In software development it is often crucial that the system implementationfollows the architecture dened through design patterns and a constraint set.In Model-Driven development most artefacts are created using models, butthe architectural design rules is one area where no standard to model therules exists. ArCon, Architecture Conformance Checker, is a tool to checkconformance of architectural design rules on a system model, dened in UML,that implements the system or application. The architectural design rules aredened in a UML model but with a specic meaning, dierent from standardUML, proposed by the authors of ArCon. Within this thesis ArCon wasextended to be able to check models created by the Open-Source modelingtool Papyrus, and integrated as a plugin on the Eclipse platform. The methodused by ArCon, to dene architectural rules, was also given a short evaluationduring the project to get a hint of its potential and future use. The case-studyshowed some problems and potential improvements of the used implementationof ArCon and its supported method.

xHypoxia and repopulation of tumour clonogens are two important determinants of treatment outcome in radiotherapy. In general clinical evidence indicates that loco-regional control may be reduced with long overall treatment times and for tumours with low pre-treatment levels of oxygen. Experimental studies with normobaric carbogen and oxygen showed a two-fold enhancement of the efficacy of radiation in a mouse tumour model when combining oxygen with treatment acceleration. It was then demonstrated that substituting carbogen for oxygen and adding high-dose nicotinamide (NAM) further increased the effect. These findings became the basis for a multi-factorial approach designed to overcome the radioprotective effect of tumour repopulation and that of perfusion–limited and diffusion–limited hypoxia. The strategy, named ARCON, combines Accelerated Radiotherapy with CarbOgen and Nicotinamide. Experimental evaluation of ARCON The therapeutic potential of carbogen combined with NAM (CON) focusing on treatment schedules that use clinically relevant radiation and drug dose levels was evaluated in tumour and normal tissue animal models. Some of the conditions under which ARCON gives the largest degree of tumour radiosensitization and therapeutic benefit were identified. Specifically, NAM-dose level, pharmacokinetics and scheduling, and the effect of NAM on repair processes in vivo were also investigated. The results showed that in conventional and accelerated radiotherapy, carbogen and CON are effective and relatively non-toxic tumour sensitizers. They also demonstrated that tumour sensitization with CON was independent of time of NAM administration but that it was drug dose dependent. Some degree of normal tissue sensitization was observed but even relative to mouse skin a significant therapeutic gain was achieved. The mechanism of action for NAM sensitization originally proposed was that of repair inhibition. In the in vivo mouse models tested, namely skin and kidney, NAM did not alter the rate nor the magnitude of repair of radiation induced damage. Clinical evaluation of ARCON In the early 90s, various centres, particularly in the UK, Sweden, Holland and Switzerland, undertook clinical trials of ARCON. The protocols were designed based on detailed considerations of the rodent and human radiation and pharmacokinetic studies. This document also discusses the findings of a phase II non-randomized trial in advanced bladder cancer of accelerated radiotherapy combined with carbogen alone and ARCON. The aim of the study was to establish the feasibility of administering carbogen and NAM to patients and to determine the extent of early and late normal tissue damage. Historical comparisons suggested no overt increase in normal tissue radiosensitivity and the data indicate that ARCON could achieve a therapeutic gain in advanced bladder cancer.

In this thesis report for Dalarna University in Borlange and Absolicon company the study of a possibility to add an array of concentrating solar collectors to a Torsång district heating system was done. The whole idea of this work was to make a simulation of this kind of system, trying to get 15-20% of solar fraction, and make an economical evaluation. At the same time, another goal was to make two comparisons: between concentrating and flat-plate collector in the same system, and between two tools for collector analysis – Polysun and Absolicon tool, based on TRNSYS, which was designed to estimate the output of the collector for a certain temperature, without any load. During the study, the analysis of the simulating tools was made and the combination of those two tools was used. Using long iteration cycles, involving changing the field layout, number of collectors and distance between collector rows in flat-plate collector case, both types of collectors were analyzed. The method of the analysis was to get an equal output of the field and see the differences, which appear while using different collector types.

One important phase in software development process is to create a design model of the system which follows all the architectural rules. Often the architectural rules are defined by the system architect and the system model is designed by the system designer. The architect defines the rules in a text file where no standard or pattern is followed. Therefore, there is always the risk of violating the architectural rules by the designer. So manual reviews on the system model should be done by the architect to ensure the system model is valid.In order to remove this manual checking which can be erroneous and time consuming ArCon (Architecture Conformance Checker) was developed by Combitech AB. ArCon is a tool which lets the architect define the architectural rules in the format of UML (Unified Modeling Language) models where the elements of the model have different meaning than the standard UML. ArCon can read this model and extract architectural rules from it and check the system model against those rules and then print all the rule violations.ArCon is an open source tool i.e. free for everyone to download and use. Currently, it supports Papyrus as the UML modeling tool. Papyrus is integrated to Eclipse platform and is a general purpose modeling tool. It supports users with all types of UML diagrams and elements.The idea for this thesis work was to implement a new feature for ArCon in order to facilitate the design process for system designers. The feature should provide the system designers only those types of elements which they are permitted to add to a specific fraction of the system model. The list of permitted element types should be extracted from the architecture model where all the architectural rules are defined in advance. This new support in ArCon was named Domain Specific Modeling (DSM) support.To evaluate the effect of DSM support on the system designers performance a few test sessions, called usability tests, were performed. The participants in the test sessions were a representative sample of software designers. After analyzing the data collected from the test sessions, the pros and cons of the new support were discovered. Furthermore, a few new ideas for enhancing DSM support were generated.