O presente estudo teve como objetivo descrever a prevalência de anemia ferropriva em crianças matriculadas em duas creches municipais de Guarapuava – PR, no ano de 2005. Caracteriza-se como seccional ou corte transversal, de prevalência e de base populacional, envolvendo 156 crianças com idade inferior a seis anos, matriculadas nas creches municipais da zona urbana da cidade. Para caracterizar a população estudada foram obtidas informações junto às fichas cadastrais nas creches sobre variáveis relativas à criança: data de nascimento e sexo. Para mensuração da dosagem de hemoglobina sangüínea, foram coletadas amostras de sangue na ponta do dedo médio, para leitura em hemoglobinômetro portátil (Hemocue). A prevalência da anemia nas creches estudadas foi de 42,9%, ou seja 67 das 156 crianças em que se determinou a concentração de hemoglobina com valores inferiores a 11 g/dl. A prevalência para o sexo feminino foi de 42,3%, ou seja, entre as 71 meninas, 30 delas apresentaram concentração de hemoglobina com valores inferiores a 11g/dl e, para o sexo masculino igual a 43,5%, ou seja, entre os 85 meninos, 37 deles apresentaram concentração de hemoglobina com valores inferiores a 11g/dl. Dentre as 67 crianças com anemia, 25 (37,3%) crianças apresentaram anemia grave, sendo que no grupo das 30 meninas com anemia, 10 ( 33,3%) apresentaram anemia grave e, no grupo dos 37 meninos com anemia, 15 (40,5%) apresentaram anemia grave. Ainda nas 67 crianças com anemia 45 (67,2%) apresentavam idade inferior a 24 meses, sendo que no grupo das 30 meninas com anemia, 21 (70%) apresentavam idade inferior a 24 meses e para o grupo das 37 meninos com anemia, 24 (64,9) apresentavam idade inferior a 24 meses. Dentre as 25 crianças com anemia grave, 17 (68,0%) apresentavam idade inferior a 24 meses, sendo que para o grupo de 10 meninas com anemia grave, 9 (90%) apresentavam idade inferior a 24 meses e, para o grupo de 15 meninos com anemia grave, 8 (53,3%) apresentavam idade inferior a 24 meses. Alguns fatores podem ter contribuído para esse resultado. Um deles é o estado nutricional das crianças antes de ingressarem nas escolas infantis, o qual poderia já estar comprometido. Outro importante fator a ser considerado é a baixa inserção sócio-econômica das crianças que freqüentam as creches municipais, a qual impõe condições de vida que as tornam mais vulneráveis à diarréia, às infecções respiratórias e às parasitoses intestinais, podendo comprometer, de forma marcante, o consumo de alimentos por redução do apetite e por diminuição da absorção de nutrientes entre eles o ferro. Espera-se que os resultados forneçam subsídios para um melhor conhecimento e acompanhamento da situação nutricional destas crianças, já que constituem instrumento essencial para a aferição das condições de saúde da população infantil, além de oferecer medidas objetivas das condições de vida da população em geral. / The present study it had as objective to describe the prevalence of iron deprive anemia in children registered two municipal day-care centers of Guarapuava - PR, in the year of 2005. Transversal cut is characterized as seccional or, of prevalence and population base, involving 156 children with lower age the six years registered the municipal day-care centers of the urban zone of the city. To characterize the studied population information together to the fiches had been gotten register in cadastre in the day-care centers on relative variable the child: date of birth and sex. For measuring of the dosage of sanguine hemoglobin, samples of blood in the tip of the average finger had been collected, for portable reading in hemoglobinometer (Hemocue). The prevalence of the anemia in the studied daycare centers was of 42.9%, or either 67 of the 156 children where if determined the concentration of hemoglobin with the lower values 11 g/dl. The prevalence for the feminine sex was of 42.3%, or either, between the 71 girls, 30 of them had presented concentration of hemoglobin with lower values 11g/dl and for equal the masculine sex 43.5%, or either, between the 85 boys, 37 of them had presented concentration of hemoglobin with lower values 11g/dl. Amongst the 67 children with anemia, 25 (37.3%) children had presented serious anemia, being that in the group of the 30 girls with anemia, 10 (33.3%) had presented serious anemia and in the group of the 37 boys with anemia, 15 (40.5%) had presented serious anemia. Still in the 67 children with anemia 45 (67.2%) they presented lower age the 24 months, being that in the group of the 30 girls with anemia, 21 (70%) presented lower age the 24 months and for the group of the 37 boys with anemia, 24 (64.9%) presented lower age the 24 months. Amongst the 25 children