at 28°C. After the evaluation period the physical properties (weight loss), morphological (light microscopy and scanning lectron microscopy) and chemical characteristics (infrared spectroscopy with Fourier transform) were observed. As a result of the properties of the blends, these proved to be immiscible, and the mechanical properties were lower than those of the PLA, without change in thermal stability and change in hydrophilicity with PP increasing. PLA decreased crystallinity after processing and PP increased. The solutions produced in liquid culture of the PLA with fungi T. villosa (Sw.) Kreisel 82I.6, S. cf. commune (Fr.) 85E.16 and A. bull Ex Juss. 551.9B and PP with the fungus T. villosa (Sw.) Kreisel 82I.6, however, the enzymes were not as efficient biological degradation in the broth. The fungi that showed higher degradation potential in solid culture of PLA were the T. villosa (Sw.) Kreisel 82I.6, S. cf. commune (Fr.) 85E.16 and A. bull Ex. Juss 551.9B below those reported in the literature time and the PP, the fungus T. villosa (Sw.) Kreisel 82I.6.; it promoted surface changes with removal of material after 28 and 75 days of incubation. The fungus T. villosa (Sw.) Kreisel 82I.6 used in the process of degradation in solid culture blend PLA/AC/PP (75/3/25), was identified that provided evidence of degradation during periods of exposure this study.
7

Avaliação da degradação biótica do poli(ácido lático), do polipropileno e suas misturas pela ação de fungos basidiomicetos

