Global ETD Search

331	The role of CFP1 in maintaining liver homeostasis in a murine model Chittajallu, Nandita 09 June 2017 (has links) Indiana University-Purdue University Indianapolis (IUPUI) / CXXC finger protein 1 (CFP1) is an epigenetic regulator of H3K4 and cytosine methylation. Due to its role in establishing and maintaining methylation patterns, CFP1 determines whether DNA is found in its euchromatin or heterochromatin state and as such whether genes are transcriptionally active or inactive. In stem cells, deficiency of CFP1 results in inability to differentiate and in murine embryos it results in periimplantation death. Despite the demonstrated importance in developing tissue, the role of CFP1 in mature tissues, such as the liver, has yet to be elucidated. This study examined the role of CFP1 in maintaining liver homeostasis under conditions involving hepatocellular stress by examining liver regeneration, pregnancy-induced hepatomegaly, and non-alcoholic steatohepatitis (NASH) disease progression. The liver’s ability to recover was analyzed through liver:body mass ratios, blood serum analysis, liver histology, and qualitative observations. Deficiency of CFP1 in the livers of animals subjected to partial hepatectomies (PH) resulted in decreased liver regeneration capacity with liver mass restoration becoming significantly different starting at 48H post-PH and remaining so until 10D post-PH. This decreased regeneration appeared to be the result of reduced hepatocyte mitosis. Mouse dams lacking hepatic CFP1 mated with males expressing CFP1 displayed a proclivity for dystocia. Mice subjected to a fast food diet resulting in NASH while lacking hepatic CFP1 experienced decreased weight gain and hepatic lipid accumulation compared to their CFP1 expressing counterparts. Through these three studies, the critical role of CFP1 for the maintenance of liver homeostasis was demonstrated. epigenetics histone methylation DNA methylation CFP1 liver homeostasis liver regeneration maternal liver non-alcoholic steatohepatitis
332	Molecular mechanisms underlying environmental and epigenetic fruit ripening control in highbush blueberry / 環境制御とエピジェネティクス制御によるハイブッシュブルーベリー果実成熟促進の分子機構 LI, TAISHAN 24 September 2021 (has links) 京都大学 / 新制・課程博士 / 博士(農学) / 甲第23526号 / 農博第2473号 / 新制\|\|農\|\|1087(附属図書館) / 学位論文\|\|R3\|\|N5357(農学部図書室) / 京都大学大学院農学研究科農学専攻 / (主査)教授田尾龍太郎, 教授那須田周平, 教授中﨑鉄也 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DGAM abscic acid blueberry cluster ripening DNA methylation fruit ripening UV-B Vaccinium corymbosum 610
333	Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation / 制御性T細胞特異的遺伝子発現調節におけるエピゲノムと転写因子FOXP3の異なる役割 Morikawa, Hiromasa 25 November 2013 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第17951号 / 医博第3835号 / 新制\|\|医\|\|1000(附属図書館) / 30781 / 京都大学大学院医学研究科医学専攻 / (主査)教授河本宏, 教授生田宏一, 教授斎藤通紀 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM Regulatory T-cell epigenome DNA methylation FoxP3 Cap analysis of gene expression 490
334	Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis / 腸管腫瘍発生に先行する加齢関連遺伝子発現の同定 Okuchi, Yoshihisa 24 November 2016 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20055号 / 医博第4163号 / 新制\|\|医\|\|1018(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授山田泰広, 教授戸井雅和, 教授野田亮 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM aging intestinal tumorigenesis DNA methylation gene expression signature colorectal cancer 490
335	Forensic age prediction by use of methylation-sensitive high resolution melting / メチル化感受性高精度融解分析を用いた法医学的年齢推定 Hamano, Yuya 26 March 2018 (has links) 京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13162号 / 論医博第2149号 / 新制\|\|医\|\|1029(附属図書館) / (主査)教授武田俊一, 教授松田文彦, 教授清水章 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM age prediction DNA methylation high resolution melting CpG site forensic science 490
336	Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation / G9a/GLP複合体によりメチル化されたDNAリガーゼ１はUHRF1をDNA複製の場にリクルートしDNAメチル化を制御する Tsusaka, Takeshi 26 March 2018 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医科学) / 甲第21028号 / 医科博第89号 / 新制\|\|医科\|\|6(附属図書館) / 京都大学大学院医学研究科医科学専攻 / (主査)教授斎藤通紀, 教授浅野雅秀, 教授玉木敬二 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM Non-histone protein methylation DNA ligase 1 DNA methylation Replication UHRF1 G9a/GLP 491
337	Novel epigenetic markers for gastric cancer risk stratification in individuals after Helicobacter pylori eradication / ヘリコバクター・ピロリ菌除菌後健康人の胃発がんリスク層別化のための新規エピゲノムマーカー Maeda, Masahiro 23 July 2018 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第21299号 / 医博第4388号 / 新制\|\|医\|\|1030(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授妹尾浩, 教授中川一路, 教授川上浩司 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM Gastric cancer Cancer risk diagnosis Epigenetics DNA methylation Helicobacter pylori 490
338	Genome-wide studies of DNA and RNA with modifications through high-throughput sequencing analysis Moreland, Blythe S. January 2018 (has links) No description available. Physics Biophysics High-throughput sequencing Methyl-CpG binding domain proteins DNA methylation Thg1 Thg1-like proteins
339	Epigenetic Regulation of the Human Angiotensinogen by Single Nucleotide Polymorphisms Perla, Sravan K. January 2018 (has links) No description available. Biomedical Research Genetics Biology
340	Genome-wide Analysis of F1 Hybrids to Determine the Initiation of Epigenetic Silencing in Maize Yang, Diya 08 January 2021 (has links) No description available. Bioinformatics Biology Epigenetic silencing small RNAs RNA-directed DNA methylation maize F1 hybrid allele-specific loci

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