Thesis (Ph. D.)--University of California, Riverside, 1993. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Martina Vítková Supervisor: RNDr. Jitka Vytlačilová, Ph.D. Title of diploma thesis: The biological activity of the selected drugs of traditional Chinese medicine The subject of this diploma thesis was to prepare aqueous extracts of five selected drugs from traditional Chinese medicine and deal with their biological effects. Namely it was Magnoliae officinalis cortex, Houttuyniae herba, Paeoniae radix alba, Psoraleae fructus and Typhae pollen. These drugs have a high potential for use in our medicine due to their beneficial effects on the human organism. The theoretical part contains a description of individual drugs and their therapeutic effects. Also there are described methods of toxicity testing. The experimental part describes the course of the acute toxicity test of used drugs on the model organism Artemia salina. LC50 was used as the endpoint. Testing with Artemia salina showed low toxicity of the tested drugs. For Magnoliae officinalis cortex the LC50 was found to be 0,6613 mg/ml, Psoraleae fructus 1,777mg/ml, Houttuyniae herba 4,079 mg/ml and Typhae pollen 4,34 mg/ml. No toxicity was detected for Paeoniae radix alba even at the highest measured concentration which was 15...

Chinese Herbal Medicine has been mainstream practice for hundreds of generations, however the merits of herbal therapeutics have been debated in the era of modern medicine. With a shift towards scientific analysis and rigorous testing of conventional pharmaceuticals in the past century, critics have questioned the proclaimed effects of herbal concoctions. Nonetheless, herbal medicines are still used frequently and have spawned clinical studies meant to determine their therapeutic efficacy. This paper aims to evaluate many aspects of Chinese Herbal Medicine applications that have already been analyzed in other papers, then propose a study which explores the effects of the herbal concoction Ban Xia Bai Zhu Tian Ma Pian in lowering blood pressure. Hypertension was chosen as the focus of the study due to its extensive presence in the population and the impact a significant outcome can provide given its prevalence. The ultimate goal is to find a balance between both eastern and western practices of medicine, thus preserving Chinese medical traditions that are concurrently buttressed by scientific research.

No / Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recognized and adhered by TCM clinical practitioners for thousands of years. However, the underlying mechanisms of TCM personalized medicine are not fully investigated so far and remained unknown. This paper discusses framework of TCM personalized medicine in classic literatures and in real-world clinical settings, and investigates the underlying mechanisms of TCM personalized medicine from the perspectives of network medicine. Based on 246 well-designed outpatient records on insomnia, by evaluating the personal biases of manifestation observation and preferences of herb prescriptions, we noted significant similarities between each herb prescriptions and symptom similarities between each encounters. To investigate the underlying mechanisms of TCM personalized medicine, we constructed a clinical phenotype network (CPN), in which the clinical phenotype entities like symptoms and diagnoses are presented as nodes and the correlation between these entities as links. This CPN is used to investigate the promiscuous boundary of syndromes and the co-occurrence of symptoms. The small-world topological characteristics are noted in the CPN with high clustering structures, which provide insight on the rationality of TCM personalized diagnosis and treatment. The investigation on this network would help us to gain understanding on the underlying mechanism of TCM personalized medicine and would propose a new perspective for the refinement of the TCM individualized clinical skills.

published_or_final_version / Community Medicine / Master / Master of Public Health

This Master's thesis focuses on the discussion about Chinese and Western Medicine in the Duli pinglun Magazine (獨立評論) in the year of 1934. Its main purpose is to introduce the lines of reasoning of its participants. The thesis introduces general historical and philosophical background crucial for the formation of the discussion about Chinese and Wester Medicine in 1930s. It describes the situation of Chinese medicine in China from the late imperial period to so called Nanjing Decade (1928-1937). It describes the discussion in the context of the intellectual discussion about social Darwinism, national essence, cultural iconoclasm and science and scientism. It introduces selected basic characteristics of Chinese Medicine crucial for the understanding of this discussion. The main actor of the discussion, Fu Sinian 傅斯年 (1896-1950), and the Duli pinglun Magazine itself are introduced here. The thesis focuses also on the first phase of the discussion, which was held in the Da gongbao Magazine 大公報. Main intellectual tendencies of the discussion about Chinese and Wester Medicine during this period were revealed through the analysis of the discussion. The results of this work cover the area of the Chinese and Wester Medicine discussion which has not been separately elaborated yet. Powered by TCPDF (www.tcpdf.org)

