Submitted by Giovanna Brasil (1154060@mackenzie.br) on 2017-05-29T19:43:53Z No. of bitstreams: 2 Alice Batistuzzo.pdf: 1303971 bytes, checksum: 797c7d5c2f252222523598936683ff00 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Rejected by Paola Damato (repositorio@mackenzie.br), reason: Olá Gionana !!! Normalmente no Mestrado não tem Coorientador.... De onde vc retirou a Mariana ???? E se já é orientador não entra como membro da Banca Ok ??!!! Bjosss Paola on 2017-05-30T16:25:56Z (GMT) / Submitted by Giovanna Brasil (1154060@mackenzie.br) on 2017-06-01T16:36:00Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Alice Batistuzzo.pdf: 1303971 bytes, checksum: 797c7d5c2f252222523598936683ff00 (MD5) / Approved for entry into archive by Paola Damato (repositorio@mackenzie.br) on 2017-06-06T15:08:11Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Alice Batistuzzo.pdf: 1303971 bytes, checksum: 797c7d5c2f252222523598936683ff00 (MD5) / Made available in DSpace on 2017-06-06T15:08:11Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Alice Batistuzzo.pdf: 1303971 bytes, checksum: 797c7d5c2f252222523598936683ff00 (MD5) Previous issue date: 2017-03-27 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / About 12 to 36% of the population presents homozygosis for a polymorphism in enzyme deiodinase type 2 (Thr92Ala-D2). Positive correlations were found between point mutations in D2 and intellectual disability, bipolarity and psychosis. It has recently been shown that this mutation leads to modifications in the cellular transcriptome in human brains that appear to relate to changes in pathways involved in the modulation of cognitive development and in Parkinson's disease, Alzheimer's and schizophrenia. Down Syndrome (DS) is the most common autosomal aneuploidy, affecting on average 1/660 newborns and represents about 18% of the total number of mentally handicapped in specialized institutions. In addition to cognitive deficits, neuropathologies such as Alzheimer's in individuals with DS are frequent. Based on the data described, we asked whether the Thr92Ala-D2 mutation could contribute to changes in the cognitive functions of individuals with DS. To answer this question, the presence of Thr92Ala-D2 in 29 children with DS, aged between 2 months and 18 years, was screened. The genotype was determined by the PCR en real time technique. The IQ was estimated in 15 participants by the SON-R 2 ½ - 7 and WASI instruments. The short-term memory was evaluated in 11 participants from the TIME instrument and the adaptive behavior was evaluated in 29 through the Vineland Questionnaire. The frequency found for the genotype was 20.69% wild (T / T), 55.17% heterozygous (A / T) and 24.14% polymorphic (A / A) and similar to that found in the population In the adaptive behavior, a significant difference was found between the A / A polymorphic group and the wild T / T in the domains Domestic, Interpersonal Relations, Play and Leisure and in the Social and Global Adaptive Level domains. The IQ values ranged from 40 to 70, and in the evaluation of short-term memory, 72.72% of the subjects had a low performance. No correlation was found between the presence of polymorphism and IQ or memory. In future studies, it is important to use a larger sample, with young and adult individuals, and to compare with individuals of typical development, since strong evidence has been found in this study that the presence of polymorphism causes impairment in the cognitive functions of individuals with DS. / Cerca de 12 a 36% da população apresenta homozigose para um polimorfismo na enzima desiodase tipo 2 (Thr92Ala-D2). Foram encontradas correlações positivas entre mutações pontuais na D2 com deficiência intelectual, bipolaridade e psicose. Recentemente foi demonstrado que essa mutação leva a modificações no transcriptoma celular em cérebros humanos que parecem se relacionar com alterações em vias envolvidas na modulação do desenvolvimento cognitivo e na doença de Parkinson, Alzheimer e esquizofrenia. A Síndrome de Down (SD) é a aneuploidia autossômica mais comum, afetando em média 1/660 recém-nascidos e representa cerca de 18% do total de deficientes intelectuais em instituições especializadas. Além do déficit cognitivo, é frequente a ocorrência de neuropatologias, como o Alzheimer, nos indivíduos com SD. Baseados nos dados descritos, nos perguntamos se a mutação Thr92Ala-D2 poderia contribuir com alterações nas funções cognitivas de indivíduos com SD. Para responder à essa pergunta, foi rastreada a presença do Thr92Ala-D2 em 29 crianças com SD, com idade entre 2 meses e 18 anos. O genótipo foi determinado pela técnica de PCR. O QI foi estimado em 15 participantes pelos instrumentos SON-R 2 ½ - 7 e WASI. A memória operacional foi avaliada em 11 participantes a partir do instrumento TIME e o comportamento adaptativo foi avaliado em 29 através do Questionário Vineland. A frequência encontrada para o genótipo foi de 20,69 % selvagem (T/T), 55,17 % heterozigotos (A/T) e 24,14% polimórficos (A/A) e é semelhante à encontrada na população. No comportamento adaptativo, foi encontrada diferença significativa entre o grupo polimórfico A/A e o selvagem T/T nos subdomínios Doméstico, Relações Interpessoais, Brincar e Lazer e nos domínios Social e Nível Adaptativo Global. Os valores de QI variaram entre 40 e 70 e na avaliação de memória operacional, 72,72% dos sujeitos tiveram desempenho considerado baixo. Não foi encontrada correlação entre a presença do polimorfismo e QI ou memória. Considera-se importante utilizar, em estudos futuros, uma amostra maior, com indivíduos jovens e adultos e comparar com indivíduos de desenvolvimento típico, visto que, neste estudo, se observou fortes indícios de que a presença do polimorfismo cause prejuízos nas funções cognitivas de indivíduos com SD.

