The primary goal of this thesis is to improve the precision and efficiency of radiation therapy treatment. This goal is achieved by developing and implementing a direct aperture optimization (DAO) platform where the multileaf collimator (MLC) is rotated between each aperture. The approach is referred to as rotating aperture optimization (RAO). A series of tests is performed to evaluate how a final optimized plan depends on MLC parameters. Imposing constraints on the leaf sequence results in increased efficiency and a simplification of the treatment plan without compromising the quality of the dose distribution. It is also shown that an arrangement of equispaced collimator angles takes full advantage of the flexibility associated with collimator rotation. A study including ten recurring nasopharynx cancer patients is used to evaluate the capabilities of RAO compared to other optimization techniques. It is shown that RAO plans require significantly less linac radiation output (monitor units or MU) while maintaining equivalent dose distribution quality compared to plans generated with the conventional fluence based approach. Furthermore with an improved collimator rotation speed, the RAO plans should be executable in the same or less time than plans generated with the fluence-based approach. For the second part of the study it is shown that plans generated with RAO are as good as or better than plans generated with standard fixed collimator DAO. Film and ion chamber measurements indicate that RAO plans can be delivered more accurately than DAO plans. Additional applications of DAO were investigated through collaboration with two PhD students. First, Monte Carlo was used to generate pencil beam dose distributions for DAO inverse treatment planning (MC-DAO). The MC-DAO technique correctly models traditionally difficult treatment geometries such as small fields and tissue inhomogeneities. The MC-DAO also takes advantage of the improved MU efficiency associated with the DAO technique. Secondly DAO is proposed for adaptive radiation therapy. The results show that plan re-adaptation can be performed more quickly than complete plan regeneration thereby minimizing the time the patient has to spend in the treatment room and reducing the potential for geometric errors in treatment delivery.

The health, safety, comfort and productivity of a room’s occupants is greatly influenced by the sound field within it. An acoustical engineer is often consulted during the design of a room to prevent or alleviate unwanted acoustical problems. Prediction models are often used to find the most cost-effective solution to a given acoustical problem. The accuracy of sound-field prediction varies with the particular model, as do the parameters predicted. Most models only predict sound-pressure levels. Many only predict energetic quantities, ignoring wave phase and, therefore, interference and modal effects in rooms. A ray-tracing model, capable of predicting sound-pressure level, reverberation time and lateral energy fraction was translated into MATLAB code and modified to increase accuracy by including phase. Modifications included phase effects due to path length travelled and phase changes imparted by surface reflections as described by complex reflection coefficients. Further modifications included predicting steady-state and transient sound-intensity levels, providing information on the direction of sound-energy flow. The modifications were validated in comparison with free-field theory and theoretical predictions of sound fields in the presence of a single surface. The complex reflection coefficients of four common building materials were measured using two methods—an impedance tube and the spherical-decoupling method. Using these coefficients, the modified program was compared with experimental data measured in configurations involving one or more surfaces made of these materials, in an anechoic chamber, a scale-model room, and a full-scale office space. Prediction accuracy in the anechoic chamber, and in the presence of a single reflecting surface, greatly improved with the inclusion of phase. Further comparison with full-scale rooms is required before the accuracy of the model in such rooms can be evaluated definitively.

No description available.

Label free detection techniques such as surface plasmon resonance, carbon nanotubes, nanowires, and interferometry have been progressing rapidly for biosensing applications. Surface plasmon resonance is considered one of the most promising label free optical techniques. The use of nanohole arrays in a metal film allows for extraordinary transmission and has been motivated by their application as biosensors. Nanohole arrays present several advantages like smaller foot print, dense integration, lower limits of detection, and collinear optical detection. This thesis presents the design parameters for the optimization of sensitivity and resolution of nanohole arrays for refractive index sensing. A systematic study is provided of the influence of the nanohole array periodicity, diameter, and gold thickness. Focused ion beam was used to fabricate the nanohole arrays. A microfluidic device with a set of embedded nanohole arrays was developed and used to measure the sensing characteristics. The results are encouraging for potential future biosensing tests. / Graduate

No description available.

Demand for high-resolution imaging capabilities for both space-based and ground-based imaging systems has created significant interest in improving the design of multi-aperture interferometry imaging systems. Interferometers are a desirable alternative to single aperture imaging systems due to the fact that the angular resolution of a single aperture system is dependent on the diameter of the aperture and the resolution of the image recording device (CCD or otherwise) which quickly results in increased size, weight, and cost. Interferometers can achieve higher angular resolutions with lower resolution recording mediums and smaller apertures by increasing the distance between the apertures. While these systems grow in both size, mechanical, and computational complexity, methods of testing large scale designs with small scale demonstration systems currently do not exist. This paper documents the performance of a small scale multi-aperture intensity correlation interferometer which is used to view a double slit image. The interferometer consists of 2 avalanche photo-diodes connected to a data acquisition computer. The image is produced by shining light through the double slit image an image containment system. The sensors are placed at the far end of the image containment system, and their voltages are recorded and digitally filtered. This study presents the formulation of the design parameters for the interferometer, the assembly and design of the interferometer, and then analyzes the results of the imaging experiment and the methods used to attempt to prevent unwanted noise from corrupting the expected interference pattern. Codes in C and C++ are used to collect and analyze the data, respectively, while Matlab® was used to produce plots of binary data. The results of the analysis are then used to show that a small scale intensity correlation interferometer is indeed feasible and has promising performance.

