: Este trabalho tem como objeto o redirecionamento na política externa (RPE) - conceituado como as mudanças mais radicais, abrangentes e rápidas em política externa. Para analisar este fenômeno, são buscadas as principais condições conjunturais que podem aumentar a chance de ocorrência deste evento. Estas condições estão relacionadas ao conceito de Janela Política, que representa o período em que é rompida a inércia política e os tomadores de decisões têm condições de iniciar um processo de RPE. Objetivo: encontrar e delimitar quais as condições conjunturais que aumentam as chances de ocorrência de um RPE. Método: são utilizadas ferramentas metodológicas qualitativas e quantitativas. No segundo capítulo, a análise é feita por meio de um modelo de sobrevivência (Cox Proportional Hazard Model) que analisa o efeito das variáveis sobre os riscos de ocorrência do evento em foco, definido como as alterações mais extremas de comportamento nas votações da Assembleia Geral das Nações Unidas. No terceiro capítulo, é desenvolvida uma análise qualitativa histórica focando especificamente nos casos mais radicais de RPE, buscando identificar padrões comuns no desencadeamento dos processos em estudo; com base nestes casos, são desenvolvidas tipologias explicativas para identificar diferentes caminhos causais que levam ao evento em tela. Resultados: foi identificado que mudanças de regime e de líder político, no âmbito doméstico, e intervenções militares de potências estrangeiras aumentam os riscos de ocorrência de RPE; adicionalmente, a alta polarização política e a mudança de regime, a crise política doméstica com envolvimento de atores internacionais, os processos de isolamento internacional com imposição de sanções econômicas e os períodos de crise econômica com questionamento do modelo econômico vigente por parte dos atores políticos podem combinadamente levar à ocorrência de RPE. Conclusões: apesar da importância do interesses de atores políticos em empreender um projeto de RPE, foi identificado que determinados eventos aumentam os riscos deste processo ocorrer. / This thesis object is the foreign policy restructuring (FPR) - conceptualized as the most radical, encompassing, and fast changes in foreign policy. To analyze this phenomenon, there will be sought the main conjuncture conditions that might enhance the chances of this event occurrence. These conditions are related to the Policy Window concept, that represents a period during which the political inertia is disrupted and decision makers have the circumstances to undertake a FPR process. Objective: find and outline the conjectural conditions and variables that increase the chances of occurrence of a FPR. Methods: it will be used qualitative and quantitative methodological tools. In the second chapter, a survival model (Cox Proportional Hazard Model) analyses the effect variables related to the Policy Window concept over the risks of happening a FPR, defined as the most extreme changes of behavior in United Nations General Assembly roll-call votes. In the third chapter, a historical qualitative analysis is undertaken focusing exclusively on the most radical cases of FPR to develop explanatory typologies in order to identify causal conjunctures and common patters that lead to the outcome. Results: we identified that regime and political leader changes, in the national context, and military interventions by foreign powers enhance the risks of FPR occurrence; additionally, high political polarization combined with regime change, political crisis with international forces involvement, processes of international isolation with economic sanctions enforcement, and economic crises with political actors questioning the current economic model might be combined, configuring causal paths to a FPR. Conclusion: despite the importance of main political actors interest in implementing a FPR process, we identified that specific conjunctures and events raise the risks of a positive outcome.