Menegotto, Morgana 31 October 2014 (has links)
Resíduos poliméricos, quando destinados em ambientes inadequados, associados a sua resistência à degradação, podem promover poluição ambiental. Desta forma, estudos que possibilitam favorecer a degradação de alguns polímeros vêm crescendo e são considerados como alternativa para os atuais problemas de poluição ambiental. Outra alternativa que possibilita alterar características de interesse dos polímeros é por meio do desenvolvimento de misturas poliméricas, sendo que suas propriedades físicas e químicas podem ser alteradas para uma vasta gama de aplicações, proporcionando desempenho desejável ao produto final. Neste trabalho foi desenvolvida misturas poliméricas entre o polipropileno (PP), polímero sintético, e o poli(ácido lático) (PLA), polímero biodegradável com e sem a presença de agente compatibilizante (AC) a base de PP modificado com anidrido maleico. O objetivo do trabalho foi avaliar as propriedades da mistura de PLA e PP sem e com a presença de agente compatibilizante, bem como a ação de 10 fungos asidiomicetos isolados dos biomas mata atlântica e pampa na degradação individualmente dos polímeros e da mistura de PLA/PP. As misturas poliméricas foram produzidas por processo de extrusão e injeção e verificadas as propriedades morfológicas, térmicas, químicas e mecânicas. Para o processo de degradação biológica em cultivo sólido in vitro foram produzidos filmes de PP, PLA e suas misturas, por moldagem por compressão. Os polímeros puros foram submetidos à exposição aos 10 fungos por períodos de 14, 28 e 75 dias a 28°C sendo os fungos Trametes villosa (Sw.) Kreisel 82I.6, Schizophyllum cf. commune (Fr.) 85E.16 e Auricularia bull Ex. Juss. 551.9B os que proporcionaram indícios de degradação nos filmes de PLA e o fungo T. villosa (Sw.) Kreisel 82I.6 nos filmes de PP. A mistura de PLA/AC/PP (75/3/25) selecionada por apresentar maior caráter hidrofílico, foi submetida à exposição ao fungo T. villosa (Sw.) Kreisel 82I.6 por 14, 28 e 60 dias a 28°C. Após o período avaliado, foram verificadas as propriedades físicas (perda de massa), morfológicas (microscopia ótica e microscopia eletrônica de varredura) e características químicas (espectroscopia no infravermelho com transformada de Fourier). Como resultados das propriedades das misturas, estas mostraram-se imiscíveis e as propriedades mecânicas foram inferiores as do PLA, sem alteração da estabilidade térmica e mudança da hidrofilia com o aumento de PP. O PLA diminuiu sua cristalinidade após o processamento e o PP aumentou. Foram produzidos extratos em cultivo líquido do PLA com os fungos T. villosa (Sw.) Kreisel 82I.6, S. cf. commune (Fr.) 85E.16 e A. bull Ex. Juss. 551.9B e do PP com o fungo T. villosa (Sw.) Kreisel 82I.6, contudo as enzimas não foram eficientes quanto a degradação biológica nos caldos. Os fungos que apresentaram maior potencial de degradação em cultivo sólido do PLA foram o T. villosa (Sw.) Kreisel 82I.6, S. cf. commune (Fr.) 85E.16 e A. bull Ex. Juss 551.9B e para o PP foi o fungo T. villosa (Sw.) Kreisel 82I.6; evidenciado na colonização da superfície com remoção de material após 28 e 75 dias de incubação. O fungo T. villosa (Sw.) Kreisel 82I.6 utilizado no processo de degradação em cultivo sólido da mistura PLA/AC/PP (75/3/25) propiciou que fosse identificado indícios de degradação nos períodos estudados. / Bolsa de Desenvolvimento Tecnológico e Inovação / Polymeric wastes when intended improperly, associated with its resistance to degradation may promote environmental pollution. Therefore, studies involving the degradation of some polymers are considered as an alternative to current environmental pollution problems. Another alternative that allows changing the characteristics of interest of the polymers is through the development of polyblends, and their physical and chemical properties can be changed to a wide range of applications, providing desirable performance to the final product. In this work were used polypropylene (PP), synthetic polymer, and polylactic acid (PLA), biodegradable polymer with and without the presence of compatibilizer (AC) based maleic anhydride modified PP. The objective of this study was to evaluate the properties of the blend of PLA and PP with and without the presence of compatibilizer as well the action of 10 basidiomycete fungi isolated from biomes, rainforest and pampa in as individually degradation polymers and the blends of PLA/PP. Polyblends of PP and PLA with and without the presence of a compatibilizer were produced by extrusion and injection process and morphological analysis, thermal, chemical and mechanical properties. For the process of biological degradation in solid culture in vitro were produced films of PP, PLA and their blend by compression molding. The pure polymers were subjected to exposure to the ten basidiomycete fungi for a period of 14, 28 and 75 days at 28°C, being the fungi Trametes villosa (Sw.) Kreisel 82I.6, Schizophyllum cf. commune (Fr.) 85E.16 and Auricularia bull Ex. Juss. 551.9B those who have provided evidence of degradation in the films of PLA and the fungus T. villosa (Sw.) Kreisel 82I.6 in the films of PP. A blend of PLA/AC/PP 75/3/25 selected due to its higher hydrophilic character, was subjected to exposure to the fungus T. villosa (Sw.) Kreisel 82I.6 during 14, 28 and 60 days at 28°C. After the evaluation period the physical properties (weight loss), morphological (light microscopy and scanning lectron microscopy) and chemical characteristics (infrared spectroscopy with Fourier transform) were observed. As a result of the properties of the blends, these proved to be immiscible, and the mechanical properties were lower than those of the PLA, without change in thermal stability and change in hydrophilicity with PP increasing. PLA decreased crystallinity after processing and PP increased. The solutions produced in liquid culture of the PLA with fungi T. villosa (Sw.) Kreisel 82I.6, S. cf. commune (Fr.) 85E.16 and A. bull Ex Juss. 551.9B and PP with the fungus T. villosa (Sw.) Kreisel 82I.6, however, the enzymes were not as efficient biological degradation in the broth. The fungi that showed higher degradation potential in solid culture of PLA were the T. villosa (Sw.) Kreisel 82I.6, S. cf. commune (Fr.) 85E.16 and A. bull Ex. Juss 551.9B below those reported in the literature time and the PP, the fungus T. villosa (Sw.) Kreisel 82I.6.; it promoted surface changes with removal of material after 28 and 75 days of incubation. The fungus T. villosa (Sw.) Kreisel 82I.6 used in the process of degradation in solid culture blend PLA/AC/PP (75/3/25), was identified that provided evidence of degradation during periods of exposure this study.
8

Analysis of sterols and sterolins in hypoxis hemerocallidea and related herbal medicine

