Rapid delivery of backfill to support underground openings attracted many mines to adopt paste backfilling methods. As a precaution to prevent liquefaction and to improve the mechanical performance of backfills, a small portion of a binder is added to the paste to form the cemented paste backfill (CPB). Recently, adding sand to mine tailings (MT) in CPB mixes has attracted attention since it enhances the flow and mechanical characteristics of the pastefill. This thesis investigates the effects of adding sand to CPB on the undrained mechanical behavior of the mixture (CPBS) under monotonic and cyclic loads. Liquefaction investigations took place at the earliest practically possible age. Beyond this age, the present research focused on characterizing the evolution of stiffness and obtaining the values of the stiffness parameters that could be useful for designing and modeling backfilling systems. The liquefaction investigation involved monotonic compression and extension triaxial tests. Neither flow nor temporary liquefaction was observed for all cemented and uncemented specimens under monotonic compression, while temporary liquefaction was observed for all specimens under monotonic extension. The addition of binder and sand to MT was found to slightly strengthen the pastefill in compression while weakening it in extension. Under cyclic loading, the addition of sand negatively impacted the cyclic resistance. However, binder was found to be more effective in the presence of sand. All specimens exhibited a cyclic mobility type of response. The evolution of effective stiffness parameters for two CPB-sand mixtures was monitored in a non-destructive triaxial test for five days. Self-desiccation was found to not be influential on the development of early age stiffness. Moreover, a framework is suggested to predict the undrained stiffness at degrees of saturation representative of the field. The credibility of the proposed test in providing stiffness parameters at representative strain levels of the field was verified.

Rapid delivery of backfill to support underground openings attracted many mines to adopt paste backfilling methods. As a precaution to prevent liquefaction and to improve the mechanical performance of backfills, a small portion of a binder is added to the paste to form the cemented paste backfill (CPB). Recently, adding sand to mine tailings (MT) in CPB mixes has attracted attention since it enhances the flow and mechanical characteristics of the pastefill. This thesis investigates the effects of adding sand to CPB on the undrained mechanical behavior of the mixture (CPBS) under monotonic and cyclic loads. Liquefaction investigations took place at the earliest practically possible age. Beyond this age, the present research focused on characterizing the evolution of stiffness and obtaining the values of the stiffness parameters that could be useful for designing and modeling backfilling systems. The liquefaction investigation involved monotonic compression and extension triaxial tests. Neither flow nor temporary liquefaction was observed for all cemented and uncemented specimens under monotonic compression, while temporary liquefaction was observed for all specimens under monotonic extension. The addition of binder and sand to MT was found to slightly strengthen the pastefill in compression while weakening it in extension. Under cyclic loading, the addition of sand negatively impacted the cyclic resistance. However, binder was found to be more effective in the presence of sand. All specimens exhibited a cyclic mobility type of response. The evolution of effective stiffness parameters for two CPB-sand mixtures was monitored in a non-destructive triaxial test for five days. Self-desiccation was found to not be influential on the development of early age stiffness. Moreover, a framework is suggested to predict the undrained stiffness at degrees of saturation representative of the field. The credibility of the proposed test in providing stiffness parameters at representative strain levels of the field was verified.

While unprotected amino aldehydes are typically not isolable due to imine formation and consequent polymerization, stable unprotected aziridine aldehydes are useful and available reagents. Moreover, reversible hemiacetal and hemiaminal formation enable these compounds to reveal both their electrophilic and nucleophilic functional groups. This exceptional arrangement allows for aziridine aldehyde dimers to participate in and disrupt the mechanisms of an array of well-known organic reactions, including isocyanide-based multicomponent reactions. The scope and selectivity patterns of aziridine aldehyde induced amino acid or peptide macrocyclization have been investigated. A small library of constrained tri-, tetra-, and penta-peptide macrocycles – representing the most difficult cyclic peptides to synthesize – has been prepared. The scope of aziridine aldehyde participation in multicomponent reactions was also expanded to Ugi and Passerini reactions that do not employ tethered amine and acid functional groups. In order to facilitate cellular imaging of peptide macrocycles a fluorescent isocyanide reagent was prepared and applied to prepare mitochondrial targeting macrocycles. Thioester isocyanide reagents were synthesized to enable rapid assembly of cycle-tail peptides through ligation technology.

