[pt] O presente estudo teve como objetivo compreender como se dá a ontogênese das funções cognitivas no período entre o nascimento até o início da adolescência. A partir da perspectiva da neurociência e neuropsicologia cognitiva, questões como as influências biológicas e ambientais, a maturação cerebral e o processo de aprendizagem, assim como as bases neuroanatômicas e circuitos neurais serão discutidas. A ênfase será dada aos marcos mais relevantes no processo típico do desenvolvimento das principais funções cognitivas tais como a sensação, a percepção, a atenção, a memória, a linguagem, as habilidades visuoconstrutivas, e as funções executivas. / [en] This study aimed to understand how the ontogeny of cognitive functions during the period from birth to early adolescence. From the perspective of neuroscience and cognitive neuropsychology, issues such as biological and environmental influences, brain maturation and learning processes, as neuroanatomical bases and neural circuits will be discussed. Emphasis will be given to the most important milestones in the typical development of the main cognitive functions such as sensation, perception, attention, memory, language, visual-constructive skills and executive functions.

Considerando a atual subutilização do espectro de rádio frequências para comunicação sem fio, o rádio cognitivo é visto como um conceito chave para permitir uma melhoria da utilização deste recurso de comunicação. A implementação de dispositivos de rádio cognitivo deve basear-se nas quatro principais funções cognitivas: sensoriamento espectral, decisão espectral, compartilhamento espectral e mobilidade espectral. Através dessas funções, um dispositivo de rádio cognitivo é capaz de procurar canais livres para transmitir de forma oportunista em uma rede de rádios cognitivos. No entanto, as redes de rádios cognitivos devem ser gerenciadas, com o objetivo de garantir seu pleno funcionamento, melhorando o desempenho destes dispositivos. Este gerenciamento deve melhorar o conhecimento do administrador sobre o funcionamento da rede. Assim, a configuração, o monitoramento e a visualização das funções cognitivas são fundamentais para o processo de aprendizagem contínua do administrador de rede. Neste trabalho, propõe-se Kitsune, um sistema de gerenciamento com base em um modelo hierárquico que permite gerenciar as informações sobre as funções cognitivas em redes de rádios cognitivos. Kitsune é projetado para gerenciar todas as quatro funções cognitivas, permitindo que o administrador da rede possa configurar os dispositivos de rádio cognitivo, monitorar os resultados de cada função cognitiva e analisar importantes visualizações destes resultados. Além disso, um protótipo de Kitsune foi desenvolvido e avaliado por meio de um cenário experimental baseado na norma IEEE 802.22. O resultado obtido mostra que Kitsune fornece ao administrador um melhor conhecimento sobre a rede, melhorando a taxa de transferência média para cada canal. / Considering the current underutilization of radio frequency spectrum for wireless communication, the Cognitive Radio is seen as a key concept to enable the improvement of the radio frequency spectrum utilization. The implementation of cognitive radio devices must be based on the four main cognitive functions: spectrum sensing, spectrum decision, spectrum sharing, and spectrum mobility. Through these functions, a cognitive radio device is able to search for vacant channels to opportunistically transmit in a cognitive radio network. However, cognitive radio networks should be managed, aiming to guaranty the proper operation of the cognitive radio devices, improving the performance of these devices. This management should improve the administrator knowledge about the cognitive radio network operation. Therefore, the configuration, monitoring and visualization of the cognitive functions are fundamental to the continuous knowledge building process of the network administrator. In this paper we propose Kitsune, a management system based on a hierarchical model allowing to manage summarized information about cognitive functions in radio networks. Kitsune is designed to manage all four cognitive functions, enabling the network administrator to configure the cognitive radio devices, monitor the results of each cognitive function, and make important visualizations of these results. Moreover, a Kitsune prototype was developed and evaluated through an experimental IEEE 802.22 scenario. The result obtained show that Kitsune allows the administrator to achieve a better knowledge about the network and improve the average throughput for each channel.