Submitted by Angela Maria de Oliveira (amolivei@uepg.br) on 2018-11-30T15:35:07Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Vera Lucia.pdf: 1869711 bytes, checksum: 2d479947d8ac00d7251c231ea52c9c12 (MD5) / Made available in DSpace on 2018-11-30T15:35:07Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Vera Lucia.pdf: 1869711 bytes, checksum: 2d479947d8ac00d7251c231ea52c9c12 (MD5) Previous issue date: 2018-07-31 / Introdução: O atendimento odontológico do bebê apresenta características peculiares e requer tecnologias apropriadas. Objetivo: Validar um dispositivo inovador, em formato de avental, criado para acomodar o bebê durante as consultas, quanto à aceitação por parte dos pacientes e avaliar a ansiedade materna frente as diferentes tecnologias utilizadas. Método: Foi delineado ensaio clínico, autocontrolado e cego, a partir de modelo experimental cruzado com períodos de wash out. O dispositivo teste foi comparado a dois controles: Macri e o sistema joelho a joelho. Inventário de Ansiedade de Beck aplicado avaliou a ansiedade das mães antes e após os atendimentos com cada método proposto. Parâmetros de pressão arterial e batimentos cardíacos maternos foram obtidos nos dois momentos. O comportamento dos bebês foi aferido pela escala de Frankl. Resultado: A população alvo foram 66 pares de mães/bebês, entre zero e 24 meses, usuários da Atenção Primária à Saúde. O comportamento dos bebês durante as consultas foi predominantemente positivo e similar para os três métodos testados, com vantagem para dispositivo Avental. Este mostrou-se similar à Macri quanto aos níveis de ansiedade materna com maior redução da Pressão Arterial Diastólica e dos batimentos cardíacos das mães. E apresentou melhores resultados quanto à redução da ansiedade materna e dos batimentos cardíacos por minuto quando comparado com o sistema joelho a joelho. Conclusão: O dispositivo Avental mostrou-se adequado ao atendimento odontológico dos bebês, com resultados similares ou melhores do que os métodos classicamente utilizados. Estudos futuros são necessários para avaliar suas qualidades do ponto de vista do profissional. / Introduction: The dental care of the baby presents peculiar characteristics and requires appropriate technologies. Objective: Validate an innovative, apron-shaped device designed to accommodate the baby during consultations, patient acceptance, and maternal anxiety about different technologies used.. Method: A clinical, selfcontrolled and blind trial was drawn from an experimental cross-over model with washout periods. The test device was compared to two controls: Macri and the knee to knee system. Beck's Anxiety Inventory applied assessed the anxiety of the mothers before and after the visits with each proposed method. Parameters of blood pressure and maternal heart rate were obtained at both moments. The behavior of the babies was measured by the Frankl scale. Outcome: The target population was 66 pairs of mothers / infants, between zero and 24 months, users of Primary Health Care. The behavior of the babies during the consultations was predominantly positive and similar for the three methods tested, with advantage to the Apron device. This was similar to Macri in terms of maternal anxiety levels with a greater reduction in diastolic blood pressure and in mothers' heart rate. And it showed better results in reducing maternal anxiety and heart rate per minute compared to the knee-to-knee system. Conclusion: The Apron device was adequate for the dental care of the babies, with similar or better results than the classically used methods. Future studies are needed to assess their qualities from the professional's point of view. Introduction: The dental care of the baby presents peculiar characteristics and requires appropriate technologies. Objective: Validate an innovative, apron-shaped device designed to accommodate the baby during consultations, patient acceptance, and maternal anxiety about different technologies used.. Method: A clinical, selfcontrolled and blind trial was drawn from an experimental cross-over model with washout periods. The test device was compared to two controls: Macri and the knee to knee system. Beck's Anxiety Inventory applied assessed the anxiety of the mothers before and after the visits with each proposed method. Parameters of blood pressure and maternal heart rate were obtained at both moments. The behavior of the babies was measured by the Frankl scale. Outcome: The target population was 66 pairs of mothers / infants, between zero and 24 months, users of Primary Health Care. The behavior of the babies during the consultations was predominantly positive and similar for the three methods tested, with advantage to the Apron device. This was similar to Macri in terms of maternal anxiety levels with a greater reduction in diastolic blood pressure and in mothers' heart rate. And it showed better results in reducing maternal anxiety and heart rate per minute compared to the knee-to-knee system. Conclusion: The Apron device was adequate for the dental care of the babies, with similar or better results than the classically used methods. Future studies are needed to assess their qualities from the professional's point of view.