with serious anemia, 17 (68.0%) presented lower age the 24 months, being that for the group of 10 girls with serious anemia, 9 (90%) presented lower age the 24 months and, for the group of 15 boys with serious anemia, 8 (53.3%) presented lower age the 24 months. Some factors can have contributed for this result. One of them is the nutricional state of the children before entering the infantile schools, which could already be engaged. Another important factor to be considered is low the partnereconomic insertion of the children who frequent municipal day-care centers, which imposes life conditions that become them more vulnerable the diarrhea, to the respiratory infections and the intestinais parasatisms, being able to compromise, of marcante form, the food consumption for reduction of the appetite and reduction of the absorption of nutrients between them the iron. One expects that the results supply to subsidies one better knowledge and accompaniment of the nutricional situation of these children, since they constitute essential instrument for the gauging of the conditions of health of the infantile population, besides offering in general measured objective of the conditions of life of the population.

O presente estudo teve como objetivo descrever a prevalência de anemia ferropriva em crianças matriculadas em duas creches municipais de Guarapuava – PR, no ano de 2005. Caracteriza-se como seccional ou corte transversal, de prevalência e de base populacional, envolvendo 156 crianças com idade inferior a seis anos, matriculadas nas creches municipais da zona urbana da cidade. Para caracterizar a população estudada foram obtidas informações junto às fichas cadastrais nas creches sobre variáveis relativas à criança: data de nascimento e sexo. Para mensuração da dosagem de hemoglobina sangüínea, foram coletadas amostras de sangue na ponta do dedo médio, para leitura em hemoglobinômetro portátil (Hemocue). A prevalência da anemia nas creches estudadas foi de 42,9%, ou seja 67 das 156 crianças em que se determinou a concentração de hemoglobina com valores inferiores a 11 g/dl. A prevalência para o sexo feminino foi de 42,3%, ou seja, entre as 71 meninas, 30 delas apresentaram concentração de hemoglobina com valores inferiores a 11g/dl e, para o sexo masculino igual a 43,5%, ou seja, entre os 85 meninos, 37 deles apresentaram concentração de hemoglobina com valores inferiores a 11g/dl. Dentre as 67 crianças com anemia, 25 (37,3%) crianças apresentaram anemia grave, sendo que no grupo das 30 meninas com anemia, 10 ( 33,3%) apresentaram anemia grave e, no grupo dos 37 meninos com anemia, 15 (40,5%) apresentaram anemia grave. Ainda nas 67 crianças com anemia 45 (67,2%) apresentavam idade inferior a 24 meses, sendo que no grupo das 30 meninas com anemia, 21 (70%) apresentavam idade inferior a 24 meses e para o grupo das 37 meninos com anemia, 24 (64,9) apresentavam idade inferior a 24 meses. Dentre as 25 crianças com anemia grave, 17 (68,0%) apresentavam idade inferior a 24 meses, sendo que para o grupo de 10 meninas com anemia grave, 9 (90%) apresentavam idade inferior a 24 meses e, para o grupo de 15 meninos com anemia grave, 8 (53,3%) apresentavam idade inferior a 24 meses. Alguns fatores podem ter contribuído para esse resultado. Um deles é o estado nutricional das crianças antes de ingressarem nas escolas infantis, o qual poderia já estar comprometido. Outro importante fator a ser considerado é a baixa inserção sócio-econômica das crianças que freqüentam as creches municipais, a qual impõe condições de vida que as tornam mais vulneráveis à diarréia, às infecções respiratórias e às parasitoses intestinais, podendo comprometer, de forma marcante, o consumo de alimentos por redução do apetite e por diminuição da absorção de nutrientes entre eles o ferro. Espera-se que os resultados forneçam subsídios para um melhor conhecimento e acompanhamento da situação nutricional destas crianças, já que constituem instrumento essencial para a aferição das condições de saúde da população infantil, além de oferecer medidas objetivas das condições de vida da população em geral. / The present study it had as objective to describe the prevalence of iron deprive anemia in children registered two municipal day-care centers of Guarapuava - PR, in the year of 2005. Transversal cut is characterized as seccional or, of prevalence and population base, involving 156 children with lower age the six years registered the municipal day-care centers of the urban zone of the city. To characterize the studied population information together to the fiches had been gotten register in cadastre in the day-care centers on relative variable the child: date of birth and sex. For measuring