Presente em todas as culturas, seja para celebrar, louvar ou registrar cerimoniais, a música marca a história. Ela registra encontros, desencontros e situações históricas, torna presente o que está ausente e conecta nossa memória automaticamente a eventos passados. Este trabalho, com foco na prática social e do cuidado, tem por objetivo apresentar a pesquisa realizada sobre a investigação da aplicabilidade de recursos da linguagem musical para promover a reabilitação de funções cognitivas de paciente com lesão cerebral. O jovem participante do estudo de caso, hemiplégico, devido a acidente automobilístico em outubro de 2007, apresenta dificuldades de diferentes ordens, pois agregada às limitações físicas apresenta limitações cognitivas. Ao considerar-se a gama de queixas relevantes sobre uma debilidade na memória, seja na aquisição de novos dados como na sua fixação, esta pesquisa foi traçada com o objetivo de investigar a viabilidade de obter através da linguagem musical em musicoterapia um recurso para amenizar tais danos. Para atender os propósitos traçados foi investigada a possibilidade de aquisição de memória através da oferta de novas canções no contexto musicoterapêutico. As sessões de musicoterapia com esta finalidade foram registradas ao longo de 16 encontros ocorridos com a periodicidade de duas vezes por semana, durante o segundo semestre de 2010. Para atender esta proposta e em respeito à Resolução 196/96, que trata da pesquisa com seres humanos, foi elaborado um Protocolo de Pesquisa, aprovado pelo CEP da Faculdades EST. Este trabalho visa apresentar os resultados da pesquisa realizada, além de atender a elaboração do Trabalho Final em Mestrado Profissional da pesquisadora. Em busca de atender os objetivos traçados e articulados à prática realizada, a pesquisa sustentou-se em bases teóricas da Musicoterapia, da Música e da Neurociência. Pode-se observar que a aplicação da linguagem musical no contexto musicoterapêutico constituiu-se como recurso auxiliar para gravação de novos conteúdos, apresentando-se como um facilitador para a memorização. O participante da pesquisa, apesar da dificuldade em atender o contorno melódico das canções sugeridas, apresentou franca condição para memorizar o texto, observando-se que o recurso da música é elemento estimulador para a fixação de conteúdos novos. / Present in all cultures, whether to celebrate, praise or register ceremonial music brand history. It records meetings, disagreements and historical situations, makes present what is absent and automatically connects our memory of past events. This paper, with focus in the practical intentions of social and the care, aims to present the research done on investigating the applicability of the musical language resources to promote the rehabilitation of cognitive function in patients with brain injury. The young participants of the case study, hemiplegic due to car accident in October 2007, presents difficulties in different orders, because of physical limitations has aggregated cognitive limitations. When considering the range of complaints relevant to a weakness in memory in the acquisition of new data and in its setting the research was drawn in order to investigate the feasibility of obtaining the musical language through music therapy in a resource to minimize such damage. To meet the purposes outlined investigated the possibility of memory acquisition by offering new songs in context with music. The music therapy sessions for this purpose were recorded over the 16 meetings that took place at intervals of twice a week during the second half of 2010. To address this proposal and in compliance with Resolution 196/96, which deals with human research, we designed a research protocol approved by the CEP Faculdades EST. This paper presents the results of research conducted in addition to meeting the development of Monograph in Master of Professional Researcher. In pursuit of meeting the objectives outlined and articulated to the practice performance, sustained research into the theoretical bases of Music Therapy, Music and neuroscience. It can be observed that the application of the musical language in the context music therapeutic established itself as an aid to writing new content, presenting itself as a facilitator for memorization. The research participant, despite the difficulty in meeting the melodic contour of the songs presented frank suggested condition to memorize the text, noting that the use of music is stimulating element for the establishment of new content.

