This Master of Science thesis is producedat SAAB Security and Defence Solutions.The purpose of the thesis is to analyzehow air surveillance work can be carriedout. This information is then used to givesuggestions for the design of a new systemcontaining only the most essentialfunctionality. This is done by examiningthe available frameworks which can informinterface design and applying a frameworkto analyze work in a complete system usedas the basis of the new Compact C2 system.The second part of the analysis isdirected towards the stripped system(Compact C2) and both parts of theanalysis are used to inform interfacedesign of the Compact C2 system. By usingthe full range of the chosen framework foranalysis of the identification process inSwedish air surveillance work, someessential functions were identified andshould also have support in a Compact C2 system.

Le Québec souffre d’une pénurie importante d’infirmières qui ne cesse d’augmenter. Le recrutement d’infirmières immigrantes est l’une des stratégies proposées pour pallier à cette pénurie. Parmi celles-ci, les infirmières immigrantes issues de la francophonie (en excluant la France, la Belgique et la Suisse) sont parmi les plus susceptibles de s’intégrer à long terme à notre système de santé. Avant de pouvoir travailler au Québec, toutefois, plusieurs d’entre elles doivent compléter la formation CWA.0B « Intégration à la profession infirmière du Québec ». Or, on observe que le taux de réussite à la formation reste faible. Les raisons de ce faible taux de réussite sont encore mal connues, puisqu’il existe peu d’études au Québec comme à l’étranger sur l’intégration des infirmières immigrantes. Cette étude a pour but d’analyser cette problématique en explorant l’expérience d’intégration des infirmières immigrantes complétant le programme CWA.0B. Il s’agit d’une étude qualitative de type exploratoire. Dix-huit infirmières immigrantes complétant le programme CWA.0B ont participé à deux entrevues semi-dirigées chacune. L’approche anthropo-biologique de Marie-France Collière et plus précisément sa dynamique structurante (2001) a permis de saisir leur expérience dans toute sa complexité en la resituant dans un contexte élargi. Les résultats révèlent plusieurs facteurs influençant l’expérience d’intégration des infirmières inscrites au programme « Intégration à la profession infirmière du Québec ». Ces facteurs sont regroupés autour de trois grands thèmes. Le premier thème révèle l’influence de l’histoire de vie sur l’expérience de la formation, soit l’impact du parcours prémigratoire, les difficultés rencontrées au cours du processus d’immigration ainsi que les stratégies employées par les participantes pour les surmonter. Le deuxième thème explore l’expérience des participantes durant le programme de formation. Celui-ci est apprécié dans son ensemble, mais à réajuster dans son volet d’encadrement clinique. Ces difficultés liées au manque d’encadrement sont également explorées. Le dernier thème dévoile l’influence du contexte socioculturel sur l’expérience de la formation, soit l’appréciation des différences culturelles entre le Québec et le pays d’origine des participantes, les défis à relever au plan de la conciliation entre les études, la famille et le travail, et finalement, les stratégies employées pour relever ces défis.

Streptococcus sanguinis is a leading cause of infective endocarditis. Bacterial adhesion to platelets is likely important in the pathogenesis of infective endocarditis. Bacterial cell wall-anchored (Cwa) proteins may mediate this adhesion. To begin to test this hypothesis, S. sanguinis adhesion to platelets was examined in vitro. The requirement of 12 Cwa proteins for S. sanguinis-platelet adhesion was individually assessed, measuring adhesion of purified platelets to polystyrene wells coated with S. sanguinis strain SK36 or 12 isogenic Cwa protein mutants. Significantly fewer platelets adhered to wells coated with one mutant strain, VT1614. However, results of a whole-cell enzyme-linked immunosorbent assay (ELISA) showed that 8 mutants, including VT1614, adhered in significantly lower numbers to wells than did SK36. After accounting for unequal bacterial numbers, we determined there was no significant difference in platelet adhesion among the strains. This suggests that none of the Cwa proteins examined were required for S. sanguinis-platelet adhesion.

