本文首先檢視國際、美國與拉丁美洲對於毒品之定義，發現國際與美國對於毒品之定義與拉丁美洲之定義不同，使毒品政策之合作在還未開始前就有了歧異。美國對拉丁美洲反毒政策的實行多是依靠其在區域中的權力分配地位而為之，從雷根政府時期開始，分為前哥倫比亞計畫、哥倫比亞計畫以及美里達計畫，論述美國在拉丁美洲的毒品政策。之後，檢視美國在拉丁美洲的毒品政策對拉丁美洲國家之影響，包括：人權問題、環境問題、經濟發展問題、貪腐問題、暴力問題和民主問題。面對美國毒品政策的負面影響，拉丁美洲國家於本世紀初開始在區域或是多邊的國際場域挑戰美國在拉丁美洲的毒品政策。最後，對於美國在拉丁美洲毒品政策的影響提出個人的看法作結。 / This essay offers a view of how U.S. antidrug policy influences Latin American, introducing its repercussions and how Latin America response to it. First, we analyze how international community, U.S. and Latin America define drugs. We find that Latin America has its own interpretation of drugs and its problem, especially when it refers to cocaine and coca leaf. Thus, it foreshadows conflicts over implementation of the U.S. antidrug policy on Latin America. Second, we review the U.S. antidrug policy on Latin America since the Raegan Administration via the aspect of asymmetric power relations in international relation, introducing and delineating important antidrug policy on Latin America; meanwhile analyze consistence and modification in different administrations. Third, we categorize the repercussions of U.S. antidrug policy on Latin America, such as violation of human rights, environmental pollution, economic issue, corruption problem and democracy development. And we raise some cases to indicate that facing those repercussions, Latin America starts to challenge U.S. antidrug policy. Last, we make a conclusion through the aspect of asymmetric power relation between U.S. and Latin America and raise opinion on whether the U.S. antidrug policy on Lain America is successful or not.