Purpose – The purpose of this paper is to examine and understand the role played by top management towards aligning an organization’s culture to achieve effective internal controls, particularly for organizations operating in emerging economies prone to corruption. Methodology – The study applies both the empirical research approach and the theoretical research approach to examine and understand the major concepts of organisational culture, effectiveness of internal controls and the role played by top management to align the organisation’s culture to achieve effective internal controls. The empirical approach employs qualitative methods to collect data and the research findings are analysed using the deductive approach. A case study of URA is used to collect primary data through the use of a questionnaire.  Findings – The study considers the role of top management in the context of the organization’s culture orientation and based on a hierarchical organizational culture background illustrated by the case study, the study concludes that managers in such an organizational culture orientation, play an influential role towards aligning an organization’s culture to achieve the desired “internal control” objective. Research limitations – There was limited time within which to conduct the research which limited the sample size for data collection. It was a huge gamble to determine the effectiveness of internal controls based on an organisation operating in an emerging corrupt economy since there is a chance that internal controls in such organisations are superficial in nature and may not be implemented in practice. Little research has been done on the concepts of organisational culture and effectiveness of internal control systems in emerging economies which limited extensive review of relevant research literature on the research problem. Research contribution – The research contributes additional literature on organizational culture in emerging economies since very little has been done in this area. The research provides practical recommendations on how top management can positively influence an organizational culture to aid the achievement of successful internal controls particularly for organizations operating in East Africa.

Human norovirus (HuNoV) is the leading cause of gastroenteritis worldwide. Despite the significant disease and economic burden, currently there are no licensed vaccines or antivirals. The understanding of norovirus biology has been hampered by the inability to cultivate HuNoV in cell culture. To establish a tissue culture system, infectious HuNoVs were purified from clinical stool samples. HuNoV replication was tested in different cell types. The B-cell and intestinal organoids culture systems were validated. In addition, using organoids culture a DNA-based reverse genetic system was shown to recover infectious HuNoV. Due to the challenges associated with cultivating HuNoV, murine norovirus (MNV) was used as a surrogate system to understand the role of eIF4E phosphorylation in norovirus pathogenesis, and VP1-RdRp interaction in regulating viral genome replication. MNV infection results in the phosphorylation of the translation initiation factor eIF4E, re-programming host-cell translation during infection. Inhibiting eIF4E phosphorylation reduces MNV replication in cell culture suggesting a role in viral replication. A mouse model with eIF4E S209A, a phosphor-ablative mutation, was established to understand the role of eIF4E phosphorylation in MNV pathogenesis. In vitro and in vivo characterisations demonstrated that eIF4E phosphorylation may have multiple roles in norovirus-host interactions, but overall has little impact on MNV pathogenesis. The shell domain (SD) of norovirus major capsid protein VP1 interacts with viral RNA-dependent RNA polymerase (RdRp) in a genogroup-specific manner to enhance de novo initiation of RdRp, and to promote negative-strand RNA synthesis. To understand how VP1 regulates norovirus genome replication, chimeric MNVs with genogroup-specific residues mutagenised were characterised in vitro and in vivo. A single amino acid mutation was shown to destabilise viral capsid. SDs with reduced VP1-RdRp interaction showed less capacity to stimulate RdRp, resulting in delayed virus replication. In vivo, the replication of an MNV-3 with homologous mutations was abolished, highlighting the crucial role of this interaction.

This thesis is a re-evaluation of a movement founded to provide what Samuel Smiles called “the road to learning” for workers in the nineteenth century. Mechanics’ institutes emerged during the 1820s to both criticism and acclaim, becoming part of the physical and intellectual fabric of the age and inspiring a nationwide building programme funded entirely by public subscription. Beginning with a handful of examples in major British cities, they eventually spread across the Anglophone world. They were at the forefront of public engagement with arts, science and technology. This thesis is a history of the mechanics’ institute movement in the British Isles from the 1820s through to the late 1860s, when State involvement in areas previously dominated by private enterprises such as mechanics’ institutes, for example library provision and elementary schooling, became more pronounced. The existing historiography on mechanics’ institutes is primarily regional in scope and this thesis breaks new ground by synthesising a national perspective on their wider social, political and cultural histories. It contributes to these broader themes, as well as areas as diverse as educational history, the history of public exhibition and public spaces, visual culture, print culture, popular literacy and literature (including literature generated by the Institutes themselves, such as poetry and prose composed by members), financial services, education in cultural and aesthetic judgement, Institutes as sources of protest by means of Parliamentary petitions, economic history, and the nature, theory and practice of the popular dissemination of ideas. These advances free the thesis from ongoing debate around the success or failure of mechanics’ institutes, allowing the emphasis to be on the experiential history of the “living” Institute. The diverse source base for the thesis includes art, sculpture, poetry and memoir alongside such things as economic data, library loan statistics, membership numbers and profit / loss accounts from institute reports. The methodology therefore incorporates qualitative (for example, tracing the evolution of attitudes towards Institutes in contemporary culture by analysing the language used to describe them over time) and quantitative (for example, exploring Institutes as providers of financial services to working people) techniques. For the first time, mechanics’ institutes are studied in relation to political corruption, debates concerning the morality of literature and literacy during the nineteenth century, and the legislative processes of the period.

La circulation des normes juridiques est un phénomène étudié par un courant international de recherche nommé policy transfer 
studies qui s'intéresse néanmoins peu aux normes pénales. Pourtant, les processus de globalisation ont rendu la circulation de ces normes plus rapide, plus intense et plus complexe durant les dernières décennies. A partir de trois études de cas, notre travail montre comment la circulation des normes pénales est largement influencée par l’harmonisation européenne, par la diffusion de l’idéologie néolibérale ayant accompagné un tournant punitif dans les politiques criminelles de la plupart des pays européens ainsi que par l’émergence de crimes transnationaux qui exigent des solutions similaires. Nous caractérisons les limites de ces convergences et les analysons dans plusieurs cadres théoriques empruntés à la sociologie de la déviance afin de comprendre ce qu'elles impliquent pour ceux qui veulent comprendre le processus législatif au niveau national / The circulation of legal norms is a phenomenon studied by an international research current named policy transfer studies which has however little interest in criminal norms. Nevertheless, during the last several decades, the globalization processes have made the circulation of these norms faster, more intense and more complex. Based on three case studies, our work shows how the circulation of criminal norms is widely influenced by European harmonization processes, by the diffusion of the neoliberal ideology that accompanied a punitive turn in the criminal policies of most European countries and by the emergence of transnational crimes that require similar solutions. We will characterize the limits of these convergences and analyze them in several theoretical frameworks borrowed from the sociology of deviance in order to understand their implications for those who want to grasp the legislative process on the national level