This thesis demonstrates the significance of Food Vessel pottery and burial in Northern England during the Early Bronze Age (c.2200 to 1800 cal BC). It represents the first original and sustained study of this burial tradition for several decades. It is argued that the interwoven relationships between Food Vessels, other ceramic types, and trade and exchange networks are both a reason why the tradition has posed interpretative problems for prehistorians, and a central component of its significance during the Early Bronze Age. The chronological relationships between British Food Vessels and other ceramic and funerary traditions are reviewed using the first comprehensive and critically assessed dataset of radiocarbon determinations. Previous approaches to Food Vessel typology are critically reviewed and a new approach based on the ‘potter’s perspective’ and contextual studies is proposed. A contextual approach is applied to Food Vessels from three regions of Northern England: the Northern Counties; North-East Yorkshire, the central lowlands and North-West England; and South-East Yorkshire. Each study reveals significant inter- and intra-regional similarities and differences in how Food Vessels were used and understood. The significance of Food Vessel pottery and burial is then discussed at a national scale.

This work discusses change and continuities taking place in the transition from the Late Bronze to the Early Iron Ages in Greece. The geographical range will cover the eastern mainland (including Euboea), Naxos and Knossos, in a period starting from the final palatial culture of LH IIIB2/13th century and ending with the Proto-Geometric/10th century burial evidence. In order to collect and observe the archaeological evidence several tombs assemblages have been researched from both original reports and visits to relevant Greek museums. Finds have been tabulated, and continuities, innovations and losses have been identified. The major categories of material evidence analysed included pottery, metalwork and jewellery but also the form of the tombs and the manner of the burials were considered. The final analysis of these categories of evidence refutes theories of major and or abrupt change, whether caused by invasion or natural phenomena. It rather indicates social modifications following the loss of the palatial centres and their administration and culminating in their gradual replacement by new forms of social structure. Although not directly demonstrable from the existing evidence, a possible scenario is proposed to explain the frequent indications of influence from SE and Central Europe during this transition.

When an ancient Near Eastern city was besieged and looted the statues and cultic appurtenances of the gods were often confiscated by the conquerors. Their loss was more than a heavy blow to the defeated people: the statue was the god‘s representation on earth and watched over and protected the city so his abandonment of his city was thought to have a lasting devastating effect. From the point of view of the conqueror the statue could be used not only as a tool of intimidation but for bribery and a crude form of diplomacy and as propaganda for his might and glory. In this thesis the history of the phenomenon of godnap is explored for the first time and there is also an investigation of related problems in religion and cultural history. At the outset a detailed investigation of the numinous character of an ancient Mesopotamian statue is given including an account of the ritual that imbued it with this divine quality. Special attention is given to Marduk of Babylon and the episodes in which even he found himself the victim of theft. The thesis includes an excursus on evocatio and parallels between Hittite and ancient Roman practices are drawn.

This dissertation demonstrates that the presence of Latin basilissai, Catholic wives of the Byzantine despots of Morea, in Mystras between 1349, when the city became the seat of the Despotate, and 1460, when it was surrendered to the Turks, had an impact on the artistic and cultural production at court. These foreign women were agents of the ruling political and economic elites of Italian and Frankish courts, and expressed their agency by mediating their specific cultural and artistic traditions into the production of their adopted city. Art and cultural historical approaches, in which attention is focused on painted and sculpted details, inscriptions, archaeological remains, architectural design, and urban planning, are used to show that the Latin women were historical agents, whose presence can be detected in Mystras. A multidisciplinary analysis of case studies reveals cross-cultural motifs in the artistic production, demonstrating the relationship between pieces of evidence. The production of the workshops of Mystras expressed features that were, in some cases, responses to Constantinopolitan and Byzantine models, while, in others, autonomous and innovative, revealing complex cross-cultural references. Ultimately, this study shows that the particular cultural and artistic landscape of Mystras is indebted to exogenous cultures linked to these women.

This thesis surveys the ninth-century metallic threads decorating silks discovered at Famen temple in Shaanxi province, China. In this research, metallic threads decorating Famen silks have been studied and documented in detail in order to understand how they were produced and how they were applied. Samples of metallic threads were selected and optical microscope and SEM/EDS were used to determine their morphology and composition. Problems regarding the current terminology used to describe metallic threads are briefly considered, and a systematic renaming of different types of metallic threads is suggested. Analysis results show that most Famen metallic threads were made of gold strips without substrate wound around a fibrous core, and that very few are silver strips without substrate wound around a fibrous core. Silver strips with paper substrate wound around a fibrous core are found among Famen silks, providing very early examples of this type of metallic thread in the world. Technical evidence demonstrates that the Famen metallic strips were cut from hammered metallic foil. It was found that metallic threads of different metal composition with different physical characteristics were selected according to the decoration techniques used and the function of the silks. The use of metallic threads with different grades of evenness in dimension and morphology for different decoration techniques was also found. The gold contents of these gold threads are all very high, and the thicknesses of the gold strips are large. All these characteristics are probably related to the function of Famen silks as objects of Buddhist worship that had been donated to the temple by members of the Tang imperial family and other high-ranking people. Technical investigation into the manufacture of modern traditional Chinese metallic threads was carried out in this research. Combined with analysis of the morphological, structural, and material nature of Famen metallic threads, the key technical characteristics of modern traditional metallic threads were found, which provided important evidence for deducing the manufacturing techniques of Famen metallic threads. Successful reconstructive experiments that produced metallic threads similar to Famen metallic threads were carried out in the laboratory by the author. The use of other known related techniques to produce Famen metallic threads was eliminated on technical grounds. With the above evidence, the manufacturing of Famen metallic threads, especially how the metallic strips were wound around the fibrous core, are reasonably deduced here. By investigating a number of currently accessible Chinese historical metallic threads from other periods, the evolutionary principles of Chinese metallic threads are concluded. The special characteristics of Famen metallic threads, the reasons determining these characteristics are better understood, and their role in the development of Chinese metallic threads is assessed.

