Thesis (Ph. D.)--University of Wisconsin, 1967. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Mémoire (M.A.)--Université du Québec à Trois-Rivières, 2004. / Bibliogr.: f. 150-153. Également disponible en format microfiche et PDF.

La vitamine D (D3 ou cholécalciférol du règne animal et D2 ou ergostérol du règne végétal) est une hormone pléiotrope qui possède de nombreux effets biologiques incluant la régulation du métabolisme du calcium et du phosphate. Chez l’Homme, ce composé est synthétisé au niveau cutané sous forme inactive. On décrit ainsi le métabolisme de la vitamine D qui conduit à la production de métabolites actifs (par les vitamine D 25- et 1α-hydroxylases codées par les gènes CYP2R1 et CYP27B1) et à leur dégradation par la vitamine D 24-hydroxylase (gène CYP24A1). L’expression des vitamine 1α- et 24-hydroxylases est finement et inversement régulée afin de maintenir l’homéostasie phosphocalcique, grâce à plusieurs boucles de rétrocontrôle impliquant entre autres la forme 1,25-dihydroxylée de la vitamine D et son récepteur VDR, la calcémie et la parathormone, la phosphatémie et le FGF23. La carence en vitamine D et les défauts de son activation sont associés à un phénotype de rachitisme, tandis que les excès en vitamine D sont associés à un phénotype d’hypercalcémie-hypercalciurie par intoxication (surdosage) ou hypersensibilité à la vitamine D (excès d’activation ou défaut de dégradation).L’objectif de ce travail de thèse est d’identifier des causes génétiques de dérégulation du métabolisme de la vitamine D et de préciser leurs mécanismes physiopathologiques par une description précise du phénotype associé. Pour ce faire, nous avons utilisé de façon conjointe les outils de la génétique (séquençage nouvelle génération et Sanger) et de la biochimie (dosage des métabolites) dans une cohorte de patients recrutés grâce au centre de référence maladies rares du métabolisme du calcium et du phosphate.Ce travail a permis de préciser le rôle de deux gènes dans les maladies liées à la dérégulation métabolisme de la vitamine D, CYP2R1 et CYP24A1, par la mise en évidence de mutations perte de fonction chez des patients avec un phénotype de rachitisme à 25-hydroxyvitamine D basse et d’hypersensibilité à la vitamine D respectivement. Notre étude a permis aussi de préciser le phénotype de ces affections. Dans la cohorte des patients étudiés, l’identification de mutations de gènes impactant le métabolisme du phosphate (SLC34A1 et SLC34A3), souligne l’intérêt de l’étude des facteurs régulateurs des activités vitamine D 1α- et 24-hydroxylases.Aucune variation significative dans les régions promotrices proximales de CYP27B1 et CYP24A1 n’a été identifiée. Le peu de connaissances sur l’ensemble des éléments régulateurs chez l’Homme n’a pas permis d’approfondir notre étude. L’identification et l’étude de ces éléments régulateurs distaux permettra de déterminer leur implication dans les maladies rares du métabolisme de la vitamine D. / The vitamin D (D3 or cholecalciferol from animal kingdom and D2 or ergosterol from plan kingdom) is a pleiotropic hormone who has numerous biological effects including the regulation of calcium and phosphate metabolism. In humans, this compound is synthetized in skin in an inactive form. Thus, we call vitamin D metabolism the biological process which leads to the production of active metabolites (by enzymes 25- and 1α-hydroxylases encoded by CYP2R1 and CYP27B1 genes) and its degradation by vitamin D 24-hydroxylase (gene CYP24A1). The expression of 1α- and 24-hydroxylases is tightly and inversely regulated to maintain calcium and phosphate homeostasis, thanks to several feedback loops including 1,25-dihydroxyvitamin D and its receptor VDR, serum calcium and parathormone, serum phosphate and FGF23. Vitamin D deficiency and vitamin D activation deficiency are associated with rickets, while vitamin D excess are associated with hypercalcemia-hypercalciuria due to vitamin D intoxication (overdose) or hypersensitivity to vitamin D (activation excess or degradation deficiency).Our aim is to identify genetic causes of vitamin D metabolism deregulation and to specify pathophysiologic mechanisms describing phenotype. Thus, we jointly used the tools of genetics (next-generation and Sanger sequencing) and biochemistry (vitamin D metabolites assay) in a cohort of human patients ascertained thanks to the national center for rare diseases of calcium and phosphate metabolism.This work allowed us to specify the role of two genes in diseases of vitamin D metabolism, CYP2R1 and CYP24A1, showing loss of function mutations in patients with rickets and low 25-hydroxyvitamin D and hypersensitivity to vitamin D, respectively. Our study brought new phenotypic elements in these affections. In our cohort of patients, the identification of mutations leading to phosphate deregulation (in SLC34A1 and SLC34A3) highlights the putative role of regulators of vitamin D 1α- and 24-hydroxylases activities in pathophysiology.No significant variation have been identified in the proximal promoting regions of CYP27B1 and CYP24A1. We could not go further considering the lack of knowledge in regulating regions and factors in humans. Identifying distal regulators will allow to study their implication in rare diseases of vitamin D metabolism.