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Metal-organic frameworks (MOFs) are a class of hybrid materials that offer a promising platform for a range of catalytic reactions. Due to their complex structure, MOFs offer unique opportunities to serve as novel catalysts, or as host to improve the properties of previously studied species. However, while other catalytic approaches have been studied for many decades, the recency of their discovery means that significant work is still needed to develop MOFs as a viable option for large scale application. Herein, we aimed to advance the field of MOFs as both novel catalysts, and as host platforms for other catalytic species. To this end, we studied synthetic pathways to produce favorable MOF properties such as higher porosity and active site concentration through introduction of defects and macromorphological control, as well as utilization of molecular catalysts imbedded in the MOF structure for multicomponent, light driven reactivity. Chapter 1 introduces the history MOFs and the pursuit of the stable structures commonly associated with MOF chemistry. The synthesis process for zirconium-based MOFs will be discussed, with specific attention given to the modulated synthesis process which can harnessed to change MOF properties and improve catalysis. Two specific reactions will be introduced which serve as a basis for study in this work. First, the hydrolysis of organophosphate nerve agents by MOFs acting as novel catalysts will be introduced. The mechanism of reaction, as well as previous work in this field will be discussed. Finally, water oxidation as part of artificial photosynthesis through incorporated molecular catalysts will be introduced. Chapter 2 presents a modulator screening study on a zirconium-based MOF, UiO-66. One of the most commonly studied MOFs, UiO-66 provides an excellent platform for synthetic modulation. Particle size and defect level were measured of 26 synthetic variations and synthetic conditions were found to isolate changes in defect level and particle size, which typically change coincident with each other. Hydrolysis of the organophosphate compound dimethyl 4-nitrophenylphosphate (DMNP) was used to study the impact of particle size and defect level on reactivity. The reaction was found to be surface limited, even at high levels of missing linker defects. In Chapter 3, the macromorphology of three zirconium-based MOFs were tuned through synthesis modification. MOF powders and xerogels were prepared and characterized to highlight the desirable properties obtained through the gelation process. The materials were compared in the hydrolysis of DMNP and significant enhancement was observed for UiO-66 and NU-1000 xerogels. This was largely attributed to the introduction of mesoporosity and nanocrystalline particle sizes, which significantly increase the number of reactive sites easily accessible for catalysis. In Chapter 4 the authors examine MOFs as a host for molecular catalysts for use in photoelectrochemical water oxidation. A ruthenium-based catalyst [Ru(tpy)(dcbpy)]2+ was incorporated into UiO-67 through a mixed linker synthesis and grown on a WO3 substrate (Ru-UiO-67/WO3). Previous work from our group demonstrated Ru-UiO-67 retained the catalytic activity as the molecular species, while improving the recyclability of the material. In this work, addition of WO3 as a light harvester allowed for the reaction to be driven at a photoelectrochemical underpotential, a first for MOF-based water oxidation. Finally, Chapter 5 offers a perspective of the field of MOF-based artificial photosynthesis. Particular attention is given to issues of diffusion, selectivity, stability, and moving towards integration of multiple components rather than the study of half-reactions. / Doctor of Philosophy / Catalysts are a key component of chemistry that has a major impact on everyday life. From biological examples to industrial settings, catalysts are used to facilitate chemical conversions to new products and compounds. Because of the high demand, development of new catalysts with improved reactivity is a significant scientific challenge. A new class of materials known as metal-organic frameworks (MOFs) have been recently shown to acts as new catalysts or improve the properties of existing catalysts. Herein, we discuss the use of MOFs as catalysts for both development of new catalysts and improving known species. MOF-based catalysts have been used in a range of reactions from destruction of toxic chemical weapons to the production of renewable energy through artificial photosynthesis. This work is intended to highlight the potential for MOF-based catalysts and the next steps to further realize their potential.