The effects of dibutyryl 3'; 5' cyclic monophosphate (dbcAMP) on several parameters of transformation were studied using a Kirsten sarcoma virus (Ki-MSV)-transformed mouse cell line (K-A31). Treated cells showed changes in morphology, decreased motility, saturation density and growth rate, and lost the capacity for anchorage-independent growth. In contrast to many other transformed cell lines, fibronectin and an elaborate cytoskeleton were present in K-A31 cells. The transcription of the proviral genome was examined using both reverse-transcribed and nick-translated ('3)H-DNA probes, and certain viral-specific RNAs were found restricted to the nucleus of dbcAMP-treated cells. Additive hybridization experiments suggested these RNAs were transcribed from rat-derived sequences located in the 5'-half of the proviral genome. These results are discussed with respect to the properties most closely associated with cellular malignancy, and the possible mechanism of dbcAMP-mediated reverse-transformation in K-A31 cells.

In Santa Barbara County, Santa Maria Pacific (an exploration and production company) is expanding their cyclic steam project in a diatomite reservoir. The hilly or mountainous topography and cut and fill restrictions have interfered with the company's ideal development plan. The steep hillsides prevent well pad development for about 22 vertical well locations in the 110 well expansion plan. Conventional production performs poorly in the area because the combination of relatively low permeability (1-10 md) and high viscosity (~220 cp) at the reservoir temperature. Cyclic steam injection has been widely used in diatomite reservoirs to take advantage of the diatomite rocks unique properties and lower the viscosity of the oil. Some companies used deviated wells for cyclic steam injection, but Santa Maria Pacific prefers the use only vertical wells for the expansion. Currently, the inability to create well pads above 22 vertical well target locations will result in an estimated $60,000,000 of lost revenue over a five year period. The target locations could be developed with unstimulated deviated or horizontal wells, but expected well rates and expenses have not been estimated. In this work, I use a thermal reservoir simulator to estimate production based on five potential development cases. The first case represents no development other than the cyclic wells. This case is used to calibrate the model based on the pilot program performance and serves as a reference point for the other cases. Two of the cases simulate a deviated well with and without artificial lift next to a cyclic well, and the final two cases simulate a horizontal well segment with and without artificial lift next to a cyclic well. The deviated well with artificial lift results in the highest NPV and profit after five years. The well experienced pressure support from the neighboring cyclic well and performed better with the cyclic well than without it. Adding 22 deviated wells with artificial lift will increase the project's net profit by an estimated $7,326,000 and NPV by $2,838,000 after five years.

Summary Background The cementation of crowns to dental implant abutments is an accepted form of crown retention that requires consideration of the properties of available cements within the applied clinical context. Most current dental cements were developed primarily for use with natural tooth crowns, but must act in a different manner with implant components. Cements are exposed to a number of stressors that may reduce crown retention in vivo, not the least of which is occlusal loading. This study investigated the influence of compressive cyclic loading on the physical retention of cast crown copings cemented to implant abutments. Method Cast crown copings were cemented to Straumann synOcta titanium implant abutments with three different readily used and available cements. Specimens were placed in a humidifier, thermocycled and subjected to one of four quantities of compressive cyclic loading. The uniaxial tensile force required to remove the cast crown copings was then recorded. Data analysis was conducted using two-way ANOVA and paired post tests. Results Statistical analysis arising from post tests following two-way ANOVA testing revealed the mean retention values for crown copings cemented with Panavia-F cement (5.103, 2.681, 3.178, 2.986MPa) were statistically significantly greater than both KetacCem (0.646, 0.701, 1.083, 0.914MPa) and TempBond non–eugenol (0.074, 0.181, 0.190, 0.303MPa) cements at each compressive cyclic loading quantity. KetacCem and TempBond non–eugenol cements produced relatively low mean retention values that were not statistically significantly different at each quantity of compressive cyclic loading. Compressive cyclic loading had a statistically significant effect on Panavia-F specimens alone, but increased loading quantities produced no further statistically significant difference in mean retention. Compressive cyclic loading had no overriding statistically significant effect on the retention of all specimens as a population. Conclusions Within the limitations of the current in vitro conditions employed in this study, the retention of cast crown copings cemented to Straumann synOcta implant abutments with Panavia-F, KetacCem, and TempBond non-eugenol was significantly affected by cement type but not compressive cyclic loading. Panavia-F is the cement of choice for the definitive non-retrievable cementation of cast crown copings to Straumann synOcta implant abutments out of the three cements tested. The implications of these results relate to the choice of cement to provide the desired crown coping retention. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1349966 / Thesis (D.Clin.Dent.) -- University of Adelaide, School of Dentistry, 2008

Thesis (Ph. D.)--University of Wyoming, 2006. / Title from PDF title page (viewed on Nov. 15, 2007). Includes bibliographical references.

Thesis (M.Res.(Med.))--University of Hong Kong, 2007.

Thesis (Ph.D.). / Written for the Dept. of Neurology and Neurosurgery. Title from title page of PDF (viewed 2008/05/12). Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [76]-87).