Migrationsverket är en myndighet som prövar ansökningar från personer som vill söka skydd, ha medborgarskap, studera eller vill jobba i Sverige. Då det på senare tid varit en stor ökning i dessa ansökningar har tiden för vilket ett beslut tar ökat. Varje typ av ansökning (exempelvis medborgarskap) är en process som består av flera steg. Hur beslutet går igenom dessa steg kallas för flöde. Migrationsverket vill därför öka sin flödeseffektivitet. När beslutet är klart och personen tagit del av det men inte är nöjd kan denne överklaga. Detta är en av de mest komplexa processerna på Migrationsverket. Syftet är analysera hur lång tid denna process tar och vilka steg i processen som påverkar tiden. Ett steg (som senare visar sig ha en stor effekt på tiden) är yttranden. Det är när domstolen begär information om vad personen som överklagar har att säga om varför denne överklagar. För att analysera detta var två metoder relevanta, accelerated failure time (AFT) och \multi-state models (MSM). Den ena kan predicera tid till händelse (AFT) medan den andra kan analysera effekten av tidspåverkan (MSM) i stegen. Yttranden tidigt i processen har stor betydelse för hur snabbt en överklagan får en dom samtidigt som att antal yttranden ökar tiden enormt. Det finns andra faktorer som påverkar tiden men inte i så stor grad som yttranden. Då yttranden tidigt i processen samtidigt som antal yttranden har betydelse kan flödeseffektiviteten ökas med att ta tid på sig att skriva ett informativt yttrande som gör att domstolen inte behöver begära flera yttranden. / The Swedish Migration Board is an agency that review applications from individuals who wish to seek shelter, have citizenship, study or want to work in Sweden. In recent time there has been a large increase in applications and the time for which a decision is made has increased. Each type of application (such as citizenship) is a process consisting of several stages. How the decision is going through these steps is called flow. The Swedish Migration Board would therefore like to increase their flow efficiency. When the decision is made and the person has take part of it but is not satisfied, he can appeal. This is one of the most complex processes at the Board. The aim is to analyze how long this process will take and what steps in the process affects the time. One step (which was later found to have a significant effect on time) is opinions. This is when the court requests information on what the person is appealing has to say about why he is appealing. To analyze this, two methods were relevant, accelerated failure time (AFT) and the multi-state models (MSM). One can predict time to event (AFT), the other to analyze the effect of time-manipulation (MSM) in the flow. Opinions early in the process is crucial to how quickly an appeal get judgment while the number of opinions increases the time enormously. There are other factors that affect the time but not so much as opinions. The flow efficiency can be increased by taking time to write an informative opinion which allows the court need not to ask for more opinions.

: Este trabalho tem como objeto o redirecionamento na política externa (RPE) - conceituado como as mudanças mais radicais, abrangentes e rápidas em política externa. Para analisar este fenômeno, são buscadas as principais condições conjunturais que podem aumentar a chance de ocorrência deste evento. Estas condições estão relacionadas ao conceito de Janela Política, que representa o período em que é rompida a inércia política e os tomadores de decisões têm condições de iniciar um processo de RPE. Objetivo: encontrar e delimitar quais as condições conjunturais que aumentam as chances de ocorrência de um RPE. Método: são utilizadas ferramentas metodológicas qualitativas e quantitativas. No segundo capítulo, a análise é feita por meio de um modelo de sobrevivência (Cox Proportional Hazard Model) que analisa o efeito das variáveis sobre os riscos de ocorrência do evento em foco, definido como as alterações mais extremas de comportamento nas votações da Assembleia Geral das Nações Unidas. No terceiro capítulo, é desenvolvida uma análise qualitativa histórica focando especificamente nos casos mais radicais de RPE, buscando identificar padrões comuns no desencadeamento dos processos em estudo; com base nestes casos, são desenvolvidas tipologias explicativas para identificar diferentes caminhos causais que levam ao evento em tela. Resultados: foi identificado que mudanças de regime e de líder político, no âmbito doméstico, e intervenções militares de potências estrangeiras aumentam os riscos de ocorrência de RPE; adicionalmente, a alta polarização política e a mudança de regime, a crise política doméstica com envolvimento de atores internacionais, os processos de isolamento internacional com imposição de sanções econômicas e os períodos de crise econômica com questionamento do modelo econômico vigente por parte dos atores políticos podem combinadamente levar à ocorrência de RPE. Conclusões: apesar da importância do interesses de atores políticos em empreender um projeto de RPE, foi identificado que determinados eventos aumentam os riscos deste processo ocorrer. / This thesis object is the foreign policy restructuring (FPR) - conceptualized as the most radical, encompassing, and fast changes in foreign policy. To analyze this phenomenon, there will be sought the main conjuncture conditions that might enhance the chances of this event occurrence. These conditions are related to the Policy Window concept, that represents a period during which the political inertia is disrupted and decision makers have the circumstances to undertake a FPR process. Objective: find and outline the conjectural conditions and variables that increase the chances of occurrence of a FPR. Methods: it will be used qualitative and quantitative methodological tools. In the second chapter, a survival model (Cox Proportional Hazard Model) analyses the effect variables related to the Policy Window concept over the risks of happening a FPR, defined as the most extreme changes of behavior in United Nations General Assembly roll-call votes. In the third chapter, a historical qualitative analysis is undertaken focusing exclusively on the most radical cases of FPR to develop explanatory typologies in order to identify causal conjunctures and common patters that lead to the outcome. Results: we identified that regime and political leader changes, in the national context, and military interventions by foreign powers enhance the risks of FPR occurrence; additionally, high political polarization combined with regime change, political crisis with international forces involvement, processes of international isolation with economic sanctions enforcement, and economic crises with political actors questioning the current economic model might be combined, configuring causal paths to a FPR. Conclusion: despite the importance of main political actors interest in implementing a FPR process, we identified that specific conjunctures and events raise the risks of a positive outcome.

