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This study tested a model to predict the likelihood of spring break travel among university students. The data were obtained from a 1996 survey sample of 303 university students.

No description available.

The tumor suppressor Breast Cancer Susceptibility Protein 1 (BRCA1) protects our cells from genomic instability in part by facilitating the efficient repair of DNA double-strand breaks. Other functions of BRCA1 include transcriptional regulation, apoptosis, DNA damage signaling, chromatin remodeling and protein ubiquitination. The major contribution of BRCA1 to maintaining genomic stability is thought to be through its role in DNA repair. BRCA1 promotes the error-free repair of double-strand breaks by homologous recombination, and is also implicated in the regulation of non-homologous end joining repair. Here we investigated the role of BRCA1 in maintaining the fidelity of non-homologous end joining repair following a double-strand break. We also examined the frequency of microhomology-mediated end joining (MMEJ) and the fidelity of double-strand break repair relative to BRCA1 protein levels in both control and tumorigenic breast epithelial cells. In addition to altered BRCA1 protein levels, we tested the effects of cellular exposure to mirin, an inhibitor of Meiotic recombination enzyme 11 (Mre11) 3' to 5' exonuclease activity. Knockdown or loss of BRCA1 protein resulted in an increased frequency of overall plasmid DNA repair mutagenesis and MMEJ following a double-strand break. Inhibition of Mre11 exonuclease activity with mirin significantly decreased the occurrence of MMEJ, but did not considerably affect the overall mutagenic frequency of plasmid double-strand break repair, although some of our data indicate that the size of sequence deletions may be reduced by mirin inhibition. The results suggest that BRCA1 protects DNA from mutagenesis during non-homologous double strand break repair in plasmid-based assays. The increased frequency of double-strand break mutagenesis and MMEJ repair in the absence of BRCA1 suggests a potential mechanism for carcinogenesis.

No description available.

Esta tese estuda a emissão de ruído de alta frequência em freios automotivos, conhecida como squeal. Para tanto, uma série de ensaios foram executados em sistemas de freio em um dinamômetro inercial. Foram colocados acelerômetros na pastilha e no caliper em três direções ortogonais, e foram testados dois diferentes tipos de sistemas de freio comerciais. Os ensaios revelaram que, durante os períodos silenciosos, o movimento vibratório da pastilha acontece tanto na direção tangencial radial quanto na direção radial no plano definido pelo disco, além da direção axial. Estas vibrações ocorrem de modo independente, não mostrando acoplamento entre os movimentos. Durante os períodos de emissão sonora intensa, os valores de vibração aumentam significativamente e ocorre o acoplamento dos movimentos nas direções tangencial e radial, que passam a apresentar sincronismo de fase e de frequência. O movimento da pastilha na direção radial é explicado pelos modos de vibração do disco, e pastilha e disco são tratados como dois osciladores fracamente acoplados. Para o tratamento de osciladores, utiliza-se o modelo de Kuramoto. O sincronismo, neste modelo, ocorre devido ao acoplamento entre os osciladores e devido à proximidade das frequências naturais de pastilha e disco. A aplicação do modelo nos sistemas ensaiados mostrou boa aderência aos dados experimentais. Finalmente, é proposta a utilização de um coeficiente adimensional de maneira a incluir no estudo dinâmico do sistema variáveis puramente tribológicas. / This paper studies friction induced high frequency noise in automotive brakes, known as squeal. Aiming this purpose, a series of experiments were performed using brake systems in an inertial dynamometer. Accelerometers were installed on pad and caliper, measuring in three orthogonal directions, in two different commercial brake systems. The tests showed that, during the silent runs, pad vibration happens in tangential and radial directions, besides the axial direction, considering the coordinate reference frame on the plane defined by the brake disc. These vibrations happen in an independent fashion, indicating no coupling between motions in different directions. During the squeal periods, however, vibration amplitudes increase sharply and phase and frequency synchronization between tangential and radial vibrations is observed, indicating vibration coupling. Pad movement in radial direction is caused by disc in-phase vibration mode. Pad and disc are treated as two harmonic oscillators according to Kuramoto model. In this model, synchronization is caused by weak coupling between pad and disc natural frequencies, due to frequency proximity. A numerical simulation of Kuramoto model was able to emulate the experimental data. Finally, a new non-dimensional coefficient is proposed in order to include in this dynamic model the influence of pure tribological effects.

When a semi-infinite body of homogeneous fluid initially at rest behind a vertical retaining wall is suddenly released by the removal of the barrier the resulting flow over a horizontal or sloping bed is referred to as a dam-break flow. When resistance to the flow is neglected the exact solution, in the case of a stable horizontal bed with or without `tail water', may be obtained on the basis of shallow-water theory via the method of characteristics and the results are well known. Discrepancies between these shallow-water based solutions and experiments have been partially accounted for by the introduction of flow resistance in the form of basal friction. This added friction significantly modifies the wave speed and flow profile near the head of the wave so that the simple exact solutions no longer apply and various asymptotic or numerical approaches must be implemented to solve these frictionally modified depth-averaged shallow-water equations. When the bed is no longer stable so that solid particles may be exchanged between the bed and the water column the dynamics of the flow becomes highly complex as the buoyancy forces vary in space and time according to the competing rates of erosion and deposition. Furthermore, when the Froude number of the flow is close to unity perturbations in the height and velocity profiles grow into N-waves and the bed below develops ripples which act to sustain the N-waves in the fluid above. It is our intention here to study dam-break flows over erodible sloping beds as agents of sediment transport taking into account basal friction as well as the effects of particle concentrations on flow dynamics including both erosion and deposition. We shall consider shallow flows over initially dry beds and investigate the effects of changes in the depositional and erosional models employed as well as in the nature of the drag acting on the flow and the slope of the bed. These models include effects hitherto neglected in such studies and offer insights into the transport of sediment in the worst case scenario of the complete and instantaneous collapse of a dam. / Mathematics