of the dosage of sanguine hemoglobin, samples of blood in the tip of the average finger had been collected, for portable reading in hemoglobinometer (Hemocue). The prevalence of the anemia in the studied daycare centers was of 42.9%, or either 67 of the 156 children where if determined the concentration of hemoglobin with the lower values 11 g/dl. The prevalence for the feminine sex was of 42.3%, or either, between the 71 girls, 30 of them had presented concentration of hemoglobin with lower values 11g/dl and for equal the masculine sex 43.5%, or either, between the 85 boys, 37 of them had presented concentration of hemoglobin with lower values 11g/dl. Amongst the 67 children with anemia, 25 (37.3%) children had presented serious anemia, being that in the group of the 30 girls with anemia, 10 (33.3%) had presented serious anemia and in the group of the 37 boys with anemia, 15 (40.5%) had presented serious anemia. Still in the 67 children with anemia 45 (67.2%) they presented lower age the 24 months, being that in the group of the 30 girls with anemia, 21 (70%) presented lower age the 24 months and for the group of the 37 boys with anemia, 24 (64.9%) presented lower age the 24 months. Amongst the 25 children with serious anemia, 17 (68.0%) presented lower age the 24 months, being that for the group of 10 girls with serious anemia, 9 (90%) presented lower age the 24 months and, for the group of 15 boys with serious anemia, 8 (53.3%) presented lower age the 24 months. Some factors can have contributed for this result. One of them is the nutricional state of the children before entering the infantile schools, which could already be engaged. Another important factor to be considered is low the partnereconomic insertion of the children who frequent municipal day-care centers, which imposes life conditions that become them more vulnerable the diarrhea, to the respiratory infections and the intestinais parasatisms, being able to compromise, of marcante form, the food consumption for reduction of the appetite and reduction of the absorption of nutrients between them the iron. One expects that the results supply to subsidies one better knowledge and accompaniment of the nutricional situation of these children, since they constitute essential instrument for the gauging of the conditions of health of the infantile population, besides offering in general measured objective of the conditions of life of the population.

The purpose of the study was to determine what nutritional, demographic, and behavioral differences existed between children one year of age from two similar WIC clinics with different prevalences of anemia. Children from the higher-prevalence site were found to consume significantly (p < .05) more B12, C, copper, fiber, folate, total kilocalories, and riboflavin than did children from the lower-prevalence site. Family income and maternal weight gain were significantly (p < .05) higher in the lower-prevalence group as compared to the higher-prevalence group. In addition, children from the higher-prevalence site were enrolled in the WIC program at a significantly (p < .05) younger age than were children from the lower-prevalence site.

Various studies have been done to determine the prevalence of anemia in our country, but these studies don't reflect the true magnitude of this sickness, considered in Ecuador a problem of public health since these investigations correspond to urban sectors and margins and not to rural places where the care is very deficient and in certain cases useless, mainly because of the difficult access and the lack of economic resources of the government institutions. The current work was realized in coordination with the school of Nutrition and Dietetics and with the help of the Benson Agriculture and Food Institute was applied in rural communities of the Indigenous, "Mixed-Race" and African-American of Imbabura taking into account kids under the age of 5 as being a population group in constant risk of suffering specific deficiencies, such as Iron deficiency and its subsequent evolution towards Anemia. In this investigation we are going to find information about the prevalence of Anemia in the before mentioned groups of kids, their relationship with the deficiency of the consumption of Iron, influence of one of the most common sicknesses in these sectors as are Intestinal Parasitism. I am sure that the content will be of enormous interest to those that desire to know and better the critical situation of health and nutrition which unwinds this people, because of the provision of updated and truthful information will permit a better orientation of the different programs and projects that are implemented in these areas.

