Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.

The involvement of dopamine in anticipatory and consummatory aspects of feeding behaviors was investigated in the present thesis. All measurements of dopaminergic activity were taken by in vivo electrochemical techniques. In Experiment 1, dopamine efflux in the nucleus accumbens and caudate of male rats was monitored during sessions in which a small, unsignalled liquid meal was consumed. Increases in the electrochemical measure of dopamine activity, which were of similar temporal pattern and magnitude, were observed in both the nucleus accumbens and striatum following meal consumption. These data suggest a possible postingestional role of dopamine in these two brain structures. In Experiment 2, a conditioned feeding paradigm was utilized to study the role of dopamine during a discrete anticipatory phase of feeding. Rats were conditioned to discriminate between a positive conditioned stimulus (CS+) predictive of meal delivery, and a negative conditioned stimulus (CS-) that was not associated with food. Increases in dopamine activity, as determined by changes in electrochemical oxidation currents, were found to be greater during the CS+ than during the CS- in both the nucleus accumbens and caudate. In addition, the magnitude of increase was greater in the nucleus accumbens than the caudate, suggesting that the accumbens may be preferentially involved in the processing of external incentive stimuli. The results support a role for dopamine in both the nucleus accumbens and caudate during appetitive or anticipatory responding for food in the male rat. / Medicine, Faculty of / Graduate

Jogo Patológico e Dependência Química são transtornos psiquiátricos que apresentam relevante relação com avidez e estados afetivos. Inevitavelmente, a avaliação destes fenômenos nas dependências químicas sofre o viés da ação farmacológica da substância sobre o humor. Jogo Patológico vem sendo considerado uma dependência comportamental e um modelo promissor na investigação psicológica e contextual de fenômenos presentes nos diagnósticos de dependências. O estudo aprofundado da relação entre avidez e afetos em jogadores patológicos e a comparação dos mesmos com dependentes químicos contribuirá para melhor caracterização do Jogo Patológico e dos tratamentos relacionados / Pathological Gambling (PG) and Chemical Dependence (CD) are psychiatry disorders that have relevant relation with craving and affects. These phenomenons have been investigated in CD, however craving and affects among gamblers did not receive the same attention. Unavoidable, the study of these phenomenons on CD are under the substance related action influence. Craving and affects would be better understood on a disorder that shares the same addictions patterns without the presence of a psycho-active. PG has been described by literature as an addictive behavior. The parallels between Substance Disorders and PG are quite pronounced. PG as a promise model to comprehend the evolving process related to addiction. This investigation might enhance PG clinical characterization and treatment improvement

Jogo Patológico e Dependência Química são transtornos psiquiátricos que apresentam relevante relação com avidez e estados afetivos. Inevitavelmente, a avaliação destes fenômenos nas dependências químicas sofre o viés da ação farmacológica da substância sobre o humor. Jogo Patológico vem sendo considerado uma dependência comportamental e um modelo promissor na investigação psicológica e contextual de fenômenos presentes nos diagnósticos de dependências. O estudo aprofundado da relação entre avidez e afetos em jogadores patológicos e a comparação dos mesmos com dependentes químicos contribuirá para melhor caracterização do Jogo Patológico e dos tratamentos relacionados / Pathological Gambling (PG) and Chemical Dependence (CD) are psychiatry disorders that have relevant relation with craving and affects. These phenomenons have been investigated in CD, however craving and affects among gamblers did not receive the same attention. Unavoidable, the study of these phenomenons on CD are under the substance related action influence. Craving and affects would be better understood on a disorder that shares the same addictions patterns without the presence of a psycho-active. PG has been described by literature as an addictive behavior. The parallels between Substance Disorders and PG are quite pronounced. PG as a promise model to comprehend the evolving process related to addiction. This investigation might enhance PG clinical characterization and treatment improvement