Background: Patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy may have extensive and complicated nursing needs with risk of complications. However, there is no research on the postoperative care at the surgical ward. Aim: The purpose was to describe, from the nurse's perspective, which nursing needs patients who had undergone CRS with HIPEC expressed and whether they received the nursing care they needed. Method: A descriptive qualitative interview study with semi-structured interviews with nurses (n = 12) was conducted on two surgical wards. Data was analyzed with a qualitative content analysis. Result: The analysis resulted in three categories: Physical nursing needs - complex to remedy and common with setbacks, To get the care adapted to individual needs and Psychosocial nursing needs are not met. The result showed that the most distinctive nursing needs in the patients were nausea, pain/anxiety and mobilization. During the care period, it was important that the nurse was responsive and that a good relationship between the healthcare staff and the patient was developed. The nurses described that patients had a need for more information and mental support. Conclusion: The results show that patients undergoing CRS with HIPEC have many nursing problems and the nursing care needs to be improved in several areas. A more structured and person-centered nursing could meet several nursing needs. This complex patient group should be cared for by nurses with professional experience and higher education, eg specialist nurses (surgical care). Further research should be conducted with patients who have undergone CRS with HIPEC as informants.