Retief, A.C. 10 March 2006 (has links)
Phytosterols and their glucosides (sterolins) have many therapeutic indications e.g. immune modulation, hypercholesterolaemia and benign prostatic hyperplasia (BPH). In this study sterolslsterolins in three BPH phytotherapeutics (Hypoxis hemerocallidea, Prunus africana and Serenoa repens) and related products were investigated. The aim of this study was to develop, evaluate and apply TLC and HPLC methods for the qualitative and quantitative analyses of sterols and sterolins. A new optimum TLC method was developed for good visibility and separation of phytosterols and sterolins and could be used to qualitatively compare sterol/sterolin content. A published HPLC method to determine the bioavailability of β-sitosterol in humans was used in a new application to quantitatively determine phytosterols in plant extracts. A new and sensitive method to determine hypoxoside (norlignan diglucoside unique to Hypoxidaceae), by isolation from the crude methanol extract with solid phase extraction (SPE) and HPLC quantification using fluorescence detection (excitation wavelength of 230 nm and emission wavelength of 345 nm), was developed. The developed TLC and adapted HPLC methods were applied to determine the stability of phytosterols, subjected to increased temperature and gamma irradiation. Phytosterols in isolated form were more stable than the phytosterols in plant material. The data from the accelerated stability tests could be used to estimate the shelf-lives of the BPH phytotherapeutics and related sterol containing products. The HPLC method to determine β-sitosterol in serum, was evaluated during a pilot study of a clinical trial, to test the bio-equivalence of different phytosterol containing products. The method was found not sensitive enough to determine β-sitosterol in serum, notwithstanding improvements made, Le. changing the extraction ratio; experimenting with higher dosages, and different products. As result, the proposed clinical trial could not be performed, in the future, serum could rather be analysed by gas chromatographic methods. TLC and HPLC analyses of medicinal African potato tea, indicated that it contained hypoxoside, but not β-sitosterol or β-sitosterolin. β-Sitosterol (accepted to be the active of H. hemerocallidea) might not be the main active in African potato tea. Hypoxoside and a compound (red spot compound), noticed on TLC plates of acetone extracts of Prunus africana, Serenoa repens, Moducare®, Harzol®, Immunochoice® and Nutricare®, were extracted with water. This general presence of the red spot compound could point to a possible important function. Preparative TLC was unsuccessful to isolate the red spot compound, but column chromagraphy was successfully applied. From the proton and carbon NMR spectra, it was concluded, that the compound was definitely not a steroid and could either be a coumarin or an isoflavanoid, with a sugar unit (possibly a rhamose) attached to it. Further analyses to elucidate the structure failed due to decomposition of the compound. Further work on structure elucidation is required and possible therapeutic activity should also be investigated. The sterols and sterolins in H. hemerocallidea and related herbal medicine can be qualitatively and quantitatively analysed with the developed TLC and adapted HPLC methods. This provides natural medicine industry with necessary procedures to ensure proper quality, safety and stability. / Dissertation (MSc (Pharmacology))--University of Pretoria, 2006. / Pharmacology / unrestricted
9

Analysis of rocks and minerals by attenuated total reflection with atlas

Anderson, Donald Franklin 01 January 1975 (has links)
Routine non-destructive analyses of rocks and minerals in slab or powder form maybe practicable by the application of the technique of attenuated total reflection [ATR] in infrared [IR] spectrophotometry. An atlas of spectra would serve the analytical chemist and geologist, who in turn would serve the miner, the lapidarist, and other groups interested in rocks and minerals. No effort has been made to produce an atlas of spectra of rocks and minerals by ATR. No ATR spectra of rocks and minerals were found in the literature. The history of ATR indicates that it is still in its early stages of development. The application of all phases of IR to the study of minerals has been employed much less than to the study of organics. For the analysis of rocks and minerals, ATR is more versatile and more convenient than most methods. It is applicable for both opaque and transparent materials of thick or thin films. It is often requires no sample preparation. This study of ATR of minerals involves the development of an atlas of mineral powder spectra and of mineral slab spectra, the comparison of the two sets of spectra with each other, and the comparison of powder spectra from ATR with transmission spectra in the literature. the study is confined to the spectral range of 0.5 - 15.5 microns.
10

Salvia officinalis (Lamiaceae) Lin. : caracterização química, atividade citotóxica e apoptótica em células de mamíferos

