• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 1
  • Tagged with
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Desenvolupament experimental de nous tractaments antifúngics per infeccions causades per llevats

Mariné Mestres, Marçal 21 May 2010 (has links)
Els estudis inclosos a la present tesi s'han centrat en el desenvolupament de noves teràpies antifúngiques per a infeccions causades per diverses espècies de Candida i per Cladophialophora bantiana. D'aquesta tesi s'han extret les següents conclusions:-La micafungina ha demostrat una eficàcia similar a la d'antifúngics tradicionals per al tractament experimental d'infeccions per C.glabrata. En combinació amb l'amfotericina B, aquest antifúngic ha demostrat, també, una gran eficàcia.-S'ha demostrat l'eficàcia del posaconazole per al tractament experimental d'infeccions disseminades per C.krusei i C.tropicalis.-L'anidulafungina, la caspofungina i la micafungina han estat efectives per al tractament d'infeccions experimentals disseminades per C.dubliniensis.-S'ha comprovat l'eficàcia de dues noves formulacions d'amfotericina B per al tractament d'infeccions experimentals per Candida.-La combinació de la micafungina amb l'itraconazole ha demostrat una bona activitat in vitro envers el gènere Candida.-La combinació del posaconazole, la micafungina i la flucitosina ha demostrat ser efectiva envers C. bantiana. / The studies included in this thesis focused on the development of new antifungal therapies for infections caused by various species of Candida and also Cladophialophora bantiana. The following conclusions were obtained in this thesis:-Micafungin demonstrated to be as effective as some traditional antifungal agents for the treatment of experimental infections by C.glabrata. This drug in combination with amphotericin B has also shown great efficacy.- Posaconazole demonstrated to be effective for the treatment of experimental infections by C.krusei and C.tropicalis. -Anidulafungin, micafungin and caspofungin were effective for the treatment of experimental disseminated infections by C.dubliniensis. -The effectiveness of two new formulations of amphotericin B has been proven for the treatment of experimental disseminated Candida infections. -The combination of micafungin with itraconazole showed good in vitro activity against the genus Candida. -The combination of posaconazole, micafungina and flucytosine has proven to be effective against C. bantiana.

Page generated in 0.0672 seconds