Orientador : José Aristodemo Pinotti / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-07-16T05:36:28Z (GMT). No. of bitstreams: 1 Kawamura_Kazue_D.pdf: 3031315 bytes, checksum: dc43f530ec918d115d30e99edd6d1fa3 (MD5) Previous issue date: 1976 / Resumo: Não informado. / Abstract: Not informed. / Doutorado / Doutor em Ciências Médicas

Orientador: Aloisio José Bedone / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-07-19T18:28:24Z (GMT). No. of bitstreams: 1 Costa-Gurgel_MariaSalete_M.pdf: 1948436 bytes, checksum: 9652cc74f1c4e8abd0a8359398a304a0 (MD5) Previous issue date: 1994 / Resumo: O tratamento do carcinoma microinvasivo do colo uterino é bastante controverso, sendo abordado diferentemente nos diversos Serviços. A histerectomia, acompanhada ou não de procedimentos mais radicais, é realizada na quase totalidade dos casos. Mais recentemente, tem-se observado uma tendência à adoção de condutas conservadoras, como a conização nos casos de invasão inicial, desde que se tenha segurança da retirada total da neoplasia. Através da revisão anatomopatológica dos 163 casos tratados no Ambulatório de Oncologia Ginecológica do Departamento de Tocoginecologia da FCM/UNICAMP, no período de 1967 a 1994, que foram submetidos à histerectomia simples ou radical após conização, procuramos estabelecer os fatores de risco para a persistência de tumor residual após esta cirurgia. Não houve influência das dimensões da microinvasão medidas pela profundidade e extensão horizontal da lesão, assim como do seu aspecto focal ou extenso e da presença de invasão vascular do estroma na ocorrência de neoplasia residual. Na análise inicial, o comprometimento das margens cirúrgicas da conização e a presença de sinais histológicos compatíveis com infecção pelo HPV demonstraram estar associados a um aumento significativo de neoplasia residual após conização uterina nos casos de carcinoma microinvasivo do colo uterino. No entanto, ao final do estudo, observou-se que houve interação entre os sinais de HPV e o comprometimento das margens cirúrgicas da conização na presença de tumor residual. / Abstract: The treatment of microinvasive carcinoma of the uterine cervix is controversial, with different approaches by different services. Hysterectomy in performed in almost all cases, associated or not with more radical procedures. Nowadays, there is a trend in adopting conservative conducts, such as conization in patients with early invasion, as long as there can be assured that the whole lesion was removed. Through histological review of 163 cases treated at the Gynecological Oncology Out patient Clinic if the Department of Gynecology and Obstetrics of the University of Campinas, from 1967 to 1994, ali of them undergone simple or radical hysterectomy after conization, it was tried to stablish the risk factors for persistency of residual tumor after conization. The microinvasion size measured by the depth and length of the lesion, its focal or extensive pattern and the presence of stromal vascular space involvement did not influence the occurrence of residual tumor. Initially the surgical margins involvement in conization and the presence of HPV histological signs were associated with on increased incidence of residual tumor after this procedure. Nonetheless, the statistical analysis showed that there was interaction between HPV histological signs and surgical margins involvement on residual tumor. / Mestrado / Mestre em Tocoginecologia

Erosion beveled the Laramide Front Range uplift in Colorado to a surface of low relief by the end of the Eocene. This study uses paleobotanic climate analysis techniques to determine the paleoelevation of this regional surface by examining the overlying 34.9 Ma Florissant flora. Multiple regression models explaining 93.4% of the variance in mean annual temperature (MAT), 86.1% of the variance in growing season precipitation (GSP) and 65.7% of the variance in rainfall distribution were derived from J. A. Wolfe's dataset of 31 leaf physiognomic character states from 86 modern vegetation sites. When applied to a new collection of 29 species from the Florissant flora, estimates of MAT = 10.7 ± 1.5°C, and GSP = 55.6 ± 12.5 cm, with precipitation occurring mostly during the growing season, are derived. This paleoclimate estimate is corroborated by data from late Eocene Sequoia affinis from Florissant. Higher mean ring width of the fossil trees as compared to modern counterparts can be explained by a climate with summer mean monthly temperatures ≥ 14°C and summer mean monthly rainfall >1.5 cm. The estimated MAT, when combined with coeval sea level MAT and terrestrial lapse rate, implies an elevation of 2.3-3.3 km for Florissant, which is indistinguishable from the modern elevation of 2.5 km. The elevation of Florissant is tied to that of the Great Plains by the Wall Mountain Tuff, so the Great Plains were also high. The elevation was created either by underplating and/or mass transfer in the Laramide, or by mantle uplift of crust thickened by pre-Laramide tectonics. This elevation estimate implies that: (1) Pliocene uplift is not required to explain the present elevation. Thus, late Tertiary plateau uplift in the western US was not a contributing factor to the marked global cooling since 15 Ma; and (2) in the late Eocene, regional surfaces of planation could be formed at elevations significantly above sea level but below tree line. The surface was possibly formed from a lack of storminess; a preponderance of small storm events will diffusively smooth topography.

