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The mechanism of transformation by the BCR-ABL tyrosine kinase oncogeneKabarowski, Janusz Henryk January 1997 (has links)
No description available.
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Studies in inspiratory muscle performanceJohnson, Paula Harriet January 1998 (has links)
No description available.
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Self-Management of Chronic Pain: Interventions, Strategies, Barriers, and FacilitatorsMann, Elizabeth Gayle 26 September 2013 (has links)
Background & Purpose:
Chronic pain is a prevalent chronic condition for which the best management options rarely provide complete relief. Individuals with chronic pain with neuropathic characteristics (NC) report more severe pain and experience less relief from interventions. Little is known about current self-management practices. The purpose of this dissertation was to inform self-management of chronic pain with and without NC at the individual, health system, and policy levels using the Innovative Care for Chronic Conditions Framework.
Methods:
The study included a systematic search and review and cross-sectional survey. The review evaluated the evidence for chronic pain self-management interventions and explored the role of health care providers in supporting self-management. The survey was mailed to 8,000 randomly selected Canadians in November 2011, and non-respondents were followed-up in May 2012. Screening questions were included for both chronic pain and NC. The questionnaire captured pain descriptions, self-management strategies, and self-management barriers, and facilitators.
Results:
Findings of the review suggested that self-management interventions are effective in improving pain and health outcomes. Health care professionals provided self-management advice and referred individuals to self-management interventions. The questionnaire was completed by 1,520 Canadians. Those with chronic pain (n=710) identified primary care physicians as the most helpful pain management professional. Overall, use of non-pharmaceutical medical self-management strategies was low. While use positive emotional self-management strategies was high, individuals with NC were more likely to use negative emotional self-management strategies compared to those without NC. Multiple self-management barriers and facilitators were identified, however those with NC were more likely than those without NC to experience low self-efficacy, depression and severe pain which may impair the ability to self-management.
Conclusions:
Health care professionals have the opportunity to improve chronic pain outcomes by providing self-management advice, referring to self-management interventions, and addressing self-management barriers and facilitators. Individuals with NC may require additional health services to address their greater self-management challenges, and further research is needed to identify non-pharmaceutical interventions effective in relieving chronic pain with NC. Public policy is needed to facilitate health systems in providing long-term self-management support for individuals with chronic pain. / Thesis (Ph.D, Nursing) -- Queen's University, 2013-09-25 12:57:58.59
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An investigation into child and parental adjustment to childhood insulin dependent diabetes : the relationship between adjustment, metabolic control and perceived severitySlinger, Richard January 1998 (has links)
No description available.
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Does pain management improve quality of life? : an idiographic approachJones, Nicola January 1999 (has links)
No description available.
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Improving the management of chronic pain using mixed methods and an analytical framework to make recommendations for improving servicesKittiboonyakun, Pattarin January 2010 (has links)
Methods: Three research methodologies were used including a comprehensive literature review, a descriptive study and a qualitative study. A revised root cause analysis framework (consisting of four major steps) adapted and created by the researcher was also applied as an analytical framework to the whole research programme to facilitate the achievement of the aim and objectives. Results: Antidepressants were the most commonly prescribed drugs followed by a combination of paracetamol and weak opioids. Drug-drug interactions between antidepressants and opioids were the most common potential MRPs. Analgesic prescribing was independently associated with cause of pain and health-related quality of life. Pain level, cause of pain and health-related quality of life were independent significant factors for adjuvant prescribing. The poorer the health-related quality of life was, the greater the number of analgesics and adjuvant drugs that were prescribed. A model of pain medication taking behaviours was developed, and relationships between MRPs, pain medication taking behaviours and considerations of patients’ perspectives on pain and pain medication taking were identified. Patient factors were the main root causes of complex MRPs. A set of recommendations (for both GPs and pharmacists) and evidence-derived questions for primary care pharmacists were proposed to help reduce and prevent MRPs. Conclusion: An intervention based on the findings of this study, and related to the pharmacist’s roles and responsibility could ultimately help to improve pharmaceutical care services for people with chronic pain in primary care.
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An evaluation of group counselling as a therapeutic intervention for patients suffering from a chronic illness with special reference to rheumatoid arthritisBalmer, Donald H. January 1987 (has links)
No description available.
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A comparison of chronic periodontitis between HIV-seropositive subjects and the general population of the Ga-Rankuwa area, South AfricaKhammissa, Razia Abdool Gafaar 13 October 2008 (has links)
ABSTRACT
Aim
The aim of this study is to compare the degree of severity of chronic periodontitis in HIVseropositive
subjects with chronic periodontitis to control subjects with chronic periodontitis,
in the Ga-Rankuwa area in South Africa.
Methods
Two cohorts of subjects with chronic periodontitis were recruited for this study over a period
of time: thirty HIV-seropositive subjects; and 30 control subjects presumed to be HIV -
seronegative and apparently in good health.