Objetivo: Determinar los factores asociados a la anemia en niños de 6 a 36 meses en el Centro de Salud Toribia Castro, Lambayeque 2020-2021. Metodología: El tipo de estudio fue observacional analítico de diseño transversal, la población estuvo formada por 1046 niños de 6 a 36 meses; teniendo en cuenta una frecuencia esperada de 40.1 %, se calculó una muestra de 273 niños los cuales fueron seleccionados a través de un muestreo aleatorio simple. En el análisis estadístico para verificar la distribución normal en las variables cuantitativas de los datos se utilizó la prueba de kolmogorov-smirnov y en las variables cualitativas, se presentaron en frecuencias absolutas y relativas. Para el análisis bivariado, se utilizaron las pruebas chi cuadrado y Fisher. Resultados: La muestra estudiada fue de 257, la frecuencia de anemia fue de 54.5 %; el 50 % de ellos tenían menor o igual a 10 meses de nacido con un rango intercuartílico entre 7 y 12 meses. En el análisis bivariado, las variables anemia gestacional, el consumo de alimentos con hierro y el grado de estudio del apoderado resultaron ser estadísticamente significativas (P<0.05). Respecto a las características clínicas, se encontró que el 64.2 % cumple con sus controles CRED, el 89.9 % recibe suplemento de hierro y no existe diferencia significativa de la anemia con respecto a las inmunizaciones, estado nutricional, EDAS, infecciones respiratorias o parasitarias. También se demostró que no existe diferencia estadísticamente significativa entre la anemia en niños de 6 a 36 meses y los factores socioeconómicos, sociodemográficos y características gestacionales de la madre. Conclusiones: La frecuencia de anemia fue de 54.5 % siendo el tipo más frecuente la anemia leve; los factores asociados fueron anemia gestacional, el consumo insuficiente de alimentos con hierro y el grado de estudios del apoderado. Los niños cuyas madres tuvieron anemia gestacional tienen 34 % más de probabilidad de presentar anemia; así mismo aquellos niños que consumen diariamente alimentos con hierro presentan 47 % menos probabilidad de presentar anemia a comparación de aquellos que consumen dichos alimentos de forma interdiaria. / Objective: To determine the factors associated with anemia in children from 6 to 36 months at the Toribia Castro Health Center, Lambayeque 2020. Methodology: The study was of type analytical observational with a cross-sectional design, the population consisted of 1046 children from 6 to 36 months treated at the Health Center; Taking into account an expected frequency of 40.1%, a sample of 273 children was calculated, who were selected through simple random sampling. In the statistical analysis, the Kolmogorov-Smirnov test was used in order to verify the normal distribution for the quantitative variables of the data. In the other hand, absolute and relative frequencies were presented for qualitative variables. Chi-square and Fisher tests were used for bivariate analysis. Results: The sample size was 257, the frequency of anemia was 54.5%; 50% of them were less than or equal to 10 months old with an interquartile range between 7 and 12 months. In the bivariate analysis, the variables gestational anemia, consumption of foods with iron and the educational level of the guardian turned out to be statistically significant (P<0.05). In relation to clinical characteristics, it was found that 64.2% of them fit their CRED controls, 89.9% receive iron supplements and there is no significant difference in anemia when it comes to immunizations, nutritional status, EDAS, respiratory or parasitic infections. It was also shown that there is no statistically significant difference between anemia in children from 6 to 36 months and socioeconomic, sociodemographic factors and gestational characteristics of the mother. Conclusions: The frequency of anemia was 54.5%, with mild anemia being the most common type; associated factors were gestational anemia, insufficient consumption of foods rich in iron and the guardian’s educational level. Children whose mothers had gestational anemia are 34% more likely to have anemia; likewise, children who consume food rich in iron daily are 47% less likely to present anemia in comparison with those who consume such foods every two days.

