Spelling suggestions: "subject:"biosythesis"" "subject:"biosynthesis""
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Structural studies on mutant insulinsTurkenburg, Johannes Piet January 1992 (has links)
No description available.
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Βραδέως εκδηλούμενη αναστολή σχηματισμού πεπτιδικών δεσμών εφαρμογή στην περίπτωση της λινκομυκίνης / Slow-onset inhibition of peptide bond formation; the case of lincomycinΚαλλία-Ραυτοπούλου, Σοφία 16 March 2010 (has links)
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Studies of lysophosphatidic acid acyltransferases generating membrane lipid diversity in bacteria / 細菌膜脂質の多様性を形成するリゾホスファチジン酸アシル基転移酵素群に関する研究Toyotake, Yosuke 25 March 2019 (has links)
京都大学 / 0048 / 新制・課程博士 / 博士(農学) / 甲第21841号 / 農博第2354号 / 新制||農||1069(附属図書館) / 学位論文||H31||N5213(農学部図書室) / 京都大学大学院農学研究科応用生命科学専攻 / (主査)教授 栗原 達夫, 教授 植田 充美, 教授 小川 順 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DGAM
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Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymesHamed, Refaat B., Henry, L., Claridge, T.D.W., Schofield, C. 2016 December 1928 (has links)
Yes / Stereoselective biocatalysis by crotonase superfamily enzymes is exemplified by use of engineered 5-carboxymethylproline synthases (CMPSs) for preparation of functionalized 5-carboxymethylproline (5-CMP) derivatives methylated at two positions (i.e. C2/C6, C3/C6 and C5/C6), including products with a quaternary centre, from appropriately-substituted-amino acid aldehydes and C-2 epimeric methylmalonyl-CoA. The enzymatically-produced disubstituted 5-CMPs were converted by carbapenam synthetase into methylated bicyclic Β-lactams, which manifest improved hydrolytic stability compared to the unsubstituted carbapenams. The results highlight the use of modi-fied carbapenem biosynthesis enzymes for production of new carbapenams with improved properties. / Medical Research Council, Biotechnology and Biological Sciences Research Council (BB/L000121/1)
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