以往重複事件分析法主要用於醫學與科學領域，近來學者逐漸將其應用至經濟、商學、社會科學等領域，本篇論文採用重複事件分析法，分析S&P 500公司股票回購的行為，回顧過去學者對股票回購之研究，我們檢視公司執行股票回購的三大原因，根據我們的實證結果發現公司可能會以股票回購作為影響公司資本結構的工具，再者亦可能用以減低剩餘資金，然而，本篇論文的實證結果較不支持訊號發射理論。 / In this study, we apply Cox proportional hazard model in recurrent event analysis, which usually used in medical and science studies, to analyze the determinants of the stock repurchase events of S&P 500 companies. We investigate three main incentives that companies conduct stock repurchase. The empirical results show that companies employ repurchase as a technique to alter capital structure. In addition, companies conduct stock repurchase to distribute excess capital. In contrast, there are little evidences to support signaling undervaluation.

Studies of predator-prey and predator-predator interactions are needed to provide information for decision-making processes in land management agencies. Mountain lions (Puma concolor) are opportunistic carnivores that prey on a wide variety of species. In the Sierra National Forest, CA, they have not been studied since 1987 and their current interactions with their prey and other predators are unknown. Forest managers in this region are concerned with declines of fishers (Pekania pennanti) and studies have shown intraguild predation to be a leading cause of fisher mortality in this area. Managers are interested in learning more about mountain lion predation patterns with regard to prey preference, but also how lions traverse and use the landscape and how anthropogenic activities may be increasing lion predation risk on fishers. Using GPS radio-collar technology, we examined mountain lion kill rates and prey composition at 250 kill sites. We found mule deer (Odocoileus hemionus) to be their main source of prey (81%) with gray foxes (Urocyon cinereoargenteus) comprising 13.2% of prey composition. We did not detect any fisher predation during our 2-year study; however, during our study, the Kings River Fisher Project experienced extremely low juvenile fisher survival. To gain a better understanding of seasonal resource selection by mountain lions, we developed resource selection functions (RSF) while they were moving through the landscape and when killing prey. We developed RSF models for all data across the study area, as well as, for a subset of data encompassing an area where LiDAR (Light Detection and Ranging) data had been collected. Within the LiDAR study area, we digitized unmapped roads and skid trails using a Bare Earth data set. We found mountain lion ‘moving’ locations showed selection for close proximity to streams during summer months and selection for ruggedness and steeper slopes during both summer and winter. With 3 of the 4 RSF models at kill sites showing high risk of predation within close proximity to either digitized roads/skid trails or mapped roads, we recommend managers map all anthropogenically created linear landscape features and consider restoring these linear features to pre-treatment landscape conditions following timber harvest.

