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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
151

A possible role for human papillomavirus as a co-factor with UV radiation in skin carcinogenesis

Purdie, Karin Jan January 1998 (has links)
No description available.
152

The role of cyclooxygenase-2 in colorectal cell transformation and tumour progression

Kouveli, Angeliki January 2002 (has links)
No description available.
153

The genetic basis of Wilms' tumour development

Wilmore, Helen Patricia January 1993 (has links)
No description available.
154

Pharmacokinetic evaluation of anticancer drugs using positron emitting nuclides

Harte, Robert J. A. January 1996 (has links)
No description available.
155

An investigation into the mechanism by which dietary fibre protects against breast and colonic malignancy

Lewis, Stephen John January 1997 (has links)
No description available.
156

The use of transvaginal and transrectal ultrasound in the assessment of uterine cervical tumour

Browning, James J. January 1992 (has links)
No description available.
157

The relationship between cellular radiation sensitivity and normal tissue response to radiotherapy : prospects for individualising radiotherapy prescriptions

Burnet, Neil Gunn January 1993 (has links)
No description available.
158

Magnetic resonance studies in oncology : measurement of the effects of hyperthermia on tumour pH

Jayasundar, Rama January 1990 (has links)
No description available.
159

Epigenetic loss of SLIT2 leads to an autocrine-to-paracrine switch of the SLIT2/ROBO1 signaling axis in pancreatic cancer

Rheinheimer, Brenna, Vrba, Lukas, Futscher, Bernard, Heimark, Ronald 09 November 2012 (has links)
University of Arizona Student Showcase 2012 President’s Award, University of Arizona Student Showcase 2012 1st Place Biological Sciences, AACR Special Meeting Pancreatic Cancer: Progress and Challenges Scholar-in-Training Award / Guidance molecules from the Netrin, Slit, Ephrin, and Semaphorin gene families were originally described as cues for the directional guidance of axons in the developing nervous system. More recently, members of these families have been found to have critical roles in epithelial development, angiogenesis and cancer. The SLIT2/ROBO1 signaling axis has properties of a potential tumor suppressor pathway via the inhibition of epithelial cell growth, directional migration, ductal morphogenesis, and is epigenetically silenced in lung, colon and breast cancers. We proposed that changes in SLIT2 and ROBO1 expression in pancreatic ductal adenocarcinoma may mediate ductal expansion following the conversion of PanIN precursor lesions to invasive carcinoma. The SLIT2 receptor, ROBO1, is a member of the immunoglobulin (Ig) superfamily and is required for lung and mammary development in mammals. ROBO1 has an alternative splice variant, DUTT1, and these two variants have different initial exons and initiating codons which may suggest the two proteins have distinct functions. In our studies, we found that all pancreatic cancer cell lines and primary pancreatic cancer specimens express only the DUTT1 isoform. We also determined that as pancreatic cancer cell lines become KRAS-independent, ROBO1 expression increases. Furthermore, using immunohistochemistry (IHC), we found that ROBO1 protein expression in primary pancreatic cancer tissue specimens is localized to the ductal compartment with no stromal staining seen. In normal pancreas, ROBO1 expression is weak while its ligand SLIT2 is strongly expressed in both the acinar and ductal compartments in vitro and in vivo. Mammals encode three SLIT genes (SLIT1-3). The secreted SLIT2 protein is not diffusible, but has a cleavage site within its EGF-like repeats creating two fragments which allow it to act either as a short or long range guidance cue with each fragment appearing to have its own cell-association characteristics. The 5’ promoter of SLIT2 has been shown to be methylated resulting in gene silencing in early stages of several epithelial cancers suggesting a possible tumor suppressor role. miR-218-1 is an intronic microRNA found between exons 15 and 16 of the SLIT2 gene and targets a complimentary sequence in the ROBO1 3’ untranslated region (UTR) indicative of a potential regulation of receptor availability in the presence of ligand. In our studies, we determined that the KRAS-dependent pancreatic cancer cell lines express SLIT2 and ROBO1 in a cell autonomous manner. The KRAS-independent cell lines, however, have silenced SLIT2 and miR-218-1 expression. Using IHC we found that high levels of SLIT2 are seen in normal pancreas localized to the acinar and ductal compartments. Reduced SLIT2 expression is seen in primary pancreatic cancer tissue specimens. We confirmed that loss of SLIT2 mRNA in KRAS-independent lines was due to DNA hypermethylation shown by methylation specific PCR and Sequenom analysis. Chromatin immunoprecipitation analysis shows that silencing histone marks are found in the 5’ promoter of the SLIT2 gene in KRAS-independent lines. Treatment with demethylating agents reactivate SLIT2 and miR-218-1 expression suggesting that epigenetic mechanisms controlling the SLIT2 promoter also regulate miR-218-1 expression. Overall, our data establishes that the SLIT2/ROBO1 signaling axis is a dynamic pathway in pancreatic cancer that can act in the tumor expansion and progression along intrapancreatic neurons that express the SLIT2 ligand.
160

Molecular Regulation of the Tumor Killing Activity of Dendritic Cells

Hanke, Neale T. January 2012 (has links)
Primarily defined by their antigen presenting function, dendritic cells (DC) are equipped with the unique ability to initiate and regulate immune responses. A less conventional characteristic of DC has been highlighted more recently: their capability to directly kill tumor cells when appropriately activated. The main objectives of the study presented herein were to analyze the molecular regulation of DC cytotoxic activity and to determine how the tumoricidal potential of DC may influence their cardinal antigen presenting function. To address these questions, DC were generated from myeloid precursors with either IL-4 (IL-4 DC) or IL-15 (IL-15 DC). We demonstrate that IL-4 and IL-15 DC exhibit similar iNOS-dependent tumor killing activity when activated with the toll-like receptor (TLR)-4 agonist LPS. However, stimulation with interferon (IFN)-γ selectively induces iNOS-dependent cytotoxic activity of IL-4 but not IL-15 DC. Possible differences in the signaling pathways controlling iNOS expression in these two DC populations were then examined. In both IL-4 and IL-15 DC, LPS initially activates NF-κB, followed by secondary activation of components of the ISGF3 transcription factor. Using inhibitors and knockout mice we established that disruption of the NF-κB or ISGF3 signaling axes impaired LPS-induced iNOS expression in IL-15 DC with little to no effect in IL-4 DC. A distinct and separate JAK-STAT pathway is required for iNOS induction in IL-4 DC activated with IFN-γ. IL-15 DC express high levels of PIAS1 and phosphorylated STAT-3 which act as independent inhibitors of iNOS expression upon stimulation with IFN-γ. Inhibiting PIAS1 with silencing RNA (siRNA) along with STAT-3 inhibition or knockdown restores iNOS expression and the tumor killing activity of IL-15 DC stimulated with IFN-γ. We further established that following culture with cancer cells, DC endowed with cytolytic activity are more efficient at presenting antigens to specific T lymphocytes compared to their counterparts generated from iNOS^(-/-) mice, which are significantly impaired in their tumoricidal function. This indicates that the capability of DC to present tumor-specific antigens may be contingent upon induction of their cytotoxic activity.

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