What is the line between the “ancient” world and the “medieval” world? Is it 476? 330? 632? 800? Most historians acknowledge there is no crisp line and that these are arbitrary distinctions, but they are made anyway, taking on lives of their own. I believe they are much the same world, except for the pervading influence of one flavor of monotheism or another. This thesis endeavors to study top-down, monotheistic conversions in Pontic-Caspian Eurasia and their respective mythologizations, preserved both textually and archaeologically, which serve as a primary factor for what we might call “state formation.” These narratives also function, in many cases, as the bases of many modern nationalisms, however haphazard they may be. I have attempted to apply this idea to Christian Rome (Byzantium)’s diachronic missionary policy around the Black Sea to reveal how what we today call the “Age of Migrations” (the so-called “Germanic” invasions of the Roman Empire), was actually in perpetual continuity all the way up to the Mongolian invasions and perhaps even later. In this way, I hope to enhance the context by which we understand the entirety of not only Western history, but to effectively bind it to a broader context of global monotheization.

Exposure to a strong T-helper 2 (Th2)-like environment during fetal development may promote allergy development. Increased cord blood (CB) levels of the Th2-associated chemokine CCL22 were associated with allergy development during the first 2 y of life. The aim of the present study was to determine whether CB Th1- and Th2-associated chemokine levels are associated with allergy development during the first 6 y of life, allowing assessment of respiratory allergic symptoms usually developing in this period. The CB levels of cytokines, chemokines, and total IgE were determined in 56 children of 20 women with allergic symptoms and 36 women without allergic symptoms. Total IgE and allergen-specific IgE antibody levels were quantified at 6, 12, 24 mo, and 6 y of age. Increased CB CCL22 levels were associated with development of allergic sensitization and asthma and increased CCL17 levels with development of allergic symptoms, including asthma. Sensitized children with allergic symptoms showed higher CB CCL17 and CCL22 levels and higher ratios between these Th2-associated chemokines and the Th1-associated chemokine CXCL10 than nonsensitized children without allergic symptoms. A pronounced Th2 deviation at birth, reflected by increased CB CCL17 and CCL22 levels, and increased CCL22/CXCL10 and CCL17/CXCL10 ratios might promote allergy development later in life.

