Bone circulation in Hemorrhagic Shock was studied in 35 male mongrel dogs. The term hemorrhagic shock is defined in this thesis as persistent profound hypotensive syndrome, due to acute hemorrhage of more than one third of blood volume. The method of induction of shock consisted of removal of one third of estimated blood volume (8% of body weight) at a rate of 25 - 50 ml/min, and subsequently dropping the systemic blood pressure in a stepwise manner until the maintaining level of 30 - 35 mmHg is reached. The central venous pressure, pulse and respiratory rates were also recorded. Bone circulation was studied by (1) recording the blood flow through a cannula inserted into the tibial nutrient vein or artery and (2) recording the intramedullary pressure of tibia. When one third of estimated blood volume was removed, the bone blood flow through the nutrient vessel decreased to 22.5 ± 3.4% of control level. The decreased bone blood flow persisted as long as the hemorrhagic shock was maintained for 4-18 hours. The decreased bone blood flow was also evidenced by a profound and persistent fall of the intramedullary pressure of bone. Reinfusion into the animal of lost blood within fifteen minutes to six hours after hemorrhage resulted in a complete or partial recovery of the control systemic blood pressure as well as the control rate of bone blood flow and the control level of intramedullary pressure of bone. The curve showing relationship between the changes in bone blood flow and the systemic blood pressure is an exponential one with concavity towards the flow axis. This indicates that bone has a vasomotor control mechanism of increasing peripheral resistance during hemorrhagic shock. This was substantiated by the following observations: (1) The severity of decrease in bone blood flow on the side of lumbar sympathectomy was much milder (16% less) compared to the side of the intact sympathetic nerve; (2) Dibenzyline (phenoxybenzamine) a sympatholytic drug or alpha-receptor blocking agent alters the pressure-flow curve of bone circulation in chock to a linear pattern which indicates that the drug blocks the bone vasoconstricting mechanism(s). It is concluded that bone blood flow decreases in hemorrhagic shock and is not merely due to a decrease in circulatory blood volume, but also due to sympathetic and catecholamine hormonal vasoconstrictor mechanisms. / Surgery, Department of / Medicine, Faculty of / Graduate

Thesis. 1977. M.S.--Massachusetts Institute of Technology. Dept. of Meteorology. / Microfiche copy available in Archives and Science. / Bibliography : leaves 38-39. / M.S.

Thesis. 1977. M.S.--Massachusetts Institute of Technology. Dept. of Meteorology. / Microfiche copy available in Archives and Science / Bibliography: leaves 47-48. / M.S.

Thesis. 1978. Ph.D.--Massachusetts Institute of Technology. Dept. of Meteorology. / Microfiche copy available in Archives and Science. / Bibliography: leaves 182-191. / by Richard Robert Babcock, Jr.. / Ph.D.

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Meteorology and Physical Oceanography, 1982. / Microfiche copy available in Archives and Science / Bibliography: leaves 40-41. / by Eduardo Pantig Olaguer. / M.S.

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

No description available.

No description available.

The objective of this thesis was to develop an experimental method to research circulation control wings using numerical analysis. Specifically, it is of interest to perform 3D wind tunnel testing on a circulation control wing in the Cal Poly Low Speed Wind Tunnel (CPLSWT). A circulation control wing was designed and analyzed to determine the feasibility of this testing. This study relied on computational fluid dynamics (CFD) simulations as a method to predict the flow conditions that would be seen in a wind tunnel test. A CFD simulation was created of a wing model in a wind tunnel domain. Due to high computational requirements, reliable 3D CFD results were not obtained. This led to utilizing 2D CFD models to make estimations about the flow conditions that would be encountered in an experimental environment. The 2D CFD model was validated with previous experimental data on circulation control wings and was shown to accurately capture the flow physics. These 2D CFD results were used to create a set of guidelines to help improve the effectiveness of a future wind tunnel test campaign and demonstrate where further design work needs to be done. The key finding is that it is feasible to perform circulation control testing in the CPLSWT with limitations on the maximum momentum coefficient. Due to internal plenum pressures reaching 66 psi at Cμ=0.35, a limitation should be placed on experimental testing below the choked condition of at Cμ=0.15. This provides a more feasible operating range for the equipment available. The main performance parameter of the airfoil was met with CLMAX=5.01 at Cμ=0.35 which required 0.9 lb/s/m mass flow rate for the 2D model.

Numerical approaches have been conducted to investigate the effect of droplet deformation and internal circulation on droplet dynamics. Although droplet drag is a classical area of study, there are still theoretical gaps in understanding the motion of large droplets. In applications such as spray combustion, droplets of various sizes are generated and move with the flow. Large droplets tend to deform in the flow, and they have complex interactions with the flow because of this deformation. To better model spray, the physical understanding of droplets needs to be improved. Under spray conditions, droplets are subjected to a high-temperature-and-pressure environment, and the coupling between liquid and gas is enhanced. Therefore the deformation and internal circulation will affect the droplet drag coefficient more significantly than they would under atmospheric conditions. To study the mechanism of how droplet shape and internal circulation influence droplet dynamics, we have used direct numerical simulation (DNS) to simulate a droplet falling at its terminal velocity in high-pressure air. An in-house code developed for interface-capturing DNS of multiphase flows is employed for the simulation. The drag coefficient is calculated, and the results are consistent with the existing literature for slightly deformed droplets. The results show that the drag coefficient is directly related to the droplet deformation and droplet internal circulation. This paper also develops an analytical theory to account for the effect of the Weber number and fluid properties on droplet deformation. / Master of Science / This study investigates how larger droplets interact with airflow in spray conditions. Classical droplet drag models are not accurate under extreme conditions due to the neglect the droplet deformation and droplet internal circulation. To better understand droplet dynamics and to improve the accuracy of droplet models, direct numerical simulations were conducted. In our simulations, a non-evaporating falling droplet in high-pressure air was modeled. Results show a direct link between drag coefficient and droplet shape and internal flow. We also derived an analytical scaling law to explore the parameters related to droplet deformation. This research enhances our understanding of droplet dynamics in spray conditions.