In this dissertation I analyze patterns of maternal-infant health in developing contexts. My first chapter uses child hemoglobin as a bio-marker for maternal malnutrition in Senegal during the 2008 food price crisis. In early 2008, world rice prices skyrocketed, causing people around the world to plunge into poverty. Senegal, in particular, depends heavily on imported foodstuffs. I find that the crisis had a large, negative impact on child anemia in urban Senegal, most likely reflecting a deterioration of maternal nutrition caused by rising food prices. In the second and third chapters, we introduce a novel indicator of maternal-infant health: childhood sex ratios. Because infant females have lower rates of mortality than infant males, the sex ratio of the surviving population reflects the level of infant mortality. Childhood sex ratios are widely available from census data, meaning we can use them to shed new light on historical populations who lack traditional sources of data on infant mortality, like birth and death records. We apply this new method to the 19th-century US, where the lack of vital statistics has left uncertainty over even approximate levels of infant mortality. We find that the level of infant mortality in the pre-industrial US was much lower than previously thought, but that racial health disparities were much greater.

L’objectif de notre travail était de déterminer le rôle joué par l’érythropoïétine et la<p>thrombopoïétine, respectivement, dans l’anémie et la thrombocytopénie observées<p>chez des enfants souffrant d’une hémopathie maligne.<p>Par le dosage simultané de la forme soluble du récepteur de la transferrine et de<p>l’érythropoïétine dans le sérum nous avons montré que l’anémie observée chez ces<p>patients est bien la conséquence d’une réduction du nombre de progéniteurs<p>érythropoïétiques (atteinte médullaire centrale) mais que celle-ci n’est pas la<p>conséquence d’une production insuffisante d’érythropoïétine. Nous avons fait la<p>même observation chez des enfants souffrant d’une tumeur solide non<p>hématologique et chez des patients en cours de traitement par chimiothérapie.<p>Chez ces derniers patients, en appliquant un modèle de culture de moelle à long<p>terme, nous avons pu démontrer l’existence d’une altération du microenvironnement<p>médullaire, probablement induite par la chimiothérapie, se<p>traduisant par une réduction de son aptitude à supporter le développement de la<p>lignée érythroïde. Ceci expliquant au moins partiellement l’inadéquation de la<p>réponse érythropoïétique observée chez ces patients en réponse à l’anémie.<p>Dans la dernière partie du travail, nous avons montré que la thrombocytopénie très<p>fréquemment observée chez les patients leucémiques s’accompagne dans la<p>majorité des cas d’une élévation exponentielle de la concentration de<p>thrombopoïétine, excepté dans les cas de leucémies de la lignée myéloïde. Chez ces<p>derniers la concentration de thrombopoïétine est proche des valeurs observées chez<p>des sujets normaux alors qu’elle devrait être 10 à 100 fois plus élevée compte tenu<p>du nombre de plaquettes extrêmement bas. Nous avons pu montrer que ces taux<p>très bas sont la conséquence de la liaison de la thrombopoïétine à un récepteur<p>spécifique et fonctionnel présent à la surface des cellules leucémiques myéloïdes<p>qui, en l’utilisant comme facteur de croissance, (stimulant leur prolifération et<p>retardant leur mort cellulaire) « consomment » la thrombopoïétine présente dans le<p>sérum. / Doctorat en Sciences médicales / info:eu-repo/semantics/nonPublished