Water quality has been an issue of concern since the settlement of man and continues to be of great concern today in many locations around the world. In the United States, to address the issues of water pollution, the U.S. Congress passed the Clean Water Act (CWA) in 1972. This study examines the implementation and prioritization of impaired water bodies listed on the Illinois CWA section 303(d) list between 1992 and 2004. This study used the Delphi survey method to obtain opinions from water quality/management experts that reside in the state of Illinois. The goal of this study was to determine if a consensus could be reached amongst water quality experts on the severity of individual water pollutants for a given designated use of a water body by assigning weights, determining if any prioritization trends exist within the current Illinois 303(d) process, as well as identifying any shortcomings of the process and suggesting possible modes of improvement. The survey identified four major shortcomings of Illinois' current approach to water quality management: 1) limited funding and manpower, 2) lack of coordination/monitoring, 3) failure to regulate point sources, and 4) lack of biological monitoring. The survey respondents indicated that the entire state needs attention in terms of water quality improvement and that agriculture and urban runoff are the most important sources of water pollution and water body impairment. They rated the current prioritization system as being between "average" and "good" and identified that development of a weighting scheme could be feasible as long as it received adequate funding and adequate stakeholder support. The measure of consensus among respondents regarding weights for individual pollutants and designated uses varied significantly; however, the overwhelming majority of consensus values improved after participants were asked to revise their original responses in an effort to move towards central tendency in the distribution of assigned ranks.

Les menaces constantes de terrorisme nécessitent le développement d'instruments permettant de détecter efficacement des agents chimiques de guerre. L'objectif de ce travail était la réalisation d'un spectromètre de masse devant effectuer des analyses de type : LC/ESI-MS et GC/EI-MS, sur des échantillons sous tous les états : solide, liquide, gazeux et qui soit rapide. Une première partie de ce travail a consisté à étudier le fonctionnement du spectromètre de masse LTQ Velos, puis de faire une étude des modes d'injection axiale et radiale des ions par simulation à l'aide du logiciel SIMION. L'étude de l'injection radiale, nous a démontré la faisabilité de ce mode d'injection dans un piège linéaire. Ainsi, lors d'applications spécifiques dans lesquelles l'axe central doit être libéré, le mode d'activation par IRMPD peut être envisagé. Une deuxième partie de ce travail a consisté à modifier la source CI du module ETD en source EI. Trois sources EI (la Thermo, la NERMAG et la source trappe) ont été étudiées afin de déterminer celle qui serait la plus efficace et offrirait un bon compromis en terme de coût et de temps de développement. La source Thermo a été retenue et a ensuite été implémentée dans le module ETD du LTQ Velos qui a été couplé à un GC rapide pour effectuer des tests préliminaires de faisabilité de ce couplage. Ainsi, ces tests ont permis de caractériser le GC/EI-LTQ Velos comme étant capable d'effectuer des analyses en GC/MS rapide (de l'ordre de ? 5 min). Ce GC/MS rapide a ensuite été intégré dans le démonstrateur ainsi que le collecteur aérien chimique et le détecteur TIC et POC. Des essais préliminaires concluants ont été réalisés sur ce démonstrateur. / Constant threats of terrorism require the development of tools to effectively detect chemical warfare agents. The aim of this work was to develop a mass spectrometer capable of performing rapid LC/ESI-MS and GC/EI-MS analyses on samples from all states: solid, liquid and gaseous. The first part of this work was to study the principle of operation of the linear ion trap LTQ Velos, then to study axial and radial ion injection in the linear ion trap by means of computer simulation using SIMION. The feasibility of performing radial ion injection has been demonstrated, thus in specific applications in which the central axis needs to be released, the IRMPD activation mode may be considered. A second part of this work was to adapt the existing ETD module to accommodate EI. Three EI sources (the Thermo, the NERMAG and the trap source) were studied to determine which one would be the most effective and offer a good compromise in terms of cost and development time. The Thermo source has been selected and modified to conduct EI within the ETD module of the LTQ Velos which was interfaced to a fast GC (Heracles II). Preliminary tests characterized the dual pressure ion trap as a mass analyzer for performing rapid GC/MS analyses. The results showed that the GC-LIT with its high scanning speed was able to provide sufficient scans across chromatographic peaks when working in both the conventional and the fast GC modes, and further offered good EI spectral information. This GC/MS was then implemented into the demonstrator as well as the air sampler and the TIC/POC detector. Conclusive preliminary tests have been made on this demonstrator.

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Thesis (Ph.D.)--Miami University, Dept. of Psychology, 2005. / Title from second page of PDF document. Document formatted into pages; contains [2], vi, 72, [22] p. : ill. Includes bibliographical references (p. 35-37).