Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.

Intravascular brachytherapy is the primary treatment for coronary in-stent restenosis. We hypothesized that differences in dose delivered to target may contribute to treatment failures. We compared dose distribution between arteries that developed recurrent restenosis (treatment failures) and those that remained patent at nine-months (treatment success). A cohort of 207 patients receiving brachytherapy for coronary in-stent restenosis with four radiation delivery devices was followed to identify treatment failures and successes. This cohort was examined to establish which patient and lesion characteristics had an effect on outcome. A nested case-control construct was then used in which treatment failures (n=14) were compared 1:2 to treatment successes (n=28) matched by two variables: radiation delivery system and angiographic pattern of in-stent restenosis. At baseline, the groups had similar patient and lesion characteristics. The dose absorbed by 90% of the artery encompassed by the external elastic membrane (D90EEM) was calculated using intravascular ultrasound (IVUS) images taken at 2-mm intervals along the treated lesion. Dose calculations were performed using dose kernel integration techniques; the dose kernels were generated from Monte Carlo simulations. The mean D90EEM minimum dose in treatment failures was 7.46±1.98 Gy, while for treatment success the mean D90EEM minimum dose was significantly higher: 8.87±1.13 Gy (p=0.007). Using a dose threshold of 8.4 Gy, a D90EEM minimum dose < 8.4 Gy occurred in 13 (93%) patients with treatment failure, but in only 9 (32%) with treatment success (p<0.001). No confounding variables were found to be statistically significant. In conclusion, current brachytherapy dose prescriptions result in significant inter- and intra-lesion variation in dose at the EEM. Arteries that receive < 8.4 Gy at any point along the EEM are more likely to be treatment failures. IVUS guided dosimetry may be critical to assure adequate dose regardless of radiation delivery system.

Diss. (sammanfattning) Göteborg : Univ. , 2009. / Härtill 3 uppsatser.

Σκοπός της μελέτης είναι η διερεύνηση της επίπτωσης του γλαυκώματος και της στεφανιαίας νόσου (ΣΝ) σε ασθενείς με καταρράκτη και ψευδοαποφολιδωτικό (ΡΕΧ) σύνδρομο. Υλικό και μέθοδοι: Πρόκειται για μια cross-sectional μελέτη 2140 ασθενών που προσέρχονταν στο Πανεπιστημιακό Νοσοκομείο της Πάτρας για να χειρουργηθούν για καταρράκτη. Μόνο ασθενείς με καταρράκτη περιλαμβάνονται στη μελέτη. Σε όλους τους ασθενείς έγινε πλήρης οφθαλμολογικός έλεγχος, που περιελάμβανε εξέταση στη σχισμοειδή λυχνία, μετά από μυδρίαση, για ανεύρεση ΡΕΧ υλικού στο πρόσθιο ημιμόριο του οφθαλμού, μετρήσεις ενδοφθάλμιας πίεσης και έλεγχο της κοίλανσης του οπτικού νεύρου. Επίσης, στους ασθενείς έγινε εκτίμηση για ΣΝ από καρδιολόγο. Οι ασθενείς θεωρήθηκαν θετικοί για ΣΝ αν είχαν ιστορικό εμφράγματος του μυοκαρδίου, ή ισχαιμίας, ή παθολογική στεφανιογραφία. Οι ασθενείς ταξινομήθηκαν σε δύο ομάδες: σε αυτούς με ΡΕΧ υλικό και αυτούς χωρίς ΡΕΧ υλικό. Αποτελέσματα: 1088 ασθενείς (50,8%) ήταν άνδρες και 1052 (49,2%) γυναίκες. Η συνολική επίπτωση του ΡΕΧ συνδρόμου ήταν 27,9% και βρέθηκε να αυξάνει με την αύξηση της ηλικίας. Η αμφοτερόπλευρη μορφή ήταν συχνότερη από την ετερόπλευρη και επίσης βρέθηκε να αυξάνει με την ηλικία. Συνολικά 132 ασθενείς (22,1%) με ΡΕΧ σύνδρομο εμφάνιζαν γλαύκωμα, ενώ από τους ασθενείς χωρίς ΡΕΧ σύνδρομο μόνο 2,6%. Το ΡΕΧ σύνδρομο βρέθηκε επίσης να σχετίζεται θετικά με τη ΣΝ στα άτομα μετά τα 50 έτη. Δε βρέθηκε σχέση μεταξύ ΣΝ και γλαυκώματος. Συμπεράσματα: Το ΡΕΧ σύνδρομο αποτελεί κύριο παράγοντα κινδύνου για εμφάνιση γλαυκώματος και πιθανό παράγοντα κινδύνου για ΣΝ. Οι ασθενείς με ΡΕΧ σύνδρομο θα πρέπει να ενημερώνονται και να εξετάζονται συχνά, αφού ο κίνδυνος υπάρχει καθ’ όλη τη διάρκεια της ζωής τους. / Purpose: To investigate the prevalence of glaucoma and coronary artery disease (CAD) in patients with cataract and pseudoexfoliation (PEX) syndrome. Methods: Cross-sectional study of 2140 consecutive patients with cataract admitted at the University Hospital of Patras, Greece, for cataract surgery. Only patients with senile cataract were included in this study. All patients underwent a complete ophthalmological examination that included slit-lamp evaluation with dilated pupil for PEX material in the anterior segment, intraocular pressure (IOP) measurements and optic disc cup examination. They also underwent an evaluation for CAD by a cardiologist. CAD was considered present if a patient had a history of myocardial infarction, or ischaemia, or abnormal coronary angiography. The patients were classified into two groups: the PEX and the non-PEX group. Results: One thousand and eighty-eight (50.8%) patients were men and 1052 (49.2%) were women. The overall prevalence of PEX syndrome was found to be 27.9% and it was found to increase with progressing age. Bilateral PEX was more frequent than unilateral PEX, with the percentage of bilateral PEX raising with progressing age. A total of 132 patients (22.1%) in the PEX group exhibited glaucoma, while in the non-PEX group only 2.6% suffered glaucoma. PEX was also found to be positively associated with the risk for CAD among subjects 50 years or older. No association between CAD and glaucoma was found. Conclusions: PEX syndrome constitutes a major glaucoma risk factor and a probable CAD risk factor. Patients with PEX should be informed and examined frequently as the risk is present throughout.

No description available.

Thesis (M.D.)--University of Utrecht, 1984. / Foreword and summary in Dutch. Includes bibliographical references (p. 161-188).

Thesis (M.S.)--University of Wisconsin--Madison, 1982. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 68-71).

Original published work submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Medicine (Internal Medicine) 18 October, 2017. / The very first coronary artery balloon angioplasty is reported to have been performed by Gruntzig in 1977.1 Subsequently to this, over the past 40 years, there have been significant advances in coronary angiography and intervention. Coronary artery interventional techniques have evolved and improved significantly. There have been considerable device developments, new generation stents and novel antiplatelet therapy which have all proved to reduce the incidence of the primary periprocedural complications associated with percutaneous coronary intervention (PCI). [No abstract provided. Information taken from introduction] / LG2018

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 4 uppsatser.