Considerando a atual subutilização do espectro de rádio frequências para comunicação sem fio, o rádio cognitivo é visto como um conceito chave para permitir uma melhoria da utilização deste recurso de comunicação. A implementação de dispositivos de rádio cognitivo deve basear-se nas quatro principais funções cognitivas: sensoriamento espectral, decisão espectral, compartilhamento espectral e mobilidade espectral. Através dessas funções, um dispositivo de rádio cognitivo é capaz de procurar canais livres para transmitir de forma oportunista em uma rede de rádios cognitivos. No entanto, as redes de rádios cognitivos devem ser gerenciadas, com o objetivo de garantir seu pleno funcionamento, melhorando o desempenho destes dispositivos. Este gerenciamento deve melhorar o conhecimento do administrador sobre o funcionamento da rede. Assim, a configuração, o monitoramento e a visualização das funções cognitivas são fundamentais para o processo de aprendizagem contínua do administrador de rede. Neste trabalho, propõe-se Kitsune, um sistema de gerenciamento com base em um modelo hierárquico que permite gerenciar as informações sobre as funções cognitivas em redes de rádios cognitivos. Kitsune é projetado para gerenciar todas as quatro funções cognitivas, permitindo que o administrador da rede possa configurar os dispositivos de rádio cognitivo, monitorar os resultados de cada função cognitiva e analisar importantes visualizações destes resultados. Além disso, um protótipo de Kitsune foi desenvolvido e avaliado por meio de um cenário experimental baseado na norma IEEE 802.22. O resultado obtido mostra que Kitsune fornece ao administrador um melhor conhecimento sobre a rede, melhorando a taxa de transferência média para cada canal. / Considering the current underutilization of radio frequency spectrum for wireless communication, the Cognitive Radio is seen as a key concept to enable the improvement of the radio frequency spectrum utilization. The implementation of cognitive radio devices must be based on the four main cognitive functions: spectrum sensing, spectrum decision, spectrum sharing, and spectrum mobility. Through these functions, a cognitive radio device is able to search for vacant channels to opportunistically transmit in a cognitive radio network. However, cognitive radio networks should be managed, aiming to guaranty the proper operation of the cognitive radio devices, improving the performance of these devices. This management should improve the administrator knowledge about the cognitive radio network operation. Therefore, the configuration, monitoring and visualization of the cognitive functions are fundamental to the continuous knowledge building process of the network administrator. In this paper we propose Kitsune, a management system based on a hierarchical model allowing to manage summarized information about cognitive functions in radio networks. Kitsune is designed to manage all four cognitive functions, enabling the network administrator to configure the cognitive radio devices, monitor the results of each cognitive function, and make important visualizations of these results. Moreover, a Kitsune prototype was developed and evaluated through an experimental IEEE 802.22 scenario. The result obtained show that Kitsune allows the administrator to achieve a better knowledge about the network and improve the average throughput for each channel.

Considerando a atual subutilização do espectro de rádio frequências para comunicação sem fio, o rádio cognitivo é visto como um conceito chave para permitir uma melhoria da utilização deste recurso de comunicação. A implementação de dispositivos de rádio cognitivo deve basear-se nas quatro principais funções cognitivas: sensoriamento espectral, decisão espectral, compartilhamento espectral e mobilidade espectral. Através dessas funções, um dispositivo de rádio cognitivo é capaz de procurar canais livres para transmitir de forma oportunista em uma rede de rádios cognitivos. No entanto, as redes de rádios cognitivos devem ser gerenciadas, com o objetivo de garantir seu pleno funcionamento, melhorando o desempenho destes dispositivos. Este gerenciamento deve melhorar o conhecimento do administrador sobre o funcionamento da rede. Assim, a configuração, o monitoramento e a visualização das funções cognitivas são fundamentais para o processo de aprendizagem contínua do administrador de rede. Neste trabalho, propõe-se Kitsune, um sistema de gerenciamento com base em um modelo hierárquico que permite gerenciar as informações sobre as funções cognitivas em redes de rádios cognitivos. Kitsune é projetado para gerenciar todas as quatro funções cognitivas, permitindo que o administrador da rede possa configurar os dispositivos de rádio cognitivo, monitorar os resultados de cada função cognitiva e analisar importantes visualizações destes resultados. Além disso, um protótipo de Kitsune foi desenvolvido e avaliado por meio de um cenário experimental baseado na norma IEEE 802.22. O resultado obtido mostra que Kitsune fornece ao administrador um melhor conhecimento sobre a rede, melhorando a taxa de transferência média para cada canal. / Considering the current underutilization of radio frequency spectrum for wireless communication, the Cognitive Radio is seen as a key concept to enable the improvement of the radio frequency spectrum utilization. The implementation of cognitive radio devices must be based on the four main cognitive functions: spectrum sensing, spectrum decision, spectrum sharing, and spectrum mobility. Through these functions, a cognitive radio device is able to search for vacant channels to opportunistically transmit in a cognitive radio network. However, cognitive radio networks should be managed, aiming to guaranty the proper operation of the cognitive radio devices, improving the performance of these devices. This management should improve the administrator knowledge about the cognitive radio network operation. Therefore, the configuration, monitoring and visualization of the cognitive functions are fundamental to the continuous knowledge building process of the network administrator. In this paper we propose Kitsune, a management system based on a hierarchical model allowing to manage summarized information about cognitive functions in radio networks. Kitsune is designed to manage all four cognitive functions, enabling the network administrator to configure the cognitive radio devices, monitor the results of each cognitive function, and make important visualizations of these results. Moreover, a Kitsune prototype was developed and evaluated through an experimental IEEE 802.22 scenario. The result obtained show that Kitsune allows the administrator to achieve a better knowledge about the network and improve the average throughput for each channel.