L’anémie est un problème de santé publique très répandu, avec des conséquences majeures sur la santé humaine et le développement économique et social. Elle affecte avec prédilection les jeunes enfants et les femmes enceintes. Ce travail avait pour objectifs d’analyser la situation de l’anémie chez les enfants âgés de 6-23 mois du district rural de Kongoussi (Burkina Faso), et de tester l’efficacité de stratégies intégrées de lutte. Il a consisté en deux enquêtes transversales et deux études d’intervention en population, menées entre janvier 2004 et juin 2006.<p><p>La prévalence (IC à 95%) de l’anémie était de 98,8% (97,6 ;99,9) parmi ces enfants, et la prévalence (IC à 95%) de l’anémie sévère de 29,5% (23,9 ;35,0). Parmi les enfants présentant une anémie, 65,1% avaient une anémie hypochrome.<p>Les enfants ne présentant pas de retard de croissance avaient un taux moyen (ES) d’hémoglobine plus élevé que les enfants présentant un retard de croissance :81,1 (2,6) contre 77,2 (2,8) g/L, (p=0,026). La prévalence (IC à 95%) du retard de croissance était de 35,8% (29,4 ;41,1). Le retard de croissance était associé aux pratiques d’alimentation de complément chez les enfants âgés de 12-23 mois. L’indice z-score de la taille pour l’âge était en moyenne (DS) de -1,33 (0,63), -1,61 (0,30), et -2,11 (0,32) chez les enfants pour lesquels étaient utilisées des céréales fortifiées, chez les enfants pour lesquels étaient utilisées des céréales non fortifiées, et chez les enfants qui ne recevaient pas d’aliments de complément, respectivement (p=0,018).<p>L’infection à Plasmodium falciparum était présente chez 52,6% des enfants, 25,6% étant non fébrile et 27,0% fébrile. En comparaison aux enfants non infectés, les enfants ayant une infection fébrile, mais aussi ceux ayant une infection non fébrile avaient un taux d’hémoglobine plus faible, les différences (ES) étant de 7,86 (1,75) g/L avec p<0,001 et de 3,52 (1,74) g/L avec p=0,044, respectivement.<p><p>Dans un contexte de prise en charge préventive et curative du paludisme et des géohelminthases, la supplémentation en fer pendant 6 mois a conduit à une augmentation moyenne (DS) du taux d’hémoglobine de 16,3 (13,6) g/L (p<0,001), alors que cette augmentation a été de 22,8 (14,6) g/L (p<0,001) pour la supplémentation en micronutriments multiples, soit une différence (IC à 95%) de 6,5 (2,0 ;11,1) avec p=0,003. La supplémentation en fer conduisait à une réduction de la prévalence de l’anémie de 40,6%, alors que cette réduction était de 62,0% avec la supplémentation en micronutriments multiples, soit un ratio ajusté de prévalences de guérison [PRR (IC à 95%)] de 1,62 (1,22 ;2,15), p<0,001.<p>Une farine améliorée à été produite à partir d’ingrédients disponibles localement ;elle se composait de petit mil (51,7%), haricots (8,8%), arachide (7,8%), malt de sorgho rouge (9,0%), soumbala (9,3%), sucre (12,7%), et de sel iodé (0,8%). La bouillie améliorée préparée avec cette farine avec une consistance de 120 mm/30 s (distance d’écoulement dans un consistomètre de Bostwick) avait une densité énergétique de 103 kcal/100 g, une teneur en fer de 2,6 mg/100 kcal, et une teneur en zinc de 1,2 mg/100 kcal. La production de la farine et la préparation de la bouillie étaient reproductibles par les ménagères.<p>La consommation de bouillie à chaque session était en moyenne de 29 ou 28 g/kg de poids corporel/repas, correspondant à 108 ou 105% de la consommation souhaitée, alors que la présence au centre de nutrition ouvert dans le village n’était que de 68 ou 58%, dans le groupe consommant la bouillie sans supplément de micronutriments et le groupe consommant la bouillie avec un supplément de micronutriment multiples, respectivement.<p>Dans un contexte de prise en charge préventive et curative du paludisme et des geohelminthases la consommation de la bouillie améliorée sans supplément de micronutriments conduisait à une augmentation du taux d’hémoglobine de 14,8 (11,8) g/L (p<0,001), et la consommation de la bouillie améliorée avec des suppléments de micronutriments multiples entraînait une augmentation de 17,3 (15,8) g/L (p<0,001), soit une différence (IC à 95%) de 3,5 (-1,0 ;8,1) g/L (p=0,13). La prévalence de l’anémie en fin d’intervention était de 67,9% et de 55,6% dans les groupes BA et BAM, respectivement (p=0,13)<p><p>Ces résultats soulignent la nécessité de mesures permettant de réduire rapidement la prévalence de l’anémie chez les enfants âgés de 6-23 mois de ce district. La stratégie de supplémentation en micronutriments multiples combinée à la prise en charge préventive et curative du paludisme et des géohelminthiases est la stratégie à préférer. <p>La supplémentation en micronutriments multiples pourrait être relayée progressivement par la stratégie basée sur une alimentation de complément améliorée au niveau des ménages, toujours dans un contexte de prise en charge préventive et curative du paludisme et des géohelminthases. Intégrés dans la routine des ménages et soutenus par une formation et une éducation nutritionnelles, les procédés de production de farine puis de bouillie améliorée devraient avoir une plus grande portée sur la prévention de l’anémie à moyen et long termes.