Chinese medicine is one of China's key national assets, an indigenous medical knowledge and practices that serves Chinese for thousands of years. As very little research has been focused on Traditional Chinese Medicine (TCM) from systems of innovation perspective, the topic of study was chosen. This qualitative case study research introduces, defines and explores how TCM organisations collaborate to innovate from an evolutionary, interactive system perspective. In particular, the focus is on the development of knowledge and capabilities related to TCM drug research and production. Thirty one TCM organisation cases were analysed and presented in this study, interpreting their behaviour in terms of ideas drawn mainly from the literatures on systems of innovation, collaboration between organisations and resource (knowledge) based theory of the firm. Actors such as government play various roles in facilitating organisational and sectoral innovation processes. 'Various policy instruments', in particular research funding and institutions (e.g., standards and regulations) were used to enhance innovation and production. Various forms of collaborative networks were found among key actors: enterprises, universities, research organisations and end users. They contribute to the active innovation processes of 'Identification, Selection, Integration and Creation' of tangible and intangible outcomes and changes. Based on the research, new insights were derived as to how indigenous resources (defined as original and/or traditional knowledge and capabilities) may lead to indigenous innovation. This thesis contributes to the academic understanding of systems of innovation operating in the context of indigenous product and related process developments with reference to various actors interplaying in complex networks (systems) of collaborations. New understandings made on the processes of indigenous innovation (using TCM as a case) through investigating the actors' roles, inter-relations and their restless attempts to identify opportunities and problems, select and integrate different indigenous, scientific, technological and managerial knowledge, capabilities, resources and institutions, to create value that may 'fit' in evolutionary terms, the demand of the key actors in the sector.

Background: Respiratory conditions are prevalent and cause an enormous burden on society. In recent decades, there has been a global increase in asthma in children and adults, yet the diagnosis of asthma must be made on clinical grounds as the diagnostic use of pharmacological reversibility of airway obstruction remains controversial. It is possible however that tools exist from different medical paradigms that may assist in the clinical diagnosis of asthma. Tools such as Traditional Chinese Medicine (TCM) enquiry, Breath Holding Time (BHT) or Electro-Dermal Screening Test (EDST) may provide useful clinical information, yet their use has not been widely explored or validated. Integrative medicine may be considered to represent a new frontier in medicine where each therapy and diagnostic method is seen to have its own advantages and limitations and where an integration of both diagnostic and therapeutic techniques from conventional and complementary medicine is seen to produce the best results. However, while there is a high community use of complementary therapies for conditions such as asthma, there is also a need to maintain accepted standards of medical and scientific principles and foster high quality research into complementary therapies. Objectives: The current study sought to determine: • If there is a correlation between conventional measures of lung function such as Forced Expiratory Volume in one second (FEV1) and less conventional measures such as airways expired NO level (eNO), electrodermal measures, TCM enquiry and BHT. • If any of the lung function measures are able to distinguish between asthmatic and healthy subjects. • If the use of a rye grass extract is better than placebo in improving requirements for bronchodilator medication, peak flow, forced expiratory volume in one second or quality of life in mild to moderate childhood asthma. Rational for carrying out two separate studies as one study; The author was interested on both the integration of diagnostic techniques as well as the effect of the herbal extract on asthma so it was decided to use the opportunity and put both in one study. Method: A range of conventional and non-conventional measures were conducted in healthy and asthmatic children including demographic details, quality of life data, spirometry measures, airway nitric oxide levels, electro-dermal measures, TCM history enquiries, breath holding time, and skin prick tests. The data were analysed to determine any significant correlations between these measures. A double blind randomized controlled pilot clinical trial was also performed to assess the effect of using rye grass extract in asthmatic children aged 8 to 16 years. Results: There were significant correlations between forced expiratory volume in one second and active quality of life, TCM spleen score and fraction of exhaled nitric oxide measurements. There were also statistically significant differences between asthmatic and healthy subjects in TCM history, breath holding time and exhaled nitric oxide. The use of rye grass extract did not produce any significant improvement over placebo in any of the asthma outcome measures. Conclusions: The use of inexpensive measures such as BHT and TCM enquiry may provide useful clinical information when assessing respiratory conditions such as asthma. However, further research is required in larger populations to confirm their use. The use of the rye grass extract at the dose given in this study did not provide any clinical benefit for the asthmatic children in this study.

The incidence rate of chronic hepatopathy in Taiwan is high, which afflicts the patients by progressively developing irreversible cirrhosis. Hepatic fibrosis is the intermediate and crucial stage of this process, characterized by reversibility. If treated properly in this stage, cirrhosis can be successfully prevented. In the liver, activated stellate cells are the key mediators of fibrosis. Transforming growth factor-

This thesis focuses on the commercialization of Chinese medicine in the post-Mao era, from 1977 to 2014. It looks at its social and environmental impact on local rural areas.