Coronary Artery Bypass Graft(CABG) Surgery increases blood flow to the endangered myocardium but does not slow the process of atherosclerosis. The only way to slow the process of coronary artery disease is to acknowledge the risk factors present and minimize or totally eliminate them from an individual's lifestyle. Men and women respond differently to stress and lifestyle modifications. The purpose of this study was to determine if there was a difference between genders in compliance to a heart healthy lifestyle pre and post CABG surgery.Thirty men and thirty women who had CABG surgery at least one year earlier were interviewed to assess coronary artery disease risk. The procedure for the protection of human subjects were followed. The instrument used was the RISKO Heart Hazard Appraisal Tool. This instrument was developed in 1985 by the American Heart Association and scored individuals on systolic blood pressure, weight, serum cholesterol level and cigarette smoking habits. Pre-operative records were also reviewed using the same tool to assess individuals preoperative risk. The research design used was 2 x 2 repeated measures. Data were analyzed using 2 x 2 repeated measures analysis of variance (ANOVA).Two findings were discovered. First there was a statistically significant difference between men and women (F=5.82 p=0.019) with men scoring lower RISKO scores than women, indicating lower risk and better compliance to a heart healthy lifestyle, both pre- and postoperatively. Second there was a significant difference between preand postoperative RISKO scores in the total population (F=8.77 p=0.004). Postoperative RISKO scores were lower indicating an improvement in heart healthy lifestyle. There was no statistically significant difference between genders in the difference of pre- and postoperative RISKO scores (F=2.56 p<.115). The significance of this study was that it looked specifically at gender differences and assessed disparities in cardiovascular risk factors and the impact of surgery on men and women.This study found that overall, men had lower RISKO scores than women. Both genders also had improved RISKO scores postoperatively from preoperatively. No statistically significant difference between genders of the RISKO scores from preoperatively to postoperatively was found. Education needs to continue to play a big part in the cardiac rehabilitation process for both genders and specifically women need to become the target of further research and education to improve compliance to a heart healthy lifestyle. / School of Nursing

Access to abstract permanently restricted to Ball State community only / Access to thesis permanently restricted to Ball State community only / School of Physical Education, Sport, and Exercise Science

The prevalence of obesity has increased dramatically in the past decade. This foreshadows an increase in the rates of morbidity and mortality from obesity related diseases. The high prevalence of coronary heart disease (CHD) is a problem throughout the world as well as in South Africa The process of urbanisation of Africans from rural to urban areas is exposing the African population to Western lifestyles, with an increase in the incidence of CHD being reported. Research is more frequently proposing that obesity may be seen as a factor linking elevated C-reactive protein (CRP) concentrations and atherosclerosis. CRP is an acute phase reactant and a sensitive marker for acute and chronic inflammation of diverse causes. This poses the question of whether the increased risk of diabetes, CHD and many other chronic diseases in the obese might be explained by a state of chronic systemic inflammation. The purpose of this study was, therefore, firstly to determine whether there is an association between CRP concentrations and body composition in 19 to 60 year old black women. Partial Pearson correlations coefficients were used to determine associations between CRP and several body composition variables. Body mass index (BMI), waist circumference, percentage body fat and waist-hip-ratio (WHR) were all significantly correlated with CRP throughout the anthropometric spectrum. An analysis of variance (ANOVA) with a Games-Howell post hoc test was done to determine statistically significant differences among the different categories within each of the body composition variables. Significant differences (p < 0.05) were found within the categories of all the measured body composition variables, except for the various WHR categories. During a signal detection analysis, BMI was identified as the best predictor of increased CRP concentrations at a cut-off point of 27.68 kg/m2. The second purpose of this study was to assess the relationship of CRP to traditional cardiovascular risk factors in the study's population sample of 19 to 60 year old black women. Pearson correlation coefficients were used to analyse log-normalized CRP concentrations as the dependent variable in relation to several variables which form part of the traditional risk factors for CHD. All of the variables were significantly correlated with CRP at the level of p ≤ 0.05, except for total cholesterol and low-density lipoprotein cholesterol. BMI, percentage body fat and fibrinogen levels were associated with InCRP at a practically significant level of r ≥ 0.5. BMI and fibrinogen were also found to be independently associated with InCRP with p ≤ 0.05 during a forward stepwise multiple linear regression analysis. Within this study's population sample, it was found that those women who presented with six traditional risk factors had a three to five-fold increase in CRF' concentrations compared to women with three or less risk factors. Further research is required to determine appropriate intervention programmes which could prevent or reduce the incidence of CHD among the obese by means of weight-loss, therefore, potentially lowering elevated CRP concentrations. / Thesis (M.Sc. (Human Movement Science))--North-West University, Potchefstroom Campus, 2005.

