Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-10-18T19:26:57Z No. of bitstreams: 1 VanessaDeFatimaLimaDePaivaMedeiros_TESE.pdf: 805024 bytes, checksum: efb811147a84e64fde7c523a46b27c9c (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-10-18T22:44:14Z (GMT) No. of bitstreams: 1 VanessaDeFatimaLimaDePaivaMedeiros_TESE.pdf: 805024 bytes, checksum: efb811147a84e64fde7c523a46b27c9c (MD5) / Made available in DSpace on 2017-10-18T22:44:14Z (GMT). No. of bitstreams: 1 VanessaDeFatimaLimaDePaivaMedeiros_TESE.pdf: 805024 bytes, checksum: efb811147a84e64fde7c523a46b27c9c (MD5) Previous issue date: 2017-07-28 / Reanima??o e tratamento de choque e sepse s?o controversos e desafiadores. O objetivo deste estudo foi examinar os efeitos da ?gua de coco + NaCl 3% + sinvastatina na reanima??o em modelo murino de sepse abdominal e choque hemorr?gico. Ratos Wistar machos adultos foram submetidos a sepse por ligadura e pun??o do ceco e choque hemorr?gico, e divididos em quatro grupos de reposi??o hidroeletrol?tica. 1. solu??o salina 0,9%; 2. ?gua de coco + NaCl 3%; 3. ?gua de coco + NaCl 3% + sinvastatina (microemuls?o) 10 mg / Kg i.v; 4. ?gua de coco n?o modificada. Escore cl?nico, histologia e fluoresc?ncia do pulm?o foram avaliados neste estudo. Dosagem s?rica das citocinas TNF-?, IL-1? e contagem de leuc?citos foram determinados. O tratamento com ?gua de coco + NaCl 3% + sinvastatina resultou em resultados significativamente melhores de sobreviv?ncia, an?lises bioqu?micas e histopatologia quando comparando com os animais submetidos aos tratamentos ?gua de coco + NaCl 3% e ?gua de coco n?o modificada. Em conclus?o, a ressuscita??o com ?gua de coco com Nacl 3% + sinvastatina teve efeito ben?fico significativo sobre a redu??o dos n?veis de citocinas e na atenua??o de les?es pulmonares em modelo de sepse abdominal e choque hemorr?gico. Tamb?m foi demonstrado que o tratamento com ?gua de coco com Nacl 3% + simvastatina atuou positivamente na fun??o do f?gado e dos rins, e no escore cl?nico. / Resuscitation and treatment of shock and sepsis are controversial and challenging. The aim of this study was to examine the effects of coconut water + Nacl 3%+ simvastatin in resuscitation in a murine model of sepsis and hemorrhagic shock. In methods, adult male Wistar rats were subjected to sepsis by cecal ligation and puncture and hemorrhagic shock assigned to four fluid replenishment groups. Animals received 1. saline 0,9%; 2. coconut water (CW) + NaCl 3%; 3. coconut water + NaCl 3% + simvastatin (microemulsion)10 mg/Kg i.v; 4. Coconut water. Clinical score was determined and lung tissue was assessed for inflammation. Serum cytokines TNF-?, IL-1 ? and leucocytes were measured. The results of this study indicated that coconut water+NaCl 3%+ simvastatin decreased significantly serum cytokines, survival, biochemical analysis and lung histopathological testing when compared to saline, water+NaCl 3% and coconut water. In conclusion, resuscitation with coconut water with Nacl 3%+simvastatin had a significant beneficial effect on downregulating cytokines and decreasing lung injury in a rat model of abdominal sepsis and hemorrhagic shock. We also demonstrated that coconut water with Nacl 3%+simvastatin administration clearly made liver and kidney function better and improved clinical score.