Thesis (doctoral)--Friedrich-Wilhelms-Universität, Bonn, Germany.

Thesis (Ph.D.)--University of Tennessee Health Science Center, 2009. / Title from title page screen (viewed on August 11, 2009). Research advisor: Patricia A. Cowan, Ph.D. Document formatted into pages (xi, 107 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 74-93).

Thesis (doctoral)--Uppsala University, 1983. / Bibliography: p. 24-28.

Thesis (M.S.)--University of Michigan, 1998. / Includes bibliographical references (leaves 51-63).

Thesis (Ph. D.)--State University of New York at Buffalo,1999. / Includes bibliographical references.

Thesis (Ph.D.)--Virginia Commonwealth University, 2009. / Prepared for: School of Pharmacy. Title from title-page of electronic thesis. Bibliography: leaves 136-149.

Thesis (doctoral)--Friedrich-Wilhelms-Universität, Bonn, Germany.

Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 112-139).

Made available in DSpace on 2014-06-11T19:28:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2006Bitstream added on 2014-06-13T19:37:31Z : No. of bitstreams: 1 passanori_ac_me_botfm.pdf: 417700 bytes, checksum: f6194c3efa3e61fad0cb952af5485dc5 (MD5) / A CEC introduzida na década de 50 do século passado mostrou sua importância no tratamento cirúrgico para correções das doenças cardiovasculares. Sua função básica é prover adequado fluxo sangüíneo oxigenado para necessidades celulares e suprir a demanda dos órgãos durante o período em que é necessário manter o coração parado. Com o avanço da cirurgia cardiovascular nas últimas décadas, o número de cirurgias aumentou e conseqüentemente aumentaram também as complicações; dentre elas, a IRA associada à CEC. Trabalhos clínicos e experimentais propuseram a participação dos íons cálcio na lesão renal isquêmica. Vários estudos especialmente relacionados à disfunção renal por ação de radiocontraste e pós-transplante renal foram publicados considerando os mecanismos de hemóstase do cálcio celular e o possível efeito intra-operatório dos inibidores dos canais de cálcio. A administração desta medicação reduz a vasoconstrição renal e melhora o aporte sangüíneo e a oxigenação dos tecidos. Assim este estudo foi delineado com o objetivo de avaliar durante o período perioperatório a influência do uso da nifedipina na evolução da função renal (creatinina sérica) dos pacientes submetidos à revascularização do miocárdio com CEC. Foram estudadas as características da casuística e as variáveis relacionadas à CEC. As dosagens da creatinina sérica foram realizadas no pré-operatório e no pós-operatório de 24, 48 horas e no 7º dia. Estabeleceu-se como definição para presença de insuficiência renal elevação da creatinina sérica de 30% em relação ao seu valor basal nas primeiras 24 ou 48 horas de pós-operatório. Os pacientes foram divididos em quatro grupos: G1, receberam a medicação no pré-operatório; G2, receberam a medicação no pós-operatório; G3, receberam a medicação no pré e pós-operatórios e, G4 não receberam a... / The cardiopulmonary bypass (CPB) introduced in the 50s has played an important role in the surgical treatment for cardiovascular diseases. Its basic function is to supply appropriate oxygenated blood stream for cells and meet the cell demand during the period which a stopped heart is necessary. With advances in heart surgery in the last decade, the number of surgeries has increased and therefore, also their complications, such as, acute renal failure (ARF) associated with CPB. Clinical and experimental studies report the participation of calcium ions in the ischemic renal injury. Several studies specially related to renal dysfunction caused by radiocontrast agents or renal post-transplant have been published considering the homeostasis mechanisms of the cellular calcium and possible intra-operative effect of inhibitors of calcium channels. The using of this medication reduces renal vasoconstriction and improves blood supply and tissue oxygenation. So, this study was designed to evaluate renal function (serum creatinine) in patients undergoing miocardium revascularization with CPB. The characteristics of casuistic and variables related to CPB were studied. The dosages of serum creatinine were performed preoperatively and postoperatively at 24 and 48 hours and in the 7th day. Renal failure was defined as a rise in serum creatinine level by 30% at 24 or 48 hours in the postoperative compared to baseline. Patients were distributed into 4 groups: G1, receiving medication preoperatively; G2, receiving medication postoperatively; G3, receiving medication pre and postoperatively; G4, did not receive any medication. There was no statistical difference among groups relating to the characteristics of the casuistic and CPB conditions. There was also no correlation between comorbidity and ARF incidence. The mean temperature during CPB showed positive correlation... (Complete abstract, click eletronic address below)

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