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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Estudo da Infecção pelo Vírus da Hepatite B (HBV) em Caminhoneiros de Rota Longa do Brasil: Soroepidemiologia e Genótipos / Study of the Hepatitis B Virus Infection (HBV) in Long Distance Trucks Drivers in Brazil : Seroepidemiology and Genotypes

MATOS, Marcos André de 20 December 2008 (has links)
Made available in DSpace on 2014-07-29T15:04:27Z (GMT). No. of bitstreams: 1 dissertacao-marcos-andre-matos.pdf: 725697 bytes, checksum: e2fcb1b4531591c5a4eeebc3b47ca54f (MD5) Previous issue date: 2008-12-20 / The aim of this study was to investigate the seroepidemiological and molecular profile of the hepatitis B virus (HBV) infection in long distance truck drivers in Brazil. From October 2005 to 2006, 641 individuals were interviewed on sociodemographic and risk factors, and blood samples were collected to test for HBV markers (HBsAg, anti- HBs and anti-HBc) by the enzyme linked immunosorbent assay (ELISA). HBsAg positive samples were submitted to HBV DNA detection by polymerase chain reaction (PCR) and genotyping by restriction fragment length polymorphism (RFLP) analysis. A global prevalence of HBV was 18.9% (95% CI: 15.9-22.2): 16 were HBsAg positive, 117 anti-HBc total and 69 anti-HBs. Thirty truck drivers were anti- HBs only, suggesting vaccination against hepatitis B. Length of profession above 20 years, time away from home more than 15 days and history of sexually transmitted diseases (STD) were independently associated to HBV positivity by multivariate analysis. Among HBsAg-positive truck drivers, one (6.2%) were HBeAg reactive, nine (56.25%) anti-HBe positive and the rest negative for both markers. HBV DNA was detected in nine samples of the HBsAg-positive individuals, being identified the genotype A (22.2%), D (55.6%) and F (22.2%). These findings ratify the high risk of hepatitis B infection in truck drivers, and highlight the importance of public health politics addressed to this group whom presents characteristics which may favour HBV acquiring and it dissemination. / O objetivo deste estudo foi investigar o perfil soroepidemiológico e molecular da infecção pelo vírus da hepatite B em caminhoneiros de rota longa no Brasil. De outubro de 2005 a outubro de 2006, 641 indivíduos foram entrevistados sobre dados sócio-demográficos e fatores de risco, e coletadas amostras sanguíneas para detecção dos marcadores sorológicos do HBV (HBsAg, anti-HBs e anti-HBc) pelo ensaio imunoenzimático (ELISA). As amostras HBsAg reagentes foram submetidas a detecção do DNA viral pela reação da polimerase em cadeia (PCR) e genotipadas pela análise do polimorfismo de comprimento dos fragmentos de restrição (RFLP). A prevalência global para os marcadores da infecção pelo HBV foi de 18,9% (IC 95%: 15,9-22,2): 16 eram HBsAg positivos, 117 anti-HBc total e 69 anti-HBs. Trinta caminhoneiros apresentaram positividade isolada ao anti-HBs, evidenciando imunidade contra hepatite B. Tempo de profissão acima de 20 anos, tempo de permanência fora do lar superior a 15 dias e história de doença sexualmente transmissível (DST) foram fatores independentemente associados à positividade ao HBV pela análise multivariada. Dentre os caminhoneiros HBsAg reagentes, um (6,2%) apresentou reatividade ao HBeAg, nove (56,2%) ao anti-HBe e o restante negativo para ambos os marcadores. HBV DNA foi detectado em nove amostras de indivíduos HBsAg reagentes, sendo identificados os genótipos A (22,2%), D (55,6%) e F (22,2%). Os resultados deste estudo ratificam o risco elevado da população caminhoneira para infecção pelo HBV, e apontam para a necessidade de políticas públicas de saúde voltadas para este grupo, que apresenta características que favorecem a aquisição e disseminação do vírus da hepatite B.

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