Water management models have evolved through three basic stages. The earliest models dealt with the problem of getting water to where it was needed. Adequate supplies of sufficiently high cudlity were assumed to exist, and thus these models attempted to determine optimal distribution networks. In 1966 J.A. Dracup developed a model of this form to explore alternate sources of supply to meet industrial and municipal demands, agricultural demand, and demand for water to provide artificial recharge of groundwater aquifers. The next developments in water management were due to the emerging awareness of the environmental impacts of water use. These models were primarily concerned with maintaining certain quality levels within the natural water system (rivers, streams, estuaries). They tended to ignore the quantity of water within the system, being concerned with optimizing over the distribution system and quality control through the use of by-pass piping, on-site and regionalized treatment plants. The final category of models is one in which both quality and quantity considerations are allowed to enter as decision variables. The most general model of this type was developed by D.E. Pingry and T.L. Shaftel in 1979. This model allows for any configuration of sources, users, piping, disposal areas, and treatment plants. Thus the problem of distribution and quality control are both handled. This model also employs realistic nonlinear cost functions through economies of scale in treatment, and diseconomies of scale in treatment efficiency. The major limitation of their model, and others of the same type, is that they have been applied only to closed water systems which do not include rivers, streams, etc., and therefore ignore the environmental impacts of the water development on the complete natural water systems (e.g., a river basin). The Pingry-Shaftel model has been expanded to allow for the integration of a river system into an optimization model where the distribution system, quality control, source development, recycling of wastewater, and other management strategy alternatives are all allowed to enter as decision variables. At the same time the quantity requirements and quality standards are being monitored in order to analyze their impacts on cost. Decomposing the problem and making use of a large-scale transportation algorithm permit a solution to be obtained in an efficient manner. The model has sufficient flexibility to permit the comparison of impacts of various natural, technological, economic, and legal constraints. The model has been applied to the Colorado River Basin under varying assumptions in order to determine the economic and environmental implications of various water supply allocations and salinity treatment strategies.

Water quality analyses in Grand Canyon examined Colorado River and tributary baseline water quality status in relation to recreational float trip use of the river corridor. Float trip use of Grand Canyon has increased over recent years (since 1966) to levels which have caused concern for water quality-river running associations. River runners have traditionally used the Colorado River and tributaries as sources of drinking and cooking water, for swimming and bathing, and, at times, as a disposal for some refuse, e.g., dishwater and leftover food. Associated with float trip use of the river corridor water resources has been potential water quality hazards. During the 1972 and 1979 float trip seasons (May through September) outbreaks of gastroenteritis occurred among river runners in Grand Canyon, prompting investigation by the Center for Disease Control, Atlanta, Georgia; an enteric pathogen Shigella sonnei was isolated from some river-trip participants. Potentially, the Colorado River or a tributary served as a source or carrier of the pathogen, though this has not been confirmed. Enteric disease organisms excreted in feces by humans, wildlife or domestic animals can become potential sources of infection; water contaminated with fecal organisms can distribute diseases. Water quality analyses of the Colorado River corridor occurred during the 1978 and 1979 river running seasons. Examination of the extensive river corridor necessitated analyses in the field. Travel through the Grand Canyon was via research rafts in a series of six float trips, April through September, in 1978, and two float trips, July and August, in 1979; 82 field days in 1978 and 22 field days in 1979. A total of 497 water quality samples were collected over two seasons from the Colorado River along the 225-mile stretch from Lees Ferry to Diamond Creek, the launch and take-out points of the research trips. The confluent reaches (within approximately 200 yards of the Colorado River) of 26 side creeks in the river corridor were also sampled in 1978; nine tributaries were sampled in 1979. Additional samples collected from upstream locations on some side creeks increased the tributary sample site total to 33 in 1978 and to 13 in 1979 for a two season total of 165 individual tributary samples. Selected microbial, physical, and chemical parameters were measured to determine baseline water quality status in the Colorado River corridor of Grand Canyon. Research emphasis was on microbial water quality; physical and chemical parameters were measured to facilitate evaluation of the microbial profiles. Microbial parameters included fecal coliform bacteria and fecal streptococcus bacteria densities; physical parameters included turbidity and water and air temperature; chemical determinations included alkalinity, hardness, phosphate, nitrate, chloride, total dissolved solids, and pH. Data from 1978 and 1979 show that the Colorado River and tributaries have similar bacterial water quality profiles. Surface waters show predominantly low FC densities, indicating high quality waters for recreational activities, based on established federal and state water quality standards. Treatment of river and tributary surface water is necessary to assure drinking water quality standards. Bottom sediment analyses modify considerably the water quality status represented by surface water analyses alone. Significant densities of enteric organisms are present in the river and tributary environments, representing an important water quality hazard. Associated with resuspension of bottom sediments is the probability of surface water contamination by enteric organisms. Recreational activities, particularly water play in confined tributary pools, can bring river runners in direct contact with concentrated sediment suspension in surface waters.

Universiẗat, Diss, --Bremen, 2005. / Literaturverz. S. 368 - 379.

Thesis (M.A.)--University of Wyoming, 2007. / Title from PDF title page (viewed on June 16, 2009). Includes bibliographical references (p. 63-70).

Thesis (M.A.)--Denver Conservative Baptist Seminary, 1987. / Folded map in pocket. Includes bibliographical references (leaves 98-103).

No description available.

No description available.