Technological advances and mechanization have reduced physical activity levels. Lifestyle in general has become more and more physically inactive. This sedentary lifestyle can lead to the development of hypokinetic diseases which inter alia include risk factors for the development of coronary heart disease. The consequences are a variety of health risk factors that can contribute to heart disease, stroke and mortality. If left unattended, these risk factors can lead to ill health and reduced productivity. Ill health in the corporate sector can lead to presenteeism, absenteeism, high health care costs and reduced productivity. The purpose of this study was to analyze the profiles of physical activity- (PAI), health status- (HSI), lifestyle- (LSI) and coronary risk indexes (CRI) among employees in a financial institution in order to evaluate the impact of physical activity. The research sample includes 475 employees (159 male and 316 female) with a mean age of 35.8 ± 8.6 and 35.1 ± 8.5 for the male and female groups respectively, divided into three age groups ≤35, 36-45 and ≥ 46 years. Results indicated that the majority of the employees were physically inactive and falling in moderate to poor category in terms of health status, lifestyle habits and coronary heart disease risk. The lifestyle index of the older males (≥ 46) was significantly better than those of the younger males. Results also indicated that coronary heart disease risk, lifestyle and health status improve as physical activity levels improve. The lifestyle index of males and females were significantly better among the physical active group. The finding suggest the need for employers and employees to prevent hypokinetic disorders which can cause “presenteeism” which may result in reduced productivity and increased health care costs. The literature also indicate the need for companies to measure and keep track of the health risk profile of their staff, since employees can migrate between low, moderate and high risk categories annually. / Thesis (M.A. (Human Movement Science))--North-West University, Potchefstroom Campus, 2007.

Technological advances and mechanization have reduced physical activity levels. Lifestyle in general has become more and more physically inactive. This sedentary lifestyle can lead to the development of hypokinetic diseases which inter alia include risk factors for the development of coronary heart disease. The consequences are a variety of health risk factors that can contribute to heart disease, stroke and mortality. If left unattended, these risk factors can lead to ill health and reduced productivity. Ill health in the corporate sector can lead to presenteeism, absenteeism, high health care costs and reduced productivity. The purpose of this study was to analyze the profiles of physical activity- (PAI), health status- (HSI), lifestyle- (LSI) and coronary risk indexes (CRI) among employees in a financial institution in order to evaluate the impact of physical activity. The research sample includes 475 employees (159 male and 316 female) with a mean age of 35.8 ± 8.6 and 35.1 ± 8.5 for the male and female groups respectively, divided into three age groups ≤35, 36-45 and ≥ 46 years. Results indicated that the majority of the employees were physically inactive and falling in moderate to poor category in terms of health status, lifestyle habits and coronary heart disease risk. The lifestyle index of the older males (≥ 46) was significantly better than those of the younger males. Results also indicated that coronary heart disease risk, lifestyle and health status improve as physical activity levels improve. The lifestyle index of males and females were significantly better among the physical active group. The finding suggest the need for employers and employees to prevent hypokinetic disorders which can cause “presenteeism” which may result in reduced productivity and increased health care costs. The literature also indicate the need for companies to measure and keep track of the health risk profile of their staff, since employees can migrate between low, moderate and high risk categories annually. / Thesis (M.A. (Human Movement Science))--North-West University, Potchefstroom Campus, 2007.

Family history (FH) is a risk factor for many diseases. Disease guidelines often include family history as important in assessing chronic disease risks, but the empirical evidence base to inform the routine use of family history in primary care in practice appears largely lacking. An environmental scan of how family history is represented in prevention guidelines for five conditions showed that, while family history is often included in guidelines, there is variation in the definition used, recommendation given and evidence cited. A dataset on cardiovascular health in women was analyzed to examine whether family history offers useful discrimination value above standard risk factors. Regression results showed that family history is an independent risk predictor for coronary heart disease which improves discrimination beyond classical clinical factors. However, the absolute amount of discriminatory ability alone or with other factors is moderate at best, raising issues regarding clinical utility.

Includes addendum and corrections (leaves 390-402) / Bibliography: leaves 333-389. / xv, 402 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Analyses the effects of N-acetylcysteine (NAC) alone and in combination with glyceryl trinitrate (GTN) on three models of myocardial ischaemia and reperfusion. A sensitive and specific assay for malondialdehyde (MDA) in plasma was developed in order to assess the extent of oxidative stress in this series of studies. / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1996

Bibliography: leaves 257-286 / xiii, 286 leaves : ill ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 1992

Coronary heart disease (CHD) is the single largest cause of death in Australia. Lack of physical activity is a primary risk factor for CHD. The thesis aimed to quantify the efficacy of walking in reducing CHD risk. Meta-analyses were performed for the quantification with the application of random-effect meta-regression models. The thesis also aimed to quantify reductions in CHD-related direct healthcare costs, productivity loss and disease burden resulting from walking interventions in Australia, using the population attributable fraction model, the work and leisure models, and the consumer surplus model. Economic evaluations were also conducted to estimate CHD-related productivity loss using the human capital and the friction methods. The results indicated that 30 minutes of normal walking a day for 5-7 days a week compared to physical inactivity reduced CHD risk by 24%. There existed a dose-response relationship between walking and CHD risk reduction. An increment of approximately 30 minutes of normal walking a day for 5 days a week reduced CHD risk by 19%. The annual productivity loss resulting from CHD was estimated at AU$1.79 billion based on the human capital method and AU$25.05 million under the friction method. 30 minutes of normal walking a day for 5-7 days a week by the country???s ???sufficient??? walking population was shown to generate an estimated $126.73 million in net direct healthcare savings annually. The net economic savings could increase to AU$419.9 million if the whole inactive population engaged in ???sufficient??? walking. The study also found that 30 minutes of normal walking a day for 5-7 days a week reduced the burden of CHD by an estimated 25,065 DALYs and the productivity loss by AU$162.65 million annually under the leisure model. If the whole inactive population engaged in such walking, the total disease burden and productivity loss could be reduced by approximately one third. The findings present epidemiological and economic evidence in support of the national physical activity guidelines, which encourage the general public to engage in moderate physical activity including walking for a minimum of 30 minutes a day for 5-7 days a week.

Thesis (Ph. D.)--University of Hong Kong, 2008. / Also available in print.