The Co-operative Party, despite representing the largest consumer and social movement in Britain, is systematically overlooked or misunderstood in twentieth century British political historiography. What makes this neglect more surprising is that from 1927 the Co-operative Party had a formal electoral agreement with the Labour Party, the basis of which remains in place today. Through this agreement the two parties agreed to work together to return joint Co-operative-Labour candidates in certain constituencies. This unique political alliance reflected a shared ideological ground between the two parties, united in their aim to displace capitalism with common ownership. However, despite this common aim, the methods through which this would be achieved varied and whilst the Labour Party focused on state ownership as key to the ‘socialist commonwealth’, the Co-operative Party, as the political arm of theco-operative movement embodied the ideal of a‘co-operative commonwealth’ built on the principles of democratic voluntary association. Historians who have addressed the relationship between the Labour Party and the co-operative movement have argued that co-operative methods of ownership were systematically marginalised, overlooked and ignored by the Labour Party, particularly during the 1945 to 1951 period of Labour Government. In this context, this thesis will examine the political relationship between the Co-operative Party and the Labour Party in the broader period from 1931 to 1951. It will argue that both organisational and ideological factors contributed to the invisibility of co-operative methods of ownership in the policies of the Labour Party. Moreover, this will provide an additional perspective to debates regarding the development of the Labour Party during the 1930s and over the future direction of nationalisation post 1945. Despite its marginality the Co-operative Party represented a large body of working class consumers and a significant business organisation, which straddled both the labour movement and co-operative movement. Whilst this thesis agrees that co-operative ideas of ownership remained a minor influence on the Labour Party throughout this period, it will nevertheless argue that Co-operative Party contributions to policy discussions provide an alternative perspective from which a growing recognition of the diversity of influences on the Labour Party can be explored. In doing so this thesis will also provide an original interpretation of the organisational and policy history of the Co-operative Party. This will highlight tensions not only with the Labour Party, but also within the co-operative movement with regards to the function and purpose of the Co-operative Party - and more significantly the role of the co-operative movement in a socialist society.

This study sets out to investigate the nature of the Victorian child's standing in society using pictorial means. It takes the view that the picture, or visual image, has something important to tell us about attitudes towards childhood, and how children were regarded as a group, between 1869 and 1908. As a piece of scholarship, it is situated between the disciplines of art history and social history. Little work has been done on the child's visual representation, and its contribution to the historical record. The rich visual material that forms part of the archive of Victorian philanthropy in general, and temperance in particular, remains largely untapped. The study is a response to this scholarly neglect, with the uses made by charity of the pictured child forming its central site of inquiry. Philanthropic images of childhood will be set in their pictorial context by reference to their appearance in other parts of the public domain. The history of the relationship between adults and children has been called `age relations' by one historian. This study will apply general and specific practical approaches, drawn from critical visual techniques, to age relations, leading to an interpretation of how Victorian childhood was pictured for its audiences. Images will be approached as pictorial puzzles, and priority will be given to those solutions which formed part of the historical record. The main analytical tool to be used is adopted from critical theory's notion of the metapicture. This acknowledges the capacity of the visual image to tell us about itself when viewed in relation to other images. It will be combined with established art historical approaches to the picture. The study discusses the range of contemporaneous meanings assigned to the picturing of childhood, and how the relationship between some of these meanings held significant implications for children's social standing. Its sustained approach to visual interpretation can be said to uncover the extent to which conflicting expectations were placed upon children by the sacrifice of the real to the ideal in adult notions of childhood.