Results
When all the periodontal indices were compared and evaluated there was no association
between HIV-serostatus and the periodontal indices. When periodontal indices were
compared between HIV-seropositive subjects using highly active anti-retroviral therapy
(HAART), and HAART-naïve subjects, there was no statistical differences regarding gingival
recession, plaque index and bleeding index. However, the mean pocket depth in HAARTnaïve
seropositive subjects was slightly greater than in HIV-seropositive subjects using
HAART. Correlation coefficient of mean pocket depth in relation to log CD4+ T cell count
in the HIV-seropositive HAART-naïve group of subjects showed a significant negative
correlation (P = -0.947), but there was no correlation between the mean gingival recession values and the log CD4+ T cell counts in the same group (P=0.303). For the HIVseropositive
subjects using HAART the correlation coefficient test failed to show significant
statistical relationships between log CD4+ T cell count and mean pocket depth (P=0.903) and
mean gingival recession (P=0.312) in HIV-seropositive subjects using HAART.
Conclusion
HIV-seropositive subjects with chronic periodontitis show clinical manifestations of similar
degree of their periodontal disease to those of healthy control subjects with chronic periodontitis, with no differences in the mean pocket depth, gingival recession, plaque index
and bleeding index.
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A Comparison of demographic variables and posture between patients with chronic cervical pain and healthy volunteers.Talbot, Heather Ann. 14 November 2006 (has links)
Faculty of Medicine
School of Physiotherapy
82-29610
Tel: 011 452 3175 / Physiotherapists commonly assess head and shoulder posture and correct poor posture on
the grounds that there is an association between the patients’ cervical symptoms and their
posture. The aims of this study were firstly to compare the sagittal head and shoulder
posture and demographic variables of patients with chronic cervical pain to those of “healthy”
volunteers. Secondly, to investigate the relationship between the frequency and severity of
pain and the sagittal head and shoulder posture of patients with chronic cervical pain.
Lateral view photographs were taken of nineteen patients (experimental group) and eighteen
“healthy” volunteers (control group) in a supported sitting position. The following five static
postural positions were assessed: (1) neutral or natural head and shoulder posture (2)
maximum head protraction (3) maximum head retraction (4) maximum shoulder protraction
and (5) maximum shoulder retraction. The active range of anteroposterior glide (total
excursion) of the participants’ head and shoulders was also assessed. The participants
completed a questionnaire that included their demographic variables, medical history and
leisure time activities.
Differences in head and shoulder posture were observed between the two groups. Some of
these differences supported postural relationships that have been described in the literature.
The experimental group had a more forward head resting position than the control group.
The range of motion (total excursion) of the head and shoulders of the experimental group
was less than the control group. In contrast to clinical assumptions that have been described
in the literature, a forward resting head posture was not related to a protracted shoulder
position or to upper cervical spine extension when measured in the sagittal plane.
A relationship was observed between the frequency and severity of pain in certain body
regions and selected postural measurements in the experimental group. It is suspected that
most of the findings might be the result of poor cervical and scapular muscle control caused
by chronic pain. This emphasises the need to assess the influence of tissue and joint
extensibility and muscle control on head and shoulder posture.
Analysis of the questionnaires demonstrated that the experimental group’s ability to carry out
activities of daily living was significantly affected by pain (p=0,001). There was no significant
difference in the number of hours worked per week between the experimental and control
groups (p=1,000). There was a tendency (p=0,118) for the control group to devote a greater
number of hours to “active” leisure time activities. The control group might have been less
symptomatic as a result thereof. This highlights the necessity to further investigate the effect
of exercise on postural correction and prevention of cervical symptoms.
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A retrospective review of lifetime prevalence of traditional healer consultation by an outpatient of Xhosa schizophrenia sufferersSutherland, T January 2015 (has links)
This research report is submitted to the Faculty of Health Sciences, University of the Witwatersrand,
Johannesburg, in partial fulfillment of the requirements for the degree of Master of Medicine in the
branch of Psychiatry. / AIM: To describe the demographic and clinical characteristics of a group of patients of Xhosa ethnicity
diagnosed with schizophrenia. To also determine the prevalence of their consultations with a traditional
healer as well as the factors associated with an increased likelihood of such consultations.
METHOD: The study was a review of a database originally compiled as part of an ongoing genetic
study. Patients on the database were all of Xhosa ethnicity, with a diagnosis of schizophrenia and had
all been recruited from community clinics and psychiatric hospitals in the Cape Town Metropole region.
RESULTS: Data was extracted and analysed for 92 patients, who met the criteria for inclusion in this
study. The majority of the patients were male (77.2%), single (88%) and unemployed (96%). The mean
duration of illness was 20.5 years and the mean number of hospital admissions for their mental illness
was 2.4. Close to half (43.5%) of the patients reported being non-compliant on their medication. Ten
percent admitted to making one or more suicide attempts in their lifetime. Nicotine was the most
commonly used substance (69.6%) followed by alcohol (55.4%), cannabis (37%) and
methamphetamines (9.8%).
Thirty eight percent of the patients reported having a traditional healer in their family. Twenty two
percent had consulted with a traditional healer. In the bivariate analysis the following factors were
significantly associated with consulting a traditional healer: having two or less psychiatric admissions
(p=0.014); compliance on medication (p=0,012); and having a traditional healer in the family
iii
(p=0.005). When controlling for age, sex and marital status only having a traditional healer in the
family was significantly associated with consulting traditional healer (p=0.011).
CONCLUSIONS: This study found that a high proportion of the participants had consulted a traditional
healer. This was significantly associated with having a traditional healer as a family member. It is
recommended that programmes, to improve the mutual understanding and co-operation between
Western practitioners and traditional healers and consequently mental health outcomes, need to be
developed and implemented.
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