O objetivo do presente estudo foi comparar os efeitos de dois tipos de programas de treinamento do equilíbrio e marcha, um baseado no Nintendo Wii Fit® e o outro baseado em exercícios convencionais sem a utilização do videogame, na eficiência da marcha, funções cognitivas e funcionalidade de idosos saudáveis. Trata-se de um ensaio clínico, cego e randomizado realizado no Departamento de Fonoaudiologia, Fisioterapia e Terapia Ocupacional no Laboratório de Aprendizagem Sensório-Motora (LASM) da Universidade de São Paulo. Participaram do estudo 32 idosos saudáveis que foram randomizados em grupo experimental (n=16) e grupo controle (n=16). Ambos os grupos realizaram 14 sessões individuais de treinamento, duas vezes na semana por sete semanas. As sessões eram divididas em duas partes: a primeira parte era composta de 30 minutos de exercícios globais que incluíam alongamento e fortalecimento muscular além de mobilidade axial; a segunda parte era composta de 30 minutos de exercícios de equilíbrio e marcha. O grupo experimental realizou os exercícios de equilíbrio e marcha por meio de 10 jogos do vídeogame Nintendo Wii Fit®, que promoviam a estimulação cognitiva e motora por meio da realimentação visual e auditiva. Já o grupo controle realizou os exercícios sem nenhuma estimulação cognitiva associada. As principais medidas do estudo foram: (1) Functional Gait Assessment (FGA); (2) Montreal Cognitive Assessment (MoCA); (3) Índice do Andar Dinâmico (IAD); (4) Falls Efficacy Scale (FES-I); (5) Teste da marcha de 30 segundos em condição de simples tarefa e dupla tarefa. A análise estatística foi realizada por meio da ANOVA de medidas repetidas e pós hoc teste de Tukey para a verificação de possíveis diferenças entre grupos e avaliações, que foram realizadas antes, depois e após 60 dias do término do treinamento. Apenas o grupo experimental apresentou melhora na FGA, MoCA, IAD, FES-I e Teste da marcha 30 segundos em simples e dupla tarefa. Concluiu-se que o treino de equilíbrio e marcha associado ao Nintendo Wii Fit® mostrou-se mais eficiente na melhora da eficiência da marcha, das funções cognitivas e da funcionalidade de idosos saudáveis em comparação ao treinamento convencional / The aim of this study was to compare the effects of two types of balance and gait training programs, one based on Nintendo Wii Fit® and the other based on conventional exercises without the use of video games, in the gait efficiency, cognitive functions and functionality in healthy elderly. This is a blind and randomized clinical trial, conducted at the Department of Speech-Language Pathology, Physiotherapy and Occupational Therapy at the Laboratory for Sensory-Motor Learning (LASM) at the University of São Paulo. The study included 32 healthy elderly individuals who were randomized into an experimental group (n = 16) and control group (n = 16). Both groups underwent 14 sessions of individual training, twice a week for seven weeks. The sessions were divided into two parts: the first part consisted of 30-minute global exercise that included stretching and muscular strengthening exercises as well as axial mobility; the second part consisted of 30 minutes of balance and gait exercises. The experimental group performed balance and gait exercises through 10 Nintendo Wii Fit® video games, which promoted cognitive and motor stimulation through visual and auditory feedback. The control group performed the exercises without any cognitive stimulation associated. The main measures of the study were: (1) Functional Gait Assessment (FGA), (2) Montreal Cognitive Assessment (MoCA), (3) Dynamic Gait Index (DGI), (4) Falls Efficacy Scale (FES-I); (5) 30-second gait test in simple and dual-task condition. Statistical analysis was performed by repeated measures ANOVA and post hoc Tukey test to check for possible differences among groups and evaluations, which were performed before, after and 60 days after the end of the training. Only the experimental group showed improvement in FGA, MoCA, DGI, FES-I and 30-second gait test in simple and dual-task. It was concluded that balance and gait training associated with Nintendo Wii Fit® was more efficient in improving the gait efficiency, cognitive function and functionality of healthy elderly compared to conventional training

Nowadays, an intelligence is a widely applied concept. The authors' opinions on its possible unification with or strict separation from the specific cognitive functions vary throughout different fields of psychology. Simultaneously, schizophrenia is a mental disorder, which is often connected to a cognitive deficit. Its assessment is usually realized on an estimation of the intelligence level. The aim was to explore how the estimation of intelligence corresponds with a cognitive profile of a patient with schizophrenia. This purpose is firstly being attained by a description of various views and theoretical objects, for instance core characteristics of a schizophrenia, a description of intelligence and selected cognitive functions. The empirical part is focused on an exploration of the relationship between a cognitive profile and the estimation of actual and premorbid intelligence of a patient with schizophrenia. A total of 120 persons with a diagnose F20 were included in this study. A cognitive profile was assessed with the usage of MATRICS battery and the intelligence levels were evaluated by selected WASI tests and Czech reading test (CRT). Results indicates that despite the level of premorbid and actual intelligence level was identified within the normal range, respondents evinced a cognitive...

