This research deals with Panevėžys city on the river Nevėžis water quality from 1994 to 2004 years. There was collect and work up the information. There was determined the water pollution of biogenical (nitrites, nitrates, phosphates) substances and of the organic substances (biochemical usage of oxygen and chemical usage of oxygen). After the statistical calculation there was determined and presented the analysis of statistical data. There was estimated preventive tools for the improvement of ecological situation. According to estimations of pollution by industrial and domestic sewage of Panevėžys on the water quality of Nevėžis river there were presented conclusions and suggestions.