<p><p>Anaemia is a widespread public health problem with major consequences for human health as well as social and economic development. Pregnant women and young children are the most affected. This work aimed at 1) analysing the anaemia situation among children aged 6-23 months of the rural district of Kongoussi (Burkina Faso), and 2) assessing the efficacy of integrated strategies. Two cross-sectional and two randomised, population-based studies were conducted over the January 2004-June 2006 period.<p><p>The prevalence (95% CI) of anaemia was 98.8% (97.6 ;99.9); that of severe anaemia was 29.5 (23.9 ;35.0). Hypochromia was retrieved in 65.1% of anaemic children.<p>Mean (SE) haemoglobin concentration was higher in non-stunted children [81.1 (2.6) g/L] than in their stunted counterparts [77.2 (2.8) g/L], p=0.026. The prevalence (95% CI) of stunting was 35.8% (29.4 ;41.1). After adjustment for children, mothers and household characteristics, and for current and past breastfeeding patterns, the height-for-age z-score (HAZ) remained associated with the mode of complementary feeding among children aged 12-23 months. The adjusted mean HAZ (SE) was –1.33 (0.63), -1.61 (0.30), and –2.11 (0.32) among children consuming fortified cereals, unfortified cereals, or no complementary food, respectively (p=0.018)<p>Plasmodium falciparum infection was noted in 52.6% of children with 25.6% being afebrile and 27.0% being febrile. Compared to uninfected children, children with febrile infection and those with afebrile infection had lower haemoglobin concentration, the differences (ES) being 7.86 (1.75) g/L (p<0.001) and 3.52 (1.74) g/L (p=0.044), respectively.<p><p>Combined with malaria and geohelminths preventive and curative care, daily iron supplementation for 6 months led to a mean increase (SD) of haemoglobin concentration of 16.3 (13.6) g/L (p<0.001), whereas the increase was 22.8 (14.6) g/L (p<0.001) with daily multiple micronutrients supplementation. The difference (95% CI) of haemoglobin concentration at the end of intervention was of 6.5 (2.0 ;11.1), p=0.003. Iron supplementation reduced the prevalence of anaemia by 40.6%, while the reduction was of 62.0% with the multiple micronutrients supplementation. The prevalence rate ratio [PRR (95% CI)] of children who were cured from anaemia at the end of intervention was 1.62 (1.22 ;2.15), p<0.001.<p>A new, local-ingredient-based flour was developed to prepare an improved mush for children. It was composed of pearl millet (51.7%), beans (8.8%), peanuts (7.8%), malted red sorghum (9.0%), soumbala (9.3%), sugar (12.7%) and iodized salt (0.8%). When this improved mush was prepared with a consistency of 120 mm/30 s (Bostwick flow distance), its volumetric mass, energy density, iron content and zinc content are 103 g/100 ml, 103 kcal/100 g, 2.6 mg/100 kcal, and 1.2 mg/100 kcal respectively. The flour production and mush preparation were reproducible by rural housewives.<p>The average mush consumption was 29 and 28 g/kg body weight/meal, corresponding to 108 and 105% of the desired consumption, whereas the child’s presence at the nutrition centre that was opened in his village was 68 and 58%, in the group consuming the mush without micronutrient supplement (MG) and that consuming the mush with a multiple micronutrients supplement (MMG). Mean (SD) haemoglobin concentration increased of [14.8 (11.8) g/L, p<0.001] in the MG and [17.3 (15.8) g/L, p<0.001] in the MMG. The between group difference (95% CI) of 3.5 (-1.0 ;8.1) g/L in mean (SD) endpoint haemoglobin concentration was not significant (p=0.13). The prevalence of anemia at the end of intervention