(in English): Electroconvulsive therapy (ECT) is a very effective treatment procedure for patients with severe and treatment resistant psychiatric disorders. This Thesis deals with the impact of electroconvulsive therapy on cognitive function, specified as a measurement of cognitive function after electroconvulsive therapy, focusing on the monitoring of cognitive function, eventually their deficits with the passage of time after ECT. At several time points (T1 week after ECT completion; T2: 6-8 weeks after ECT completion) from ECT completion the progression of cognitive performance of patients was repeatedly measured. Respondents were divided according to their diagnosis (mood disorders groop and schizophrenia group). The groups were compared with each other. The aim of the Thesis is the observance of the cognitive changes in patients over time after electroconvulsive therapy. In the final stage 18 subjects were submissed into the study (10 women and 8 men). In terms of diagnosis 39% were diagnosed with the disease in the ICD category F20-F29; 33% were diagnosed with mood disorders (category ICD: F30-F39) and 28% were diagnosed with F06.3 organic affective disorder. The MCCB (MATRICS Consensus Cognitive Battery) was chosen as a method for data scan, it has very good psychometric properties also...

Les personnes civiles traumatisées (ESPT) de la guerre du Congo rapportent de nombreuses intrusions de pensées par des images et des scènes des évènements vécus. Ces intrusions apportent une souffrance clinique importante. Elles font revivre le traumatisme en permanence sans aucun contrôle cognitif ne soit apparemment possible. Dans notre travail de thèse nous soutenons l’idée que ces intrusions sont la conséquence d’une modification profonde des processus cognitif de contrôle chez les personnes civiles traumatisées de la guerre du Congo. Plus particulièrement, nous supposons que le processus susceptible d’être en cause dans l’absence de contrôle sur les images et les pensées serait un déficit du mécanisme d’inhibition cognitive. Afin de mettre nos hypothèse à l’épreuve nous avons construit différentes tâches composées pour chacune d’un matériel à valence « neutre » et d’un matériel à valence « traumatique, négative ». Ces tâches sont reconnues pour mesurer les capacités de contrôle cognitif. Il s’agit de la tâche de Stroop (Stroop, 1935), de la tâche d’Oubli dirigé (Bjork, Bjork, & Anderson, 1998), d’un matériel issus du paradigme DRM (Deese, 1959 ; Roediger, & McDermott, 1995) et R/K (Tulving, 1985) et enfin d’une épreuve de glissement de mémoire (Jacoby, 1991 ; Haye, & Jacoby, 1996, 1999 ; Guerdoux, 2009). Ces tâches ont été administrées à une première population de personnes civiles traumatisées de la guerre du Congo en comparaison à une population de personnes du Burkina-Faso non traumatisées. Nos résultats ont invalidé nos hypothèses quant à l’existence d’un déficit d’inhibition notamment en présence d’un matériel verbal émotionnel en lien avec les évènements traumatiques vécus. Les résultats de nos études militent pour un hypercontrôle et une hyperinhibition de tout matériel en lien avec le traumatisme. C’est pourquoi, nous tentons d’expliquer cet hypercontrôle comme le signe d’un refoulement émotionnel tel que défini par Freud (1926) ou bien encore le signe d’une dissociation psychique définie par Janet (1986, 1987). / The traumatized civil persons (PTSD) of the Congo War bring back numerous interventions of thoughts by images and scenes of the lived events. These interventions bring an important clinical suffering. They make relive the trauma permanently without any cognitive control is apparently possible. In our work of thesis we support the idea that these interventions are the consequences of a deep modification of the processes cognitive of control at the civil persons traumatized by the Congo War. More particularly, we suppose that the process susceptible to be involved (to be in question) in the absence of control over the images and the thoughts would be a deficit of the mechanism of cognitive inhibition. To put our hypothesis in the test we built various tasks consisted for each of a material with "neutral" valency and a material with "traumatic, negative" valency. These tasks are recognized to measure the capacities of cognitive control. It is about the task of Stroop (Stroop, 1935), of the task of directed Forgetting (Bjork, Bjork, & Anderson, 1996), of a material stemming of paradigm DRM (Deese, 1959; Roediger, & McDermott, 1995) and R/K (Tulving, 1985) and finally a memory–slip test (Jacoby, 1991; Hay, & Jacoby, 1996, 1999; Guerdoux, 2009). These tasks were administered to a first population of civil persons traumatized by the Congo War in comparison to a population of persons of the Burkina Faso not traumatized. Our results invalidated our hypotheses as for the existence of a deficit of inhibition in particular in the presence of an emotional verbal material in connection with the lived traumatic events. The results of our studies militate for a hypercontrol and a hyperinhibition of any material in connection with the trauma. That is why we try to explain this hypercontrol as the sign of an emotional expulsion such as defined by Freud (1926) or the sign of a psychic dissociation defined by Janet (1986, 1987).

