No description available.

No description available.

Metastatic carcinomas to the thyroid are quite rare in daily cytology practice. However, when present they may produce a diagnostic dilemma, particularly when they share some morphologic similarities with primary thyroid lesions and when occurring in patients with occult malignant history. Herein, we report a case of metastatic gastric signet ring cell carcinoma to the thyroid. Our patient presented with an isolated right thyroid nodule, which was clinically considered to be a primary thyroid neoplasm. Fine-needle aspiration (FNA) cytology of the nodule revealed a cellular specimen with cohesive fragments and scattered individual neoplastic cells. The neoplastic cells had enlarged nuclei, fine chromatin, and inconspicuous nucleoli. Nuclear crowding, molding, and grooving were prominent. Intranuclear inclusion-like clearance was identified. Some tumor cells also had eccentric nuclei, creating a signet ring cell appearance. The colloid was scant. These cytological features may be seen in cases of papillary thyroid carcinoma or signet ring cell follicular adenoma; however, the presence of the signet ring cells is unusual in primary thyroid lesions and raises the possibility of a metastatic lesion to the thyroid. In our case, the tumor cells were positive for AE1/AE3, mucicarmine, and periodic acid-Schiff, but negative for thyroglobulin and thyroid transcription factor-1. The patient was also found to have a 3.7-cm mass in the distal esophagus/proximal stomach. Biopsy of this mass showed an invasive signet ring cell carcinoma. The purpose of our study is to discuss the cytological features and the differential diagnosis of this unusual thyroid FNA case.

Diagnosis of two distinct malignant entities existing concurrently and at the same location (synchronous malignancy) by fine-needle aspiration (FNA) is unusual but may occur. Small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) in particular is associated with an increased incidence of secondary tumor, likely due to associated immunodeficiency. Co-occurrence of some carcinomas such as squamous cell carcinoma (SCC), may show especially aggressive behavior. A 57-year-old Caucasian male presented with recurrent upper extremity lymphedema and diffuse lymphadenopathy ofthe axillary and cervical regions. FNA ofa large cervical lymph node was diagnostic for both atypical lymphocytic proliferation and SCC. Flow cytometric analysis showed the atypical lymphocytic proliferation to be positive for CD5, CD23, CD19, CD20, HLA-DR, CD38, and the population was kappa light chain restricted. These cells were negative for CD-10 and FMC-7 antigens, suggesting a phenotype of B-cell SLL/CLL. We report a rare occurrence of metastatic SCC to a lymph node infiltrated by SLL/CLL. The diagnosis was achieved by a combination of cytomorphologic examination of FNA smears, immunohistochemical staining of cell block material, and flow cytometry on the sample obtained by FNA. To the best of our knowledge, only three cases of SCC metastasis to SLL/CLL diagnosed by FNA have been reported in the English literature. Though rare, awareness of such a possibility and careful cytological examination under the appropriate clinical conditions is warranted.

Basal cell carcinoma is an indolent, slow-growing tumor that rarely metastasizes. Approximately 70% of tumors occur in the head and neck regions. If a basal cell tumor metastasizes, it usually spreads to the regional lymph nodes first, followed by the lungs. We describe a patient with basal cell carcinoma of the right lower extremity with skin metastases. Skin biopsy of one tumor revealed fibroepithelioma of Pinkus, a rare variant of basal cell carcinoma.

Final article is available at "wileyonlinelibrary.com" Takako Okamoto, Masaki Mandai, Noriomi Matsumura, Ken Yamaguchi, Hiroshi Kondoh, Yasuaki Amano, Tsukasa Baba, Junzo Hamanishi, Kaoru Abiko, Kenzo Kosaka, Susan K. Murphy, Seiichi Mori, Ikuo Konishi "Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma" Molecular Carcinogenesis 54:35–49 (2013) / 京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第12804号 / 論医博第2076号 / 新制||医||1001(附属図書館) / 80848 / 京都大学大学院医学研究科医学専攻 / (主査)教授 野田 亮, 教授 武藤 学, 教授 稲垣 暢也 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19888号 / 医博第4137号 / 新制||医||1016(附属図書館) / 32965 / 京都大学大学院医学研究科医学専攻 / (主査)教授 清水 章, 教授 柳田 素子, 教授 武藤 学 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第21417号 / 医博第4407号 / 京都大学大学院医学研究科医学専攻 / (主査)教授 羽賀 博典, 教授 小川 誠司, 教授 万代 昌紀 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(医科学) / 甲第21699号 / 医科博第103号 / 新制||医科||7(附属図書館) / 京都大学大学院医学研究科医科学専攻 / (主査)教授 妹尾 浩, 教授 渡邊 直樹, 教授 松原 和夫 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Early investigations of the urokinase type plasminogen activator (uPA) receptor (uPAR) and its ligand, uPA, were limited to their role in degradation of the extracellular matrix (ECM) and invasion. Emerging evidence revealed that uPAR and its relationship with uPA and/or transmembrane proteins, such as the integrins, affects cell-ECM adhesion events and proliferation. These events are tightly coordinated and essential for epithelial tissue development. However, unregulated expression of molecules involved in cell adhesion and proliferation plays a significant role in tumour development and metastasis. The overexpression of uPAR is linked to several cancer types, including human oesophageal squamous cell carcinoma (HOSCC). This study examines the contribution of uPAR, and its communication with extracellular components, to cell-ECM adhesion and/or proliferation of HOSCC cells. The confirmation of the uPAR and 1-integrin expression as well as uPA secretion in the HOSCC cells lines, established these lines as excellent models for further investigation. In all the HOSCC cell lines, uPAR associated with integrin-linked kinase, a scaffolding protein in cell-ECM adhesion events. Data presented in this investigation confirmed that the interaction of uPAR with uPA or 1-integrin contributed to adhesion of the HOSCC cell lines on collagen type I and vitronectin. It was clearly established that uPAR also played a part in the proliferation of all the HOSCC cell lines. The uPAR role in proliferation is influenced by: a) The absence or presence of collagen type I or vitronectin substrates; b) The activation of uPAR by endogenous uPA; c) The uPAR/1-integrin interaction; d) the presence of transforming growth factor  and epidermal growth factor. In the current study, it was successfully demonstrated that uPAR, and its relationship with the ECM and growth factors, contributes to adhesion and proliferation during the progression of HOSCC. This gives uPAR a considerable value as a therapeutic target for HOSCC.