Ecosystems transition quickly in the Anthropocene, whereas biodiversity adapts more slowly. Here we simulated a shifting woodland ecosystem on the Colorado Plateau of western North America by using as its proxy over space and time the fundamental niche of the Arizona black rattlesnake (Crotalus cerberus). We found an expansive (= end-of-Pleistocene) range that contracted sharply (= present), but is blocked topographically by Grand Canyon/Colorado River as it shifts predictably northwestward under moderate climate change (= 2080). Vulnerability to contemporary wildfire was quantified from available records, with forested area reduced more than 27% over 13 years. Both 'ecosystem metrics' underscore how climate and wildfire are rapidly converting the Plateau ecosystem into novel habitat. To gauge potential effects on C. cerberus, we derived a series of relevant 'conservation metrics' (i.e. genetic variability, dispersal capacity, effective population size) by sequencing 118 individuals across 846 bp of mitochondrial (mt)DNA-ATPase8/6. We identified five significantly different clades (net sequence divergence = 2.2%) isolated by drainage/topography, with low dispersal (F-ST = 0.82) and small sizes (2N(ef) = 5.2). Our compiled metrics (i.e. small-populations, topographic-isolation, low-dispersal versus conserved-niche, vulnerable-ecosystem, dispersal barriers) underscore the susceptibility of this woodland specialist to a climate and wildfire tandem. We offer adaptive management scenarios that may counterbalance these metrics and avoid the extirpation of this and other highly specialized, relictual woodland clades.

Mechanically interacting fault systems on Earth are often associated with groundwater flow (e.g. Curewitz and Karson, 1997) by facilitating water storage and flow through fracture conduits before, during, and after seismic events (e.g. Sibson, 1975). Similar associations between interacting fault segments and fluid flow are present on Mars (Davatzes and Gulick, 2007a). The Cerberus Fossae compose a system of elongate topographic lows, a portion of which coincides with the source region of the outflow channel Athabasca Valles. The Cerberus Fossae and source area were mapped using Thermal Emission Imaging System (THEMIS) daytime IR mosaics and Context camera (CTX) images to establish spatial relations of structural features. Mars Orbiter Laser Altimeter (MOLA) elevation data were plotted to construct the depth profiles of the fossae to test the hypothesis that the Cerberus Fossae are normal fault-bounded graben. High Resolution Imaging Science Experiment (HiRISE) images were mapped for fractures within the fault damage zones with the degree of fracture plotted as a function of distance along strike. This plot established the spatial relations between fractures, mechanically interacting fossae segments, and Athabasca Valles. The depth profiles of the Cerberus Fossae are consistent with the displacement distribution of terrestrial normal faults with a surface expression consistent with fault propagation from depth and mechanical interaction among segments. Similarly, regions of interpreted mechanical interaction indicated by slip distribution and segment overlap correspond to increased fracture intensity and density. On Earth, such regions of mechanical interaction tend to have high fracture intensity (e.g. Davatzes et al., 2005), are associated with hydrothermal fluid flow (Curewitz and Karson, 1997), and have evidence of extensive long-term fluid flow as evidenced by diagenetic alterations (Eichhubl et al., 2004). Higher fracture intensities and densities near the head of Athabasca Valles as a proxy for increased permeability provide a potential mechanism and a necessary condition for the localized fluid flux necessary to supply the outflow channel. Thus, I conclude the Cerberus Fossae are mechanically interacting normal fault-bounded graben with highly permeable damage zones that would act to quickly dewater an aquifer resulting in the carving of Athabasca Valles. / Geology