In this dissertation we studied the pharmacological and functional consequences of adenosine A2A receptor interaction with other proteins, as other neurotransmitter receptores localized in the human brain and an important enzyme regulating the extracellular concentration of adenosine, the ecto-ADA (adenosine desaminase). The first aim of this thesis was to study the molecular and functional interaction of A(2A)Rwith ADA. We found out that A(2A)Racted as a membrane anchoring protein of ADA, more exactly, that ADA bound to A2A receptor homomers and induced a strong modification of their quaternary structure in the way it behaved as a positive allosteric ligand. In addition at the functional level, ADA markedly enhanced A2A receptor signalling, increasing the A2A receptor agonist-induced ERK 1/2 phosphorylation. This powerful regulation of A2A function exerted by ADA might have important implications in the physiology and pharmacology of neuronal A2A receptors that are implicated in the striatal motor regulation. The second aim of this thesis was to search for a compound possibly useful in the treatment Huntington´s disease (among other neurological diseases), concretely a more selective antagonist of A2A receptor for presynaptic A1-A2A receptor heteromers versus postsynaptic A2A-D2 receptor heteromers. Applying in vitro and in vivo approaches, we discovered that the A2A receptor antagonists SCH-442416 showed a presynaptically preferential profile and, on the other hand, the KW-6002 behaved as a postsynaptically preferential A(2A)Rantagonist. Other analysed compounds ZM-241385, MSX-2, SCH-420814, and SCH-58261 showed no clear presynaptic or postsynaptic preference, i.e. presented a mixed profiles. The presynaptic preference of SCH-442416 was due to a strong negative cooperativity induced by the physical presence of dopamine D2 receptor in the A2A-D2 receptor heteromer that was detected by the compound SCH-442416. This cooperativity also indicates that A2A-A2A receptor homodimers are present in the A2A-D2 receptor heteromers. In summary, on the basis of their preferential pre- versus postsynaptic actions, SCH-442416 can be used as a lead compound in the development of antidyskinetic drugs in Huntington’s disease, meanwhile KW-6002 confirms to be possibly beneficial in Parkinson’s disease. The third aim of this thesis consisted in investigation of pharmacological and functional properties of A2A receptors in the A2A-CB1 receptor heteromers and determination whether selective A2A receptor antagonists show different selectivity for A2A receptors or A2A-CB1 receptor heteromers. We observed that adenosine A2A receptor changed its G-protein coupling from stimulatory Gs to inhibitory Gi protein when it formed heteromer with CB1 receptor and a synergistic cross-talk in G-protein activation was observed when both receptors were co-activated. At the same time, we saw that CB1 receptor mainly controled the ERK 1/2 signalling under the A2A-CB1 receptor heteromer. The A2A-CB1 receptor heteromers did not show allosteric effects at the ligand binding level. The two specific A2A receptor antagonist, KW-6002 and VER-7835 lost affinity for A2A receptors when expressed in A2A-CB1 receptor heteromers. This all means that A2A-CB1 receptor heteromers constitute a singular unit for adenosine and cannabinoids signalling, introducing diversity in A2A receptor signalling that can be therapeutically relevant in neurological diseases involving striatal neurons. In summary, the results presented in this Thesis show the importance of GPCR heteromers in the brain striatum and their physiological importance for the treatment of neurological diseases. / En esta Tesis hemos estudiado las consecuencias farmacológicas y funcionales de la interacción del receptor A2A de adenosina con otras proteínas, concretamente con otros receptores de neurotransmisores localizados en el cerebro humano y la enzima ecto-adenosina desaminasa. Hemos demostrado que el A2AR actúa como una proteína de anclaje de ADA que se une a los homodímeros de este receptor y a su vez induce una fuerte modificación en su estructura cuarternaria. Esta propiedad hace de ADA un ligando alostérico de los A2AR que modula positivamente la unión de agonistas y antagonistas al sitio ortostérico de este receptor. En segundo lugar, buscamos un antagonista de A2AR potencialmente útil para el tratamiento de la enfermedad de Huntigton, concretamente un antagonista preferencialmente más selectivo para el heterodímero "presináptico" A1R-A2AR versus el heterodímero "postsináptico" A2AR-D2R. Encontramos un compuesto, SCH-442416, que mostró este perfil presináptico, cual fue debido a una fuerte cooperatividad negativa inducida por presencia física del receptor de dopamina D2 en el heterómero A2AR-D2R. Al revés, otro compuesto, KW-6002, mostró un perfil preferencial postsináptico. Por ello, SCH-442416 puede ser utilizado como un compuesto de partida para el desarrollo de fármacos antidiscinéticos para la enfermedad de Huntington, y por su parte KW-6002 comprobó ser posiblemente beneficioso en la enfermedad de Parkinson. En tercer lugar demostramos que el receptor CB1 influye al A2AR cual cambia su acoplamiento de una proteína Gs estimuladora a una Gi inhibidora en el heterodímero A2AR-CB1R y también controla la señalización de ERK 1/2 y que el KW-6002 pierde afinidad por los receptores A2A en este heterómero. En resumen esta Tesis muestra la importancia de heterómeros de receptores acoplados a proteína G en el cerebro y su relevancia fisiológica a la hora de búsqueda de tratamiento para las enfermedades neurológicas.

This thesis investigates the Flavian Amphitheatre, better known as the Colosseum, in its relation to setting, symbolic meaning and its afterlife. Crucial to the discussion is the ancient art of memory, through which the Colosseum&rsquo / s ambivalent role as a means of Imperial power is elucidated. Equally important, the buildings&rsquo / iconographic connotations are studied in terms of the architectural orders employed on the fa&ccedil / ade. The Colosseum&rsquo / s extended use and its later emblematic significance comprise the concluding discussion of the thesis.

In my doctoral dissertation I explore the key role played by the eighteenth-century enlightened narrative of civilisation in the shaping of a Eurocentric/racist construction of the world. I do this by analysing how, in sources from the realms of moral philosophy and natural history, the intertwining discourses of luxury, sensibility, taste and climate that fuelled the narrative of civilisation created an understanding of human nature that made eighteenth-century scientific racism possible. The entire non-European world (the East, Africa and America) was presented as a space inhabited by unnatural bodies. Although Europe itself was not characterised as monolithic, (these writers saw a clear boundary between Northern and Southern Europe), the joint efforts of both moral philosophers and natural historians clearly distinguished Europe and the European body from the rest of the world. The Eurocentric/racist eighteenth-century construction of the world was so powerful in naturalising the European human and national prototype as a universal normative standard that it even found agents in other continents who were willing to argue that they too belonged to the European civilisation. Even those whom Europeans explicitly cast as inhabiting spaces unfit for the unfolding of civilisation, and thus as spaces where the European human prototype inevitably degenerated, might insist that they too conformed to the European human and national prototype. The idea of Europe as the centre of the world would not have triumphed had agents outside Europe not participated in its making. This was the case of the New Granadan Creoles, the founding fathers of the Colombian nation, who far from questioning the Eurocentric racist/lens of civilisation whereby European savants had dismissed the non-European world as inferior, instead reinforced it.