Global ETD Search

1	The Role of Human Leukocyte Antigen-G in Cardiac Allograft Vasculopathy Mociornita, Amelia Georgiana 05 December 2013 (has links) Human leukocyte antigen-G (HLA-G), a non-classical MHC I protein, plays an essential role in immune tolerance and is associated with a lower incidence of graft rejection and cardiac allograft vasculopathy (CAV). To examine the pattern of HLA-G expression post-transplantation we determined that HLA-G can be up-regulated in smooth muscle cells (SMCs) following exposure to everolimus. We also determined that HLA-G at 500 and 1000 ng/ml reduces SMC proliferation. In further studies, treatment with HLA-G inhibited TNFα-stimulated neutrophil adhesion to endothelial cells (ECs) at all concentrations tested (0.1-1 ng/ml), suggesting a role in inflammation. The expression of HLA-G is influenced by a polymorphism in the HLA-G gene. We sought to determine if the 14bp insertion/deletion polymorphism can predict the development of CAV. There was no association between this polymorphism and CAV; however, this study had a small number of patients; therefore further investigations are needed to confirm these findings. HLA-G Heart Transplantation Cardiac Allograft Vasculopathy Immune System 0982
2	The Role of Human Leukocyte Antigen-G in Cardiac Allograft Vasculopathy Mociornita, Amelia Georgiana 05 December 2013 (has links) Human leukocyte antigen-G (HLA-G), a non-classical MHC I protein, plays an essential role in immune tolerance and is associated with a lower incidence of graft rejection and cardiac allograft vasculopathy (CAV). To examine the pattern of HLA-G expression post-transplantation we determined that HLA-G can be up-regulated in smooth muscle cells (SMCs) following exposure to everolimus. We also determined that HLA-G at 500 and 1000 ng/ml reduces SMC proliferation. In further studies, treatment with HLA-G inhibited TNFα-stimulated neutrophil adhesion to endothelial cells (ECs) at all concentrations tested (0.1-1 ng/ml), suggesting a role in inflammation. The expression of HLA-G is influenced by a polymorphism in the HLA-G gene. We sought to determine if the 14bp insertion/deletion polymorphism can predict the development of CAV. There was no association between this polymorphism and CAV; however, this study had a small number of patients; therefore further investigations are needed to confirm these findings. HLA-G Heart Transplantation Cardiac Allograft Vasculopathy Immune System 0982
3	Acute and Chronic Rejection: Compartmentalization and Kinetics of Counterbalancing Signals in Cardiac Transplants KAUL, ANUPURNA January 2014 (has links) No description available. Biology Immunology Molecular Biology Acute Rejection Chronic Rejection CAV Cardiac Allograft Vasculopathy Cardiac Transplant PDL1, Programmed Cell Death 1 Hyaluronan
4	Evaluation de la fonction microvasculaire myocardique par résonance magnétique cardiaque sensible à l'oxygène chez des transplantés cardiaques Iannino, Nadia 04 1900 (has links) No description available. transplantation cardiaque vasculopathie du greffon rejet chronique circulation coronaire microvascularisation manoeuvres respiratoires oxygénation cardiac transplantation heart transplantation cardiac allograft vasculopathy chronic rejection coronary circulation microcirculation breathing maneuvers oxygenation

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