Current competitive status among potable and non-potable use makes the water reuse mandatory. Presently, water reuse is common only for reclaimed water coming from municipal or industrial water treatment plants. In those facilities, the treatment includes disinfection. The disinfection methods widely used are chlorination and Ultra Violet (UV) lamps adapted to the conditions of large volume of municipal and industrial systems. This study proposes a disinfection method adequate to the household level to reuse graywater. The method is called solar disinfection (SODIS), which allows the reuse of graywater even though it contains fecal contamination. In this research, natural sun radiation as a free source of heat and UV radiation was utilized. In a first stage, periods of sun exposure, graywater depth, and cell covers as external factors were studied. In later stages, the graywater temperature (GWT) and the UV radiation effects on the reduction of the microbial indicators were observed. Results showed that graywater depth of five cm had a statistical significant reduction rather than ten cm depth (p = 0.0035). Plexiglas and poly-vinyl chloride (PVC), as transparent covers, had a statistical significant reduction (p<0.00001) due to the greenhouse effect increasing the GWT. The black cover had the lowest GWT and reduction of the bacterial and viral indicators. This research found different behavior between bacteria and virus reduction by graywater solar disinfection. In order to reduce the concentration of total coliforms, Escheriquia coli (E. coli) and enterococcus to non-detectable levels (<1.0 most probable number, MPN 100 ml⁻¹), a combination of GWT >45 °C, and UV radiation >24 W m⁻² was required. In contrast, coliphage MS-2, as viral indicator, was resistant to different UV radiation magnitudes (up to 50 W m⁻²), but with a GWT >55 °C non-detectable levels (<1.0 plaques forming units, PFU) were reached.