Intensity modulated radiotherapy (IMRT) can potentially increase the dose delivered to liver tumours while sparing normal tissues from dose. More complex IMRT, with more modulation of the radiation beam is more susceptible to geometric and dosimetric uncertainties than simpler radiotherapy plans. Simple breath-hold liver IMRT using few radiation beam segments (<30) was investigated in 27 patients to determine the quality of treatment in terms of tumour dose coverage and normal tissue sparing as compared to index IMRT using >30 segments. In all 27 plans number of segments was reduced to <30 without compromising tumour coverage or normal tissue dose constraints, at the expense of dose conformity. Delivered tumour and normal tissue dose did not differ statistically between IMRT plans when accounting for treatment residual geometric error. This research supports considering the use of simple IMRT for treatment of liver cancer, except when loss of dose conformation is undesirable (i.e. very high doses).

The health, safety, comfort and productivity of a room’s occupants is greatly influenced by the sound field within it. An acoustical engineer is often consulted during the design of a room to prevent or alleviate unwanted acoustical problems. Prediction models are often used to find the most cost-effective solution to a given acoustical problem. The accuracy of sound-field prediction varies with the particular model, as do the parameters predicted. Most models only predict sound-pressure levels. Many only predict energetic quantities, ignoring wave phase and, therefore, interference and modal effects in rooms. A ray-tracing model, capable of predicting sound-pressure level, reverberation time and lateral energy fraction was translated into MATLAB code and modified to increase accuracy by including phase. Modifications included phase effects due to path length travelled and phase changes imparted by surface reflections as described by complex reflection coefficients. Further modifications included predicting steady-state and transient sound-intensity levels, providing information on the direction of sound-energy flow. The modifications were validated in comparison with free-field theory and theoretical predictions of sound fields in the presence of a single surface. The complex reflection coefficients of four common building materials were measured using two methods—an impedance tube and the spherical-decoupling method. Using these coefficients, the modified program was compared with experimental data measured in configurations involving one or more surfaces made of these materials, in an anechoic chamber, a scale-model room, and a full-scale office space. Prediction accuracy in the anechoic chamber, and in the presence of a single reflecting surface, greatly improved with the inclusion of phase. Further comparison with full-scale rooms is required before the accuracy of the model in such rooms can be evaluated definitively.

Intensity Modulated Radiation Therapy (IMRT) is a modern radiotherapy treatment technique used to obtain highly conformal dose distributions. The delivery of IMRT is commonly achieved through the use of a multileaf collimator (MLC). One of the hindrances at present to the widespread use of IMRT is the increased time required for its planning, delivery and verification. In this thesis one particular method of MLC based IMRT, known as Static Multileaf Collimator based IMRT (SMLC-IMRT), has been studied along with methods for improving it???s delivery efficiency. The properties of an MLC commonly used in SMLC-IMRT have been characterised. The potential ramifications of these properties on the dosimetric accuracy of the delivered IMRT field were also investigated. An Interactive Leaf Sequencing (ILS) program was developed that allowed for the manipulation and processing of intensity maps using a variety of methods. The objective of each method was to improve the delivery efficiency whilst maintaining the dosimetric quality of the IMRT treatment. The different methods investigated were collimator angle optimisation, filtration, and intensity level optimisation. The collimator was optimised by identifying the angle at which the minimum monitor unit???s (MU???s) were required when using a sliding-window delivery method. A Savitzky-Golay filter was applied to random intensity maps and suitable filtration parameters identified for filtering clinical IMRT fields, and the intensity levels were optimised based on a deviation threshold. The deviation threshold identified the acceptable level of difference tolerable between the original and modified intensity map. Several IMRT cases were investigated and the impact of each the methods on MU???s, segments and dose distribution observed. As the complexity of IMRT fields increases the dosimetric impact of the MLC properties increases. Complex SMLC-IMRT fields require longer delivery times due to the increased number of MU???s and segments. Collimator optimisation was shown to be a fast and effective means of improving delivery efficiency with negligible dosimetric change to the optimised plan. Modifying intensity maps by applying a filter and optimising the intensity levels did reduce the complexity and improve the delivery efficiency, but also required a dosimetric compromise of the optimised plan.

Thesis (M.S.)--Ohio University, June, 2007. / Title from PDF t.p. Includes bibliographical references.