When a semi-infinite body of homogeneous fluid initially at rest behind a vertical retaining wall is suddenly released by the removal of the barrier the resulting flow over a horizontal or sloping bed is referred to as a dam-break flow. When resistance to the flow is neglected the exact solution, in the case of a stable horizontal bed with or without `tail water', may be obtained on the basis of shallow-water theory via the method of characteristics and the results are well known. Discrepancies between these shallow-water based solutions and experiments have been partially accounted for by the introduction of flow resistance in the form of basal friction. This added friction significantly modifies the wave speed and flow profile near the head of the wave so that the simple exact solutions no longer apply and various asymptotic or numerical approaches must be implemented to solve these frictionally modified depth-averaged shallow-water equations. When the bed is no longer stable so that solid particles may be exchanged between the bed and the water column the dynamics of the flow becomes highly complex as the buoyancy forces vary in space and time according to the competing rates of erosion and deposition. Furthermore, when the Froude number of the flow is close to unity perturbations in the height and velocity profiles grow into N-waves and the bed below develops ripples which act to sustain the N-waves in the fluid above. It is our intention here to study dam-break flows over erodible sloping beds as agents of sediment transport taking into account basal friction as well as the effects of particle concentrations on flow dynamics including both erosion and deposition. We shall consider shallow flows over initially dry beds and investigate the effects of changes in the depositional and erosional models employed as well as in the nature of the drag acting on the flow and the slope of the bed. These models include effects hitherto neglected in such studies and offer insights into the transport of sediment in the worst case scenario of the complete and instantaneous collapse of a dam. / Mathematics

This thesis discusses the field testing of a newly-developed product, a geosynthetic capillary break (GCB). The GCB was developed for use in engineered soil covers when a cover incorporating a capillary break effect would be desirable, but the coarse-grained material (gravel or sand) is unavailable or uneconomical. Engineered soil covers aim to reduce the amount of acid generated from sulphide bearing waste by limiting the ingress of water and/or oxygen. The GCB is a geosynthetic system that is composed of a finely ground rock flour sandwiched between two nonwoven geotextiles and manufactured as a composite layer by needle punching in a process similar to the used for GCL (geosynthetic clay liner). The goal of the GCB is to recreate the capillary break that is achieved with soil layers using a geosynthetic product that is only a few centimetres thick and that can be rolled up and for transportation, The GCB concept has been demonstrated in a previous study (Park, 2005) based on laboratory column studies and computer modelling. The goal of this project was to determine the effectiveness of the GCB when applied at field scale. Four 25 square test plots were constructed at the tailings management area (TMA) of the HudBay Minerals Inc.(HudBay) mine site located near Flin Flon, MB. One plot contained 1 m of cover soil over top of the GCB (Plot A), one contained only 1 m of cover soil (Plot B), one contained 0.3 m of cover soil over top the GCB (Plot C), and one consisted of a conventional capillary break system with 1 m of cover soil over lying 0.2 m of sand. All of the plots, along with a control plot with no cover, were instrumented with water content sensors and gas sampling ports to monitor the movement of water and oxygen through the various covers. Matric suction sensors were also installed in Plots A and B to measure the water suction within the covers. A meteorological station was installed to gather climatic data which was used to develop a water balance for each of the plots. The plots were constructed and instrumented in the fall of 2005. Data was collected and analyzed until spring of 2007. Data from the water content sensors show that the GCB was effective in increasing the water content in the soil portion of the cover system. The suction sensors show that the suction across the GCB drops significantly (40 kPa versus less than 1 kPa) as compared to plots which contain no GCB. Data from the gas concentration sensors show that the plots containing capillary breaks reduce the oxygen flux into the tailings. The plots containing the GCB (Plots A and C) resulted in the lowest flux rates, followed by the sand capillary break (Plot D )and no capillary break (Plot B), respectively. This reduction in oxygen flux will reduce the amount of acid generated from waste, as oxygen is required for the creation of acid mine drainage. Overall the study demonstrated that at field scale that the GCB is effective in limiting the ingress of water and oxygen into the tailings under the observed conditions and the manufactured GCB is comparable to the performance of the previous hand constructed column tests.

The thesis consists of two main results. The first main result is a proof that C^1 rigidity holds for circle maps with a break point for almost all rotation numbers. The second main result is a proof that C^1 robust rigidity holds for circle maps in the fractional linear transformation (FLT) pair family. That is, for this family, C^1 rigidity holds for all irrational rotation numbers. The approach taken here of proving a more general theorem that C^1 rigidity holds for circle maps with a break point satisfying a `derivatives close condition', allows us to obtain both of our main results as corollaries of this more general theorem.