A single industry town and an important munitions centre, Barrow-in-Furness experienced the full force of industrial mobilisation, government intervention, and mass unemployment in the years between 1914 and 1926. In analysing the responses to these events, the thesis will give insights into their impact on a town dependent on industries stimulated by war and crippled in the post-war economic climate. The study comprises of two interrelated components. The first section establishes the socio-economic context at the outbreak of the war and examines the influence of war and depression on the occupational and social structure of the town, together with health trends and housing conditions. In doing so, the thesis will analyse the dual effects of higher wartime earnings and long term mass unemployment on popular health, and the role of housing reform in maintaining social stability. Having established the context in which ideology and social attitudes developed, the second section will interpret the impact of war and depression in terms of the pressures placed on industry, the local authority and the wider population. This section will address three key themes, beginning with an examination of the divisive impact of leftwing ideology on the Labour Party, political allegiances and the composition of local authority bodies. Moving on, the study will assess the implications of these developments for local authority policy and the material well-being of the unemployed, giving particular attention to the distinctive response of Barrow's Board of Guardians and the application of the Poor Law. Thirdly the thesis examines the strategies adopted by the wider community to meet the demands of the depression, beginning with key local organisations, but focussing closely on methods of working class self-sufficiency. The thesis will conclude by addressing three important questions which emerge from this study. Firstly, drawing the various themes together, the thesis will analyse the impact of war and depression on social perceptions and levels of social antagonism. In demonstrating that to focus on workplace militancy and 'class conflict' is to miss the thrust of local developments, the thesis will argue that the tensions, hardships and uncertainties of the period stimulated social cohesion rather than class conflict. Secondly, the thesis will examine the nature of the communal identity that emerged during these years, and finally, will determine whether Barrow, as a result of the town's distinctive response to the post-war crisis, can be included among the 'Little Moscows'of the period. By examining these salient themes, the thesis provides fresh insights into the nature of social relationships and levels of class antagonism throughout the period, and makes a valuable contribution to the understanding of the impact of war and depression, and the social dynamics of distress.

No description available.

This thesis examines a suspected demographic crisis in Lancashire in the latter years of the 1720s utilising evidence from a wide selection of parish registers and a number of contemporary accounts. Lancashire has proved to be an excellent county to study this crisis given its diverse topographic and economic characteristics, and a division of the county into four regions enhances the understanding of the incidence of crisis. Previously this crisis had been unexplored in Lancashire, with the regional studies conducted in the midlands and to the east of the country. Glimpses of crisis were evident in the forewords of the transcriptions of the parish registers by the Lancashire Parish Register Society and from contemporary accounts. Thus a full study of the parish registers would enhance the knowledge of the crisis in Lancashire. During the undertaking of this study an article considering the experience of the Lancashire crisis was published, which has provided a number of suppositions which this study explores in greater detail. In considering the data provided by the parish registers, the study explores a number of observations; a subsistence caused by harvest failures and disease, with the countryside being greatly affected. That the experience of crisis was socially selective in which the older members of the community formed the majority of the burials and that the poor and vulnerable were hardest hit Consideration of the experience of crisis is best explored through the review of one community that recorded exceptionally high levels of modality and had not only detailed registers but a record of the poor accounts.

Vitamin D deficiency has been linked with many health problems. Early research demonstrated the importance of vitamin D for bone health, but it may also play a larger role than first reported in muscle health and function. Specifically, low vitamin D may hinder athletic performance, as such evaluation of serum vitamin D levels in high volume training athletes has merit. The purpose of this study was to evaluate serum levels of 25(OH)D in college athletes to determine how many had levels below the recommended values. Data from student-athletes who were attending a large university in the south included: serum vitamin D levels, demographics information, and injury reports. Mean serum vitamin D level for the group was 34.17 ng/mL ± 0.88. Average injury for the group was 1.3± 0.14. The mean value of serum vitamin D for Caucasian players was 38.3 ng/mL ± 1.33 with a range of 23-59 ng/mL. The mean value of serum vitamin D for African American players was 31.16 ng/mL ± 1.08 with a range of 16-52 ng/mL. African American players had significantly lower serum vitamin D levels (p<0.01) than Caucasian players. Players with one or more injury had significantly lower serum vitamin D values (p<0.05) than players who had zero injuries. Forty-eight players (44.4%) had insufficient levels of vitamin D (20-31.9ng/ml). 60 players (55.6%) had values within normal limits (>32 ng/ml). Players with one or more musculoskeletal injury or fracture had significantly lower serum vitamin D levels (p<0.05) compared to players that had zero injuries. African American players had significantly lower serum vitamin D levels (p<0.01) compared to Caucasian players. It is important for athletes to monitor serum vitamin D levels and adhere to a supplementation protocol when levels are insufficient. / text

No description available.