Abstract The embryonic urogenital system (UGS) generates the metanephric kidney, gonad and the adrenal gland. It is well known that the development of the UGS is regulated by sequential and reciprocal epithelial and mesenchymal tissue interactions but the secreted mediators involved are still poorly known. The action of such inductive signals is typically regulated by specific antagonists. The Sprouty (Spry) proteins compose one family of cytoplasmic regulators that typically repress the function of the receptor tyrosine kinase (RTK) signal transduction pathways. The DAN/Cerberus (Cer) family that encodes secreted proteins bind and antagonize the Bmp, Wnt and Nodal signals. In this study the roles of Spry and Cer1 was addressed during mouse UGS development by targeted expression of SPROUTY2 (SPRY2) and Cer1 in the ureteric bud and Wolffian duct under the Pax2 promoter. Changes induced in the UGS assembly process were analyzed in detail to reveal the normal developmental roles of these proteins. SPRY2 expression led to either complete lack of the kidney, reduction in the kidney size or formation of unilateral kidney with reduced size. The SPRY2 mediated reduction in kidney size was accompanied by inhibition of expression of genes that are known to regulate kidney development. The results indicated that the Spry may take part in kidney development by coordinating the reciprocal cell signaling between the ureteric bud, the mesenchymal cells and stromal cells. In addition to the kidney, the gain of SPRY2 function revealed an important role in the control of male gonadogenesis. SPRY2 over expression in the Wolffian duct malformed the Wolffian duct derivatives, diminished the number of seminiferous tubules and the amount of the interstitial tissue associated with reduced mesonephric cell migration to the testis. Exogenous FGF9 rescued mesonephric cell migration inhibited by SPRY2. It was concluded that Spry protein contribute to male sexual organogenesis by antagonizing Fgf9 signaling. When the Cer1 gene was over expressed in the ureteric bud this lead unexpectedly to increased kidney size. The Cer1 mediated promotion of kidney size was demonstrated to involve enhanced ureteric bud morphogenesis. At the molecular level Cer1 protein function lead to inhibition of Bmp4 gene expression and concurrent upregulation of Gdnf and Wnt11 expression. Notably, excess BMP4 reduced the Cer1 stimulated ureteric bud branching and downregulated normally expression of Gdnf and Wnt11 in the embryonic kidney. Based on the presented data it is proposed that the establishment of mammalian organ size is under the control of both systemic and the intrinsic factors. Together the work demonstrates significant roles for the proteins that typically inhibit growth factor signaling or signal transduction. Hence organogenesis is controlled by coordination between positive and negative growth factor regulator signals.

Mars est un objet privilégié pour comprendre l'évolution d'une planète. Des témoins géologiques de son activité interne et des échanges surface-atmosphère sont préservés sur 4 Ga. Cette thèse étudie ces échanges au travers de la circulation des fluides dans la croûte. Le climat froid et sec de l'Amazonien (< 3 Ga) implique la condensation, sublimation et diffusion des espèces volatiles dans le régolithe. Ce paradigme est modifié par la découverte de l'importance de la convection d'air dans les sols poreux (aérothermalisme). Ce processus a été mis en évidence par l'imagerie thermique (Mars Odyssey/THEMIS) et la morphologie (e.g., Mars Express/HRSC) pour Cerberus Fossae et le volcan Arsia Mons. La période Hespérienne est marquée par la libération massive d'eau aboutissant à la formation des terrains chaotiques et des chenaux de débâcle. Nous proposons que ces objets résultent de la convection d'argiles. Cette hypothèse originale est corroborée par les détections de phyllosilicates (données CRISM et OMEGA).

Les plaines de laves de Cerberus sur Mars présentent des morphologies volcaniques, fluviatiles et tectoniques. Une étude détaillée de cette région a permis de compiler diverses observations dans une carte géologique dont les morphologies fluviatiles et volcaniques. Les plaines de laves sont datées au plus de 250 millions d'années, et présentent des relations stratigraphiques complexes entre les volcans boucliers et les grosses coulées de lave. Les volumes de laves ont été contraints, à l'aide d'une modélisation originale de bassin, à un maximum de 17.104 km3. La cartographie des plaines de laves à permis de développer deux axes de recherche : (1) L'étude des dépôts volcaniques éoliens. L'étude de la tâche de faible albédo de Cerberus, suggère qu'il s'agit d'une strate de cendres ou de téphras mise à jour par la formation de Grjota' Vallis, distribuée par les vents vers le sud ouest de la zone. Cette tâche est finalement un témoin possible de l'activité explosive de Cerberus. (2) l'étude des dépôts effusifs. L'étude de la rhéologie des coulées de laves met en évidence deux types de viscosités indépendantes des taux d'émission, dont une se situe dans les valeurs de viscosité trouvées sur d'autres édifices martiens (105 Pa.s), et une autre qui présente les plus faibles valeurs de viscosité sur Mars (<103 Pa.s). L'absence d'édifice majeur fait des plaines de Cerberus une province volcanique unique sur Mars, dont l'évolution future reste incertaine.