In this paper, we estimate the parameters $S_0(t)$ and $ eta$ in Cox proportional hazard model when data are all interval-censored. For the application of this model, data should be either exact or right-censored, therefore we transform interval-censored data into exact data by three di®erent methods and then apply Nelson-Aalen estimate to obtain $S_0(t)$ and $ eta$. The test statistic $hat{ eta}^2I(hat{ eta})$ is not approximately distributed as $chi^2_{(1)}$ but $chi^2_{(1)}$ times a constant c.

No description available.

The advancement in data acquiring technology continues to see survival data sets with many covariates. This has posed a new challenge for researchers in identifying important covariates for inference and prediction for a time-to-event response variable. In this dissertation, common Cox proportional hazards model selection techniques and a random survival forest technique were compared using five performance criteria measures. These performance measures were concordance index, integrated area under the curve, and , and R2 . To carry out this exercise, a multicentre clinical trial data set was used. A simulation study was also implemented for this comparison. To develop a Cox proportional model, a training dataset of 75% of the observations was used and the model selection techniques were implemented to select covariates. Full Cox PH models containing all covariates were also incorporated for analysis for both the clinical trial data set and simulations. The clinical trial data set showed that the full model and forward selection technique performed better with the performance metrics employed, though they do not reduce the complexity of the model as much as the Lasso technique does. The simulation studies also showed that the full model performed better than the other techniques, with the Lasso technique overpenalising the model from the simulation with the smaller data set and many covariates. AIC and BIC were less effective in computation than the rest of the variable selection techniques, but effectively reduced model complexity than their counterparts for the simulations. The integrated area under the curve was the performance metric of choice for choosing the final model for analysis on the real data set. This performance metric gave more efficient outcomes unlike the other metrics on all selection techniques. This dissertation hence showed that variable selection techniques differ according to the study design of the research as well as the performance measure used. Hence, to have a good model, it is important to not use a model selection technique in isolation. There is therefore need for further research and publish techniques that work generally well for different study designs to make the process shorter for most researchers.

Indiana University-Purdue University Indianapolis (IUPUI) / Background: Tobacco use is associated with an increased risk of developing Alzheimer's disease (AD). 14% of the incidence of AD is associated with various types of tobacco exposure. Additional real-world evidence is warranted to reveal the association between tobacco use and AD in age/gender-specific subpopulations. Method: In this thesis, the relationships between diagnoses related to tobacco use and diagnoses of AD in gender- and age-specific subgroups were investigated, using health information exchange data. The non-parametric Kaplan-Meier method was used to estimate the incidence of AD. Furthermore, the log-rank test was used to compare incidence between individuals with and without tobacco related diagnoses. In addition, we used semi-parametric Cox models to examine the association between tobacco related diagnoses and diagnoses of AD, while adjusting covariates. Results: Tobacco related diagnosis was associated with increased risk of developing AD comparing to no tobacco related diagnosis among individuals aged 60-74 years (female hazard ratio [HR] =1.26, 95% confidence interval [CI]: 1.07 – 1.48, p-value = 0.005; and male HR =1.33, 95% CI: 1.10 - 1.62, p-value =0.004). Tobacco related diagnosis was associated with decreased risk of developing AD comparing to no tobacco related diagnosis among individuals aged 75-100 years (female HR =0.79, 95% CI: 0.70 - 0.89, p-value =0.001; and male HR =0.90, 95% CI: 0.82 - 0.99, p-value =0.023). Conclusion: Individuals with tobacco related diagnoses were associated with an increased risk of developing AD in older adults aged 60-75 years. Among older adults aged 75-100 years, individuals with tobacco related diagnoses were associated with a decreased risk of developing AD.

Indiana University-Purdue University Indianapolis (IUPUI) / The counting process is the fundamental of many real-world problems with event data. Poisson process, used as the background intensity of Hawkes process, is the most commonly used point process. The Hawkes process, a self-exciting point process fits to temporal event data, spatial-temporal event data, and event data with covariates. We study the Hawkes process that fits to heterogeneous drug overdose data via a novel semi-parametric approach. The counting process is also related to survival data based on the fact that they both study the occurrences of events over time. We fit a Cox model to temporal event data with a large corpus that is processed into high dimensional covariates. We study the significant features that influence the intensity of events.