was 67.9% and 55.6% in the MG and MMG, respectively (p=0.13)<p><p>These results underline the need of urgent actions to rapidly reduce the prevalence of anemia. The multiple micronutrients supplementation combined with malaria and geohelminths preventive and curative care is the strategy to prefer. However, this strategy could be progressively replaced by that including complementary feeding improvement. To increase the mush consumption and better meet the needs of young children, flour and mush production must enter the routines of individual households. If this integration is to succeed, it should be supported by a large-scale program of training and nutrition education.<p> / Doctorat en sciences médicales / info:eu-repo/semantics/nonPublished

Introducción: La violencia física de pareja hacia la mujer es un problema de salud pública que afecta física y mentalmente a las mujeres y sus hijos, quienes desarrollarán principalmente desnutrición y retardo en crecimiento y desarrollo. Existen pocos estudios sobre la relación entre anemia en niños y violencia de pareja. En esta investigación propusimos que la exposición a violencia física de pareja hacia la mujer se asocia con la presencia de anemia en su último hijo entre 6-59 meses.   Métodos: Se realizó un estudio transversal analítico con información de la ENDES de mujeres de 15 – 49 años que sufrieron violencia física en los últimos doce meses, con hijos entre 6-59 meses de edad. Se realizó un análisis de regresión lineal generalizado crudo y ajustado, se utilizaron razones de prevalencia las cuales se ajustaron por variables confusoras ingresadas por mecanismo epidemiológico. Se realizó un análisis estratificado por edades, 6-24 y 25-59 meses para examinar la variación entre ambos grupos. Resultados: La violencia física hacia la madre [PR: 1.12, IC 95%: 1.05- 1.20] se asoció a la presencia de anemia en niños. Otros factores de riesgo fueron el área de residencia rural, el grado de anemia severo en la madre de niños de 6-24 y anemia moderada de la madre de niños de 25-59 meses. Conclusiones: Existe una asociación entre la violencia de la pareja íntima contra las mujeres y la anemia en niños de 25 a 59 meses. Por ello, el síndrome anémico en un niño de este rango de edad, puede tener relación con el estado de la salud mental de su madre, vulnerado por su pareja. Este trabajo es útil para considerar otros factores influyentes en la salud infantil. / Introduction: Physical intimate partner violence against women is a public problem that affects physically and mentally women’s health and their children, being more likely to develop malnutrition, stunting and retarded development. Few studies describe the association between anemia in children and intimate partner violence. In this research, we propose that the exposure to physical violence caused by the partner towards women is associated with the presence of anemia in her last child between 6-59 months. Methods: An analytical cross-sectional study was conducted with information from the ENDES of women aged 15-49 years who suffered physical violence in the last twelve months, with children between 6-59 months of age. A crude and adjusted generalized linear regression analysis was performed using prevalence ratios which were adjusted for confounding variables entered by epidemiological mechanism. The authors implemented a stratified analysis by age, 6-24 and 25-59 months to examine the variation between both groups. Results: Physical violence towards the mother [PR: 1.12, 95% CI: 1.05-120] was associated with the presence of anemia in children. Other risk factors were the rural area of ​​residence, severe degree of anemia in the mother of children aged 6-24, and moderate anemia of mothers of children aged 25-59 months. Conclusions: There is an association between intimate partner violence against women and anemia in children aged 25 to 59 months. For this reason, the anemic syndrome in a child of this age may be related to the state of the mother's mental health, which is violated by her partner. This work is useful to consider other factors influencing child health. / Tesis