Garcia, Charlene Silvestrin Celi 05 September 2014 (has links)
Salvia officinalis (Lamiaceae), conhecida popularmente como sálvia, tem sido muito utilizada no sul do Brasil como condimento nos alimentos, tintura hidroalcoólica e chá para o tratamento de vários distúrbios de saúde. As propriedades dessa planta são estudadas por apontar possíveis mecanismos de ação antioxidante e antitumoral. Neste trabalho, o extrato hidroalcoólico e aquoso de sálvia foram analisados quimicamente por meio de cromatografia gasosa acoplada a espectrômetro de massas (GC-MS) e electrospray de alta resolução acoplada a espectrômetro de massas (ESI-QTOF MS/MS) em modo negativo. A identificação química mostrou a presença de ácidos como caféico, rosmarínico, málico, succínico, tartárico, cítrico, ursólico e compostos como luteolina-7-O-glucoronide, eucaliptol, β-tujona, β-cariofileno, α-cariofileno, α- tujona, cânfora viridiflorol, mannol, rosmanol e seus isômeros metilcarnosato e ácido 12-metoxicarnosinico. Os extratos apresentaram compostos polifenólicos com capacidade de varrer os radicais 2,2-difenil-1-picrilhidrazil (DPPH•) e 2,2’- azino-bis(3-etilbenzotiazolina-6-ácido sulfônico) (ABTS•+), além de atividade catalase (CATlike) e superóxido dismutase (SOD-like). Ambos os extratos apresentaram menor citotoxicidade em linhagens não tumorais (HeK-293 e MRC-5) e seletividade para linhagens tumorais (Hep-2, HeLa, A-549, HT-29, A-375 e HepG2). Além disso, verificou-se que o aumento do tempo de exposição ao extrato hidroalcoólico diminuiu a viabilidade em linhagens tumorais. Foram observadas alterações morfológicas por coloração de Giemsa e a avaliação da apoptose com anexina V e iodeto de propídeo mostraram a maioria das células tumorais em estágios finais do processo de apoptose e necrose após 24h de tratamento em ambos os extratos. Sugere-se que o extrato de Salvia officinalis (L.) possui atividade biológica em células tumorais, podendo ser objetivo de mais estudos com a finalidade de comprovar sua eficácia como possível agente para o tratamento do câncer. / Submitted by Ana Guimarães Pereira (agpereir@ucs.br) on 2015-02-12T12:00:17Z No. of bitstreams: 1 Dissertacao Charlene Silvestrin Celi Garcia.pdf: 2151872 bytes, checksum: 7bfd73bdf5fd152982466e3f75044d21 (MD5) / Made available in DSpace on 2015-02-12T12:00:17Z (GMT). No. of bitstreams: 1 Dissertacao Charlene Silvestrin Celi Garcia.pdf: 2151872 bytes, checksum: 7bfd73bdf5fd152982466e3f75044d21 (MD5) / Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, FAPERGS / Salvia officinalis (Lamiaceae), popularly known as sage, has been used in south of Brazil as a condiment in foods, as tincture and tea for the treatment various health disorders. The properties of this plant have been studied and suggest possible mechanisms of antioxidant and antitumor action. Here, the sage hydroalcoholic and aqueous extract were chemically analyzed by gas chromatography-mass spectrometry (GC-MS) and by high-resolution electrospray ionization mass spectrometry (ESI-HRMS) in negative mode. The chemical identification showed the presence of acids as caffeic, rosmarinic, malic, succinic, tartaric, citric, ursolic and compouns like luteolin-7-O-glucoronide, eucalyptol, β-thujone, β-caryophyllene, α-caryophyllenen and α-thujone, camphor, viridiflorol, mannol, rosmanol and its isomers methylcarnosate and 12-methoxycarnosinic acid. The extracts showed the content of polyphenolic compounds, ability to scavenge the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), moreover catalase (CAT-like) and superoxide dismutase (SOD-like) activity. Both extracts showed lower cytotoxicity in non-tumor lines (HEK-293 and MRC-5) and selectivity for tumor cell lines (Hep-2, HeLa, A-549, HT-29, A-375 e HepG2). Furthermore, it was found that increasing the treatment exposure time of the hydroalcoholic extract decreases the tumor cell viability. Morphological changes by giemsa were observed and staining for annexin V and propidium iodide showed majority of tumor cells at late stages of the apoptotic process and necrosis after 24h treatment with both extracts. The results of this study suggest that the extract of Salvia officinalis (L.) has biological activity against tumor cell and may be the objective of further studies in order to prove its effectiveness as a possible agent for the treatment of cancer.

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