Les dernières années témoignent d'une remarquable accélération dans la compréhension des facteurs génétiques impliqués dans la déficience intellectuelle (DI) et de nombreux gènes responsables ont été identifiés. Néanmoins, les mécanismes cellulaires et moléculaires sous-jacents à la DI sont encore mal connus. Une hypothèse attractive est que les mutations à l’origine de DI affectent la neurogenèse hippocampique adulte (NGA), une forme de plasticité qui joue un rôle crucial dans la mémoire. L'objectif de ce projet est d’entreprendre une analyse comparative de la NGA chez trois modèles murins de pathologies d’origine génétique, menant à une DI sévère, impliquant des gènes localisés sur le chromosome X et participant à différentes voies de signalisation susceptibles de moduler la NGA : le syndrome de Coffin-Lowry (gène rsk2), la dystrophie musculaire de Duchenne (gène dmd) et une DI liée au gène pak3. Mes recherches actuelles montrent que ces trois modèles présentent des déficits cognitifs dépendants de l’hippocampe, dont des altérations de la fonction de séparation de patterns. Nous avons également mis en évidence des altérations de la NG adulte, avec, entre autres, des altérations du recrutement des jeunes neurones par l’apprentissage qui pourraient contribuer aux déficits cognitifs observés en particulier dans la fonction de séparation de patterns. Toutefois, selon les gènes en cause, les déficits ne sont pas observés dans les mêmes étapes de la NGA ni dans les mêmes situations comportementales. L’ensemble de ces résultats laisse donc suggérer que chacun des gènes étudiés pourrait jouer un rôle différent dans la NGA, mais qu'in fine des altérations de cette forme de plasticité contribuent, au moins en partie, aux déficits cognitifs associés à la DI dans les trois modèles. Ensemble, ces résultats apportent des informations supplémentaires qui seront directement pertinentes pour d’autres pathologies neuro-développementales conduisant à des déficits cognitifs liés à des altérations de la NG, et pourraient ouvrir de nouvelles pistes thérapeutiques. / Recent years have shown a remarkable acceleration in the understanding of genetic factors involved in intellectual disability (ID) and many genes responsible have been identified. However, the cellular and molecular underlying mechanisms are still poorly understood. An attractive hypothesis is that mutations causing ID may affect adult hippocampal neurogenesis (ANG), a form of plasticity that plays a crucial role in learning and memory. The objective of this project was to undertake a comparative analysis of adult hippocampal neurogenesis in three mouse models of genetic diseases involving genes located on the X chromosome and participating in different signalling pathways that may modulate ANG: the Coffin-Lowry syndrome (rsk2 gene), Duchenne muscular dystrophy (dmd gene) and ID due to mutation of the pak3 gene. My current research shows that these three models present hippocampal dependent cognitive deficits. Among these deficits, major deficits in spatial pattern separation function have been highlighted. We also showed specific alterations of basal ANG, together with alterations in the recruitment of young newborn neurons by learning that could contribute to the observed cognitive deficits, in particular in pattern separation function. However, depending on the genes involved, the deficits are not observed in the same steps of adult NG and in the same behavioural situations. In all, the results suggest that each of the genes plays a different role in ANG, but finally that alterations of this form of plasticity may contribute to the cognitive deficits associated with ID in the three models. Together, these results provide additional information that will be directly relevant to other neurodevelopmental disorders leading to cognitive deficits related to NG alterations, and could open new therapeutic tracks.